CA2472633C - S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer - Google Patents

S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer Download PDF

Info

Publication number: CA2472633C
Authority: CA; Canada
Prior art keywords: cancer; cooh; compound; mer1; significant
Prior art date: 2002-01-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA2472633A

Other languages

English (en)

French (fr)

Other versions

CA2472633A1 (en

Inventor

Ralph A. Zingaro

Emil L. Freireich

Hatice Duzkale

Hagop Kantarjian

Srdan Verstovsek

Merida Sotelo-Lerma

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Texas A&M University System

University of Texas System

Original Assignee

Texas A&M University System

University of Texas System

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-07

Filing date

2003-01-07

Publication date

2014-07-08

2003-01-07 Application filed by Texas A&M University System, University of Texas System filed Critical Texas A&M University System

2003-07-17 Publication of CA2472633A1 publication Critical patent/CA2472633A1/en

2014-07-08 Application granted granted Critical

2014-07-08 Publication of CA2472633C publication Critical patent/CA2472633C/en

2023-01-07 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/66—Arsenic compounds
- C07F9/70—Organo-arsenic compounds
- C07F9/72—Aliphatic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA2472633A 2002-01-07 2003-01-07 S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer Expired - Fee Related CA2472633C (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US34649202P	2002-01-07	2002-01-07
US60/346,492		2002-01-07
PCT/US2003/000281 WO2003057012A2 (en)	2002-01-07	2003-01-07	S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Publications (2)

Publication Number	Publication Date
CA2472633A1 CA2472633A1 (en)	2003-07-17
CA2472633C true CA2472633C (en)	2014-07-08

Family

ID=23359639

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2472633A Expired - Fee Related CA2472633C (en)	2002-01-07	2003-01-07	S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Country Status (6)

Country	Link
US (4)	US6911471B2 (2)
EP (3)	EP1474128B1 (2)
JP (4)	JP4571408B2 (2)
AU (1)	AU2003207455B2 (2)
CA (1)	CA2472633C (2)
WO (1)	WO2003057012A2 (2)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1474128B1 (en) *	2002-01-07	2016-06-01	Board Of Regents, The University Of Texas System	S-dimethylarsino-thiosuccinic acid, s-dimethylarsino-2-thiobenzoic acid, s-(dimethylarsino)glutathione as treatments for cancer
AU2011204901B2 (en) *	2004-07-16	2013-09-12	Board Of Regents, The University Of Texas System	Compounds and methods for treatment of cancer
TWI411431B (zh) *	2004-07-16	2013-10-11	Texas A & M Univ Sys	有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
JP4994374B2 (ja) *	2005-07-29	2012-08-08	ジオファームオンコロジー，インコーポレイテッド	がんを治療するための化合物および方法
CN101395166B (zh) *	2006-01-13	2014-07-09	得克萨斯州A&M大学系统	用于治疗癌症的化合物和方法
TW200829261A (en) *	2006-09-29	2008-07-16	Ziopharm Oncology Inc	Method for controlling angiogenesis in animals
EP2069371B1 (en) *	2006-11-01	2013-03-13	NewSouth Innovations Pty Limited	Organo-arsenoxide compounds and use thereof
CN101903029B (zh) *	2007-11-02	2012-09-26	Zio医药肿瘤学公司	使用有机砷化物的联合治疗
WO2009075870A1 (en) *	2007-12-12	2009-06-18	Ziopharm Oncology, Inc.	Compounds and methods for the treatment of cancer
WO2009153131A1 (en) *	2008-05-28	2009-12-23	Basf Se	Means and methods for assessing liver enzyme induction
PT2321012T (pt)	2008-08-20	2019-01-11	Solasia Pharma K K	Compostos organoarsénicos e métodos para o tratamento de cancro
JP5469779B2 (ja) *	2010-04-19	2014-04-16	エスアールアイインターナショナル	多発性骨髄腫の治療のための組成物および方法
CN105899486A (zh) *	2013-12-05	2016-08-24	日本苏爱康制药有限公司	用于治疗癌症的化合物和方法
CN112941027B (zh) *	2021-03-19	2021-11-02	苏州大学	二甲基亚胂酸致人角质形成细胞恶性转化细胞株及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2349729A (en) *	1940-08-24	1944-05-23	Parke Davis & Co	Therapeutic arsenic preparation
US2701812A (en) *	1951-06-26	1955-02-08	Dainippon Pharmaceutical Co	Diarylarsenious acid derivatives and the preparation thereof
DE3229565A1 (de) *	1982-08-07	1984-02-16	Etschenberg, Eugen, Dr., 5000 Köln	Arsenhaltige nucleoside
FR2640269B1 (fr) *	1988-12-13	1991-03-15	Maes Ludo	Composes organometalliques, leurs modes de preparation et compositions pharmaceutiques les contenant
US6875451B2 (en)	1997-10-15	2005-04-05	Polarx Biopharmaceuticals Inc.	Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
TR200002243T2 (tr)	1997-11-10	2000-12-21	Memorial Sloan-Kettering Cancer Center	Arsenik trioksitin hazırlanması için işlem ve bunların kanser tedavisi için kullanımı.
CN1233476A (zh) *	1998-04-24	1999-11-03	陆道培	治疗急性白血病的药物及其制备方法
EP1002537A1 (en)	1998-10-30	2000-05-24	Assistance Publique, Hopitaux De Paris	Use of melarsoprol for the manufacture of a medicament for treating B-cell lymphoproliferative diseases, such as multiple myeloma
US6191123B1 (en)	1999-03-19	2001-02-20	Parker Hughes Institute	Organic-arsenic compounds
AUPQ296799A0 (en)	1999-09-20	1999-10-14	Unisearch Limited	A cell-membrane impermeable trivalent organoarsenical derivative and use thereof
US7022315B2 (en)	2000-04-26	2006-04-04	Oregon Health & Science University	Administration of a thiol-based chemoprotectant compound
AUPR379801A0 (en)	2001-03-19	2001-04-12	Unisearch Limited	Use of a substantially cell membrane impermeable compound for treating arthritis
AUPR598901A0 (en)	2001-06-28	2001-07-19	Unisearch Limited	Inhibition of angiogenesis by targeting protein tyrosine phosphatases
EP1411876B1 (en)	2001-07-06	2009-10-28	Cochlear Limited	Configuration of implanted devices
EP1474128B1 (en)	2002-01-07	2016-06-01	Board Of Regents, The University Of Texas System	S-dimethylarsino-thiosuccinic acid, s-dimethylarsino-2-thiobenzoic acid, s-(dimethylarsino)glutathione as treatments for cancer
EP1563099B1 (en)	2002-11-07	2009-07-22	Newsouth Innovations Pty Limited	Induction of the mitochondrial permeability transition
TWI411431B (zh)	2004-07-16	2013-10-11	Texas A & M Univ Sys	有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
EP2069371B1 (en)	2006-11-01	2013-03-13	NewSouth Innovations Pty Limited	Organo-arsenoxide compounds and use thereof

2003
- 2003-01-07 EP EP03705662.9A patent/EP1474128B1/en not_active Expired - Lifetime
- 2003-01-07 AU AU2003207455A patent/AU2003207455B2/en not_active Ceased
- 2003-01-07 CA CA2472633A patent/CA2472633C/en not_active Expired - Fee Related
- 2003-01-07 JP JP2003557380A patent/JP4571408B2/ja not_active Expired - Lifetime
- 2003-01-07 WO PCT/US2003/000281 patent/WO2003057012A2/en not_active Ceased
- 2003-01-07 EP EP11187256A patent/EP2462932A1/en not_active Withdrawn
- 2003-01-07 EP EP20110187261 patent/EP2420229A1/en not_active Withdrawn
- 2003-01-07 US US10/337,969 patent/US6911471B2/en not_active Expired - Lifetime
2005
- 2005-01-13 US US11/035,178 patent/US6995188B2/en not_active Expired - Lifetime
2006
- 2006-02-06 US US11/349,043 patent/US7619000B2/en not_active Expired - Lifetime
2007
- 2007-08-20 US US11/894,807 patent/US20080090904A1/en not_active Abandoned
2009
- 2009-12-09 JP JP2009279362A patent/JP5603593B2/ja not_active Expired - Fee Related
2013
- 2013-08-22 JP JP2013172071A patent/JP2013237701A/ja active Pending
2015
- 2015-03-16 JP JP2015051753A patent/JP2015120745A/ja active Pending

Also Published As

Publication number	Publication date
EP2420229A1 (en)	2012-02-22
EP1474128A4 (en)	2006-05-03
US20040034095A1 (en)	2004-02-19
WO2003057012A2 (en)	2003-07-17
WO2003057012A3 (en)	2004-07-08
JP2005527487A (ja)	2005-09-15
WO2003057012A8 (en)	2004-04-01
EP2462932A1 (en)	2012-06-13
US6911471B2 (en)	2005-06-28
US6995188B2 (en)	2006-02-07
JP5603593B2 (ja)	2014-10-08
JP2010090149A (ja)	2010-04-22
EP1474128A2 (en)	2004-11-10
US20060189687A1 (en)	2006-08-24
US20050131062A1 (en)	2005-06-16
US20080090904A1 (en)	2008-04-17
AU2003207455B2 (en)	2007-09-20
AU2003207455A2 (en)	2003-07-24
EP1474128B1 (en)	2016-06-01
US7619000B2 (en)	2009-11-17
JP2015120745A (ja)	2015-07-02
JP4571408B2 (ja)	2010-10-27
AU2003207455A1 (en)	2003-07-24
CA2472633A1 (en)	2003-07-17
JP2013237701A (ja)	2013-11-28

Legal Events

Date	Code	Title	Description
2007-10-29	EEER	Examination request
2017-02-20	MKLA	Lapsed	Effective date: 20170109