CA2493673A1 - Procede de preparation de lentilles intraoculaires pour implantation - Google Patents

Procede de preparation de lentilles intraoculaires pour implantation Download PDF

Info

Publication number
CA2493673A1
CA2493673A1 CA002493673A CA2493673A CA2493673A1 CA 2493673 A1 CA2493673 A1 CA 2493673A1 CA 002493673 A CA002493673 A CA 002493673A CA 2493673 A CA2493673 A CA 2493673A CA 2493673 A1 CA2493673 A1 CA 2493673A1
Authority
CA
Canada
Prior art keywords
inner mold
intraocular lens
optic
mold
posterior
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002493673A
Other languages
English (en)
Other versions
CA2493673C (fr
Inventor
Gholam-Reza Zadno-Azizi
Albert C. Ting
Tuan Anh Nguyen
Valdemar Portney
Hai-Minh Pham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Visiogen Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/207,708 external-priority patent/US6884261B2/en
Priority claimed from US10/207,717 external-priority patent/US20030078657A1/en
Priority claimed from US10/207,688 external-priority patent/US6818158B2/en
Priority claimed from US10/207,718 external-priority patent/US20030078658A1/en
Priority claimed from US10/207,701 external-priority patent/US7198640B2/en
Application filed by Individual filed Critical Individual
Priority to CA2767318A priority Critical patent/CA2767318C/fr
Publication of CA2493673A1 publication Critical patent/CA2493673A1/fr
Application granted granted Critical
Publication of CA2493673C publication Critical patent/CA2493673C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1629Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing longitudinal position, i.e. along the visual axis when implanted
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1637Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
    • A61F2/164Aspheric lenses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1648Multipart lenses
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29DPRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00Producing optical elements, e.g. lenses or prisms
    • B29D11/02Artificial eyes from organic plastic material
    • B29D11/023Implants for natural eyes
    • B29D11/026Comprising more than one lens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1601Lens body having features to facilitate aqueous fluid flow across the intraocular lens, e.g. for pressure equalization or nutrient delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1654Diffractive lenses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2002/16965Lens includes ultraviolet absorber
    • A61F2002/1699Additional features not otherwise provided for
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001Designing or manufacturing processes
    • A61F2240/002Designing or making customized prostheses
    • A61F2240/004Using a positive or negative model, e.g. moulds

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Transplantation (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Mechanical Engineering (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
CA2493673A 2002-07-25 2003-07-24 Procede de preparation de lentilles intraoculaires pour implantation Expired - Fee Related CA2493673C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2767318A CA2767318C (fr) 2002-07-25 2003-07-24 Systeme de lentille intraoculaire d'accommodation a element de separation

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US10/207,708 US6884261B2 (en) 2001-01-25 2002-07-25 Method of preparing an intraocular lens for implantation
US10/207,717 US20030078657A1 (en) 2001-01-25 2002-07-25 Materials for use in accommodating intraocular lens system
US10/207,688 2002-07-25
US10/207,688 US6818158B2 (en) 2001-01-25 2002-07-25 Accommodating intraocular lens system and method of making same
US10/207,708 2002-07-25
US10/207,718 US20030078658A1 (en) 2001-01-25 2002-07-25 Single-piece accomodating intraocular lens system
US10/207,717 2002-07-25
US10/207,718 2002-07-25
US10/207,701 2002-07-25
US10/207,701 US7198640B2 (en) 2001-01-25 2002-07-25 Accommodating intraocular lens system with separation member
PCT/US2003/023077 WO2004010905A2 (fr) 2002-07-25 2003-07-24 Systeme de lentille intraoculaire

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2767318A Division CA2767318C (fr) 2002-07-25 2003-07-24 Systeme de lentille intraoculaire d'accommodation a element de separation

Publications (2)

Publication Number Publication Date
CA2493673A1 true CA2493673A1 (fr) 2004-02-05
CA2493673C CA2493673C (fr) 2012-04-10

Family

ID=31192462

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2849167A Expired - Fee Related CA2849167C (fr) 2002-07-25 2003-07-24 Lentilles intraoculaires et procedes de preparation ou de fabrication decelles-ci
CA2493673A Expired - Fee Related CA2493673C (fr) 2002-07-25 2003-07-24 Procede de preparation de lentilles intraoculaires pour implantation
CA2767318A Expired - Fee Related CA2767318C (fr) 2002-07-25 2003-07-24 Systeme de lentille intraoculaire d'accommodation a element de separation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2849167A Expired - Fee Related CA2849167C (fr) 2002-07-25 2003-07-24 Lentilles intraoculaires et procedes de preparation ou de fabrication decelles-ci

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2767318A Expired - Fee Related CA2767318C (fr) 2002-07-25 2003-07-24 Systeme de lentille intraoculaire d'accommodation a element de separation

Country Status (5)

Country Link
EP (1) EP1524953A2 (fr)
JP (1) JP5276762B2 (fr)
AU (1) AU2003252137A1 (fr)
CA (3) CA2849167C (fr)
WO (1) WO2004010905A2 (fr)

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* Cited by examiner, † Cited by third party
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US8556967B2 (en) 1999-04-09 2013-10-15 Faezeh Mona Sarfarazi Interior bag for a capsular bag and injector
US7780729B2 (en) 2004-04-16 2010-08-24 Visiogen, Inc. Intraocular lens
US7217112B2 (en) 2003-05-27 2007-05-15 Faezeh Mona Sarfarazi Mold for intraocular lens
IL161706A0 (en) 2004-04-29 2004-09-27 Nulens Ltd Intraocular lens fixation device
US8057217B2 (en) * 2004-09-30 2011-11-15 Bausch + Lomb Incorporated Apparatus and method for injection molding an intraocular lens device
WO2006103674A2 (fr) 2005-03-30 2006-10-05 Nulens Ltd Ensembles lentille intraoculaire accommodative (aiol) et composants separes pour lesdits ensembles
US20070260309A1 (en) * 2006-05-08 2007-11-08 Richardson Gary A Accommodating intraocular lens having a recessed anterior optic
US7998198B2 (en) * 2008-02-07 2011-08-16 Novartis Ag Accommodative IOL with dynamic spherical aberration
TWI507183B (zh) * 2009-09-04 2015-11-11 Alcon Inc 具晶體間混濁化抗性之眼內晶體
CN102724932A (zh) * 2009-11-17 2012-10-10 爱克透镜国际公司 受睫块驱动的可调节人工晶状体
WO2011137191A1 (fr) * 2010-04-27 2011-11-03 Ramgopal Rao Dispositif de lentille intraoculaire accomodative
WO2012045183A1 (fr) * 2010-10-06 2012-04-12 Eduard Anton Haefliger Implant de lentille intraoculaire
CA2824656A1 (fr) * 2010-12-29 2012-07-05 Elenza, Inc. Dispositifs et procedes pour mouvement de focalisation dynamique
WO2012106673A1 (fr) 2011-02-04 2012-08-09 Forsight Labs, Llc Lentille intraoculaire d'accommodation
US9372282B1 (en) 2011-08-31 2016-06-21 Novartis Ag Styrenic ophthalmic and otorhinolaryngological materials and devices formed therewith
DE102012016893A1 (de) * 2012-08-24 2014-05-15 Be Innovative Gmbh Intraokularlinse, insbesondere Kapselsackintraokularlinse
US9486311B2 (en) 2013-02-14 2016-11-08 Shifamed Holdings, Llc Hydrophilic AIOL with bonding
CA3193600A1 (fr) 2013-03-21 2014-09-25 Shifamed Holdings, Llc Mise en place de lentille intraoculaire
US10195018B2 (en) 2013-03-21 2019-02-05 Shifamed Holdings, Llc Accommodating intraocular lens
JP5481588B1 (ja) 2013-05-13 2014-04-23 株式会社Frontier Vision 調節眼内レンズ
AU2015236131B2 (en) 2014-03-28 2019-05-30 Forsight Vision6, Inc. Accommodating intraocular lens
AU2015306613B2 (en) 2014-08-26 2018-01-25 Shifamed Holdings, Llc Accommodating intraocular lens
JP6708653B2 (ja) * 2015-03-11 2020-06-10 アルコン インコーポレイティド 眼内レンズを製造する装置および方法
US11141263B2 (en) 2015-11-18 2021-10-12 Shifamed Holdings, Llc Multi-piece accommodating intraocular lens
JP6934197B2 (ja) 2015-11-18 2021-09-15 シファメド・ホールディングス・エルエルシー 複数片の調節式眼内レンズ
EP3531973A4 (fr) 2016-10-28 2020-07-15 Forsight Vision6, Inc. Lentille intraoculaire d'accommodation et procédés d'implantation
US10350056B2 (en) 2016-12-23 2019-07-16 Shifamed Holdings, Llc Multi-piece accommodating intraocular lenses and methods for making and using same
CN120000379A (zh) 2016-12-23 2025-05-16 施菲姆德控股有限责任公司 多片式调节性人工晶状体及其制造和使用方法
CN110996848B (zh) 2017-05-30 2023-08-04 施菲姆德控股有限责任公司 调节性人工晶状体的表面处理以及相关方法和装置
EP4205702B1 (fr) 2017-06-07 2025-09-10 Shifamed Holdings, LLC Lentilles intraoculaires à puissance optique réglable
GB2565152B (en) * 2017-08-04 2020-06-03 Rayner Intraocular Lenses Ltd Intraocular lens
BR112021019254A2 (pt) 2019-03-25 2021-11-30 Akkolens Int B V Combinação de lentes intraoculares para restauração da refração e acomodação e métodos relacionados
US20220218466A1 (en) 2019-05-15 2022-07-14 Akkolens International B.V. Accommodating Intraocular Lenses with Combination of Mechanical Driving Components
EP3996629A4 (fr) 2019-07-11 2023-08-09 Shifamed Holdings, LLC Lentilles intraoculaires adaptatives et procédés associés
WO2021034187A1 (fr) 2019-08-19 2021-02-25 Akkolens International B.V. Combinaison de lentille intraoculaire accommodative à sections de lentille à puissance fixe et variable indépendantes
NL2027301B1 (en) 2020-01-13 2021-10-26 Akkolens Int B V Mechanical means for accommodative intraocular lens
KR102482346B1 (ko) * 2020-01-22 2022-12-29 주식회사 오토스윙 용접 정보 제공 장치
NL2028038B1 (en) 2020-05-11 2022-07-04 Akkolens Int B V Method to connect and distance hydrophilic intraocular lens elements
WO2022155325A1 (fr) 2021-01-13 2022-07-21 Forsight Vision6, Inc. Membrane dynamique à épaisseur variable destinée à recevoir des lentilles intraoculaires

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CS271606B1 (en) * 1988-04-11 1990-10-12 Sulc Jiri Intraocular optical system
US5275623A (en) * 1991-11-18 1994-01-04 Faezeh Sarfarazi Elliptical accommodative intraocular lens for small incision surgery
FR2747564B1 (fr) * 1996-04-22 1999-01-29 W K Et Associes Emballage pour le pliage des implants intraoculaires
US5876406A (en) * 1996-08-02 1999-03-02 Staar Surgical Company, Inc. Deformable intraocular lens injecting apparatus with transverse hinged lens cartridge
US6488708B2 (en) * 1999-04-09 2002-12-03 Faezeh Sarfarazi Open chamber, elliptical, accommodative intraocular lens system
US6616692B1 (en) * 1999-04-30 2003-09-09 Advanced Medical Optics, Inc. Intraocular lens combinations
US6599317B1 (en) * 1999-09-17 2003-07-29 Advanced Medical Optics, Inc. Intraocular lens with a translational zone
JP3728155B2 (ja) * 1999-10-05 2005-12-21 キヤノンスター株式会社 眼内挿入用レンズの挿入システム
US6797004B1 (en) * 2000-03-02 2004-09-28 Advanced Medical Optics, Inc. Holders for intraocular lenses
ES2320687T3 (es) * 2001-01-25 2009-05-27 Visiogen, Inc. Sistema de lentes intraoculares acomodativas.
US6884263B2 (en) * 2001-07-17 2005-04-26 Medennium, Inc. Accommodative intraocular lens

Also Published As

Publication number Publication date
WO2004010905A2 (fr) 2004-02-05
JP2005533611A (ja) 2005-11-10
CA2849167C (fr) 2016-06-28
JP5276762B2 (ja) 2013-08-28
CA2767318A1 (fr) 2004-02-05
CA2849167A1 (fr) 2004-02-05
CA2493673C (fr) 2012-04-10
WO2004010905A3 (fr) 2004-05-13
EP1524953A2 (fr) 2005-04-27
CA2767318C (fr) 2014-07-22
AU2003252137A1 (en) 2004-02-16

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Effective date: 20220301

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Effective date: 20200831