CA2413451A1 - Techniques d'identification d'antagonistes specifiques de sous type de recepteurs gabab - Google Patents
Techniques d'identification d'antagonistes specifiques de sous type de recepteurs gabab Download PDFInfo
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- 150000003568 thioethers Chemical class 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 230000010474 transient expression Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 239000003656 tris buffered saline Substances 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000010865 video microscopy Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
- G01N33/9426—GABA, i.e. gamma-amino-butyrate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des techniques d'identification de substances qui sont des agonistes des récepteurs GABA¿B? et qui sont des hétéromères des sous unités gb1 et gb2 ou des sous unités gb1c et gb2. Ces substances conviennent pour le traitement d'une variété de pathologies, par exemple l'épilepsie et certains syndromes de la douleur.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21242600P | 2000-06-19 | 2000-06-19 | |
| US60/212,426 | 2000-06-19 | ||
| US28596901P | 2001-04-24 | 2001-04-24 | |
| US60/285,969 | 2001-04-24 | ||
| PCT/CA2001/000909 WO2001098779A2 (fr) | 2000-06-19 | 2001-06-19 | Techniques d'identification d'antagonistes specifiques de sous type de recepteurs gabab |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2413451A1 true CA2413451A1 (fr) | 2001-12-27 |
Family
ID=26907127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002413451A Abandoned CA2413451A1 (fr) | 2000-06-19 | 2001-06-19 | Techniques d'identification d'antagonistes specifiques de sous type de recepteurs gabab |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1297341A2 (fr) |
| JP (1) | JP2004501375A (fr) |
| CA (1) | CA2413451A1 (fr) |
| WO (1) | WO2001098779A2 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1423168T3 (da) | 2001-09-03 | 2006-05-15 | Newron Pharm Spa | Farmaceutisk præparat omfattende gabapentin eller en analog deraf og et alfa-aminoamid og dets analgetiske anvendelse |
| US7473548B2 (en) | 2003-04-25 | 2009-01-06 | Medtronic, Inc. | Optical detector for enzyme activation |
| CN1849336A (zh) * | 2003-09-12 | 2006-10-18 | 詹森药业有限公司 | 嵌合gabab受体 |
| EP1963280B1 (fr) | 2005-12-22 | 2015-10-28 | Newron Pharmaceuticals S.p.A. | Dérivés 2-phényléthylamino comme modulateurs des canaux de calcium et/ou sodium |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000014222A2 (fr) * | 1998-09-07 | 2000-03-16 | Glaxo Group Limited | Sous-types gabab-r1c et gabab-r2 du recepteur gabab et leurs heterodimeres |
| EP1188056A1 (fr) * | 1999-06-01 | 2002-03-20 | Merck Frosst Canada & Co. | Utilisation de gabapentine dans des analyses destinees a identifier des effecteurs du recepteur gabab |
-
2001
- 2001-06-19 CA CA002413451A patent/CA2413451A1/fr not_active Abandoned
- 2001-06-19 JP JP2002504488A patent/JP2004501375A/ja not_active Withdrawn
- 2001-06-19 EP EP01949137A patent/EP1297341A2/fr not_active Withdrawn
- 2001-06-19 WO PCT/CA2001/000909 patent/WO2001098779A2/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1297341A2 (fr) | 2003-04-02 |
| JP2004501375A (ja) | 2004-01-15 |
| WO2001098779A3 (fr) | 2002-12-12 |
| WO2001098779A2 (fr) | 2001-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |