CA2441702A1 - Proteines secretees par l'homme - Google Patents

Proteines secretees par l'homme Download PDF

Info

Publication number
CA2441702A1
CA2441702A1 CA002441702A CA2441702A CA2441702A1 CA 2441702 A1 CA2441702 A1 CA 2441702A1 CA 002441702 A CA002441702 A CA 002441702A CA 2441702 A CA2441702 A CA 2441702A CA 2441702 A1 CA2441702 A1 CA 2441702A1
Authority
CA
Canada
Prior art keywords
seq
polypeptide
referenced
fragment
cdna clone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002441702A
Other languages
English (en)
Inventor
Craig A. Rosen
Steven M. Ruben
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2441702A1 publication Critical patent/CA2441702A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des polypeptides sécrétés par l'homme et des molécules d'acides nucléiques isolées codant lesdits polypeptides, servant au diagnostic et au traitement du cancer et d'autres maladies et troubles hyperproliférants. L'invention concerne également des anticorps liant ces polypeptides, des vecteurs, des cellules hôtes, et des procédés de recombinaison et de synthèse destinés à la fabrication desdits polynucléotides, polypeptides et/ou anticorps. L'invention concerne également des procédés de criblage destinés à identifier des agonistes et des antagonistes des polynucléotides et polypeptides selon l'invention. L'invention concerne également des procédés et des compostions destinés à inhiber ou promouvoir la production et la fonction des polypeptides selon l'invention.
CA002441702A 2001-03-21 2002-03-19 Proteines secretees par l'homme Abandoned CA2441702A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US27734001P 2001-03-21 2001-03-21
US60/277,340 2001-03-21
US30617101P 2001-07-19 2001-07-19
US60/306,171 2001-07-19
US33128701P 2001-11-13 2001-11-13
US60/331,287 2001-11-13
PCT/US2002/008123 WO2002102993A2 (fr) 2001-03-21 2002-03-19 Proteines secretees par l'homme

Publications (1)

Publication Number Publication Date
CA2441702A1 true CA2441702A1 (fr) 2002-12-27

Family

ID=27402891

Family Applications (7)

Application Number Title Priority Date Filing Date
CA002441702A Abandoned CA2441702A1 (fr) 2001-03-21 2002-03-19 Proteines secretees par l'homme
CA002441832A Abandoned CA2441832A1 (fr) 2001-03-21 2002-03-19 Proteines secretees humaines
CA002441840A Abandoned CA2441840A1 (fr) 2001-03-21 2002-03-19 Proteines secretees humaines
CA002441397A Abandoned CA2441397A1 (fr) 2001-03-21 2002-03-19 Proteines humaines secretees
CA002441416A Abandoned CA2441416A1 (fr) 2001-03-21 2002-03-19 Proteines humaines secretees
CA002441417A Abandoned CA2441417A1 (fr) 2001-03-21 2002-03-19 Proteines secretees par les humains
CA002441755A Abandoned CA2441755A1 (fr) 2001-03-21 2002-03-19 Proteines secretees humaines

Family Applications After (6)

Application Number Title Priority Date Filing Date
CA002441832A Abandoned CA2441832A1 (fr) 2001-03-21 2002-03-19 Proteines secretees humaines
CA002441840A Abandoned CA2441840A1 (fr) 2001-03-21 2002-03-19 Proteines secretees humaines
CA002441397A Abandoned CA2441397A1 (fr) 2001-03-21 2002-03-19 Proteines humaines secretees
CA002441416A Abandoned CA2441416A1 (fr) 2001-03-21 2002-03-19 Proteines humaines secretees
CA002441417A Abandoned CA2441417A1 (fr) 2001-03-21 2002-03-19 Proteines secretees par les humains
CA002441755A Abandoned CA2441755A1 (fr) 2001-03-21 2002-03-19 Proteines secretees humaines

Country Status (4)

Country Link
EP (7) EP1423134A2 (fr)
AU (6) AU2002332391A1 (fr)
CA (7) CA2441702A1 (fr)
WO (7) WO2003038063A2 (fr)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7196164B2 (en) 1997-07-08 2007-03-27 Human Genome Sciences, Inc. Secreted protein HHTLF25
JP2002513295A (ja) 1997-07-08 2002-05-08 ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド 123種類のヒト分泌タンパク質
US20040141975A1 (en) 1998-06-01 2004-07-22 Raitano Arthur B. Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer
US6833438B1 (en) 1999-06-01 2004-12-21 Agensys, Inc. Serpentine transmembrane antigens expressed in human cancers and uses thereof
US6329503B1 (en) 1998-06-01 2001-12-11 Agensys, Inc. Serpentine transmembrane antigens expressed in human cancers and uses thereof
US20060052321A1 (en) 2002-04-05 2006-03-09 Raitano Arthur B Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer
US20030149531A1 (en) 2000-12-06 2003-08-07 Hubert Rene S. Serpentine transmembrane antigens expressed in human cancers and uses thereof
EP1141027A1 (fr) 1999-01-15 2001-10-10 Biogen, Inc. Antagonistes de la proteine tweak et du recepteur de tweak, et leur utilisation pour traiter des affections immunitaires
US20060073150A1 (en) 2001-09-06 2006-04-06 Mary Faris Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer
US7291719B2 (en) 2000-07-25 2007-11-06 Genentech, Inc. PRO4332 antibodies
EP1666490A3 (fr) * 2000-07-25 2006-11-02 Genentech, Inc. Polypeptides sécrétés et transmembranaires ainsi que les acides nucléiques codant pour ceux-ci
JP2004528823A (ja) 2000-10-31 2004-09-24 ディアデクサス インコーポレーテッド 大腸特異的遺伝子およびタンパク質に関する組成物および方法
US20020111302A1 (en) * 2000-11-30 2002-08-15 Y. Tom Tang Novel nucleic acids and polypeptides
WO2002083921A2 (fr) 2001-04-10 2002-10-24 Agensys, Inc. Acides nucleiques et proteines correspondantes utiles pour la detection et le traitement de divers cancers
US7250495B2 (en) 2001-06-20 2007-07-31 Genentech, Inc. PRO20044 polypeptides
US7494646B2 (en) 2001-09-06 2009-02-24 Agensys, Inc. Antibodies and molecules derived therefrom that bind to STEAP-1 proteins
EP1439235A4 (fr) 2001-10-12 2006-01-18 Astellas Pharma Inc Methode de criblage d'inhibiteur de mort cellulaire
AU2003224950B2 (en) 2002-04-09 2006-09-14 Biogen Ma Inc. Methods for treating tweak-related conditions
AU2003900747A0 (en) * 2003-02-18 2003-03-06 Garvan Institute Of Medical Research Diagnosis and treatment of pancreatic cancer
US20050025763A1 (en) 2003-05-08 2005-02-03 Protein Design Laboratories, Inc. Therapeutic use of anti-CS1 antibodies
US7709610B2 (en) 2003-05-08 2010-05-04 Facet Biotech Corporation Therapeutic use of anti-CS1 antibodies
WO2005019258A2 (fr) * 2003-08-11 2005-03-03 Genentech, Inc. Compositions et methodes de traitement de maladies relatives au systeme immunitaire
US7687233B2 (en) 2003-09-23 2010-03-30 The University Of North Carolina At Chapel Hill Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin K epoxide reductase gene and warfarin dosage
ES2379764T3 (es) * 2003-10-14 2012-05-03 Baxter International Inc. Polipéptido VKORC1 de reciclaje de la vitamina K-epóxido, una diana terapéutica de la curamina y sus derivados
EP1714154A2 (fr) * 2004-02-03 2006-10-25 Bayer HealthCare AG Agents diagnostiques et therapeutiques pour des maladies associes a la glutamate carboxypeptidase (pgcp) plasmatique
US20050186577A1 (en) 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
MXPA06012187A (es) 2004-04-22 2007-03-28 Agensys Inc Anticuerpos y moleculas derivadas de estas que se enlazan a las proteinas steap-1.
US8759305B2 (en) * 2004-09-01 2014-06-24 Dynavax Technologies Corporation Methods and compositions for inhibition of innate immune responses and autoimmunity
JP2008512099A (ja) * 2004-09-07 2008-04-24 テレソン インスティテュート フォー チャイルド ヘルス リサーチ アレルギー性疾患の処置または予防のための物質
WO2006026808A1 (fr) * 2004-09-07 2006-03-16 Telethon Institute For Child Health Research Methode de diagnostic et/ou de prediction du developpement d'une affection allergique
US20090124993A1 (en) 2005-02-17 2009-05-14 Burkly Linda C Treating neurological disorders
US9617523B2 (en) 2005-02-28 2017-04-11 Baxalta GmbH Nucleic acids encoding vitamin K expoxide reductase subunit 1 and vitamin K dependent protein expression and methods of using same
AU2005329450A1 (en) 2005-03-15 2006-09-28 University Of North Carolina At Chapel Hill Methods and compositions for producing active Vitamin K-dependent proteins
JP5339901B2 (ja) 2005-05-10 2013-11-13 バイオジェン・アイデック・エムエイ・インコーポレイテッド 炎症傷害の処置および評価
WO2006138219A2 (fr) 2005-06-13 2006-12-28 Biogen Idec Ma Inc. Procedes d'evaluation de patients
GB2445882B (en) * 2005-09-01 2011-02-23 Florey Howard Inst Prophylactic and therapeutic agents and compositions and uses therefor and methods for determining the presence or severity of neuronal damage
GB0521488D0 (en) * 2005-10-21 2005-11-30 Ares Trading Sa Integral membrane protein
US7572618B2 (en) 2006-06-30 2009-08-11 Bristol-Myers Squibb Company Polynucleotides encoding novel PCSK9 variants
NZ576132A (en) 2006-10-27 2012-04-27 Genentech Inc Antibodies and immunoconjugates and uses therefor
WO2008063382A2 (fr) 2006-11-07 2008-05-29 Merck & Co., Inc. Antagonistes de pcsk9
US8093222B2 (en) * 2006-11-27 2012-01-10 Isis Pharmaceuticals, Inc. Methods for treating hypercholesterolemia
WO2008118386A2 (fr) * 2007-03-27 2008-10-02 Merck & Co., Inc. Procédé de détection de pcsk9 sécrétée, autogénérée
JOP20080381B1 (ar) 2007-08-23 2023-03-28 Amgen Inc بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
EP2209896B1 (fr) 2007-10-26 2017-03-01 Dynavax Technologies Corporation Procédés et compositions pour inhiber les réponses immunitaires et l'auto-immunité
US8017573B2 (en) * 2007-11-30 2011-09-13 Siemens Healthcare Diagnostics Inc. Adiponectin receptor fragments and methods of use
AR070315A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Anticuerpos 1b20 antagonistas de pcsk9
AR070316A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9)
US8748115B2 (en) 2008-12-12 2014-06-10 Merck Sharp & Dohme Corp. PCSK9 immunoassay
AU2010313324A1 (en) 2009-10-30 2012-04-12 Merck Sharp & Dohme Corp. AX213 and AX132 PCSK9 antagonists and variants
US8802827B2 (en) 2009-10-30 2014-08-12 Merck Sharp & Dohme Corp. AX1 PCSK9 antagonists
CN103153346A (zh) 2010-06-16 2013-06-12 戴纳瓦克斯技术公司 使用tlr7和/或tlr9抑制剂的治疗方法
JP6012605B2 (ja) 2010-09-22 2016-10-25 アリオス バイオファーマ インク. 置換されたヌクレオチドアナログ
US9631002B2 (en) 2010-12-21 2017-04-25 The University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin K-dependent proteins
JOP20200043A1 (ar) 2011-05-10 2017-06-16 Amgen Inc طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول
WO2013096680A1 (fr) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Analogues de nucléotide phosphorothioate substitués
EP2828277A1 (fr) 2012-03-21 2015-01-28 Vertex Pharmaceuticals Incorporated Formes solides d'un promédicament nucléotidique thiophosphoramidate
WO2013142157A1 (fr) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Combinaisons pharmaceutiques comprenant un analogue thionucléotidique
US8992927B1 (en) 2014-07-15 2015-03-31 Kymab Limited Targeting human NAV1.7 variants for treatment of pain
US9051378B1 (en) 2014-07-15 2015-06-09 Kymab Limited Targeting rare human PCSK9 variants for cholesterol treatment
US8980273B1 (en) 2014-07-15 2015-03-17 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US9045548B1 (en) 2014-07-15 2015-06-02 Kymab Limited Precision Medicine by targeting rare human PCSK9 variants for cholesterol treatment
US8945560B1 (en) 2014-07-15 2015-02-03 Kymab Limited Method of treating rheumatoid arthritis using antibody to IL6R
US9067998B1 (en) 2014-07-15 2015-06-30 Kymab Limited Targeting PD-1 variants for treatment of cancer
US9023359B1 (en) 2014-07-15 2015-05-05 Kymab Limited Targeting rare human PCSK9 variants for cholesterol treatment
US9017678B1 (en) 2014-07-15 2015-04-28 Kymab Limited Method of treating rheumatoid arthritis using antibody to IL6R
US8986691B1 (en) 2014-07-15 2015-03-24 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US8986694B1 (en) 2014-07-15 2015-03-24 Kymab Limited Targeting human nav1.7 variants for treatment of pain
US9045545B1 (en) 2014-07-15 2015-06-02 Kymab Limited Precision medicine by targeting PD-L1 variants for treatment of cancer
US9034332B1 (en) 2014-07-15 2015-05-19 Kymab Limited Precision medicine by targeting rare human PCSK9 variants for cholesterol treatment
US8883157B1 (en) 2013-12-17 2014-11-11 Kymab Limited Targeting rare human PCSK9 variants for cholesterol treatment
US9914769B2 (en) 2014-07-15 2018-03-13 Kymab Limited Precision medicine for cholesterol treatment
US9682218B2 (en) 2013-12-23 2017-06-20 Carefusion 2200, Inc. Pleurodesis device and method
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US9150660B1 (en) 2014-07-15 2015-10-06 Kymab Limited Precision Medicine by targeting human NAV1.8 variants for treatment of pain
US9139648B1 (en) 2014-07-15 2015-09-22 Kymab Limited Precision medicine by targeting human NAV1.9 variants for treatment of pain
KR102379464B1 (ko) 2016-06-20 2022-03-29 키맵 리미티드 항-pd-l1 항체
EP3534947A1 (fr) 2016-11-03 2019-09-11 Kymab Limited Anticorps, combinaisons comprenant des anticorps, biomarqueurs, utilisations et procédés
WO2018119354A1 (fr) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Édition génique de pcsk9
BR112019018767A2 (pt) 2017-04-03 2020-05-05 Hoffmann La Roche anticorpos, molécula de ligação ao antígeno biespecífica, um ou mais polinucleotídeos isolados, um ou mais vetores, célula hospedeira, método para produzir um anticorpo, composição farmacêutica, usos, método para tratar uma doença em um indivíduo e invenção
WO2018237213A1 (fr) 2017-06-22 2018-12-27 The Procter & Gamble Company Films comprenant une couche hydrosoluble et un revêtement inorganique déposé en phase vapeur
WO2018237212A1 (fr) 2017-06-22 2018-12-27 The Procter & Gamble Company Films comprenant une couche hydrosoluble et un revêtement organique déposé en phase vapeur
BR112022020428A2 (pt) 2020-04-09 2023-03-07 Verve Therapeutics Inc Edição base do angptl3 e métodos de uso do mesmo para tratamento de doenças

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100236393B1 (ko) * 1996-02-02 1999-12-15 나까니시 히로유끼 사람성장호르몬을 함유하는 의약제제
WO2002026931A2 (fr) * 2000-09-25 2002-04-04 Human Genome Sciences, Inc. 71 proteines humaines secretees
US5858716A (en) * 1997-05-30 1999-01-12 Smithkline Beecham Corporation H2CAA71 polynucleotides
JP2002520050A (ja) * 1998-07-15 2002-07-09 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド 71個のヒト分泌タンパク質

Also Published As

Publication number Publication date
CA2441416A1 (fr) 2003-01-16
EP1414845A2 (fr) 2004-05-06
EP1390390A2 (fr) 2004-02-25
WO2002102993A2 (fr) 2002-12-27
EP1390390A4 (fr) 2009-07-08
CA2441840A1 (fr) 2002-11-28
WO2002102994A3 (fr) 2003-07-24
EP1379132A4 (fr) 2009-07-01
WO2003038063A3 (fr) 2003-12-11
WO2002090526A2 (fr) 2002-11-14
AU2002324424A1 (en) 2002-12-03
EP1379264A1 (fr) 2004-01-14
CA2441417A1 (fr) 2002-11-14
EP1379132A2 (fr) 2004-01-14
CA2441755A1 (fr) 2003-05-08
WO2002095010A2 (fr) 2002-11-28
WO2003004622A2 (fr) 2003-01-16
WO2003004622A3 (fr) 2004-02-19
EP1379264A4 (fr) 2009-07-08
EP1404702A4 (fr) 2009-07-08
EP1404702A2 (fr) 2004-04-07
WO2002076488A1 (fr) 2002-10-03
WO2002090526A3 (fr) 2003-10-30
WO2002102993A3 (fr) 2004-03-25
WO2002102994A2 (fr) 2002-12-27
CA2441397A1 (fr) 2002-10-03
AU2002326293A1 (en) 2003-01-02
WO2002095010A3 (fr) 2004-02-12
AU2002320013A1 (en) 2002-11-18
EP1423134A2 (fr) 2004-06-02
AU2002363296A1 (en) 2003-05-12
EP1414845A4 (fr) 2009-07-08
AU2002332391A1 (en) 2003-01-02
WO2003038063A2 (fr) 2003-05-08
CA2441832A1 (fr) 2002-12-27
EP1381622A2 (fr) 2004-01-21
AU2002354719A1 (en) 2003-01-21

Similar Documents

Publication Publication Date Title
CA2441702A1 (fr) Proteines secretees par l'homme
CA2442797A1 (fr) Proteines secretees humaines
CA2393616A1 (fr) Acides nucleiques, proteines et anticorps
US20020015950A1 (en) Atherosclerosis-associated genes
JP4208951B2 (ja) 幹細胞増殖因子様ポリペプチドおよびポリヌクレオチドに関する方法および材料
CA2395885A1 (fr) Acides nucleiques, proteines et anticorps
EP1355666B1 (fr) Utilisation de "repulsive guidance molecule" (RGM) et de ses modulateurs
CA2421949A1 (fr) Noveaux acides nucleiques et polypeptides
CA2291260A1 (fr) 207 proteines secretees par l'etre humain
CA2332109A1 (fr) 97 proteines humaines secretees
JP2002501738A (ja) 67個のヒト分泌タンパク質
JP2002502600A (ja) ヒトセリンプロテアーゼおよびセルピンポリペプチド
JP2001514885A (ja) 70個のヒト分泌タンパク質
JP2001514024A (ja) 50個のヒト分泌タンパク質
JP2003525566A (ja) 125個のヒト分泌タンパク質
EP1572887A2 (fr) Peptides de regeneration neurale et procedes d'utilisation de ces derniers dans le traitement des lesions cerebrales
AU2002252266A1 (en) Human serpin polypeptides
JP2003521865A (ja) 148個のヒト分泌タンパク質
WO2004074436A2 (fr) Procede d'utilisation d'un gpcr pour diagnostiquer et traiter le cancer du colon et du poumon
CN101550185B (zh) 新的肿瘤相关基因或蛋白及其应用
JP2002360254A (ja) 新規膜結合型−分泌型megf8遺伝子及びそれにコードされる蛋白質
JP2004518425A (ja) 幹細胞成長因子様ポリペプチドおよびポリヌクレオチドに関連した方法および物質
JP2003523733A (ja) 10個のヒト分泌タンパク質
EP1683865A2 (fr) Protéines de mammifères en particulier CD200
JPWO2001009321A1 (ja) 新規なtsp1様蛋白質をコードする遺伝子

Legal Events

Date Code Title Description
FZDE Dead