CA2416207C - Procede electrochimique pour mesurer des vitesses de reactions chimiques - Google Patents
Procede electrochimique pour mesurer des vitesses de reactions chimiques Download PDFInfo
- Publication number
- CA2416207C CA2416207C CA2416207A CA2416207A CA2416207C CA 2416207 C CA2416207 C CA 2416207C CA 2416207 A CA2416207 A CA 2416207A CA 2416207 A CA2416207 A CA 2416207A CA 2416207 C CA2416207 C CA 2416207C
- Authority
- CA
- Canada
- Prior art keywords
- working electrode
- reagent
- electrode
- electrochemical cell
- counter electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 91
- 238000002848 electrochemical method Methods 0.000 title description 4
- 238000000034 method Methods 0.000 claims abstract description 91
- 238000005259 measurement Methods 0.000 claims abstract description 7
- 239000003153 chemical reaction reagent Substances 0.000 claims description 70
- 230000001419 dependent effect Effects 0.000 claims description 39
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 claims description 38
- 239000007788 liquid Substances 0.000 claims description 33
- 210000004369 blood Anatomy 0.000 claims description 25
- 239000008280 blood Substances 0.000 claims description 25
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 24
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 23
- 239000008103 glucose Substances 0.000 claims description 23
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 22
- 229910052799 carbon Inorganic materials 0.000 claims description 22
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 22
- XOLBLPGZBRYERU-UHFFFAOYSA-N tin dioxide Chemical compound O=[Sn]=O XOLBLPGZBRYERU-UHFFFAOYSA-N 0.000 claims description 22
- 229910001887 tin oxide Inorganic materials 0.000 claims description 22
- 238000003487 electrochemical reaction Methods 0.000 claims description 17
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 16
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 16
- 229910052709 silver Inorganic materials 0.000 claims description 16
- 239000004332 silver Substances 0.000 claims description 16
- 238000009792 diffusion process Methods 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 14
- 230000008859 change Effects 0.000 claims description 13
- YAGKRVSRTSUGEY-UHFFFAOYSA-N ferricyanide Chemical compound [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 claims description 13
- 229910003437 indium oxide Inorganic materials 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 13
- 229910052763 palladium Inorganic materials 0.000 claims description 12
- 239000011230 binding agent Substances 0.000 claims description 11
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims description 11
- PJXISJQVUVHSOJ-UHFFFAOYSA-N indium(iii) oxide Chemical compound [O-2].[O-2].[O-2].[In+3].[In+3] PJXISJQVUVHSOJ-UHFFFAOYSA-N 0.000 claims description 11
- 229910052741 iridium Inorganic materials 0.000 claims description 11
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 claims description 11
- 229910052697 platinum Inorganic materials 0.000 claims description 11
- 238000012546 transfer Methods 0.000 claims description 11
- 108090000790 Enzymes Proteins 0.000 claims description 9
- 102000004190 Enzymes Human genes 0.000 claims description 9
- 229940088598 enzyme Drugs 0.000 claims description 9
- 229910052738 indium Inorganic materials 0.000 claims description 9
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 8
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 8
- 229910000831 Steel Inorganic materials 0.000 claims description 8
- 239000011651 chromium Substances 0.000 claims description 8
- 229910052804 chromium Inorganic materials 0.000 claims description 8
- 229910052802 copper Inorganic materials 0.000 claims description 8
- 239000010949 copper Substances 0.000 claims description 8
- 230000003100 immobilizing effect Effects 0.000 claims description 8
- 229910052759 nickel Inorganic materials 0.000 claims description 8
- 239000010935 stainless steel Substances 0.000 claims description 8
- 229910001220 stainless steel Inorganic materials 0.000 claims description 8
- 239000010959 steel Substances 0.000 claims description 8
- -1 silver ferricyanide Chemical compound 0.000 claims description 7
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 claims description 6
- 108010015776 Glucose oxidase Proteins 0.000 claims description 5
- 239000004366 Glucose oxidase Substances 0.000 claims description 5
- 229940116332 glucose oxidase Drugs 0.000 claims description 5
- 235000019420 glucose oxidase Nutrition 0.000 claims description 5
- 239000011159 matrix material Substances 0.000 claims description 5
- JKFYKCYQEWQPTM-UHFFFAOYSA-N 2-azaniumyl-2-(4-fluorophenyl)acetate Chemical compound OC(=O)C(N)C1=CC=C(F)C=C1 JKFYKCYQEWQPTM-UHFFFAOYSA-N 0.000 claims description 4
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims description 4
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims description 4
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical compound N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 claims description 4
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims description 4
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims description 4
- 229910021607 Silver chloride Inorganic materials 0.000 claims description 4
- 229910021612 Silver iodide Inorganic materials 0.000 claims description 4
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 claims description 4
- 239000012965 benzophenone Substances 0.000 claims description 4
- 150000002907 osmium Chemical class 0.000 claims description 4
- ADZWSOLPGZMUMY-UHFFFAOYSA-M silver bromide Chemical compound [Ag]Br ADZWSOLPGZMUMY-UHFFFAOYSA-M 0.000 claims description 4
- 229940045105 silver iodide Drugs 0.000 claims description 4
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims description 4
- 230000001747 exhibiting effect Effects 0.000 claims 2
- 239000000758 substrate Substances 0.000 abstract description 9
- 239000000376 reactant Substances 0.000 abstract description 7
- 239000012491 analyte Substances 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 4
- 239000007795 chemical reaction product Substances 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 description 38
- 241000894007 species Species 0.000 description 38
- 238000005534 hematocrit Methods 0.000 description 13
- 239000003963 antioxidant agent Substances 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 5
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 239000007800 oxidant agent Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- KURZCZMGELAPSV-UHFFFAOYSA-N [Br].[I] Chemical compound [Br].[I] KURZCZMGELAPSV-UHFFFAOYSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000003869 coulometry Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000011263 electroactive material Substances 0.000 description 1
- 230000005518 electrochemistry Effects 0.000 description 1
- 238000003411 electrode reaction Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/004—Enzyme electrodes mediator-assisted
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
- C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
La présente invention concerne la mesure de l'évolution d'une réaction chimique qui génère un produit réactionnel électroactif qui est ensuite détecté selon un procédé ampérométrique ou coulométrique, au niveau d'une électrode. Le procédé selon l'invention peut être mis en oeuvre quand on veut suivre l'évolution d'une réaction chimique, en particulier dans des applications de détection pour lesquelles l'évolution de la réaction d'un analyte peut être utile dans la détermination de la concentration d'analyte. Les capteurs utilisés dans de tels applications peuvent comprendre une électrode de travail (2) et une contre-électrode (3) placées sur un substrat (1) électro-isolant, et ils peuvent également comprendre un second substrat (5), sur lequel est déposée une couche de réactifs chimiques (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2733852A CA2733852A1 (fr) | 2000-07-14 | 2001-07-06 | Procede electrochimique pour mesurer des vitesses de reactions chimiques |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61643300A | 2000-07-14 | 2000-07-14 | |
| US09/616,512 US6632349B1 (en) | 1996-11-15 | 2000-07-14 | Hemoglobin sensor |
| US09/616,433 | 2000-07-14 | ||
| US09/615,691 US6638415B1 (en) | 1995-11-16 | 2000-07-14 | Antioxidant sensor |
| US09/615,691 | 2000-07-14 | ||
| US09/616,512 | 2000-07-14 | ||
| US09/616,556 | 2000-07-14 | ||
| US09/616,556 US6444115B1 (en) | 2000-07-14 | 2000-07-14 | Electrochemical method for measuring chemical reaction rates |
| PCT/US2001/021314 WO2002006788A2 (fr) | 2000-07-14 | 2001-07-06 | Procede electrochimique pour mesurer des vitesses de reactions chimiques |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2733852A Division CA2733852A1 (fr) | 2000-07-14 | 2001-07-06 | Procede electrochimique pour mesurer des vitesses de reactions chimiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2416207A1 CA2416207A1 (fr) | 2002-01-24 |
| CA2416207C true CA2416207C (fr) | 2011-08-30 |
Family
ID=27505127
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2416207A Expired - Lifetime CA2416207C (fr) | 2000-07-14 | 2001-07-06 | Procede electrochimique pour mesurer des vitesses de reactions chimiques |
| CA002416249A Abandoned CA2416249A1 (fr) | 2000-07-14 | 2001-07-12 | Detecteur d'antioxydant |
| CA002415342A Abandoned CA2415342A1 (fr) | 2000-07-14 | 2001-07-12 | Detecteur d'hemoglobine |
| CA2415602A Expired - Lifetime CA2415602C (fr) | 2000-07-14 | 2001-07-13 | Immunodetecteur |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002416249A Abandoned CA2416249A1 (fr) | 2000-07-14 | 2001-07-12 | Detecteur d'antioxydant |
| CA002415342A Abandoned CA2415342A1 (fr) | 2000-07-14 | 2001-07-12 | Detecteur d'hemoglobine |
| CA2415602A Expired - Lifetime CA2415602C (fr) | 2000-07-14 | 2001-07-13 | Immunodetecteur |
Country Status (18)
| Country | Link |
|---|---|
| EP (4) | EP1303758B1 (fr) |
| JP (3) | JP4948737B2 (fr) |
| KR (5) | KR20030038664A (fr) |
| CN (4) | CN1441902A (fr) |
| AR (1) | AR029723A1 (fr) |
| AT (1) | ATE349695T1 (fr) |
| AU (6) | AU7319701A (fr) |
| CA (4) | CA2416207C (fr) |
| CZ (2) | CZ2003409A3 (fr) |
| DE (1) | DE60125544T2 (fr) |
| ES (1) | ES2277933T3 (fr) |
| IL (4) | IL153583A0 (fr) |
| MX (2) | MXPA03000382A (fr) |
| NO (2) | NO20030017L (fr) |
| PL (2) | PL359335A1 (fr) |
| SG (2) | SG140463A1 (fr) |
| TW (1) | TWI238890B (fr) |
| WO (4) | WO2002006788A2 (fr) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8075760B2 (en) | 1995-06-19 | 2011-12-13 | Lifescan, Inc. | Electrochemical cell |
| US6413410B1 (en) | 1996-06-19 | 2002-07-02 | Lifescan, Inc. | Electrochemical cell |
| US6863801B2 (en) | 1995-11-16 | 2005-03-08 | Lifescan, Inc. | Electrochemical cell |
| AUPN661995A0 (en) | 1995-11-16 | 1995-12-07 | Memtec America Corporation | Electrochemical cell 2 |
| US9075004B2 (en) | 1996-06-19 | 2015-07-07 | Lifescan, Inc. | Electrochemical cell |
| AUPO581397A0 (en) | 1997-03-21 | 1997-04-17 | Memtec America Corporation | Sensor connection means |
| US6294281B1 (en) | 1998-06-17 | 2001-09-25 | Therasense, Inc. | Biological fuel cell and method |
| US7005273B2 (en) | 2001-05-16 | 2006-02-28 | Therasense, Inc. | Method for the determination of glycated hemoglobin |
| EP1442289A2 (fr) | 2001-10-10 | 2004-08-04 | Lifescan, Inc. | Cellule electrochimique |
| GB0130684D0 (en) | 2001-12-21 | 2002-02-06 | Oxford Biosensors Ltd | Micro-band electrode |
| US20030180814A1 (en) * | 2002-03-21 | 2003-09-25 | Alastair Hodges | Direct immunosensor assay |
| US20060134713A1 (en) * | 2002-03-21 | 2006-06-22 | Lifescan, Inc. | Biosensor apparatus and methods of use |
| US7368190B2 (en) | 2002-05-02 | 2008-05-06 | Abbott Diabetes Care Inc. | Miniature biological fuel cell that is operational under physiological conditions, and associated devices and methods |
| RU2235998C2 (ru) * | 2002-11-14 | 2004-09-10 | Уральский государственный экономический университет | Способ определения оксидантной/антиоксидантной активности растворов |
| US7473264B2 (en) | 2003-03-28 | 2009-01-06 | Lifescan, Inc. | Integrated lance and strip for analyte measurement |
| US20040193202A1 (en) | 2003-03-28 | 2004-09-30 | Allen John J. | Integrated lance and strip for analyte measurement |
| WO2004113903A1 (fr) | 2003-06-19 | 2004-12-29 | Arkray, Inc. | Instrument d'analyse a ouverture pratiquee dans un film isolant |
| US7999003B2 (en) * | 2003-08-26 | 2011-08-16 | Mannatech, Incorporated | Antioxidant compositions and methods thereto |
| US7723099B2 (en) * | 2003-09-10 | 2010-05-25 | Abbott Point Of Care Inc. | Immunoassay device with immuno-reference electrode |
| SG148163A1 (en) | 2003-11-06 | 2008-12-31 | Lifescan Inc | Drug delivery pen with event notification means |
| EP3059580A1 (fr) | 2004-05-21 | 2016-08-24 | Agamatrix, Inc. | Dispositif de cellules électrochimiques pour mesure électrochimique |
| US20050284773A1 (en) | 2004-06-29 | 2005-12-29 | Allen John J | Method of preventing reuse in an analyte measuring system |
| CN1323296C (zh) * | 2004-07-05 | 2007-06-27 | 江苏省肿瘤医院 | 硅烷交联壳聚糖膜基的流动注射化学发光免疫检测池及制备方法 |
| RU2384832C2 (ru) * | 2005-01-21 | 2010-03-20 | Михаил Евгеньевич Гиваргизов | Подложка для реализации метода комплексных действий с материалами, способ ее изготовления, способ изготовления материалов на подложке и устройства для работы с ней |
| CN1858613B (zh) * | 2005-05-08 | 2010-08-11 | 王宏栋 | 锂离子电池材料测试方法与测试装置 |
| TW200706650A (en) * | 2005-08-11 | 2007-02-16 | Toyo Boseki | A substrate specificity improved composition for glucose measurement |
| GB0524770D0 (en) * | 2005-12-03 | 2006-01-11 | Univ Bristol | A low cost water test device for use in developing countries in remote field conditions |
| ES2326286T3 (es) | 2005-12-19 | 2009-10-06 | F. Hoffmann-La Roche Ag | Sensor tipo sandwich para determinar la concentracion de un analito. |
| EP1797817A1 (fr) * | 2005-12-19 | 2007-06-20 | F.Hoffmann-La Roche Ag | Capteur de type sandwich pour la détermination de la concentration des analytes |
| US8409864B2 (en) * | 2006-01-06 | 2013-04-02 | Renal Solutions, Inc. | Ammonia sensor and system for use |
| CA2656133A1 (fr) * | 2006-07-03 | 2008-01-10 | Sebo Gmbh | Procede et dispositif pour le traitement d'un fluide biologique en vue de la detection d'un analyte |
| EP2074421B1 (fr) | 2006-10-12 | 2014-12-17 | Koninklijke Philips N.V. | Biocapteur rapide présentant une couche réactive |
| CN1975373B (zh) * | 2006-12-12 | 2010-11-10 | 西安交通大学 | 一种测定液固反应速率的装置及方法 |
| TWI516601B (zh) * | 2007-10-26 | 2016-01-11 | 環球生物醫療感測器私人有限公司 | 電化學檢測之裝置及方法 |
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