CA2438032C - Derives de benzothiazole et compositions et utilisations connexes - Google Patents

Derives de benzothiazole et compositions et utilisations connexes Download PDF

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Publication number
CA2438032C
CA2438032C CA2438032A CA2438032A CA2438032C CA 2438032 C CA2438032 C CA 2438032C CA 2438032 A CA2438032 A CA 2438032A CA 2438032 A CA2438032 A CA 2438032A CA 2438032 C CA2438032 C CA 2438032C
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CA
Canada
Prior art keywords
compound
brain
amyloid
minutes
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2438032A
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English (en)
Other versions
CA2438032A1 (fr
Inventor
William E. Klunk
Chester A. Mathis, Jr.
Yanming Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/388,173 external-priority patent/US7270800B2/en
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Priority to US10/645,847 priority Critical patent/US20050043523A1/en
Priority to CA2438032A priority patent/CA2438032C/fr
Priority claimed from US10/645,847 external-priority patent/US20050043523A1/en
Priority to PCT/US2004/007797 priority patent/WO2004083195A1/fr
Publication of CA2438032A1 publication Critical patent/CA2438032A1/fr
Application granted granted Critical
Publication of CA2438032C publication Critical patent/CA2438032C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention présente des composés dérivés de benzothiazole, les compositions comprenant de tels composés, des méthodes de préparation de tels composés et des méthodes d'utilisation de tels composés pour détecter les dépôts amyloïdes et diagnostiquer une maladie, un trouble ou un état caractérisés par des dépôts amyloïdes.
CA2438032A 2003-03-14 2003-08-22 Derives de benzothiazole et compositions et utilisations connexes Expired - Lifetime CA2438032C (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/645,847 US20050043523A1 (en) 2003-08-22 2003-08-22 Benzothiazole derivative compounds, compositions and uses
CA2438032A CA2438032C (fr) 2003-03-14 2003-08-22 Derives de benzothiazole et compositions et utilisations connexes
PCT/US2004/007797 WO2004083195A1 (fr) 2003-03-14 2004-03-15 Composes derives de benzothiazole, compositions et utilisations

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/388,173 US7270800B2 (en) 2000-08-24 2003-03-14 Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US10/645,847 US20050043523A1 (en) 2003-08-22 2003-08-22 Benzothiazole derivative compounds, compositions and uses
CA2438032A CA2438032C (fr) 2003-03-14 2003-08-22 Derives de benzothiazole et compositions et utilisations connexes

Publications (2)

Publication Number Publication Date
CA2438032A1 CA2438032A1 (fr) 2005-02-22
CA2438032C true CA2438032C (fr) 2013-05-07

Family

ID=34426453

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2438032A Expired - Lifetime CA2438032C (fr) 2003-03-14 2003-08-22 Derives de benzothiazole et compositions et utilisations connexes

Country Status (2)

Country Link
CA (1) CA2438032C (fr)
WO (1) WO2004083195A1 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2800237C (fr) 2002-12-19 2016-05-17 The Scripps Research Institute Compositions et methodes permettant de stabiliser la transthyretine et d'inhiber un mauvais repliement de la transthyretine
WO2005113523A1 (fr) 2004-05-20 2005-12-01 Foldrx Pharmaceuticals, Inc. Composés 2-(hétéroaryl)benzoxazoles et dérivés, compositions et procédés servant à stabiliser la transthyrétine et à inhiber le mauvais repliement de la transthyrétine
AU2005270026A1 (en) 2004-07-02 2006-02-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Use of thioflavin radiolabeled derivatives in amyloid imaging for assessing anti-amyloid therapies
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
WO2006019831A1 (fr) 2004-07-14 2006-02-23 Ptc Therapeutics, Inc. Procedes pour le traitement de l'hepatite c
WO2006019832A1 (fr) 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines utilisees pour traiter l'hepatite c
GB0516564D0 (en) * 2005-08-12 2005-09-21 Ge Healthcare Ltd Fluorination process
CN101355940B (zh) * 2005-09-16 2013-03-27 匹兹堡大学高等教育联邦体系 用于检测具有至少一种促淀粉样变蛋白的淀粉样沉积物的体内或体外方法
JP5301999B2 (ja) † 2005-10-31 2013-09-25 メルク・シャープ・アンド・ドーム・コーポレーション Ｃｅｔｐ阻害薬
WO2007063946A1 (fr) 2005-11-30 2007-06-07 Fujifilm Ri Pharma Co., Ltd. Diagnostic et remede pour une maladie provoquee par l’aggregation et/ou le depot d’amyloide
CN101351458A (zh) * 2005-12-01 2009-01-21 匹兹堡大学 作为促淀粉样变蛋白成像剂的同位素标记的苯并噻唑化合物
GB0525949D0 (en) * 2005-12-21 2006-02-01 Hammersmith Imanet Ltd Pet radiotracers
TW201018678A (en) 2006-01-27 2010-05-16 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
TW200813035A (en) 2006-06-19 2008-03-16 Astrazeneca Ab Novel heteroaryl substituted benzoxazoles
MX2009009113A (es) * 2007-03-06 2009-09-04 Astrazeneca Ab Nuevos indoles 2-heteroaril sustituidos 695.
TW200901998A (en) 2007-03-06 2009-01-16 Astrazeneca Ab Novel 2-heteroaryl substituted benzothiophenes and benzofuranes
US7858803B2 (en) * 2007-04-27 2010-12-28 The General Hospital Corporation Imaging tracers for early detection and treatment of amyloid plaques caused by Alzheimer's disease and related disorders
RU2475267C2 (ru) 2007-08-30 2013-02-20 Джи-И Хелткер Лимитед Радиофармацевтическая композиция
ITMC20080089A1 (it) * 2008-05-23 2008-08-22 Sparkle S R L Sintesi chimica di i-124[6-oh-bta-1-3'-i] iodine-124[2-(3'-iodo-4'-methylaminophenyl)-6-hydroxy-benzothialzole] per indagini pet e radioterapia.
AU2009260519A1 (en) 2008-05-30 2009-12-23 Merck Sharp & Dohme Corp. Novel substituted azabenzoxazoles
CA2737028C (fr) * 2008-09-23 2017-06-27 Wista Laboratories Ltd. Ligands pour molecules de la proteine tau agglomerees
CA2741668A1 (fr) * 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Nouveaux azabenzoxazoles substitues
RU2586330C2 (ru) 2011-09-16 2016-06-10 Пфайзер Инк. Твердые формы ингибитора диссоциации транстиретина
DK2890700T3 (en) 2012-08-28 2018-03-12 Univ Tuebingen Medizinische Fakultaet HALOGENATED BENZOXAZINES AND THEIR USE
CA2920068A1 (fr) * 2013-09-26 2015-04-02 F. Hoffmann-La Roche Ag Imidazo[1,2-a]pyridin-7-amines en tant qu'outils d'imagerie
WO2015051188A1 (fr) 2013-10-02 2015-04-09 Washington University Molécules hétérocycliques pour l'imagerie biomédicale et leurs applications thérapeutiques
CA2959505A1 (fr) 2014-08-29 2016-03-03 Chdi Foundation, Inc. Sondes d'imagerie de la proteine huntingtine
EA035646B1 (ru) 2014-08-29 2020-07-21 Сиэйчдиай Фаундэйшн, Инк. Зонды для визуализации белка хантингтина
JP6485914B2 (ja) * 2015-10-28 2019-03-20 日本メジフィジックス株式会社 フルテメタモルの製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9919673D0 (en) * 1999-08-20 1999-10-20 Cancer Res Campaign Tech 2-Arlybenzazole compounds
RU2324686C2 (ru) * 2000-08-24 2008-05-20 Юнивесити Оф Питсбэг ПРОИЗВОДНЫЕ ТИОФЛАВИНА, СВЯЗЫВАЮЩИЕ АМИЛОИД, СПОСОБ ОБНАРУЖЕНИЯ in vivo ОТЛОЖЕНИЙ АМИЛОИДА И СПОСОБ РАСПОЗНАВАНИЯ БОЛЕЗНИ АЛЬЦГЕЙМЕРА
US7270800B2 (en) * 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
CA2444214A1 (fr) * 2001-04-23 2002-10-31 The Trustees Of The University Of Pennsylvania Inhibiteurs d'agregation de plaque amyloide et agents d'imagerie diagnostique

Also Published As

Publication number Publication date
CA2438032A1 (fr) 2005-02-22
WO2004083195A1 (fr) 2004-09-30

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Effective date: 20230822