CA2431002A1 - Zinc containing dentifrice of reduced astringency - Google Patents

Zinc containing dentifrice of reduced astringency Download PDF

Info

Publication number: CA2431002A1
Authority: CA; Canada
Prior art keywords: composition; zinc; pyrophosphate; salt; weight
Prior art date: 2000-12-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002431002A

Other languages

English (en)

French (fr)

Inventor

Diego A. Hoic

Michael Prencipe

Bernie Blackwell

James R. Brown

Mahmoud Hassan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Colgate Palmolive Co

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-05

Filing date

2001-12-04

Publication date

2002-06-13

2001-12-04 Application filed by Individual filed Critical Individual

2002-06-13 Publication of CA2431002A1 publication Critical patent/CA2431002A1/en

Status Abandoned legal-status Critical Current

Links

235000019606 astringent taste Nutrition 0.000 title claims abstract description 20
239000011701 zinc Substances 0.000 title claims abstract description 16
229910052725 zinc Inorganic materials 0.000 title claims abstract description 16
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title claims abstract description 15
239000000551 dentifrice Substances 0.000 title description 18
239000000203 mixture Substances 0.000 claims abstract description 50
XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims abstract description 20
150000003751 zinc Chemical class 0.000 claims abstract description 18
229920000642 polymer Polymers 0.000 claims abstract description 16
125000000129 anionic group Chemical group 0.000 claims abstract description 15
229920005646 polycarboxylate Polymers 0.000 claims abstract description 15
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
239000003906 humectant Substances 0.000 claims description 8
229920001577 copolymer Polymers 0.000 claims description 7
WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical group [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 6
239000011746 zinc citrate Substances 0.000 claims description 6
235000006076 zinc citrate Nutrition 0.000 claims description 6
229940068475 zinc citrate Drugs 0.000 claims description 6
235000011180 diphosphates Nutrition 0.000 claims description 5
FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical group [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 4
235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 4
QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical group C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 claims 2
RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 claims 2
239000000047 product Substances 0.000 description 10
239000004615 ingredient Substances 0.000 description 8
229920000388 Polyphosphate Polymers 0.000 description 6
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
239000000796 flavoring agent Substances 0.000 description 6
235000019634 flavors Nutrition 0.000 description 6
239000001205 polyphosphate Substances 0.000 description 6
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
-1 NaZP20~ Chemical class 0.000 description 5
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical group O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 5
235000011176 polyphosphates Nutrition 0.000 description 5
150000003839 salts Chemical class 0.000 description 5
239000004094 surface-active agent Substances 0.000 description 5
235000003599 food sweetener Nutrition 0.000 description 4
239000003765 sweetening agent Substances 0.000 description 4
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
239000003082 abrasive agent Substances 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
239000013078 crystal Substances 0.000 description 3
235000014113 dietary fatty acids Nutrition 0.000 description 3
239000000194 fatty acid Substances 0.000 description 3
229930195729 fatty acid Natural products 0.000 description 3
UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 3
229910052700 potassium Inorganic materials 0.000 description 3
239000011591 potassium Substances 0.000 description 3
239000000377 silicon dioxide Substances 0.000 description 3
239000002562 thickening agent Substances 0.000 description 3
LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 2
BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 2
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
229920006318 anionic polymer Polymers 0.000 description 2
239000001506 calcium phosphate Substances 0.000 description 2
235000010418 carrageenan Nutrition 0.000 description 2
239000000679 carrageenan Substances 0.000 description 2
229920001525 carrageenan Polymers 0.000 description 2
229940113118 carrageenan Drugs 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
150000004665 fatty acids Chemical class 0.000 description 2
239000000499 gel Substances 0.000 description 2
235000011187 glycerol Nutrition 0.000 description 2
235000019629 palatability Nutrition 0.000 description 2
239000000049 pigment Substances 0.000 description 2
239000004033 plastic Substances 0.000 description 2
229920003023 plastic Polymers 0.000 description 2
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000011734 sodium Substances 0.000 description 2
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
235000019333 sodium laurylsulphate Nutrition 0.000 description 2
235000019832 sodium triphosphate Nutrition 0.000 description 2
239000000600 sorbitol Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
239000004408 titanium dioxide Substances 0.000 description 2
239000003981 vehicle Substances 0.000 description 2
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 description 2
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
RPZANUYHRMRTTE-UHFFFAOYSA-N 2,3,4-trimethoxy-6-(methoxymethyl)-5-[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane;1-[[3,4,5-tris(2-hydroxybutoxy)-6-[4,5,6-tris(2-hydroxybutoxy)-2-(2-hydroxybutoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]butan-2-ol Chemical compound COC1C(OC)C(OC)C(COC)OC1OC1C(OC)C(OC)C(OC)OC1COC.CCC(O)COC1C(OCC(O)CC)C(OCC(O)CC)C(COCC(O)CC)OC1OC1C(OCC(O)CC)C(OCC(O)CC)C(OCC(O)CC)OC1COCC(O)CC RPZANUYHRMRTTE-UHFFFAOYSA-N 0.000 description 1
LFJJOPDNPVFCNZ-UHFFFAOYSA-N 2-[hexadecanoyl(methyl)amino]acetic acid Chemical class CCCCCCCCCCCCCCCC(=O)N(C)CC(O)=O LFJJOPDNPVFCNZ-UHFFFAOYSA-N 0.000 description 1
NGOZDSMNMIRDFP-UHFFFAOYSA-N 2-[methyl(tetradecanoyl)amino]acetic acid Chemical class CCCCCCCCCCCCCC(=O)N(C)CC(O)=O NGOZDSMNMIRDFP-UHFFFAOYSA-N 0.000 description 1
UBLAMKHIFZBBSS-UHFFFAOYSA-N 3-Methylbutyl pentanoate Chemical compound CCCCC(=O)OCCC(C)C UBLAMKHIFZBBSS-UHFFFAOYSA-N 0.000 description 1
MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
RFRMMZAKBNXNHE-UHFFFAOYSA-N 6-[4,6-dihydroxy-5-(2-hydroxyethoxy)-2-(hydroxymethyl)oxan-3-yl]oxy-2-(hydroxymethyl)-5-(2-hydroxypropoxy)oxane-3,4-diol Chemical compound CC(O)COC1C(O)C(O)C(CO)OC1OC1C(O)C(OCCO)C(O)OC1CO RFRMMZAKBNXNHE-UHFFFAOYSA-N 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
206010006326 Breath odour Diseases 0.000 description 1
241000206575 Chondrus crispus Species 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
208000002064 Dental Plaque Diseases 0.000 description 1
235000019739 Dicalciumphosphate Nutrition 0.000 description 1
RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 1
208000032139 Halitosis Diseases 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 description 1
229920002582 Polyethylene Glycol 600 Polymers 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
238000004220 aggregation Methods 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
150000008051 alkyl sulfates Chemical class 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
150000008064 anhydrides Chemical class 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
239000000440 bentonite Substances 0.000 description 1
229910000278 bentonite Inorganic materials 0.000 description 1
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 1
229940043256 calcium pyrophosphate Drugs 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
239000003086 colorant Substances 0.000 description 1
239000006071 cream Substances 0.000 description 1
239000002178 crystalline material Substances 0.000 description 1
229940023487 dental product Drugs 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
235000019821 dicalcium diphosphate Nutrition 0.000 description 1
NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
229940038472 dicalcium phosphate Drugs 0.000 description 1
LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 1
POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical class CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
239000000975 dye Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
150000004673 fluoride salts Chemical class 0.000 description 1
238000005187 foaming Methods 0.000 description 1
238000009472 formulation Methods 0.000 description 1
229940005740 hexametaphosphate Drugs 0.000 description 1
239000008240 homogeneous mixture Substances 0.000 description 1
229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
239000000463 material Substances 0.000 description 1
229940041616 menthol Drugs 0.000 description 1
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
244000005700 microbiome Species 0.000 description 1
239000000178 monomer Substances 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
239000013588 oral product Substances 0.000 description 1
229940023486 oral product Drugs 0.000 description 1
239000006072 paste Substances 0.000 description 1
238000005498 polishing Methods 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
229940099402 potassium metaphosphate Drugs 0.000 description 1
235000019828 potassium polyphosphate Nutrition 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
235000011151 potassium sulphates Nutrition 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
108700004121 sarkosyl Proteins 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
229960004029 silicic acid Drugs 0.000 description 1
239000002002 slurry Substances 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
239000011775 sodium fluoride Substances 0.000 description 1
235000013024 sodium fluoride Nutrition 0.000 description 1
235000019983 sodium metaphosphate Nutrition 0.000 description 1
235000019830 sodium polyphosphate Nutrition 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000000758 substrate Substances 0.000 description 1
AGGIJOLULBJGTQ-UHFFFAOYSA-N sulfoacetic acid Chemical class OC(=O)CS(O)(=O)=O AGGIJOLULBJGTQ-UHFFFAOYSA-N 0.000 description 1
150000003464 sulfur compounds Chemical class 0.000 description 1
235000019640 taste Nutrition 0.000 description 1
230000008719 thickening Effects 0.000 description 1
239000000606 toothpaste Substances 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
235000019731 tricalcium phosphate Nutrition 0.000 description 1
229940078499 tricalcium phosphate Drugs 0.000 description 1
150000004684 trihydrates Chemical class 0.000 description 1
UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
239000011592 zinc chloride Substances 0.000 description 1
235000005074 zinc chloride Nutrition 0.000 description 1
229960001939 zinc chloride Drugs 0.000 description 1
229940085658 zinc citrate trihydrate Drugs 0.000 description 1
229940077935 zinc phosphate Drugs 0.000 description 1
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
229960001763 zinc sulfate Drugs 0.000 description 1
229910000368 zinc sulfate Inorganic materials 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Birds (AREA)
Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cosmetics (AREA)
Medicinal Preparation (AREA)

CA002431002A 2000-12-05 2001-12-04 Zinc containing dentifrice of reduced astringency Abandoned CA2431002A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US73014300A	2000-12-05	2000-12-05
US09/730,143		2000-12-05
PCT/US2001/046895 WO2002045678A2 (en)	2000-12-05	2001-12-04	Zinc containing dentifrice of reduced astringency

Publications (1)

Publication Number	Publication Date
CA2431002A1 true CA2431002A1 (en)	2002-06-13

Family

ID=24934113

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002431002A Abandoned CA2431002A1 (en)	2000-12-05	2001-12-04	Zinc containing dentifrice of reduced astringency

Country Status (18)

Country	Link
EP (1)	EP1345581A2 (es)
JP (1)	JP2004517833A (es)
KR (1)	KR20030068166A (es)
CN (1)	CN1220479C (es)
AR (1)	AR031782A1 (es)
AU (1)	AU2002232507A1 (es)
BR (1)	BR0115949A (es)
CA (1)	CA2431002A1 (es)
CZ (1)	CZ20031836A3 (es)
EC (1)	ECSP034678A (es)
HU (1)	HUP0600590A2 (es)
MX (1)	MXPA03004922A (es)
PL (1)	PL361856A1 (es)
RU (1)	RU2259193C2 (es)
SK (1)	SK8642003A3 (es)
WO (1)	WO2002045678A2 (es)
YU (1)	YU44003A (es)
ZA (1)	ZA200304561B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG169990A1 (en)	2005-12-21	2011-04-29	Colgate Palmolive Co	Improved oral compositions comprising zinc citrate and/or tocopherol agents
US8628755B2 (en)	2007-01-30	2014-01-14	Colgate-Palmolive Company	Dentifrice containing zinc ions and polyphosphate ions
CA2753671C (en) *	2009-04-02	2014-11-18	Colgate-Palmolive Company	Dentifrice composition
TWI442937B (zh) *	2009-05-26	2014-07-01	美國棕欖公司	較高含量的含鋅薄膜
CN102596154B (zh)	2009-10-29	2014-12-24	高露洁-棕榄公司	包含氟化亚锡加柠檬酸锌和低水平水的洁齿剂
TWI554286B (zh) *	2010-01-29	2016-10-21	美國棕欖公司	用於敏感性琺瑯質照護之口腔照護產品（二）
SG182316A1 (en) *	2010-01-29	2012-08-30	Colgate Palmolive Co	Oral care product for sensitive enamel care
CN103260704B (zh) *	2010-11-04	2016-09-07	高露洁-棕榄公司	涩味降低的洁齿组合物
MX353686B (es)	2012-12-18	2018-01-24	Colgate Palmolive Co	Composiciones que contienen iones de metales estables.
CN106456461B (zh) *	2014-04-30	2020-03-06	高露洁-棕榄公司	含有二氧化硅和柠檬酸锌的口腔护理组合物
CN106255487B (zh) *	2014-05-14	2020-06-16	宝洁公司	具有改善的稳定性的口腔护理组合物
RU2726198C2 (ru)	2015-07-17	2020-07-09	Колгейт-Палмолив Компани	Композиции для ухода за полостью рта
MX375425B (es)	2015-11-13	2025-03-06	Procter & Gamble	Composiciones dentifricas con captacion de fluoruro mejorada
MX383491B (es) *	2015-11-13	2025-03-14	Procter & Gamble	Composiciones dentífricas con beneficios antisarro y antibacterianos.
CN117338605A (zh)	2015-11-13	2024-01-05	宝洁公司	具有双氟化物源与改善的氟化物摄取的洁齿剂组合物
MX366957B (es)	2015-11-13	2019-07-29	Procter & Gamble	Composiciones dentífricas con estabilidad mejorada del fluoruro.
CN109152719A (zh) *	2016-05-10	2019-01-04	高露洁-棕榄公司	藻酸盐洁牙剂组合物及其制备方法
CN106955244B (zh) *	2017-03-03	2019-09-24	广州薇美姿实业有限公司	一种遮盖不良口感的组合物及其在口腔护理产品中的应用
GB201811065D0 (en) *	2018-07-05	2018-08-22	GlaxoSmithKline Consumer Healthcare UK IP Ltd	Novel composition
BR112022017654A2 (pt)	2020-03-03	2022-10-18	Unilever Ip Holdings B V	Gel dentifrício aquoso sem álcool
CN112315827B (zh) *	2020-09-25	2023-02-28	好维股份有限公司	一种口腔护理组合物及应用
JP2022100677A (ja) *	2020-12-24	2022-07-06	ライオン株式会社	歯磨剤組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4138477A (en) *	1976-05-28	1979-02-06	Colgate Palmolive Company	Composition to control mouth odor
US5334375A (en) *	1988-12-29	1994-08-02	Colgate Palmolive Company	Antibacterial antiplaque oral composition
US5000944A (en) *	1989-06-09	1991-03-19	Colgate-Palmolive Company	Zinc-containing oral products with reduced astringency
HUT72042A (en) *	1992-12-18	1996-03-28	Procter & Gamble	Oral compositions containing antiplaque, anticalculus agents
US6169118B1 (en) *	1998-11-12	2001-01-02	Block Drug Company, Inc.	Flavor blend for masking unpleasant taste of zinc compounds

2001
- 2001-12-04 MX MXPA03004922A patent/MXPA03004922A/es not_active Application Discontinuation
- 2001-12-04 HU HU0600590A patent/HUP0600590A2/hu unknown
- 2001-12-04 CN CNB01820063XA patent/CN1220479C/zh not_active Expired - Fee Related
- 2001-12-04 AU AU2002232507A patent/AU2002232507A1/en not_active Abandoned
- 2001-12-04 RU RU2003120062/15A patent/RU2259193C2/ru not_active IP Right Cessation
- 2001-12-04 JP JP2002547464A patent/JP2004517833A/ja active Pending
- 2001-12-04 PL PL01361856A patent/PL361856A1/xx not_active Application Discontinuation
- 2001-12-04 EP EP01992031A patent/EP1345581A2/en not_active Withdrawn
- 2001-12-04 KR KR10-2003-7007402A patent/KR20030068166A/ko not_active Withdrawn
- 2001-12-04 WO PCT/US2001/046895 patent/WO2002045678A2/en not_active Ceased
- 2001-12-04 AR ARP010105634A patent/AR031782A1/es not_active Application Discontinuation
- 2001-12-04 YU YU44003A patent/YU44003A/sh unknown
- 2001-12-04 CZ CZ20031836A patent/CZ20031836A3/cs unknown
- 2001-12-04 CA CA002431002A patent/CA2431002A1/en not_active Abandoned
- 2001-12-04 SK SK864-2003A patent/SK8642003A3/sk unknown
- 2001-12-04 BR BR0115949-6A patent/BR0115949A/pt not_active IP Right Cessation
2003
- 2003-06-11 ZA ZA200304561A patent/ZA200304561B/en unknown
- 2003-06-27 EC EC2003004678A patent/ECSP034678A/es unknown

Also Published As

Publication number	Publication date
ECSP034678A (es)	2003-08-29
SK8642003A3 (en)	2003-12-02
YU44003A (sh)	2006-01-16
CN1479607A (zh)	2004-03-03
HUP0600590A2 (en)	2007-01-29
AR031782A1 (es)	2003-10-01
RU2259193C2 (ru)	2005-08-27
ZA200304561B (en)	2004-08-03
MXPA03004922A (es)	2003-09-10
JP2004517833A (ja)	2004-06-17
RU2003120062A (ru)	2005-02-10
WO2002045678A3 (en)	2003-01-16
PL361856A1 (en)	2004-10-04
AU2002232507A1 (en)	2002-06-18
KR20030068166A (ko)	2003-08-19
WO2002045678A2 (en)	2002-06-13
BR0115949A (pt)	2003-11-04
CZ20031836A3 (cs)	2003-11-12
CN1220479C (zh)	2005-09-28
EP1345581A2 (en)	2003-09-24

Legal Events

Date	Code	Title	Description
2006-09-01	EEER	Examination request
2008-12-04	FZDE	Discontinued

Publication	Publication Date	Title
CA2431002A1 (en)	2002-06-13	Zinc containing dentifrice of reduced astringency
CA2290615C (en)	2008-07-15	Desensitizing dentifrice having limited astringency
US5578293A (en)	1996-11-26	Oral compositions containing stabilized stannous compounds having antiplaque and antitartar efficacy
US5730959A (en)	1998-03-24	Storage stable aqueous dentifrice compositions having improved anticalculus properties
AU691681B2 (en)	1998-05-21	Dentifrice compositions containing reactive ingredients stabilized with alkali metal compounds
US5180576A (en)	1993-01-19	Anticalculus dentifrices
US5487906A (en)	1996-01-30	Method of forming stable aqueous solutions of stannous compounds
US5932192A (en)	1999-08-03	Lower astringent two component stannous and potassium salt containing dentifrice
US5456903A (en)	1995-10-10	Method of making a tartar control baking soda dentifrice
JP2002167318A (ja)	2002-06-11	固体口腔用組成物
US5885556A (en)	1999-03-23	Tartar control oral compositions
WO2023049279A1 (en)	2023-03-30	Oral care compositions comprising guanidine and stannous ion source and methods
JP7630247B2 (ja)	2025-02-17	歯磨剤組成物
MXPA97004415A (es)	1998-07-03	Formacion de soluciones acuosas estables decompuestos estannosos
HK1026844B (en)	2005-12-30	Desensitizing dentifrice having limited astringency
MXPA99010453A (es)	2000-09-04	Dentifrico desensibilizador que tiene una astringencia limitada