CA2536305C - Epitopes sod-1 et anticorps - Google Patents

Epitopes sod-1 et anticorps Download PDF

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Publication number
CA2536305C
CA2536305C CA2536305A CA2536305A CA2536305C CA 2536305 C CA2536305 C CA 2536305C CA 2536305 A CA2536305 A CA 2536305A CA 2536305 A CA2536305 A CA 2536305A CA 2536305 C CA2536305 C CA 2536305C
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CA
Canada
Prior art keywords
polypeptide
antibody
epitope
disease
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2536305A
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English (en)
Other versions
CA2536305A1 (fr
Inventor
Neil R. Cashman
Marty Lehto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Promis Neurosciences Inc
Original Assignee
Amorfix Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002437675A external-priority patent/CA2437675A1/fr
Priority claimed from CA2437999A external-priority patent/CA2437999C/fr
Application filed by Amorfix Life Sciences Ltd filed Critical Amorfix Life Sciences Ltd
Priority to CA2536305A priority Critical patent/CA2536305C/fr
Priority claimed from PCT/CA2004/001503 external-priority patent/WO2005019828A1/fr
Publication of CA2536305A1 publication Critical patent/CA2536305A1/fr
Application granted granted Critical
Publication of CA2536305C publication Critical patent/CA2536305C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne un dosage de protection d'épitope destiné à servir dans le diagnostic, le pronostic et l'intervention thérapeutique dans le cas de maladies qui impliquent, par exemple, l'agrégation de polypeptides, telles que des infections par le prion. Les procédés selon l'invention permettent de bloquer en premier lieu l'épitope cible de polypeptide accessible au moyen d'un agent bloquant. Après dénaturation du polypeptide, on utilise un agent de détection pour détecter la protéine renfermant l'épitope cible qui était accessible lors du contact avec l'agent bloquant.
CA2536305A 2003-08-20 2004-08-20 Epitopes sod-1 et anticorps Expired - Lifetime CA2536305C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2536305A CA2536305C (fr) 2003-08-20 2004-08-20 Epitopes sod-1 et anticorps

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US49638103P 2003-08-20 2003-08-20
CA2,437,675 2003-08-20
CA002437675A CA2437675A1 (fr) 2003-08-20 2003-08-20 Methodes de detection de proteine prion
US60/496,381 2003-08-20
US49736203P 2003-08-21 2003-08-21
US60/497,362 2003-08-21
CA2,437,999 2003-08-21
CA2437999A CA2437999C (fr) 2003-08-20 2003-08-21 Methodes de detection d'une proteine prion
CA2536305A CA2536305C (fr) 2003-08-20 2004-08-20 Epitopes sod-1 et anticorps
PCT/CA2004/001503 WO2005019828A1 (fr) 2003-08-20 2004-08-20 Dosage de protection d'epitope et procede de detection de conformations proteiques

Publications (2)

Publication Number Publication Date
CA2536305A1 CA2536305A1 (fr) 2005-03-03
CA2536305C true CA2536305C (fr) 2015-10-27

Family

ID=36242730

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2536305A Expired - Lifetime CA2536305C (fr) 2003-08-20 2004-08-20 Epitopes sod-1 et anticorps

Country Status (1)

Country Link
CA (1) CA2536305C (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9637552B2 (en) 2005-12-02 2017-05-02 Promis Neurosciences Inc. Methods and compositions to treat and detect misfolded-SOD1 mediated diseases

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1668369B1 (fr) 2003-08-20 2016-01-06 ProMIS Neurosciences Inc. Dosage de protection d'epitope et procede de detection de conformations proteiques
US7794692B2 (en) 2005-12-02 2010-09-14 Amorfix Life Sciences Ltd. Methods and compositions for detecting amyotrophic lateral sclerosis
US7887803B2 (en) 2005-12-02 2011-02-15 Amorfix Life Sciences Methods and compositions to treat misfolded-SOD1 mediated diseases
IL300267A (en) * 2020-07-30 2023-03-01 Diadem S P A Post-translational modifications of P53 as markers in the diagnosis and prognosis of neurodegenerative diseases

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9637552B2 (en) 2005-12-02 2017-05-02 Promis Neurosciences Inc. Methods and compositions to treat and detect misfolded-SOD1 mediated diseases

Also Published As

Publication number Publication date
CA2536305A1 (fr) 2005-03-03

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Effective date: 20250221