CA2437013A1 - Microscope u.v. transposant les couleurs - Google Patents
Microscope u.v. transposant les couleurs Download PDFInfo
- Publication number
- CA2437013A1 CA2437013A1 CA002437013A CA2437013A CA2437013A1 CA 2437013 A1 CA2437013 A1 CA 2437013A1 CA 002437013 A CA002437013 A CA 002437013A CA 2437013 A CA2437013 A CA 2437013A CA 2437013 A1 CA2437013 A1 CA 2437013A1
- Authority
- CA
- Canada
- Prior art keywords
- image
- light
- sample
- microscope
- illuminating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 claims abstract description 53
- 230000003287 optical effect Effects 0.000 claims abstract description 42
- 230000003595 spectral effect Effects 0.000 claims description 75
- 238000005286 illumination Methods 0.000 claims description 72
- 238000001914 filtration Methods 0.000 claims description 16
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 230000001351 cycling effect Effects 0.000 claims description 7
- 238000009416 shuttering Methods 0.000 claims description 3
- 238000013507 mapping Methods 0.000 claims 8
- 230000008878 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 238000005859 coupling reaction Methods 0.000 claims 3
- 238000003384 imaging method Methods 0.000 abstract description 27
- 230000033001 locomotion Effects 0.000 abstract description 21
- 230000008569 process Effects 0.000 abstract description 16
- 238000001069 Raman spectroscopy Methods 0.000 abstract description 10
- 230000001360 synchronised effect Effects 0.000 abstract description 10
- 238000013519 translation Methods 0.000 abstract description 7
- 238000011160 research Methods 0.000 abstract description 3
- 230000003068 static effect Effects 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 173
- 230000006870 function Effects 0.000 description 25
- 238000000386 microscopy Methods 0.000 description 22
- 238000010521 absorption reaction Methods 0.000 description 21
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 20
- 230000009102 absorption Effects 0.000 description 20
- 238000013461 design Methods 0.000 description 20
- 239000010453 quartz Substances 0.000 description 17
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 17
- 230000015572 biosynthetic process Effects 0.000 description 15
- 238000012545 processing Methods 0.000 description 15
- 239000000463 material Substances 0.000 description 13
- 230000008901 benefit Effects 0.000 description 12
- 238000001228 spectrum Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 8
- 229910052805 deuterium Inorganic materials 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 230000005540 biological transmission Effects 0.000 description 7
- 229910052736 halogen Inorganic materials 0.000 description 7
- 150000002367 halogens Chemical class 0.000 description 7
- 238000007654 immersion Methods 0.000 description 6
- PQXKHYXIUOZZFA-UHFFFAOYSA-M lithium fluoride Chemical compound [Li+].[F-] PQXKHYXIUOZZFA-UHFFFAOYSA-M 0.000 description 6
- 230000007935 neutral effect Effects 0.000 description 6
- 238000011045 prefiltration Methods 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 238000012546 transfer Methods 0.000 description 6
- 239000012472 biological sample Substances 0.000 description 5
- 239000006059 cover glass Substances 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 230000035945 sensitivity Effects 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 230000006399 behavior Effects 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 230000009977 dual effect Effects 0.000 description 4
- 239000000428 dust Substances 0.000 description 4
- 230000005684 electric field Effects 0.000 description 4
- 230000009931 harmful effect Effects 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 230000004304 visual acuity Effects 0.000 description 4
- 229910052724 xenon Inorganic materials 0.000 description 4
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 3
- 230000004075 alteration Effects 0.000 description 3
- 238000000701 chemical imaging Methods 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 229940039231 contrast media Drugs 0.000 description 3
- 239000002872 contrast media Substances 0.000 description 3
- 230000001627 detrimental effect Effects 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 230000010287 polarization Effects 0.000 description 3
- 229910052594 sapphire Inorganic materials 0.000 description 3
- 239000010980 sapphire Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 238000001429 visible spectrum Methods 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 238000003332 Raman imaging Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 2
- 229910001634 calcium fluoride Inorganic materials 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 238000013016 damping Methods 0.000 description 2
- 230000001066 destructive effect Effects 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000010408 film Substances 0.000 description 2
- 239000000834 fixative Substances 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005088 metallography Methods 0.000 description 2
- 238000001000 micrograph Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000008447 perception Effects 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000006798 recombination Effects 0.000 description 2
- 238000005215 recombination Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 2
- 229910052721 tungsten Inorganic materials 0.000 description 2
- 239000010937 tungsten Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 229910021532 Calcite Inorganic materials 0.000 description 1
- 229910001051 Magnalium Inorganic materials 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- -1 P20 must be used Chemical compound 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000002178 crystalline material Substances 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000002050 diffraction method Methods 0.000 description 1
- 238000004141 dimensional analysis Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000009189 diving Effects 0.000 description 1
- 238000004980 dosimetry Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000004313 glare Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 229910001004 magnetic alloy Inorganic materials 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000007620 mathematical function Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229910000595 mu-metal Inorganic materials 0.000 description 1
- 230000003534 oscillatory effect Effects 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000000063 preceeding effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011029 spinel Substances 0.000 description 1
- 229910052596 spinel Inorganic materials 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229910000859 α-Fe Inorganic materials 0.000 description 1
Landscapes
- Microscoopes, Condenser (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4185597P | 1997-04-09 | 1997-04-09 | |
| US60/041,855 | 1997-04-09 | ||
| US4424797P | 1997-04-23 | 1997-04-23 | |
| US60/044,247 | 1997-04-23 | ||
| US90019397A | 1997-07-25 | 1997-07-25 | |
| US08/900,193 | 1997-07-25 | ||
| CA002322800A CA2322800C (fr) | 1997-04-09 | 1998-04-09 | Microscope u.v. transposant les couleurs |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002322800A Division CA2322800C (fr) | 1997-04-09 | 1998-04-09 | Microscope u.v. transposant les couleurs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2437013A1 true CA2437013A1 (fr) | 1998-10-15 |
Family
ID=29219740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002437013A Abandoned CA2437013A1 (fr) | 1997-04-09 | 1998-04-09 | Microscope u.v. transposant les couleurs |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2437013A1 (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6865013B2 (en) | 2000-12-01 | 2005-03-08 | Auburn University | High-resolution optical microscope |
| US6992819B2 (en) | 2000-12-01 | 2006-01-31 | Auburn University | High-resolution optical microscope for quick detection of pathogens |
-
1998
- 1998-04-09 CA CA002437013A patent/CA2437013A1/fr not_active Abandoned
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6865013B2 (en) | 2000-12-01 | 2005-03-08 | Auburn University | High-resolution optical microscope |
| US6992819B2 (en) | 2000-12-01 | 2006-01-31 | Auburn University | High-resolution optical microscope for quick detection of pathogens |
| US7106503B2 (en) | 2000-12-01 | 2006-09-12 | Auburn University | High-resolution optical microscope |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6961080B2 (en) | Color translating UV microscope | |
| EP0978008B1 (fr) | Microscope u.v. de traduction de couleurs | |
| Treado et al. | High-fidelity Raman imaging spectrometry: a rapid method using an acousto-optic tunable filter | |
| DE69911030T2 (de) | Mikroskop mit umgewandeltem dunkelfeldkontrast und entsprechendes verfahren | |
| US8704196B2 (en) | Combination microscopy | |
| JP3324780B2 (ja) | 紫外線顕微鏡 | |
| US12411088B2 (en) | Optimized photon collection for light-sheet microscopy | |
| US6865013B2 (en) | High-resolution optical microscope | |
| US5233197A (en) | High speed digital imaging microscope | |
| EP0883829B1 (fr) | Microscope optique equipe de filtres acousto-optiques syntonisables | |
| US20150077842A1 (en) | High-resolution scanning microscopy | |
| JP2005331888A (ja) | 蛍光顕微鏡 | |
| EP1403675B1 (fr) | Microscope ultraviolet à décalage de couleur | |
| US10989903B2 (en) | Modular scanning confocal optical profile microscopy with digital imaging processing | |
| JPS6353443A (ja) | 高空間・時間分解計測装置 | |
| Salmon et al. | High resolution multimode digital imaging system for mitosis studies in vivo and in vitro | |
| JP2002098899A (ja) | 蛍光顕微鏡 | |
| Fuseler et al. | Types of confocal instruments: Basic principles and advantages and disadvantages | |
| CA2437013A1 (fr) | Microscope u.v. transposant les couleurs | |
| Benedetti et al. | Confocal‐line microscopy | |
| CA2365093C (fr) | Microscope a contraste fond noir inverse et methode afferente | |
| Beghuin et al. | Compact laser scanning confocal microscope | |
| Gao | Development of Image Mapping Spectrometer (IMS) for hyperspectral microscopy | |
| Heiden et al. | New epifluorescence microscope providing pairs of specific fluorescence images of double-stained cells for simultaneous visual perception and for quantification | |
| EP1684106A2 (fr) | Microscope optique haute résolution |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |