CA2450779C - Formation de poudre par lyophilisation a pulverisation atmospherique - Google Patents

Formation de poudre par lyophilisation a pulverisation atmospherique Download PDF

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Publication number
CA2450779C
CA2450779C CA2450779A CA2450779A CA2450779C CA 2450779 C CA2450779 C CA 2450779C CA 2450779 A CA2450779 A CA 2450779A CA 2450779 A CA2450779 A CA 2450779A CA 2450779 C CA2450779 C CA 2450779C
Authority
CA
Canada
Prior art keywords
flow
chamber
coolant
liquid droplets
frozen particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2450779A
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English (en)
Other versions
CA2450779A1 (fr
Inventor
Warren H. Finlay
Zhaolin Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Aerosol Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aerosol Therapeutics LLC filed Critical Aerosol Therapeutics LLC
Priority to CA2450779A priority Critical patent/CA2450779C/fr
Priority to PCT/CA2004/002160 priority patent/WO2005061088A1/fr
Priority to JP2006545859A priority patent/JP5183068B2/ja
Priority to EP04802335.2A priority patent/EP1697035B1/fr
Publication of CA2450779A1 publication Critical patent/CA2450779A1/fr
Priority to US12/050,654 priority patent/US8322046B2/en
Application granted granted Critical
Publication of CA2450779C publication Critical patent/CA2450779C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • F26B5/065—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing the product to be freeze-dried being sprayed, dispersed or pulverised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Drying Of Solid Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Glanulating (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention a trait à une méthode de fabrication de poudre pharmaceutique sensible à la chaleur. Les substances pharmaceutiques d'origine sont dissoutes dans une solution ou mises en suspension, laquelle est pulvérisée par une buse de pulvérisation et congelée dans une phase à gaz froid, ou par de l'azote liquide pulvérisée directement dans la chambre de congélation par pulvérisation ou dans la gaine de gaz en même temps (aux fins de refroidissement). Les particules sont lyophilisées essentiellement à la pression atmosphérique dans un flux de liquide descendant, avec un filtre de sortie à cet endroit pour éliminer l'humidité retenue sur les particules congelées ou à l'intérieur de celles-ci. Le système peut également servir à former d'autres poudres.
CA2450779A 2003-12-22 2003-12-22 Formation de poudre par lyophilisation a pulverisation atmospherique Expired - Lifetime CA2450779C (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA2450779A CA2450779C (fr) 2003-12-22 2003-12-22 Formation de poudre par lyophilisation a pulverisation atmospherique
PCT/CA2004/002160 WO2005061088A1 (fr) 2003-12-22 2004-12-20 Fomation de poudre par lyophilisation par vaporisation atmospherique
JP2006545859A JP5183068B2 (ja) 2003-12-22 2004-12-20 大気噴出凍結乾燥法による粉末形成
EP04802335.2A EP1697035B1 (fr) 2003-12-22 2004-12-20 Fomation de poudre par lyophilisation par vaporisation atmospherique
US12/050,654 US8322046B2 (en) 2003-12-22 2008-03-18 Powder formation by atmospheric spray-freeze drying

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA2450779A CA2450779C (fr) 2003-12-22 2003-12-22 Formation de poudre par lyophilisation a pulverisation atmospherique

Publications (2)

Publication Number Publication Date
CA2450779A1 CA2450779A1 (fr) 2005-06-22
CA2450779C true CA2450779C (fr) 2012-10-16

Family

ID=34683000

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2450779A Expired - Lifetime CA2450779C (fr) 2003-12-22 2003-12-22 Formation de poudre par lyophilisation a pulverisation atmospherique

Country Status (1)

Country Link
CA (1) CA2450779C (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1798504A1 (fr) * 2005-12-19 2007-06-20 Koninklijke Philips Electronics N.V. Procédé de fabrication de particules séchées
CN110639427A (zh) * 2018-12-10 2020-01-03 金昌正旭工贸有限责任公司 一种硫磺熔融液喷雾水冷介质造粒工艺
CN118856807B (zh) * 2024-07-19 2026-04-21 东富龙科技集团股份有限公司 实验型雾化冷冻装置及操作方法

Also Published As

Publication number Publication date
CA2450779A1 (fr) 2005-06-22

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Effective date: 20231222