CA2445013A1 - Polypeptides d'un recepteur de lymphocytes t alpha/beta des murides specifique de la proteine hdm2, acides nucleiques les codant et leur utilisation - Google Patents
Polypeptides d'un recepteur de lymphocytes t alpha/beta des murides specifique de la proteine hdm2, acides nucleiques les codant et leur utilisation Download PDFInfo
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- CA2445013A1 CA2445013A1 CA002445013A CA2445013A CA2445013A1 CA 2445013 A1 CA2445013 A1 CA 2445013A1 CA 002445013 A CA002445013 A CA 002445013A CA 2445013 A CA2445013 A CA 2445013A CA 2445013 A1 CA2445013 A1 CA 2445013A1
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- hdm2
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- 108010003137 tyrosyltyrosine Proteins 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1
- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical class [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
L'invention concerne des polypeptides d'un récepteur de lymphocytes T .alpha./.beta. des muridés induisant une réponse spécifique de la protéine hdm2 ou de variantes fonctionnelles ou de leurs parties ou des acides nucléiques les codant, des variantes fonctionnelles ou leurs parties. Ils ont pour effet de permettre d'identifier des cellules de lymphocytes T exprimant la protéine hdm2, qui ont été pourvues de ces gènes, d'exprimer de la cytokine et d'obtenir une lyse induite par lymphocyte T et/ou l'apoptose de cellules tumorales ou leucémiques.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10109854A DE10109854A1 (de) | 2001-03-01 | 2001-03-01 | Polypeptide eines hdm2-Protein spezifischen murinen alpha/beta T-Zell Rezeptors, diese kodierende Nukleinsäuren und deren Verwendung |
| DE10109854.5 | 2001-03-01 | ||
| PCT/EP2002/002187 WO2002070552A2 (fr) | 2001-03-01 | 2002-02-28 | POLYPEPTIDES D'UN RECEPTEUR DE LYMPHOCYTES T Α/β DES MURIDES SPECIFIQUE DE LA PROTEINE HDM2, ACIDES NUCLEIQUES LES CODANT ET LEUR UTILISATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2445013A1 true CA2445013A1 (fr) | 2002-09-12 |
Family
ID=7675927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002445013A Abandoned CA2445013A1 (fr) | 2001-03-01 | 2002-02-28 | Polypeptides d'un recepteur de lymphocytes t alpha/beta des murides specifique de la proteine hdm2, acides nucleiques les codant et leur utilisation |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1363942A2 (fr) |
| JP (1) | JP2004535778A (fr) |
| CA (1) | CA2445013A1 (fr) |
| DE (1) | DE10109854A1 (fr) |
| WO (1) | WO2002070552A2 (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110070191A1 (en) * | 2008-03-19 | 2011-03-24 | Wong Hing C | T cell receptor fusions and conjugates and methods of use there of |
| US9062127B2 (en) | 2002-09-24 | 2015-06-23 | Johannes Gutenberg-Universitat Mainz | Method for rational mutagenesis of α/βT-cell receptors and correspondingly mutated MDM2-protein specific α/βT-cell receptors |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4832757B2 (ja) | 2002-09-11 | 2011-12-07 | エヌエックスピー ビー ヴィ | データ・キャリア整理分類方法 |
| DE10259713A1 (de) * | 2002-12-19 | 2004-07-08 | Johannes-Gutenberg-Universität Mainz | Verfahren zur Expressionsstabilisierung und Verbesserung der spezifischen Effektorfunktion von Einzelketten-Antigenerkennenden genetischen Konstrukten (scARC) und entsprechend mutierten MDM2-Protein spezifischen scT-Zell Rezeptoren |
| GB0427585D0 (en) * | 2004-12-16 | 2005-01-19 | Avidex Ltd | Assay |
| AU2011304728A1 (en) * | 2010-09-20 | 2013-03-14 | Biontech Ag | Antigen-specific T cell receptors and T cell epitopes |
| ES2861901T3 (es) | 2014-10-03 | 2021-10-06 | Univ Oxford Innovation Ltd | Análisis de monotipia de células T |
| CN107207371A (zh) * | 2014-10-20 | 2017-09-26 | 斯克利普斯研究院 | 用于选择结合配偶体的基于邻近度的方法 |
| AU2015338984A1 (en) * | 2014-10-31 | 2017-04-27 | The Trustees Of The University Of Pennsylvania | Methods and compositions for modified T cells |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU728794B2 (en) * | 1996-03-05 | 2001-01-18 | Scripps Research Institute, The | Recombinant constructs encoding T cell receptors specific for human HLA-restricted tumor antigens |
-
2001
- 2001-03-01 DE DE10109854A patent/DE10109854A1/de not_active Withdrawn
-
2002
- 2002-02-28 CA CA002445013A patent/CA2445013A1/fr not_active Abandoned
- 2002-02-28 WO PCT/EP2002/002187 patent/WO2002070552A2/fr not_active Ceased
- 2002-02-28 EP EP02722160A patent/EP1363942A2/fr not_active Withdrawn
- 2002-02-28 JP JP2002569871A patent/JP2004535778A/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9062127B2 (en) | 2002-09-24 | 2015-06-23 | Johannes Gutenberg-Universitat Mainz | Method for rational mutagenesis of α/βT-cell receptors and correspondingly mutated MDM2-protein specific α/βT-cell receptors |
| US20110070191A1 (en) * | 2008-03-19 | 2011-03-24 | Wong Hing C | T cell receptor fusions and conjugates and methods of use there of |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002070552A2 (fr) | 2002-09-12 |
| DE10109854A1 (de) | 2002-09-12 |
| WO2002070552A3 (fr) | 2002-12-12 |
| WO2002070552A8 (fr) | 2002-10-10 |
| JP2004535778A (ja) | 2004-12-02 |
| EP1363942A2 (fr) | 2003-11-26 |
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