CA2496017A1 - Architecture de microreacteur et procedes associes - Google Patents
Architecture de microreacteur et procedes associes Download PDFInfo
- Publication number
- CA2496017A1 CA2496017A1 CA002496017A CA2496017A CA2496017A1 CA 2496017 A1 CA2496017 A1 CA 2496017A1 CA 002496017 A CA002496017 A CA 002496017A CA 2496017 A CA2496017 A CA 2496017A CA 2496017 A1 CA2496017 A1 CA 2496017A1
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- chip
- reaction site
- membrane
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- predetermined reaction
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- 238000000399 optical microscopy Methods 0.000 description 1
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- KUBDTFZQCYLLGC-VZORSVKHSA-N phallacidin Chemical compound N1C(=O)[C@@H]([C@@H](O)C(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C[C@@](C)(O)CO)NC(=O)[C@H](C2)NC(=O)[C@H](C)NC(=O)[C@@H]3C[C@H](O)CN3C(=O)[C@@H]1CSC1=C2C2=CC=CC=C2N1 KUBDTFZQCYLLGC-VZORSVKHSA-N 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
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- 239000005033 polyvinylidene chloride Substances 0.000 description 1
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- 239000011591 potassium Substances 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 229960004109 potassium acetate Drugs 0.000 description 1
- WFIZEGIEIOHZCP-UHFFFAOYSA-M potassium formate Chemical compound [K+].[O-]C=O WFIZEGIEIOHZCP-UHFFFAOYSA-M 0.000 description 1
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- 238000004801 process automation Methods 0.000 description 1
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- 238000005067 remediation Methods 0.000 description 1
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- 239000011347 resin Substances 0.000 description 1
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- PKFZNOZRJYLKGV-UHFFFAOYSA-L ruthenium(2+);dichloride;pentahydrate Chemical compound O.O.O.O.O.Cl[Ru]Cl PKFZNOZRJYLKGV-UHFFFAOYSA-L 0.000 description 1
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- 238000013341 scale-up Methods 0.000 description 1
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- 229910010271 silicon carbide Inorganic materials 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- JZNWSCPGTDBMEW-YFKPBYRVSA-N sn-glycero-3-phosphoethanolamine Chemical compound NCCO[P@@](O)(=O)OC[C@@H](O)CO JZNWSCPGTDBMEW-YFKPBYRVSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229960004249 sodium acetate Drugs 0.000 description 1
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical group [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
- 235000019254 sodium formate Nutrition 0.000 description 1
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- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- GFISHBQNVWAVFU-UHFFFAOYSA-K terbium(iii) chloride Chemical compound Cl[Tb](Cl)Cl GFISHBQNVWAVFU-UHFFFAOYSA-K 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 239000012780 transparent material Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Sustainable Development (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Clinical Laboratory Science (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
L'invention concerne, dans son ensemble, des puces de réaction chimique, biologique et/ou biochimique et d'autres systèmes de réaction tels que des systèmes de microréacteur, ainsi que des systèmes et des procédés pour réaliser et utiliser de tels dispositifs. Dans un mode de réalisation, une puce ou un autre système de réaction sont conçus pour favoriser la croissance cellulaire à l'intérieur de ceux-ci. Dans certains modes de réalisation, les puces ou les autres systèmes de réaction comportent un ou plusieurs sites de réaction, lesquels peuvent être très petits, par exemple, avoir un volume inférieur à environ 1 ml. Dans un autre mode de réalisation, la puce peut détecter, mesurer et/ou contrôler un facteur environnemental, tel que température, pression, concentration de CO¿2?, concentration de O¿2?, humidité relative, pH, etc., associé à un ou plusieurs sites de réaction, au moyen d'un ou de plusieurs capteurs, actionneurs processeurs et/ou systèmes de contrôle. La présente invention porte également sur des matériaux et des systèmes dotés de contrôle d'humidité et/ou de gaz pour, par exemple, être utilisés avec une puce, ces matériaux pouvant présenter une grande perméabilité à l'oxygène et/ou une faible perméabilité à la vapeur d'eau. Cette invention porte aussi, dans son ensemble, à des composants interagissant avec la lumière et pouvant être utilisés dans des puces et d'autres systèmes de réaction. Ces composants peuvent comprendre des guides d'ondes, des fibres optiques, des sources de lumière, des photodétecteurs, des éléments optiques, etc.
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22356202A | 2002-08-19 | 2002-08-19 | |
| US10/223,562 | 2002-08-19 | ||
| US40927302P | 2002-09-09 | 2002-09-09 | |
| US60/409,273 | 2002-09-09 | ||
| US45704803A | 2003-06-05 | 2003-06-05 | |
| US45693403A | 2003-06-05 | 2003-06-05 | |
| US45613303A | 2003-06-05 | 2003-06-05 | |
| US10/457,015 | 2003-06-05 | ||
| US10/457,049 | 2003-06-05 | ||
| US10/456,934 | 2003-06-05 | ||
| US10/456,133 | 2003-06-05 | ||
| US10/457,015 US20040058407A1 (en) | 2001-04-10 | 2003-06-05 | Reactor systems having a light-interacting component |
| US10/457,048 | 2003-06-05 | ||
| US10/457,049 US20040058437A1 (en) | 2001-04-10 | 2003-06-05 | Materials and reactor systems having humidity and gas control |
| PCT/US2003/025943 WO2004069983A2 (fr) | 2002-08-19 | 2003-08-19 | Architecture de microréacteur et procédés associés |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2496017A1 true CA2496017A1 (fr) | 2004-08-19 |
Family
ID=31892403
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002496017A Abandoned CA2496017A1 (fr) | 2002-08-19 | 2003-08-19 | Architecture de microreacteur et procedes associes |
| CA002495617A Abandoned CA2495617A1 (fr) | 2002-08-19 | 2003-08-19 | Determination et/ou regulation de conditions environnementales d'un reacteur |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002495617A Abandoned CA2495617A1 (fr) | 2002-08-19 | 2003-08-19 | Determination et/ou regulation de conditions environnementales d'un reacteur |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP1567637A2 (fr) |
| JP (2) | JP2005536233A (fr) |
| AU (3) | AU2003272223A1 (fr) |
| CA (2) | CA2496017A1 (fr) |
| WO (3) | WO2004069983A2 (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7485454B1 (en) | 2000-03-10 | 2009-02-03 | Bioprocessors Corp. | Microreactor |
| US9943847B2 (en) | 2002-04-17 | 2018-04-17 | Cytonome/St, Llc | Microfluidic system including a bubble valve for regulating fluid flow through a microchannel |
| GB0210809D0 (en) * | 2002-05-11 | 2002-06-19 | Univ Durham | Reactor |
| WO2007021762A2 (fr) | 2005-08-09 | 2007-02-22 | The University Of North Carolina At Chapel Hill | Procedes et materiaux permettant de fabriquer des dispositifs microfluidiques |
| JP4664646B2 (ja) * | 2004-10-20 | 2011-04-06 | 一般社団法人オンチップ・セロミクス・コンソーシアム | 細胞培養用マイクロチャンバーおよび細胞構造構築法 |
| JP2008519598A (ja) * | 2004-11-11 | 2008-06-12 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 細胞培養デバイス |
| EP1817568B1 (fr) | 2004-12-03 | 2019-04-17 | Cytonome/ST, LLC | Cartouche unitaire pour traitement de particules |
| US9260693B2 (en) | 2004-12-03 | 2016-02-16 | Cytonome/St, Llc | Actuation of parallel microfluidic arrays |
| DE102005004075B4 (de) * | 2005-01-28 | 2008-04-03 | Umicore Ag & Co. Kg | Keramischer Mikroreaktor |
| DE102006030068A1 (de) * | 2006-06-28 | 2008-01-03 | M2P-Labs Gmbh | Vorrichtung und Verfahren zur Zu- und Abfuhr von Fluiden in geschüttelten Mikroreaktoren Arrays |
| AU2007338862B2 (en) | 2006-07-19 | 2014-02-06 | Bionano Genomics, Inc. | Nanonozzle device arrays: their preparation and use for macromolecular analysis |
| US7811359B2 (en) | 2007-01-18 | 2010-10-12 | General Electric Company | Composite membrane for separation of carbon dioxide |
| JP2008194029A (ja) * | 2007-01-19 | 2008-08-28 | Tosoh Corp | 細胞融合装置及びそれを用いた細胞融合方法 |
| KR101522741B1 (ko) * | 2007-03-28 | 2015-05-26 | 바이오나노 제노믹스, 인크. | 나노채널 어레이를 사용하는 거대분자 분석 방법 |
| JP4963437B2 (ja) * | 2007-03-30 | 2012-06-27 | 京セラ株式会社 | 流路体、配線基板、流路形成配線基板、流路形成方法、流路体の製造方法、ならびに流路体キット |
| JP2011500018A (ja) * | 2007-10-11 | 2011-01-06 | エージェンシー フォー サイエンス， テクノロジー アンド リサーチ | ケージ中で一時的リンカーを用いて細胞構造体を形成する方法 |
| CN102057034A (zh) * | 2008-06-13 | 2011-05-11 | 福斯分析股份公司 | 生物技术工艺的过程控制 |
| US8628919B2 (en) | 2008-06-30 | 2014-01-14 | Bionano Genomics, Inc. | Methods and devices for single-molecule whole genome analysis |
| WO2010059731A2 (fr) | 2008-11-18 | 2010-05-27 | Bionanomatrix, Inc. | Cartographie et séquences de polynucléotide |
| DE102014214077A1 (de) * | 2014-07-18 | 2016-01-21 | Hamilton Bonaduz Ag | Laborbehälter, insbesondere Zellkulturbehälter, mit einer in das Behältervolumen hinein verlaufenden Gas-Ausgleichsleitung |
| WO2016121767A1 (fr) * | 2015-01-26 | 2016-08-04 | 宇部興産株式会社 | Culture de cellules à long terme utilisant une membrane poreuse en polyimide et procédé de cryoconservation de cellules utilisant ladite membrane poreuse en polyimide |
| NL2020612B1 (en) | 2017-12-22 | 2019-07-02 | Illumina Inc | Light detection devices with protective liner and methods of manufacturing same |
| CN109799012B (zh) * | 2019-01-23 | 2021-01-22 | 河南工程学院 | 一种基于纤维素的类三明治结构压力传感器及其制备方法 |
| JP7491136B2 (ja) * | 2020-08-20 | 2024-05-28 | 大日本印刷株式会社 | マイクロ流路構造体、マイクロ流路構造体の製造方法及びマイクロ流路デバイス |
| WO2023057602A1 (fr) * | 2021-10-08 | 2023-04-13 | Philip Morris Products S.A. | Détection d'agents bioactifs dans un milieu environnant |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5580523A (en) * | 1994-04-01 | 1996-12-03 | Bard; Allen J. | Integrated chemical synthesizers |
| US5800778A (en) * | 1995-05-31 | 1998-09-01 | Biomerieux Vitek, Inc. | Sealant for sample holder |
| DE19753598C1 (de) * | 1997-12-03 | 1999-07-01 | Micronas Intermetall Gmbh | Vorrichtung zum Messen physiologischer Parameter |
| JP2899701B1 (ja) * | 1998-06-19 | 1999-06-02 | 工業技術院長 | 透過スイッチ型カーボン膜 |
| GB9912641D0 (en) * | 1999-05-28 | 1999-07-28 | Ashby Scient Ltd | Textured and porous silicone rubber |
| JP2001157879A (ja) * | 1999-08-31 | 2001-06-12 | Tadahiro Omi | 水溶液のｐＨ制御の方法及びその装置 |
| JP3200631B2 (ja) * | 1999-09-08 | 2001-08-20 | 北陸先端科学技術大学院大学長 | 細胞の代謝活性に及ぼす影響を測定するためのバイオセンサー |
| JP2001129557A (ja) * | 1999-11-08 | 2001-05-15 | Japan Organo Co Ltd | 水処理方法 |
| US7485454B1 (en) * | 2000-03-10 | 2009-02-03 | Bioprocessors Corp. | Microreactor |
| US6673532B2 (en) * | 2000-08-14 | 2004-01-06 | University Of Maryland, Baltimore County | Bioreactor and bioprocessing technique |
| EP1325110A4 (fr) * | 2000-10-02 | 2009-03-25 | Thomas F Cannon | Bioculture automatisee et systeme d'experiences bioculturales |
| US6770434B2 (en) * | 2000-12-29 | 2004-08-03 | The Provost, Fellows And Scholars Of The College Of The Holy & Undivided Trinity Of Queen Elizabeth Near Dublin | Biological assay method |
| JP2002218974A (ja) * | 2001-01-24 | 2002-08-06 | Ebara Corp | 反応プローブチップ及び検出システム |
| US6418968B1 (en) * | 2001-04-20 | 2002-07-16 | Nanostream, Inc. | Porous microfluidic valves |
| CA2449193C (fr) * | 2001-06-08 | 2010-04-20 | Centre National De La Recherche Scientifique | Procede de fabrication d'une structure microfluidique, en particulier une puce a adn et structure obtenue par ledit procede |
-
2003
- 2003-08-19 CA CA002496017A patent/CA2496017A1/fr not_active Abandoned
- 2003-08-19 JP JP2005502070A patent/JP2005536233A/ja active Pending
- 2003-08-19 AU AU2003272223A patent/AU2003272223A1/en not_active Abandoned
- 2003-08-19 AU AU2003265491A patent/AU2003265491A1/en not_active Abandoned
- 2003-08-19 EP EP03815293A patent/EP1567637A2/fr not_active Withdrawn
- 2003-08-19 JP JP2005515706A patent/JP2006521786A/ja active Pending
- 2003-08-19 AU AU2003303303A patent/AU2003303303A1/en not_active Abandoned
- 2003-08-19 WO PCT/US2003/025943 patent/WO2004069983A2/fr not_active Ceased
- 2003-08-19 CA CA002495617A patent/CA2495617A1/fr not_active Abandoned
- 2003-08-19 WO PCT/US2003/025907 patent/WO2004016729A2/fr not_active Ceased
- 2003-08-19 EP EP03754396A patent/EP1530626A1/fr not_active Withdrawn
- 2003-08-19 WO PCT/US2003/025956 patent/WO2004016727A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003265491A1 (en) | 2004-03-03 |
| WO2004069983A2 (fr) | 2004-08-19 |
| AU2003272223A1 (en) | 2004-03-03 |
| WO2004016727B1 (fr) | 2004-07-08 |
| AU2003265491A8 (en) | 2004-03-03 |
| WO2004016729A3 (fr) | 2005-06-30 |
| WO2004069983A9 (fr) | 2005-02-03 |
| WO2004016727A1 (fr) | 2004-02-26 |
| WO2004069983A3 (fr) | 2005-07-14 |
| JP2006521786A (ja) | 2006-09-28 |
| JP2005536233A (ja) | 2005-12-02 |
| AU2003303303A1 (en) | 2004-08-30 |
| WO2004016727A9 (fr) | 2004-05-27 |
| WO2004016729A2 (fr) | 2004-02-26 |
| EP1530626A1 (fr) | 2005-05-18 |
| EP1567637A2 (fr) | 2005-08-31 |
| CA2495617A1 (fr) | 2004-02-26 |
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