CA2446776A1 - Souche de lactococcus a auto-confinement - Google Patents
Souche de lactococcus a auto-confinement Download PDFInfo
- Publication number
- CA2446776A1 CA2446776A1 CA002446776A CA2446776A CA2446776A1 CA 2446776 A1 CA2446776 A1 CA 2446776A1 CA 002446776 A CA002446776 A CA 002446776A CA 2446776 A CA2446776 A CA 2446776A CA 2446776 A1 CA2446776 A1 CA 2446776A1
- Authority
- CA
- Canada
- Prior art keywords
- lactococcus
- strain
- gene
- transformed strain
- transformed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000194036 Lactococcus Species 0.000 title abstract 4
- 241000178948 Lactococcus sp. Species 0.000 claims 11
- 108010022394 Threonine synthase Proteins 0.000 claims 3
- 230000000069 prophylactic effect Effects 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 239000013612 plasmid Substances 0.000 claims 2
- 230000001131 transforming effect Effects 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102000003814 Interleukin-10 Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 241000194035 Lactococcus lactis Species 0.000 claims 1
- 235000014897 Streptococcus lactis Nutrition 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940076144 interleukin-10 Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000035899 viability Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01045—Thymidylate synthase (2.1.1.45)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Abstract
L'invention concerne une souche de Lactococcus recombinant à croissance et viabilité limitées du point de vue de l'environnement. Plus précisément, l'invention concerne un Lactococcus recombinant pouvant uniquement survivre dans un milieu dans lequel des composés de milieu bien définis sont présents. Dans un mode de réalisation préféré, le Lactococcus peut uniquement survivre dans un organisme hôte dans lequel lesdits composés de milieu sont présents, ne pouvant pas survivre en dehors de l'organisme hôte en l'absence des composés de milieu.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01201631.7 | 2001-05-03 | ||
| EP01201631 | 2001-05-03 | ||
| EP01204785 | 2001-12-07 | ||
| EP01204785.8 | 2001-12-07 | ||
| PCT/EP2002/004942 WO2002090551A2 (fr) | 2001-05-03 | 2002-05-03 | Souche de lactococcus a auto-confinement |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2446776A1 true CA2446776A1 (fr) | 2002-11-14 |
| CA2446776C CA2446776C (fr) | 2011-07-12 |
Family
ID=26076897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2446776A Expired - Fee Related CA2446776C (fr) | 2001-05-03 | 2002-05-03 | Souche de lactococcus a auto-confinement |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1383897B1 (fr) |
| JP (2) | JP4347575B2 (fr) |
| AT (1) | ATE331789T1 (fr) |
| AU (1) | AU2002314040B2 (fr) |
| CA (1) | CA2446776C (fr) |
| DE (1) | DE60212825T2 (fr) |
| DK (1) | DK1383897T3 (fr) |
| ES (1) | ES2266515T3 (fr) |
| WO (1) | WO2002090551A2 (fr) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7780961B2 (en) | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
| DE60319822T2 (de) | 2002-06-19 | 2009-06-04 | Actogenix Nv | Verfahren und mittel zur erhöhung der darmabsorption |
| WO2004056850A2 (fr) * | 2002-12-19 | 2004-07-08 | Vib Vzw | Proteines mutantes a secretion accrue |
| JP4589618B2 (ja) * | 2003-11-28 | 2010-12-01 | 独立行政法人農業生物資源研究所 | 免疫調節性機能を誘導する乳酸菌類とその成分 |
| ES2439698T3 (es) | 2004-08-20 | 2014-01-24 | Actogenix N.V. | Procedimiento para mejorar la conservación de lactococos |
| AU2006319216B2 (en) * | 2005-11-29 | 2012-09-13 | Intrexon Actobiotics Nv | Induction of mucosal tolerance to antigens |
| JP2010513245A (ja) * | 2006-12-14 | 2010-04-30 | アクトジェニックス・エヌブイ | 免疫調節を誘起するための結合分子の送達 |
| EP2115146B1 (fr) * | 2007-01-12 | 2016-07-06 | Intrexon Actobiotics NV | Promoteurs lactococcus et leurs utilisations |
| CN103933563B (zh) | 2007-01-25 | 2016-09-28 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 使用遗传修饰的乳杆菌通过抗原的粘膜递送治疗免疫疾病 |
| DK3181682T3 (da) * | 2008-09-29 | 2021-07-05 | Intrexon Actobiotics Nv | Reduceret kolonisering af mikrober på slimhinden |
| WO2012164083A1 (fr) | 2011-06-01 | 2012-12-06 | Actogenix N.V. | Système d'expression polycistronique pour des bactéries |
| WO2013041672A1 (fr) | 2011-09-23 | 2013-03-28 | Actogenix Nv | Bactéries gram positif modifiées et leurs utilisations |
| EP3382006B1 (fr) | 2011-09-23 | 2021-02-17 | Intrexon Actobiotics NV | Bactéries gram positif modifiées et leurs utilisations |
| US9688967B2 (en) | 2014-12-05 | 2017-06-27 | Synlogic, Inc. | Bacteria engineered to treat diseases associated with hyperammonemia |
| US10610546B2 (en) | 2015-05-13 | 2020-04-07 | Synlogic Operating Company Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| US20160206666A1 (en) | 2014-12-22 | 2016-07-21 | Synlogic, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier |
| BR112017018656B1 (pt) * | 2015-03-02 | 2021-11-30 | Synlogic, Inc | Bactéria geneticamente modificada, composição farmaceuticamente aceitável compreendendo a dita bactéria e uso da dita composição para tratar ou prevenir uma doença ou condição associada à inflamação intestinal e/ou função da barreira intestinal comprometida |
| CN106148254B (zh) * | 2015-03-26 | 2019-11-12 | 南京华贞生物医药科技有限公司 | 一种用于减肥降脂的转化体及其构建方法与应用 |
| US11685925B2 (en) | 2015-10-30 | 2023-06-27 | Synlogic Operating Company, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier |
| WO2017087580A1 (fr) | 2015-11-16 | 2017-05-26 | Synlogic, Inc. | Bactéries génétiquement modifiées pour réduire l'hyperphénylalaninémie |
| CA3011331C (fr) | 2016-01-14 | 2025-05-13 | Intrexon Actobiotics N.V. | Compositions et procédés de traitement du diabète de type 1 |
| JP7016865B2 (ja) | 2016-09-02 | 2022-03-03 | イントレクソン・アクトバイオテイクス・エヌブイ | Ｉｌ－１０およびインスリンを安定的に発現する遺伝子改変された細菌 |
| CN109983028B (zh) | 2016-09-13 | 2023-10-20 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 黏膜黏附性微生物 |
| CN111655841A (zh) | 2017-06-21 | 2020-09-11 | 同生运营公司 | 用于治疗紊乱的细菌 |
| US20210393711A1 (en) | 2018-10-11 | 2021-12-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Bacteria expressing single chain antibodies against toll-like receptors |
| CA3156035A1 (fr) | 2019-09-27 | 2021-04-01 | Intrexon Actobiotics Nv D/B/A Precigen Actobio | Traitement de la maladie cliaque |
| CN115298308A (zh) | 2020-03-20 | 2022-11-04 | 同生运营公司 | 经工程化以减轻高苯丙氨酸血症的微生物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4231764A1 (de) * | 1992-09-23 | 1994-03-24 | Inst Pflanzengenetik & Kultur | Verfahren zur chromosomalen Integration eines Produkt-Gens |
-
2002
- 2002-05-03 WO PCT/EP2002/004942 patent/WO2002090551A2/fr not_active Ceased
- 2002-05-03 JP JP2002587611A patent/JP4347575B2/ja not_active Expired - Fee Related
- 2002-05-03 CA CA2446776A patent/CA2446776C/fr not_active Expired - Fee Related
- 2002-05-03 AU AU2002314040A patent/AU2002314040B2/en not_active Ceased
- 2002-05-03 EP EP02740565A patent/EP1383897B1/fr not_active Expired - Lifetime
- 2002-05-03 AT AT02740565T patent/ATE331789T1/de active
- 2002-05-03 DK DK02740565T patent/DK1383897T3/da active
- 2002-05-03 ES ES02740565T patent/ES2266515T3/es not_active Expired - Lifetime
- 2002-05-03 DE DE60212825T patent/DE60212825T2/de not_active Expired - Lifetime
-
2008
- 2008-10-07 JP JP2008260591A patent/JP2009060913A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002090551A2 (fr) | 2002-11-14 |
| ATE331789T1 (de) | 2006-07-15 |
| CA2446776C (fr) | 2011-07-12 |
| ES2266515T3 (es) | 2007-03-01 |
| JP2009060913A (ja) | 2009-03-26 |
| JP4347575B2 (ja) | 2009-10-21 |
| AU2002314040B2 (en) | 2007-06-28 |
| DK1383897T3 (da) | 2006-10-30 |
| EP1383897A2 (fr) | 2004-01-28 |
| WO2002090551A3 (fr) | 2003-03-27 |
| JP2004533246A (ja) | 2004-11-04 |
| DE60212825D1 (de) | 2006-08-10 |
| DE60212825T2 (de) | 2007-01-11 |
| EP1383897B1 (fr) | 2006-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20220301 |
|
| MKLA | Lapsed |
Effective date: 20200831 |