CA2432474C - Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie - Google Patents
Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie Download PDFInfo
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- CA2432474C CA2432474C CA2432474A CA2432474A CA2432474C CA 2432474 C CA2432474 C CA 2432474C CA 2432474 A CA2432474 A CA 2432474A CA 2432474 A CA2432474 A CA 2432474A CA 2432474 C CA2432474 C CA 2432474C
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- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
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Abstract
La présente invention concerne des fractions de fixation de la fibrine qui possèdent diverses utilisations, que ce soit dans la détection, dans l'isolation ou dans la localisation de la fibrine, et plus particulièrement la fibrine en tant qu'opposé au fibrinogène, est intéressante. Cette invention concerne particulièrement des polypeptides isolés synthétiques capables de se fixer à la fibrine et de reconnaître la forme de la fibrine polymérisée trouvée dans les thrombi. Par ailleurs, ces polypeptides possèdent une vitesse de dissociation des thrombi faible, ce qui améliore leur capacité de former une image de contraste au niveau d'un site de caillot de fibrine et rend ces fractions de fixation particulièrement utiles comme agents d'imagerie pour les thrombi.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74740300A | 2000-12-23 | 2000-12-23 | |
| US09/747,403 | 2000-12-23 | ||
| PCT/US2001/049534 WO2002055544A2 (fr) | 2000-12-23 | 2001-12-21 | Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2432474A1 CA2432474A1 (fr) | 2002-07-18 |
| CA2432474C true CA2432474C (fr) | 2012-06-26 |
Family
ID=25004908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2432474A Expired - Lifetime CA2432474C (fr) | 2000-12-23 | 2001-12-21 | Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1348026A2 (fr) |
| JP (1) | JP3991086B2 (fr) |
| AU (1) | AU2002248222B2 (fr) |
| CA (1) | CA2432474C (fr) |
| WO (1) | WO2002055544A2 (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003032866A2 (fr) * | 2001-10-16 | 2003-04-24 | Epix Medical, Inc. | Detection et traitement de lesions intravasculaires |
| KR20110086881A (ko) * | 2002-12-20 | 2011-08-01 | 암겐 인코포레이티드 | 미오스타틴을 저해하는 결합제 |
| WO2004069284A2 (fr) | 2003-02-04 | 2004-08-19 | Bracco International B.V. | Agents de contraste pour ultrasons et procede pour leur elaboration |
| WO2005029066A2 (fr) * | 2003-05-22 | 2005-03-31 | Agilent Technologies, Inc. | Marqueurs de diagnostic et cibles pharmacologiques utilises dans l'insuffisance cardiaque, et reactifs connexes et leurs procedes d'utilisation |
| JP5513708B2 (ja) | 2003-12-22 | 2014-06-04 | ブラッコ・シュイス・ソシエテ・アノニム | 造影イメージング用の気体封入マイクロベシクル・アセンブリー |
| EP2404899A1 (fr) * | 2004-02-25 | 2012-01-11 | Astellas Pharma Inc. | Moyen de contraste pour le dépistage de thrombi |
| ATE411006T1 (de) | 2004-06-03 | 2008-10-15 | Bracco Research Sa | Liposomale anordnung für die therapeutische und/oder diagnostische anwendung |
| US9248204B2 (en) | 2004-08-18 | 2016-02-02 | Bracco Suisse S.A. | Gas-filled microvesicles composition for contrast imaging |
| EP1714642A1 (fr) | 2005-04-18 | 2006-10-25 | Bracco Research S.A. | Formulation pharmaceutique comprenant des microcapsules remplies de gaz pour la délibération échographique |
| US8815804B2 (en) | 2006-02-06 | 2014-08-26 | Sanford-Burnham Medical Research Institute | Methods and compositions related to targeting tumors and wounds |
| US9446156B2 (en) | 2006-09-05 | 2016-09-20 | Bracco Suisse S.A. | Gas-filled microvesicles with polymer-modified lipids |
| EP2097438B1 (fr) * | 2006-12-11 | 2015-08-26 | Bracco Imaging S.p.A | Conjugues peptidiques se liant a la fibrine pour des applications de diagnostic et therapeutiques |
| WO2008075192A2 (fr) | 2006-12-19 | 2008-06-26 | Bracco International Bv | Composés de ciblage et composés thérapeutiques, et microvésicules remplies de gaz comprenant lesdits composés |
| JP2010514839A (ja) * | 2007-01-03 | 2010-05-06 | バーナム インスティテュート フォー メディカル リサーチ | クロット結合化合物に関連する方法および組成物 |
| IT1391546B1 (it) * | 2008-09-05 | 2012-01-11 | Univ Firenze | Complessi di manganese e cobalto, loro preparazione ed uso |
| US9192685B2 (en) | 2008-10-07 | 2015-11-24 | Bracco Suisse S.A. | Targeting construct comprising anti-polymer antibody and contrast/therapeutic agents binding to the same |
| KR101474063B1 (ko) | 2012-05-23 | 2014-12-19 | 동국대학교 산학협력단 | 피브린 표적 펩타이드 서열이 결합된 글라이콜 키토산-금 나노입자를 포함하는 혈전 탐지용 ｃｔ 조영제 |
| CN105026030B (zh) | 2012-12-21 | 2017-04-12 | 博莱科瑞士股份有限公司 | 充气微泡 |
| CN109127131A (zh) * | 2018-07-18 | 2019-01-04 | 沛县育龙粮油工贸有限公司 | 一种高效重金属污染大米的清洗方法 |
| US20200360289A1 (en) | 2019-05-15 | 2020-11-19 | Bracco Suisse Sa | Freeze-dried product and gas-filled microvesicles suspension |
| US11717570B2 (en) | 2019-05-15 | 2023-08-08 | Bracco Suisse Sa | Gas-filled microvesicles |
| MX2021005089A (es) * | 2021-04-30 | 2022-11-01 | Instituto Nac De Investigaciones Nucleares | Radiofarmacos basados en el acido ((r)-1-((6-hidrazinilnicotinoil) d-alanil)pirrolidin-2-il)boronico (hynic-ifap) para la deteccion de la sobreexpresion de la proteina de activacion de fibrolastos. |
| JP2023121104A (ja) * | 2022-02-18 | 2023-08-30 | コニカミノルタ株式会社 | 肺塞栓症診断支援装置、肺塞栓症診断支援方法及びプログラム |
| US12616436B2 (en) | 2022-02-18 | 2026-05-05 | Konica Minolta, Inc. | Pulmonary embolism diagnosis support apparatus, pulmonary embolism diagnosis support method, and storage medium |
| WO2025073838A1 (fr) | 2023-10-04 | 2025-04-10 | Bracco Suisse Sa | Procédé de lyophilisation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4219724A1 (de) | 1992-06-13 | 1993-12-16 | Schering Ag | Verwendung von Mikrokapseln als Kontrastmittel für die Farbdoppler-Sonographie |
| AU3695589A (en) * | 1988-06-03 | 1990-01-05 | Celltech Limited | Hybrid proteins |
| US5364612A (en) * | 1991-05-06 | 1994-11-15 | Immunomedics, Inc. | Detection of cardiovascular lesions |
| CA2376245A1 (fr) * | 1999-07-29 | 2001-02-08 | Dyax Corp. | Fractions se liant a la fibrine |
-
2001
- 2001-12-21 AU AU2002248222A patent/AU2002248222B2/en not_active Expired
- 2001-12-21 CA CA2432474A patent/CA2432474C/fr not_active Expired - Lifetime
- 2001-12-21 JP JP2002556612A patent/JP3991086B2/ja not_active Expired - Lifetime
- 2001-12-21 EP EP01997103A patent/EP1348026A2/fr not_active Withdrawn
- 2001-12-21 WO PCT/US2001/049534 patent/WO2002055544A2/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002055544A3 (fr) | 2003-03-27 |
| AU2002248222B2 (en) | 2006-04-27 |
| CA2432474A1 (fr) | 2002-07-18 |
| WO2002055544A2 (fr) | 2002-07-18 |
| JP3991086B2 (ja) | 2007-10-17 |
| JP2004523514A (ja) | 2004-08-05 |
| EP1348026A2 (fr) | 2003-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20211221 |