CA2410094A1 - Compositions et methodes destinees a la modulation de l'expression specifique des tumeurs - Google Patents
Compositions et methodes destinees a la modulation de l'expression specifique des tumeurs Download PDFInfo
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- CA2410094A1 CA2410094A1 CA002410094A CA2410094A CA2410094A1 CA 2410094 A1 CA2410094 A1 CA 2410094A1 CA 002410094 A CA002410094 A CA 002410094A CA 2410094 A CA2410094 A CA 2410094A CA 2410094 A1 CA2410094 A1 CA 2410094A1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La présente invention concerne des promoteurs, des activateurs et autres éléments régulateurs qui régissent l'expression à l'intérieur des cellules tumorales, notamment les séquences nucléotidiques tirées de la région régulatrice 5' et leurs fragments transcriptionnellement actifs, qui régulent l'expression d'une protéine associée à l'hypernéphrome, MN-CA9. L'invention concerne, en particulier, des vecteurs d'expression, des cellules hôtes et des animaux transgéniques caractérisés en ce qu'ils comportent une région régulatrice de MN-CA9 capable de réguler l'expression d'un gène hétérologue, de surexprimer un gène endogène ou un inhibiteur de processus pathologique ou encore d'exprimer par <= knock out >= ungène spécifique considéré comme responsable du développement et/ou de la progression du cancer. L'invention concerne, en outre, des méthodes d'utilisation desdits vecteurs, cellules et animaux dans le cadre du criblage de molécules candidates agonistes et antagonistes intervenant dans le développement et/ou la progression du cancer. L'invention concerne enfin des compositions et des méthodes permettant de moduler l'expression de composés à l'intérieur des cellules tumorales et de cribler les composés modulant l'expression à l'intérieur des cellules tumorales, ainsi que des méthodes d'utilisation des molécules et composés identifiés par ces procédés de criblage dans le cadre de traitements thérapeutiques.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20790000P | 2000-05-25 | 2000-05-25 | |
| US60/207,900 | 2000-05-25 | ||
| PCT/US2001/016944 WO2001090306A2 (fr) | 2000-05-25 | 2001-05-24 | Compositions et methodes destinees a la modulation de l'expression specifique des tumeurs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2410094A1 true CA2410094A1 (fr) | 2001-11-29 |
Family
ID=22772429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002410094A Abandoned CA2410094A1 (fr) | 2000-05-25 | 2001-05-24 | Compositions et methodes destinees a la modulation de l'expression specifique des tumeurs |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1287362A4 (fr) |
| JP (1) | JP2004510406A (fr) |
| CN (1) | CN1447920A (fr) |
| AU (1) | AU2001268087A1 (fr) |
| CA (1) | CA2410094A1 (fr) |
| WO (1) | WO2001090306A2 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2788426T3 (es) * | 2014-06-16 | 2020-10-21 | Univ Johns Hopkins | Composiciones y métodos para la expresión de ARNs de guía de CRISPR utilizando el promotor de H1 |
| CN109609505A (zh) * | 2019-01-14 | 2019-04-12 | 中国科学院成都生物研究所 | 一种体内筛选的剪切rna的锤头状核酶 |
| KR20220056847A (ko) * | 2019-06-21 | 2022-05-06 | 커날 바이오로직스, 인크. | 조작된 종양선택적 단백질 발현 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5972353A (en) * | 1992-03-11 | 1999-10-26 | Institute Of Virology, Slovak Academy Of Sciences | MN proteins, polypeptides, fusion proteins and fusion polypeptides |
-
2001
- 2001-05-24 WO PCT/US2001/016944 patent/WO2001090306A2/fr not_active Ceased
- 2001-05-24 CA CA002410094A patent/CA2410094A1/fr not_active Abandoned
- 2001-05-24 AU AU2001268087A patent/AU2001268087A1/en not_active Abandoned
- 2001-05-24 EP EP01945989A patent/EP1287362A4/fr not_active Withdrawn
- 2001-05-24 CN CN01813165A patent/CN1447920A/zh active Pending
- 2001-05-24 JP JP2001587102A patent/JP2004510406A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001268087A1 (en) | 2001-12-03 |
| EP1287362A2 (fr) | 2003-03-05 |
| CN1447920A (zh) | 2003-10-08 |
| EP1287362A4 (fr) | 2004-05-12 |
| JP2004510406A (ja) | 2004-04-08 |
| WO2001090306A3 (fr) | 2002-04-04 |
| WO2001090306A2 (fr) | 2001-11-29 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20050524 |