CA2413596A1 - Lignees cellulaires et dosages a base de cellules permettant d'identifier des modulateurs de recepteurs d'androgenes - Google Patents
Lignees cellulaires et dosages a base de cellules permettant d'identifier des modulateurs de recepteurs d'androgenes Download PDFInfo
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- CA2413596A1 CA2413596A1 CA002413596A CA2413596A CA2413596A1 CA 2413596 A1 CA2413596 A1 CA 2413596A1 CA 002413596 A CA002413596 A CA 002413596A CA 2413596 A CA2413596 A CA 2413596A CA 2413596 A1 CA2413596 A1 CA 2413596A1
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- 210000002536 stromal cell Anatomy 0.000 description 1
- 230000002739 subcortical effect Effects 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000003151 transfection method Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000003146 transient transfection Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
L'invention concerne des lignées cellulaires musculaires stables comprenant un récepteur androgène, et des méthodes d'utilisation de ces cellules dans des dosages de transactivation fonctionnelle permettant d'évaluer l'efficacité de composés comme modulateurs de récepteurs androgènes dans un échantillon de contrôle musculaire.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21439200P | 2000-06-28 | 2000-06-28 | |
| US60/214,392 | 2000-06-28 | ||
| PCT/US2001/019609 WO2002000716A2 (fr) | 2000-06-28 | 2001-06-20 | Lignees cellulaires et dosages a base de cellules permettant d'identifier des modulateurs de recepteurs d'androgenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2413596A1 true CA2413596A1 (fr) | 2002-01-03 |
Family
ID=26680504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002413596A Abandoned CA2413596A1 (fr) | 2000-06-28 | 2001-06-20 | Lignees cellulaires et dosages a base de cellules permettant d'identifier des modulateurs de recepteurs d'androgenes |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1297108A2 (fr) |
| JP (1) | JP2004517606A (fr) |
| AU (1) | AU2001267008A1 (fr) |
| CA (1) | CA2413596A1 (fr) |
| MX (1) | MXPA02012573A (fr) |
| WO (1) | WO2002000716A2 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0303172A3 (en) | 2000-06-28 | 2006-05-29 | Bristol Myers Squibb Co | Selective androgen receptor modulators and methods for their identification, desing and use |
| EP1359160A1 (fr) * | 2002-02-28 | 2003-11-05 | Pfizer Products Inc. | Myoblastes squelettiques, qui surexpriment un récepteur androgène |
| AU2003251931B2 (en) * | 2002-07-17 | 2008-03-06 | Bristol-Myers Squibb Company | Transgenic non-human mammals expressing a reporter nucleic acid under the regulation of androgen response elements |
| WO2009136629A1 (fr) * | 2008-05-09 | 2009-11-12 | あすか製薬株式会社 | Agent prophylactique/thérapeutique pour des maladies liées au mode de vie |
| US9175291B2 (en) | 2012-10-11 | 2015-11-03 | Isis Pharmaceuticals Inc. | Modulation of androgen receptor expression |
| CN105758916B (zh) * | 2016-03-16 | 2018-04-13 | 济南大学 | 一种基于电化学发光激发的溴氰菊酯光电化学传感器的制备方法及应用 |
| CN115181748A (zh) * | 2022-08-08 | 2022-10-14 | 湖州师范学院 | 一种雄性激素的生物学检测方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5071773A (en) * | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
| US6492137B1 (en) * | 1989-11-16 | 2002-12-10 | The Salk Institute For Biological Studies | Response element compositions and assays employing same |
| JPH11506722A (ja) * | 1995-06-07 | 1999-06-15 | ベイラー・カレッジ・オブ・メディスン | 細胞に核酸を送達するための核酸運搬体 |
| DE69932712T2 (de) * | 1998-04-23 | 2007-09-06 | Duke University | Vorhersage über die rezeptor-modulierende wirkung von verbindungen |
-
2001
- 2001-06-20 EP EP01944616A patent/EP1297108A2/fr not_active Withdrawn
- 2001-06-20 WO PCT/US2001/019609 patent/WO2002000716A2/fr not_active Ceased
- 2001-06-20 AU AU2001267008A patent/AU2001267008A1/en not_active Abandoned
- 2001-06-20 CA CA002413596A patent/CA2413596A1/fr not_active Abandoned
- 2001-06-20 MX MXPA02012573A patent/MXPA02012573A/es unknown
- 2001-06-20 JP JP2002505838A patent/JP2004517606A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1297108A2 (fr) | 2003-04-02 |
| MXPA02012573A (es) | 2003-05-14 |
| AU2001267008A1 (en) | 2002-01-08 |
| WO2002000716A3 (fr) | 2002-06-13 |
| JP2004517606A (ja) | 2004-06-17 |
| WO2002000716A2 (fr) | 2002-01-03 |
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