CA2512399A1 - Antagonistes du recepteur de f11 (f11r) en tant qu'agents therapeutiques - Google Patents

Antagonistes du recepteur de f11 (f11r) en tant qu'agents therapeutiques Download PDF

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Publication number
CA2512399A1
CA2512399A1 CA002512399A CA2512399A CA2512399A1 CA 2512399 A1 CA2512399 A1 CA 2512399A1 CA 002512399 A CA002512399 A CA 002512399A CA 2512399 A CA2512399 A CA 2512399A CA 2512399 A1 CA2512399 A1 CA 2512399A1
Authority
CA
Canada
Prior art keywords
seq
peptide
peptides
antagonist
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002512399A
Other languages
English (en)
Inventor
Elizabeth Kornecki
Anna Babinska
Yigal H. Ehrlich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2512399A1 publication Critical patent/CA2512399A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention concerne une molécule d'adhésion cellulaire (CAM), désignée en tant que récepteur de F11 (F11R), qui fait partie de la superfamille de l'immunoglobuline localisée à la surface des plaquettes humaines, et a pour rôle de promouvoir l'agrégation des plaquettes, la sécrétion, l'étalement des plaquettes et l'adhésion cellulaire. L'invention a également pour objet de l'ADNc de F11R cloné, de l'ADNc de F11R pleine longueur et des séquences d'acides aminés, ainsi que des antagonistes de F11R et des procédés pour prévenir et traiter la thrombose, l'infarctus du myocarde, l'accident vasculaire cérébral et autres troubles cliniques liés à la formation de thrombus.
CA002512399A 2003-01-03 2003-12-16 Antagonistes du recepteur de f11 (f11r) en tant qu'agents therapeutiques Abandoned CA2512399A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43866903P 2003-01-03 2003-01-03
US60/438,669 2003-01-03
PCT/US2003/039890 WO2004063327A2 (fr) 2003-01-03 2003-12-16 Antagonistes du recepteur de f11 (f11r) en tant qu'agents therapeutiques

Publications (1)

Publication Number Publication Date
CA2512399A1 true CA2512399A1 (fr) 2004-07-29

Family

ID=32713364

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002512399A Abandoned CA2512399A1 (fr) 2003-01-03 2003-12-16 Antagonistes du recepteur de f11 (f11r) en tant qu'agents therapeutiques

Country Status (5)

Country Link
EP (1) EP1581551A4 (fr)
JP (1) JP2006516255A (fr)
AU (1) AU2003297124A1 (fr)
CA (1) CA2512399A1 (fr)
WO (1) WO2004063327A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050265992A1 (en) * 2003-01-03 2005-12-01 The Research Foundation Of State University Of New York F11 receptor (F11R) antagonists as therapeutic agents
US8557957B2 (en) 2003-01-03 2013-10-15 Elizabeth Kornecki Methods of treating disorders by administration of F11 receptor antagonists
US20220339248A1 (en) 2019-06-19 2022-10-27 The Research Foundation For The State University Of New York Methods for treating neointimal hyperlasia using f11r/jam-a inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665701A (en) * 1994-11-17 1997-09-09 The Research Foundation Of State University Of New York Platelet membrane glycoprotein F11 and polypeptide fragments thereof
WO1999002561A1 (fr) * 1997-07-10 1999-01-21 Smithkline Beecham Corporation Antigene f11 humain, constituant un recepteur de surface cellulaire implique dans l'agregation plaquettaire
US6699688B1 (en) * 1998-09-16 2004-03-02 The Research Foundation Of The State University Of New York Human platelet F11 receptor

Also Published As

Publication number Publication date
AU2003297124A8 (en) 2004-08-10
WO2004063327A2 (fr) 2004-07-29
AU2003297124A1 (en) 2004-08-10
EP1581551A4 (fr) 2007-12-12
EP1581551A2 (fr) 2005-10-05
WO2004063327A3 (fr) 2005-04-21
JP2006516255A (ja) 2006-06-29

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20150616