CA2474844A1 - Inhibiteurs de cks1 - Google Patents
Inhibiteurs de cks1 Download PDFInfo
- Publication number
- CA2474844A1 CA2474844A1 CA002474844A CA2474844A CA2474844A1 CA 2474844 A1 CA2474844 A1 CA 2474844A1 CA 002474844 A CA002474844 A CA 002474844A CA 2474844 A CA2474844 A CA 2474844A CA 2474844 A1 CA2474844 A1 CA 2474844A1
- Authority
- CA
- Canada
- Prior art keywords
- cksl
- skp2
- cells
- antisense
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne des inhibiteurs des protéines humaines Cks1 et Skp2, y compris des oligonucléotides anti-sens, des méthodes et des compositions spécifiques aux protéines humaines Cks1 Skp2. L'invention concerne également des méthodes d'utilisation des compositions dans la modulation de l'expression de Cks1 et de Skp2, et dans la régulation de la croissance cellulaire, en particulier la croissance des cellules tumorales.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35690602P | 2002-02-12 | 2002-02-12 | |
| US60/356,906 | 2002-02-12 | ||
| PCT/US2003/004550 WO2003068939A2 (fr) | 2002-02-12 | 2003-02-12 | Inhibiteurs de cks1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2474844A1 true CA2474844A1 (fr) | 2003-08-21 |
Family
ID=27734702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002474844A Abandoned CA2474844A1 (fr) | 2002-02-12 | 2003-02-12 | Inhibiteurs de cks1 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1480995A4 (fr) |
| JP (1) | JP2005523280A (fr) |
| AU (1) | AU2003215235A1 (fr) |
| CA (1) | CA2474844A1 (fr) |
| WO (1) | WO2003068939A2 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2954896A1 (fr) * | 2014-06-13 | 2015-12-16 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibiteurs à petite molécule de la ligase de Skp2 E3 dans la dépression et d'autres maladies |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5801015A (en) * | 1995-06-05 | 1998-09-01 | Mitotix, Inc. | Nucleic acid encoding a Candida cell cycle regulatory protein, TYP1 polypeptide |
| US5981702A (en) * | 1995-09-21 | 1999-11-09 | Cold Spring Harbor Laboratory | Cyclin/CDK associated proteins, and uses related thereto |
| WO1998041642A1 (fr) * | 1997-03-14 | 1998-09-24 | Cropdesign N.V. | Procede et moyens de modulation des proteines du cycle cellulaire des plantes et utilisation de ces moyens pour controler la croissance cellulaire des plantes |
| US6573094B1 (en) * | 1997-10-16 | 2003-06-03 | Baylor College Of Medicine | F-box genes and proteins |
| EP1352080A4 (fr) * | 2001-01-05 | 2005-04-06 | Univ New York | Procedes destines a identifier des composes utiles dans le traitement de troubles de proliferation et de differenciation |
| KR100876327B1 (ko) * | 2001-02-21 | 2008-12-31 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 진단에서의, 그리고 암에서 치료 표적으로서의 ｔｔｋ |
-
2003
- 2003-02-12 CA CA002474844A patent/CA2474844A1/fr not_active Abandoned
- 2003-02-12 WO PCT/US2003/004550 patent/WO2003068939A2/fr not_active Ceased
- 2003-02-12 AU AU2003215235A patent/AU2003215235A1/en not_active Abandoned
- 2003-02-12 EP EP03711050A patent/EP1480995A4/fr not_active Withdrawn
- 2003-02-12 JP JP2003568054A patent/JP2005523280A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003068939A2 (fr) | 2003-08-21 |
| WO2003068939A3 (fr) | 2003-12-31 |
| JP2005523280A (ja) | 2005-08-04 |
| AU2003215235A1 (en) | 2003-09-04 |
| EP1480995A4 (fr) | 2006-09-13 |
| AU2003215235A8 (en) | 2003-09-04 |
| EP1480995A2 (fr) | 2004-12-01 |
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| FZDE | Dead |