CA2429007C - Sample introduction device for mass spectrometry using a fast fluidic system to synchronize multiple parallel liquid sample streams - Google Patents
Sample introduction device for mass spectrometry using a fast fluidic system to synchronize multiple parallel liquid sample streams Download PDFInfo
- Publication number
- CA2429007C CA2429007C CA002429007A CA2429007A CA2429007C CA 2429007 C CA2429007 C CA 2429007C CA 002429007 A CA002429007 A CA 002429007A CA 2429007 A CA2429007 A CA 2429007A CA 2429007 C CA2429007 C CA 2429007C
- Authority
- CA
- Canada
- Prior art keywords
- mass spectrometer
- introduction device
- sample
- valve
- sample introduction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007788 liquid Substances 0.000 title claims description 48
- 238000004949 mass spectrometry Methods 0.000 title claims description 6
- 239000012530 fluid Substances 0.000 claims abstract description 108
- 238000012546 transfer Methods 0.000 claims abstract description 56
- 238000000034 method Methods 0.000 claims description 35
- 239000007921 spray Substances 0.000 claims description 21
- 239000006199 nebulizer Substances 0.000 claims description 16
- 230000004044 response Effects 0.000 claims description 7
- 230000001360 synchronised effect Effects 0.000 claims description 5
- 230000005540 biological transmission Effects 0.000 claims description 4
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- 238000009834 vaporization Methods 0.000 claims description 3
- 238000004807 desolvation Methods 0.000 claims 2
- 239000000523 sample Substances 0.000 description 161
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 230000001351 cycling effect Effects 0.000 description 5
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- 238000001179 sorption measurement Methods 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 206010016803 Fluid overload Diseases 0.000 description 2
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
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- 238000011144 upstream manufacturing Methods 0.000 description 2
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- 238000012800 visualization Methods 0.000 description 2
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
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- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 150000005829 chemical entities Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000000132 electrospray ionisation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
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- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000000752 ionisation method Methods 0.000 description 1
- 230000003446 memory effect Effects 0.000 description 1
- 238000005459 micromachining Methods 0.000 description 1
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Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Electron Tubes For Measurement (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25361600P | 2000-11-28 | 2000-11-28 | |
| US60/253,616 | 2000-11-28 | ||
| US27006701P | 2001-02-20 | 2001-02-20 | |
| US60/270,067 | 2001-02-20 | ||
| PCT/CA2001/001673 WO2002044684A2 (en) | 2000-11-28 | 2001-11-28 | Sample introduction device for mass spectrometry using a fast fluidic system to synchronize multiple parallel liquid sample streams |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2429007A1 CA2429007A1 (en) | 2002-06-06 |
| CA2429007C true CA2429007C (en) | 2008-11-25 |
Family
ID=26943414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002429007A Expired - Fee Related CA2429007C (en) | 2000-11-28 | 2001-11-28 | Sample introduction device for mass spectrometry using a fast fluidic system to synchronize multiple parallel liquid sample streams |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1338026B1 (de) |
| JP (1) | JP3917938B2 (de) |
| AT (1) | ATE502391T1 (de) |
| AU (2) | AU2002223343B2 (de) |
| CA (1) | CA2429007C (de) |
| DE (1) | DE60144243D1 (de) |
| WO (1) | WO2002044684A2 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6812458B2 (en) | 2002-08-08 | 2004-11-02 | Nanostream, Inc. | Systems and methods for high-throughput microfluidic sample analysis |
| US7132650B1 (en) | 2003-09-26 | 2006-11-07 | Nanostream, Inc. | High throughput multi-dimensional sample analysis |
| US7214320B1 (en) | 2002-08-08 | 2007-05-08 | Nanostream, Inc. | Systems and methods for high throughput sample analysis |
| US6987263B2 (en) * | 2002-12-13 | 2006-01-17 | Nanostream, Inc. | High throughput systems and methods for parallel sample analysis |
| JP5695561B2 (ja) | 2008-05-27 | 2015-04-08 | パーキンエルマー・ヘルス・サイエンシーズ・インコーポレイテッドＰｅｒｋｉｎｅｌｍｅｒ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． | クロマトグラフィーシステムおよびそれを用いた方法 |
| AU2010228936B2 (en) | 2009-03-24 | 2015-07-09 | Perkinelmer U.S. Llc | Sorbent devices with longitudinal diffusion paths and methods of using them |
| US8388736B2 (en) | 2009-10-02 | 2013-03-05 | Perkinelmer Health Sciences, Inc. | Sorbent devices and methods of using them |
| AU2011267964B2 (en) | 2010-06-14 | 2015-07-09 | Perkinelmer U.S. Llc | Fluidic devices and methods of using them |
| EP2618913B1 (de) | 2010-09-22 | 2019-07-03 | PerkinElmer Health Sciences, Inc. | Rückspülungsverfahren und -vorrichtungen für chromatographiezwecke |
| US10111651B2 (en) | 2012-11-02 | 2018-10-30 | Coloplast A/S | System and method of anchoring support material to tissue |
| US9241779B2 (en) | 2012-11-02 | 2016-01-26 | Coloplast A/S | Male incontinence treatment system |
| US9522000B2 (en) | 2013-11-08 | 2016-12-20 | Coloplast A/S | System and a method for surgical suture fixation |
| JP6362161B2 (ja) * | 2014-05-27 | 2018-07-25 | 国立大学法人 名古屋工業大学 | 質量分析装置 |
| EP3317434A4 (de) | 2015-06-30 | 2018-06-06 | PerkinElmer Health Sciences, Inc. | Chromatographiesysteme mit mobilen phasengeneratoren |
| WO2017046849A1 (ja) * | 2015-09-14 | 2017-03-23 | 株式会社日立ハイテクノロジーズ | 質量分析装置 |
| GB2572671B (en) | 2019-02-01 | 2021-09-22 | Agilent Technologies Inc | Interface device between sample separation device and mass spectrometer having multiple sample capillaries |
| US20220250102A1 (en) * | 2019-07-31 | 2022-08-11 | National Institute Of Advanced Industrial Science And Technology | Spray ionization device, analysis device, and surface coating device |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0169469A3 (de) * | 1984-07-27 | 1987-10-14 | BASF Corporation | Analysegerät |
| US5872010A (en) * | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
| US6054047A (en) * | 1998-03-27 | 2000-04-25 | Synsorb Biotech, Inc. | Apparatus for screening compound libraries |
| US6066848A (en) * | 1998-06-09 | 2000-05-23 | Combichem, Inc. | Parallel fluid electrospray mass spectrometer |
-
2001
- 2001-11-28 AT AT01998807T patent/ATE502391T1/de not_active IP Right Cessation
- 2001-11-28 JP JP2002546183A patent/JP3917938B2/ja not_active Expired - Fee Related
- 2001-11-28 AU AU2002223343A patent/AU2002223343B2/en not_active Ceased
- 2001-11-28 DE DE60144243T patent/DE60144243D1/de not_active Expired - Lifetime
- 2001-11-28 CA CA002429007A patent/CA2429007C/en not_active Expired - Fee Related
- 2001-11-28 EP EP01998807A patent/EP1338026B1/de not_active Expired - Lifetime
- 2001-11-28 WO PCT/CA2001/001673 patent/WO2002044684A2/en not_active Ceased
- 2001-11-28 AU AU2334302A patent/AU2334302A/xx active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2429007A1 (en) | 2002-06-06 |
| AU2334302A (en) | 2002-06-11 |
| EP1338026A2 (de) | 2003-08-27 |
| JP3917938B2 (ja) | 2007-05-23 |
| ATE502391T1 (de) | 2011-04-15 |
| WO2002044684A2 (en) | 2002-06-06 |
| EP1338026B1 (de) | 2011-03-16 |
| AU2002223343B2 (en) | 2007-01-18 |
| JP2004525483A (ja) | 2004-08-19 |
| DE60144243D1 (de) | 2011-04-28 |
| WO2002044684A3 (en) | 2003-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20171128 |