CA2464681C - Elaboration de composes de thioarabinofuranosyl et leurs applications - Google Patents

Elaboration de composes de thioarabinofuranosyl et leurs applications Download PDF

Info

Publication number: CA2464681C
Authority: CA; Canada
Prior art keywords: compound; thio; reacting; cytosine; arabinofuranosyl
Prior art date: 1998-07-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA2464681A

Other languages

English (en)

Other versions

CA2464681A1 (fr

Inventor

John A. Secrist, Iii

Kamal N. Tiwari

John A. Montgomery

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Southern Research Institute

Original Assignee

Southern Research Institute

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-23

Filing date

1999-07-23

Publication date

2010-05-25

1999-07-23 Application filed by Southern Research Institute filed Critical Southern Research Institute

1999-07-23 Priority claimed from CA002338415A external-priority patent/CA2338415C/fr

2000-02-03 Publication of CA2464681A1 publication Critical patent/CA2464681A1/fr

2010-05-25 Application granted granted Critical

2010-05-25 Publication of CA2464681C publication Critical patent/CA2464681C/fr

2019-07-23 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 70
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229940104302 cytosine Drugs 0.000 claims abstract description 31
239000000203 mixture Substances 0.000 claims abstract description 21
-1 arabinofuranosyl compound Chemical class 0.000 claims abstract description 20
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239000005450 thionucleoside Substances 0.000 description 1
HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
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UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
238000005406 washing Methods 0.000 description 1

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CA2464681A 1998-07-23 1999-07-23 Elaboration de composes de thioarabinofuranosyl et leurs applications Expired - Lifetime CA2464681C (fr)

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US9386998P	1998-07-23	1998-07-23
US60/093,869		1998-07-23
CA002338415A CA2338415C (fr)	1998-07-23	1999-07-23	Elaboration de composes de thioarabinofuranosyl et leurs applications

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CA002338415A Division CA2338415C (fr)	1998-07-23	1999-07-23	Elaboration de composes de thioarabinofuranosyl et leurs applications

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CA2464681C true CA2464681C (fr)	2010-05-25

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Publication	Publication Date	Title
US8178510B2 (en)	2012-05-15	Preparation of thioarabinofuranosyl compounds and use thereof
CA1333390C (fr)	1994-12-06	Nucleosides fluores et methode de traitement des infections retrovirales avec ces nucleosides
US6949522B2 (en)	2005-09-27	β-2′- or 3′-halonucleosides
US9085599B2 (en)	2015-07-21	2′allene-substituted nucleoside derivatives
CA2163520C (fr)	2006-01-10	Analogues de l-2',3'-didesoxy nucleoside, agents anti-hepatite b et anti-vih
EP0526537B1 (fr)	1995-07-12	Derives de barbituriques au 5-benzyle
US20100056468A1 (en)	2010-03-04	Pyrimidine Derivatives As Anticancer Agents
JPH0780898B2 (ja)	1995-08-30	抗ウイルスヌクレオシド
EP0788506A2 (fr)	1997-08-13	Nucleosides de l-ribofuranosyle
JPH06507902A (ja)	1994-09-08	肝臓で代謝される薬物前駆物の決定とその治療的利用
JPH04226999A (ja)	1992-08-17	抗ウイルス剤
US20200054661A1 (en)	2020-02-20	Multitargeted nucleoside derivatives
CA2464681C (fr)	2010-05-25	Elaboration de composes de thioarabinofuranosyl et leurs applications
US5153180A (en)	1992-10-06	Fluorinated nucleosides and process for treating retrovirus infections therewith
JPH0413328B2 (fr)	1992-03-09
Van Poecke	2011	Synthesis and biological evaluation of pyrimidine nucleosides and nucleoside phosphonates
CA2203672A1 (fr)	1996-05-09	Nucleosides de l-ribofuranosyle