CA2474035C - Peptides macrocycliques actifs contre le virus de l'hepatite c - Google Patents

Peptides macrocycliques actifs contre le virus de l'hepatite c Download PDF

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Publication number
CA2474035C
CA2474035C CA2474035A CA2474035A CA2474035C CA 2474035 C CA2474035 C CA 2474035C CA 2474035 A CA2474035 A CA 2474035A CA 2474035 A CA2474035 A CA 2474035A CA 2474035 C CA2474035 C CA 2474035C
Authority
CA
Canada
Prior art keywords
compound
hcv
alkyl
acid
hcv agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2474035A
Other languages
English (en)
Other versions
CA2474035A1 (fr
Inventor
Montse Llinas-Brunet
Vida J. Gorys
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Canada Ltd
Original Assignee
Boehringer Ingelheim Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002369711A external-priority patent/CA2369711A1/fr
Application filed by Boehringer Ingelheim Canada Ltd filed Critical Boehringer Ingelheim Canada Ltd
Priority to CA2474035A priority Critical patent/CA2474035C/fr
Publication of CA2474035A1 publication Critical patent/CA2474035A1/fr
Application granted granted Critical
Publication of CA2474035C publication Critical patent/CA2474035C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés de formule générale (I), dans laquelle R?1¿ est hydroxy ou NHSO¿2?R?1A¿, R?1A¿ étant (C¿1-8?)alkyle, (C¿3-7?)cycloalkyle ou {(C¿1-6?)alkyle-(C¿3-7?)cycloalkyle} qui sont tous éventuellement substitués de 1 à 3 fois par halo, cyano, nitro, O(C¿1-6?)alkyle, amido, amino ou phényle, ou R?1A¿ étant C¿6? ou C¿10? aryle éventuellement substitué de 1 à 3 fois par halo, cyano, nitro, (C¿1-6?)alkyle, O(C¿1-6?)alkyle, amido, amino ou phényle; R?2¿ est (C¿5-6?)cycloalkyle et R?3¿ est cyclopentyle; ou un sel pharmaceutiquement acceptable correspondant, utilisés en tant qu'inhibiteurs de la protéase HCV NS3.
CA2474035A 2002-01-30 2003-01-24 Peptides macrocycliques actifs contre le virus de l'hepatite c Expired - Fee Related CA2474035C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2474035A CA2474035C (fr) 2002-01-30 2003-01-24 Peptides macrocycliques actifs contre le virus de l'hepatite c

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA2,369,711 2002-01-30
CA002369711A CA2369711A1 (fr) 2002-01-30 2002-01-30 Peptides macrocycliques qui agissent contre le virus de l'hepatite c
PCT/CA2003/000089 WO2003064455A2 (fr) 2002-01-30 2003-01-24 Peptides macrocycliques actifs contre le virus de l'hepatite c
CA2474035A CA2474035C (fr) 2002-01-30 2003-01-24 Peptides macrocycliques actifs contre le virus de l'hepatite c

Publications (2)

Publication Number Publication Date
CA2474035A1 CA2474035A1 (fr) 2003-08-07
CA2474035C true CA2474035C (fr) 2011-09-20

Family

ID=32991605

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2474035A Expired - Fee Related CA2474035C (fr) 2002-01-30 2003-01-24 Peptides macrocycliques actifs contre le virus de l'hepatite c

Country Status (1)

Country Link
CA (1) CA2474035C (fr)

Also Published As

Publication number Publication date
CA2474035A1 (fr) 2003-08-07

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Legal Events

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EEER Examination request
MKLA Lapsed

Effective date: 20150126