CA2425563A1 - Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence - Google Patents

Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence Download PDF

Info

Publication number: CA2425563A1
Authority: CA; Canada
Prior art keywords: denotes; dimethylamino; phen; iminoimidazolidine; methyl
Prior art date: 2000-10-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002425563A

Other languages

English (en)

French (fr)

Inventor

Franz Esser

Pascale Arielle Jane-Josee Pouzet

Hisato Kitagawa

Kenji Sakai

Ikunobu Muramatsu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Pharma GmbH and Co KG

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-14

Filing date

2001-10-11

Publication date

2002-04-25

2001-10-11 Application filed by Individual filed Critical Individual

2002-04-25 Publication of CA2425563A1 publication Critical patent/CA2425563A1/en

Status Abandoned legal-status Critical Current

Links

206010046543 Urinary incontinence Diseases 0.000 title claims abstract description 18
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229910052794 bromium Inorganic materials 0.000 claims abstract description 28
229910052731 fluorine Inorganic materials 0.000 claims abstract description 22
229910052801 chlorine Inorganic materials 0.000 claims abstract description 19
150000003839 salts Chemical class 0.000 claims abstract description 19
VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 claims abstract description 9
239000003814 drug Substances 0.000 claims abstract description 4
150000001875 compounds Chemical class 0.000 claims description 59
229910052739 hydrogen Inorganic materials 0.000 claims description 26
238000002360 preparation method Methods 0.000 claims description 8
238000000034 method Methods 0.000 claims description 4
206010066218 Stress Urinary Incontinence Diseases 0.000 claims description 3
201000010099 disease Diseases 0.000 claims description 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
208000022170 stress incontinence Diseases 0.000 claims description 3
DISXFZWKRTZTRI-UHFFFAOYSA-N 4,5-dihydro-1h-imidazol-2-amine Chemical compound NC1=NCCN1 DISXFZWKRTZTRI-UHFFFAOYSA-N 0.000 claims 1
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125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract description 6
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JJJNSPRIMJIECZ-UHFFFAOYSA-N n-(4-bromo-2-methyl-3-nitrophenyl)acetamide Chemical compound CC(=O)NC1=CC=C(Br)C([N+]([O-])=O)=C1C JJJNSPRIMJIECZ-UHFFFAOYSA-N 0.000 description 1
JCOPITWIWLFFPC-UHFFFAOYSA-N n-phenyl-4,5-dihydro-1h-imidazol-2-amine Chemical class N1CCN=C1NC1=CC=CC=C1 JCOPITWIWLFFPC-UHFFFAOYSA-N 0.000 description 1
YEPNQNIIERDOCM-UHFFFAOYSA-N n-phenylimidazol-2-imine Chemical class N1=CC=NC1=NC1=CC=CC=C1 YEPNQNIIERDOCM-UHFFFAOYSA-N 0.000 description 1
210000005036 nerve Anatomy 0.000 description 1
230000000422 nocturnal effect Effects 0.000 description 1
239000010502 orange oil Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
208000024449 overflow incontinence Diseases 0.000 description 1
230000036407 pain Effects 0.000 description 1
229920002866 paraformaldehyde Polymers 0.000 description 1
239000012071 phase Substances 0.000 description 1
SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 1
229960001802 phenylephrine Drugs 0.000 description 1
ULSIYEODSMZIPX-UHFFFAOYSA-N phenylethanolamine Chemical class NCC(O)C1=CC=CC=C1 ULSIYEODSMZIPX-UHFFFAOYSA-N 0.000 description 1
235000011007 phosphoric acid Nutrition 0.000 description 1
230000008092 positive effect Effects 0.000 description 1
ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 1
230000035935 pregnancy Effects 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000011514 reflex Effects 0.000 description 1
238000010992 reflux Methods 0.000 description 1
239000000243 solution Substances 0.000 description 1
230000002557 soporific effect Effects 0.000 description 1
210000005070 sphincter Anatomy 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
231100000167 toxic agent Toxicity 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
210000000626 ureter Anatomy 0.000 description 1
206010046494 urge incontinence Diseases 0.000 description 1
210000001635 urinary tract Anatomy 0.000 description 1
230000003313 weakening effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Urology & Nephrology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CA002425563A 2000-10-14 2001-10-11 Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence Abandoned CA2425563A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10051005.1		2000-10-14
DE10051005		2000-10-14
PCT/EP2001/011764 WO2002032876A2 (de)	2000-10-14	2001-10-11	Neue m-amino-phenylimino-imidazolidin-derivate zur behandlung der harninkontinenz

Publications (1)

Publication Number	Publication Date
CA2425563A1 true CA2425563A1 (en)	2002-04-25

Family

ID=7659815

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002425563A Abandoned CA2425563A1 (en)	2000-10-14	2001-10-11	Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence

Country Status (23)

Country	Link
EP (1)	EP1328517A2 (es)
JP (1)	JP2004511547A (es)
KR (1)	KR20030046503A (es)
CN (1)	CN1471514A (es)
AR (1)	AR035923A1 (es)
AU (1)	AU2002215943A1 (es)
BG (1)	BG107711A (es)
BR (1)	BR0114603A (es)
CA (1)	CA2425563A1 (es)
CZ (1)	CZ20031333A3 (es)
DE (1)	DE10150312A1 (es)
EA (1)	EA200300460A1 (es)
EC (1)	ECSP034517A (es)
EE (1)	EE200300177A (es)
HU (1)	HUP0302245A3 (es)
IL (1)	IL155338A0 (es)
MX (1)	MXPA03003162A (es)
NO (1)	NO20031697L (es)
PL (1)	PL361359A1 (es)
SK (1)	SK4342003A3 (es)
WO (1)	WO2002032876A2 (es)
YU (1)	YU28203A (es)
ZA (1)	ZA200302345B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4168086B1 (ja) *	2008-04-16	2008-10-22	国立大学法人福井大学	イミダゾリン誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2806811A1 (de) *	1978-02-17	1979-08-23	Boehringer Sohn Ingelheim	Neue substituierte 2-phenylimino- imidazolidine, deren saeureadditionssalze, diese enthaltene arzneimittel und verfahren zur herstellung derselben
CA1201066A (en) *	1981-11-20	1986-02-25	Alcon Laboratories, Inc.	N-¬3,5-dichloro-4-(2-imidazolidinylideneamino)- phenyl\|-acetamide solutions for lowering intraocular pressure
DE19514579A1 (de) *	1995-04-20	1996-10-24	Boehringer Ingelheim Kg	Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz

2001
- 2001-10-11 CA CA002425563A patent/CA2425563A1/en not_active Abandoned
- 2001-10-11 EP EP01987747A patent/EP1328517A2/de not_active Withdrawn
- 2001-10-11 PL PL01361359A patent/PL361359A1/xx not_active Application Discontinuation
- 2001-10-11 EE EEP200300177A patent/EE200300177A/xx unknown
- 2001-10-11 IL IL15533801A patent/IL155338A0/xx unknown
- 2001-10-11 KR KR10-2003-7005143A patent/KR20030046503A/ko not_active Withdrawn
- 2001-10-11 EA EA200300460A patent/EA200300460A1/ru unknown
- 2001-10-11 JP JP2002536060A patent/JP2004511547A/ja active Pending
- 2001-10-11 AU AU2002215943A patent/AU2002215943A1/en not_active Abandoned
- 2001-10-11 HU HU0302245A patent/HUP0302245A3/hu unknown
- 2001-10-11 CZ CZ20031333A patent/CZ20031333A3/cs unknown
- 2001-10-11 YU YU28203A patent/YU28203A/sh unknown
- 2001-10-11 MX MXPA03003162A patent/MXPA03003162A/es unknown
- 2001-10-11 BR BR0114603-3A patent/BR0114603A/pt not_active IP Right Cessation
- 2001-10-11 WO PCT/EP2001/011764 patent/WO2002032876A2/de not_active Ceased
- 2001-10-11 DE DE10150312A patent/DE10150312A1/de not_active Withdrawn
- 2001-10-11 CN CNA018170870A patent/CN1471514A/zh active Pending
- 2001-10-11 SK SK434-2003A patent/SK4342003A3/sk not_active Application Discontinuation
- 2001-10-12 AR ARP010104787A patent/AR035923A1/es not_active Application Discontinuation
2003
- 2003-03-17 EC EC2003004517A patent/ECSP034517A/es unknown
- 2003-03-26 ZA ZA200302345A patent/ZA200302345B/en unknown
- 2003-04-08 BG BG107711A patent/BG107711A/xx unknown
- 2003-04-11 NO NO20031697A patent/NO20031697L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20030046503A (ko)	2003-06-12
EP1328517A2 (de)	2003-07-23
IL155338A0 (en)	2003-11-23
AR035923A1 (es)	2004-07-28
SK4342003A3 (en)	2003-10-07
MXPA03003162A (es)	2004-12-06
AU2002215943A1 (en)	2002-04-29
YU28203A (sh)	2006-05-25
BR0114603A (pt)	2003-10-14
EE200300177A (et)	2003-08-15
WO2002032876A2 (de)	2002-04-25
ECSP034517A (es)	2003-04-25
CN1471514A (zh)	2004-01-28
EA200300460A1 (ru)	2004-02-26
HUP0302245A2 (hu)	2003-10-28
PL361359A1 (en)	2004-10-04
CZ20031333A3 (cs)	2003-08-13
NO20031697L (no)	2003-05-26
BG107711A (bg)	2004-02-27
JP2004511547A (ja)	2004-04-15
NO20031697D0 (no)	2003-04-11
DE10150312A1 (de)	2002-07-04
HUP0302245A3 (en)	2004-01-28
ZA200302345B (en)	2004-04-23
WO2002032876A3 (de)	2002-07-18

Legal Events

Date	Code	Title	Description
2003-11-19	EEER	Examination request
2009-10-13	FZDE	Discontinued

Publication	Publication Date	Title
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CA2425563A1 (en)	2002-04-25	Novel m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence
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US20020169193A1 (en)	2002-11-14	Alkylphenyliminoimidazolidine derivatives for treating urinary incontinence
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