CA2466701C - Utilisation de la prolyl-glycine cyclique a des fins de neuroprotection - Google Patents
Utilisation de la prolyl-glycine cyclique a des fins de neuroprotection Download PDFInfo
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- CA2466701C CA2466701C CA2466701A CA2466701A CA2466701C CA 2466701 C CA2466701 C CA 2466701C CA 2466701 A CA2466701 A CA 2466701A CA 2466701 A CA2466701 A CA 2466701A CA 2466701 C CA2466701 C CA 2466701C
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention se rapporte à l'utilisation de la prolyl-glycine cyclique (<= PG cyclique >= ou <= CPG >=) et de ses analogues et mimétiques en tant qu'agents neuroprotecteurs pour le traitement et/ou la prévention de troubles neurologiques comprenant, non exclusivement, l'ischémie cérébrale ou l'infarctus cérébral résultant d'une diversité de phénomènes du type attaque d'apoplexie thromboembolique ou attaque d'apoplexie hémorragique, basospasmes cérébraux, hypoglycémie, arrêt cardiaque, status epilepticus, asphyxie périnatale, anoxie telle que l'anoxie par noyade, chirurgie pulmonaire et traumatisme cérébral, lesdits agents pouvant également servir au traitement et à la prévention de troubles neurodégénératifs chroniques tels que la maladie d'Alzheimer, la maladie de Parkinson et la maladie de Huntington, ainsi qu'en tant qu'anti-convulsifs.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ515432 | 2001-11-13 | ||
| NZ51543201 | 2001-11-13 | ||
| US40590902P | 2002-08-26 | 2002-08-26 | |
| US60/405,909 | 2002-08-26 | ||
| PCT/US2002/036639 WO2003041655A2 (fr) | 2001-11-13 | 2002-11-12 | Composition d'agents therapeutiques et procede d'utilisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2466701A1 CA2466701A1 (fr) | 2003-05-22 |
| CA2466701C true CA2466701C (fr) | 2013-11-12 |
Family
ID=26652293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2466701A Expired - Fee Related CA2466701C (fr) | 2001-11-13 | 2002-11-12 | Utilisation de la prolyl-glycine cyclique a des fins de neuroprotection |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2002363800A1 (fr) |
| CA (1) | CA2466701C (fr) |
| WO (1) | WO2003041655A2 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7232798B2 (en) | 2001-11-13 | 2007-06-19 | Tran Loi H | Neuroprotection and neuroegenisis by administering cyclic prolyl glycine |
| AUPS255202A0 (en) * | 2002-05-27 | 2002-06-13 | Monash University | Agents and methods for the treatment of disorders associated with motor neuron degeneration |
| EP1664050B1 (fr) | 2003-09-03 | 2015-12-09 | Neuren Pharmaceuticals Limited | Composes neuroprotecteurs bicycliques et procedes d'utilisation correspondants |
| US8791117B2 (en) | 2003-09-03 | 2014-07-29 | Neuren Pharmaceuticals Limited | Cyclic glycyl-2-allyl proline improves cognitive performance in impaired animals |
| RU2355413C1 (ru) * | 2007-12-06 | 2009-05-20 | Закрытое Акционерное Общество "Биоген Технолоджиз" | Фармацевтическое средство для лечения демиелинизирующих заболеваний нервной системы, средство, способствующее восстановлению миелиновой оболочки нервного волокна, и способ лечения демиелинизирующих заболеваний нервной системы |
| EP2338492A1 (fr) * | 2009-12-24 | 2011-06-29 | Universidad del Pais Vasco | Procédés et compositions pour le traitement de la maladie d'Alzheimer |
| US10842849B2 (en) | 2011-02-28 | 2020-11-24 | The Schepens Eye Research Institute, Inc. | Methods for promoting neuronal outgrowth by insulin-like growth factor binding protein-like 1 (IGFBPL-1) in glaucoma or leber's optic neuropathy |
| MA53500A (fr) | 2018-05-15 | 2021-08-18 | Lloyd Hung Loi Tran | Composition d'agent thérapeutique et procédé d'utilisation, pour le traitement d'un trouble cognitif léger, de la dépression et de troubles psychologiques |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840736A (en) * | 1996-11-13 | 1998-11-24 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
| US5942422A (en) * | 1996-11-14 | 1999-08-24 | The Trustees Of Columbia University In The City Of New York | Method for generating a directed, recombinant fusion nucleic acid |
| US6121416A (en) * | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
| US6291511B1 (en) * | 1997-05-29 | 2001-09-18 | Merck & Co., Inc. | Biarylalkanoic acids as cell adhesion inhibitors |
| US6258582B1 (en) * | 1998-09-30 | 2001-07-10 | Millennium Pharmaceuticals, Inc. | CSAPTP nucleic acid molecules and uses therefor |
| US6303576B1 (en) * | 1999-04-21 | 2001-10-16 | Adherex Technologies Inc. | Compounds and methods for modulating β-catenin mediated gene expression |
-
2002
- 2002-11-12 CA CA2466701A patent/CA2466701C/fr not_active Expired - Fee Related
- 2002-11-12 WO PCT/US2002/036639 patent/WO2003041655A2/fr not_active Ceased
- 2002-11-12 AU AU2002363800A patent/AU2002363800A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003041655A2 (fr) | 2003-05-22 |
| CA2466701A1 (fr) | 2003-05-22 |
| AU2002363800A1 (en) | 2003-05-26 |
| WO2003041655A3 (fr) | 2004-09-10 |
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