CA2428018A1 - Promedicaments tetrapartates - Google Patents
Promedicaments tetrapartates Download PDFInfo
- Publication number
- CA2428018A1 CA2428018A1 CA002428018A CA2428018A CA2428018A1 CA 2428018 A1 CA2428018 A1 CA 2428018A1 CA 002428018 A CA002428018 A CA 002428018A CA 2428018 A CA2428018 A CA 2428018A CA 2428018 A1 CA2428018 A1 CA 2428018A1
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- Prior art keywords
- compound
- substituted
- group
- moiety
- alkyls
- Prior art date
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- Abandoned
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- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyethers (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'invention concerne un composé de la formule I donnant des promédicaments tétrapartates. L¿1? représente un groupe de liaison bi-fonctionnel; D représente un groupe fonctionnel qui est un groupe partant, ou un résidu d'un composé à administrer dans une cellule; Z est lié de manière covalente à [D]¿y?, Z étant choisi dans le groupe formé d'un groupe fonctionnel activement transporté dans une cellule cible, d'un groupe fonctionnel hydrophobe et de leurs combinaisons; Y¿1?, Y¿2?, Y¿3? et Y¿4? représentent chacun indépendamment O, S, ou NR¿12?; R¿11? représente un résidu polymère mono- ou bivalent; R¿1?, R¿4?, R¿9?, R¿10? et R¿12? sont choisis indépendamment dans le groupe formé d'hydrogène, de C¿1-6? alkyles, de C¿3-12? alkyles ramifiés, de C¿3-8 ?cycloalkyles, de C¿1-6? alkyles substitués, de C¿3-8 ?cycloalkyles substitués, d'aryles, d'aryles substitués, d'aralkyles, de C¿1-6 ?hétéroalkyles et de C¿1-6 ?hétéroalkyles substitués; R¿2?, R¿3?, R¿5? et R¿6 ?sont choisis indépendamment dans le groupe formé d'hydrogène, de C¿1-6? alkyles, de C¿1-6? alcoxy, de phénoxy, de C¿1-8? hétéroalkyles, de C¿1-8? hétéroalcoxy, de C¿1-6? alkyles substitués, de C¿3-8? cycloalkyles, de C¿3-8? cycloalkyles substitués, d'aryles, d'aryles substitués, d'aralkyles, de halo-, de nitro- et cyano-, de carboxy-, de C¿1-6? carboxyalkyles et de C¿1-6? alkylcarbonyles; Ar représente un groupe fonctionnel qui, lorsqu'il intégré dans la formule (I), constitue un hydrocarbure aromatique multi-substitué ou un groupe hétérocyclique multi-substitué; (m), (r), (s), (t) et (u) représentent indépendamment zéro ou un; (p) représente zéro ou un entier positif; et (y) représente 1 ou 2. L'invention concerne également des procédés de préparation et d'utilisation de ces nouveaux promédicaments tétrapartates.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72851200A | 2000-12-01 | 2000-12-01 | |
| US09/728,512 | 2000-12-01 | ||
| US09/758,993 US6720306B2 (en) | 1997-12-17 | 2001-01-12 | Tetrapartate prodrugs |
| US09/758,993 | 2001-01-12 | ||
| PCT/US2001/045127 WO2002043663A2 (fr) | 2000-12-01 | 2001-11-30 | Promedicaments tetrapartates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2428018A1 true CA2428018A1 (fr) | 2002-06-06 |
Family
ID=27111706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002428018A Abandoned CA2428018A1 (fr) | 2000-12-01 | 2001-11-30 | Promedicaments tetrapartates |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1343494A4 (fr) |
| JP (1) | JP2004518776A (fr) |
| AU (1) | AU2002239405A1 (fr) |
| CA (1) | CA2428018A1 (fr) |
| WO (1) | WO2002043663A2 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6624142B2 (en) * | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
| WO2003095496A1 (fr) * | 2002-05-08 | 2003-11-20 | Medical Enzymes Ag | Reactifs protecteurs contenant des carbohydrates actifs destines a des modifications chimiques, et production et utilisation de ces reactifs |
| WO2005030835A1 (fr) * | 2003-09-25 | 2005-04-07 | Terumo Kabushiki Kaisha | Derives de polyethylene glycol et vecteurs de medicament contenant ces derives en tant que constituants membranaires |
| CN100415801C (zh) * | 2003-10-28 | 2008-09-03 | 北京键凯科技有限公司 | 聚乙二醇氨基酸n-内环羰酐活性衍生物及其药物键合物和凝胶 |
| CN100543063C (zh) * | 2006-04-03 | 2009-09-23 | 中国科学院过程工程研究所 | 氨基酸端基聚乙二醇及其制备方法 |
| MX2009002859A (es) * | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Enlazadores biodegradables a base de ester impedido para suministro de oligonucleotidos. |
| EP2063912A4 (fr) * | 2006-09-15 | 2010-07-28 | Enzon Pharmaceuticals Inc | Polyalkylène oxydes présentant des segments de liaison biodégradables à base d'ester encombré |
| DE102011118029A1 (de) | 2011-06-20 | 2012-12-20 | Universität Leipzig | Modifizierte antibiotische Peptide mit variabler systemischer Freisetzung |
| KR20150086308A (ko) * | 2012-11-12 | 2015-07-27 | 이그니타, 인코포레이티드 | 벤다무스틴 유도체 및 그의 사용 방법 |
| EP3054981B1 (fr) | 2013-10-08 | 2020-07-29 | Ascendis Pharma A/S | Groupe protecteur comprenant une étiquette de purification |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9501052D0 (en) * | 1995-01-19 | 1995-03-08 | Cancer Res Campaign Tech | Improvements relating to prodrugs |
| PT751144E (pt) * | 1995-06-27 | 2004-12-31 | Pharmachemie Bv | Novos pro-farmacos antraciclinicos, metodo para preparacao e tambem a sua utilizacao em quimioterapia selectiva |
| WO1999030727A1 (fr) * | 1997-12-17 | 1999-06-24 | Enzon, Inc. | Prodrogues polymeriques d'agents bioactifs contenant amine ou hydroxy |
-
2001
- 2001-11-30 CA CA002428018A patent/CA2428018A1/fr not_active Abandoned
- 2001-11-30 AU AU2002239405A patent/AU2002239405A1/en not_active Abandoned
- 2001-11-30 WO PCT/US2001/045127 patent/WO2002043663A2/fr not_active Ceased
- 2001-11-30 JP JP2002545642A patent/JP2004518776A/ja active Pending
- 2001-11-30 EP EP01987164A patent/EP1343494A4/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002239405A1 (en) | 2002-06-11 |
| WO2002043663A3 (fr) | 2002-07-25 |
| WO2002043663A2 (fr) | 2002-06-06 |
| JP2004518776A (ja) | 2004-06-24 |
| EP1343494A4 (fr) | 2005-08-03 |
| EP1343494A2 (fr) | 2003-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |