CA2538009A1 - Combinaison d'amides de l'acide phenylcarboxylique avec des bloquants des recepteurs beta-adrenergiques et leur utilisation dans le traitement d'arythmies atriales - Google Patents

Combinaison d'amides de l'acide phenylcarboxylique avec des bloquants des recepteurs beta-adrenergiques et leur utilisation dans le traitement d'arythmies atriales Download PDF

Info

Publication number: CA2538009A1
Authority: CA; Canada
Prior art keywords: beta; blockers; carbon atoms; compounds; atenolol
Prior art date: 2003-09-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002538009A

Other languages

English (en)

Inventor

Klaus Wirth

Joachim Brendel

Heinz Goegelein

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Sanofi Aventis Deutschland GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-08

Filing date

2004-09-03

Publication date

2005-03-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34202398&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2538009(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-09-03 Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH

2005-03-24 Publication of CA2538009A1 publication Critical patent/CA2538009A1/fr

Status Abandoned legal-status Critical Current

Links

KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical class NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title claims abstract description 32
238000011282 treatment Methods 0.000 title abstract description 12
206010003130 Arrhythmia supraventricular Diseases 0.000 title abstract description 8
102000012740 beta Adrenergic Receptors Human genes 0.000 title description 2
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150000003839 salts Chemical class 0.000 claims abstract description 49
150000001875 compounds Chemical class 0.000 claims description 83
239000002876 beta blocker Substances 0.000 claims description 70
229940097320 beta blocking agent Drugs 0.000 claims description 70
METKIMKYRPQLGS-GFCCVEGCSA-N (R)-atenolol Chemical compound CC(C)NC[C@@H](O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-GFCCVEGCSA-N 0.000 claims description 48
229960002274 atenolol Drugs 0.000 claims description 48
125000004432 carbon atom Chemical group C* 0.000 claims description 44
125000000217 alkyl group Chemical group 0.000 claims description 28
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PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 claims description 28
AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims description 28
239000003814 drug Substances 0.000 claims description 24
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 24
206010003658 Atrial Fibrillation Diseases 0.000 claims description 23
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238000002560 therapeutic procedure Methods 0.000 claims description 16
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 16
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206010003662 Atrial flutter Diseases 0.000 claims description 15
-1 cetiprolol Chemical compound 0.000 claims description 15
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CEMAWMOMDPGJMB-UHFFFAOYSA-N (+-)-Oxprenolol Chemical compound CC(C)NCC(O)COC1=CC=CC=C1OCC=C CEMAWMOMDPGJMB-UHFFFAOYSA-N 0.000 claims description 14
GOEMGAFJFRBGGG-UHFFFAOYSA-N acebutolol Chemical compound CCCC(=O)NC1=CC=C(OCC(O)CNC(C)C)C(C(C)=O)=C1 GOEMGAFJFRBGGG-UHFFFAOYSA-N 0.000 claims description 14
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NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 claims description 14
IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 claims description 14
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PAZJSJFMUHDSTF-UHFFFAOYSA-N alprenolol Chemical compound CC(C)NCC(O)COC1=CC=CC=C1CC=C PAZJSJFMUHDSTF-UHFFFAOYSA-N 0.000 claims description 13
125000001424 substituent group Chemical group 0.000 claims description 13
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CHDSRMIDIQABTP-UHFFFAOYSA-N 2-[2-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]phenyl]-n-(2-pyridin-3-ylethyl)benzamide Chemical compound C1=CC(OC)=CC=C1CC(=O)NCC1=CC=CC=C1C1=CC=CC=C1C(=O)NCCC1=CC=CN=C1 CHDSRMIDIQABTP-UHFFFAOYSA-N 0.000 claims description 9
VYUUPUMKBLIKJV-NRFANRHFSA-N 5-fluoro-n-[(1s)-1-phenylpropyl]-2-(quinolin-8-ylsulfonylamino)benzamide Chemical compound C1([C@@H](NC(=O)C=2C(=CC=C(F)C=2)NS(=O)(=O)C=2C3=NC=CC=C3C=CC=2)CC)=CC=CC=C1 VYUUPUMKBLIKJV-NRFANRHFSA-N 0.000 claims description 8
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LWAFSWPYPHEXKX-UHFFFAOYSA-N carteolol Chemical compound N1C(=O)CCC2=C1C=CC=C2OCC(O)CNC(C)(C)C LWAFSWPYPHEXKX-UHFFFAOYSA-N 0.000 claims description 6
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ILYSAKHOYBPSPC-UHFFFAOYSA-N 2-phenylbenzoic acid Chemical compound OC(=O)C1=CC=CC=C1C1=CC=CC=C1 ILYSAKHOYBPSPC-UHFFFAOYSA-N 0.000 claims description 5
XPQIPUZPSLAZDV-UHFFFAOYSA-N 2-pyridylethylamine Chemical compound NCCC1=CC=CC=N1 XPQIPUZPSLAZDV-UHFFFAOYSA-N 0.000 claims description 5
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HQIRNZOQPUAHHV-UHFFFAOYSA-N bupranolol Chemical compound CC1=CC=C(Cl)C(OCC(O)CNC(C)(C)C)=C1 HQIRNZOQPUAHHV-UHFFFAOYSA-N 0.000 claims description 5
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AQNDDEOPVVGCPG-UHFFFAOYSA-N esmolol Chemical compound COC(=O)CCC1=CC=C(OCC(O)CNC(C)C)C=C1 AQNDDEOPVVGCPG-UHFFFAOYSA-N 0.000 claims description 5
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KQXKVJAGOJTNJS-HNNXBMFYSA-N penbutolol Chemical compound CC(C)(C)NC[C@H](O)COC1=CC=CC=C1C1CCCC1 KQXKVJAGOJTNJS-HNNXBMFYSA-N 0.000 claims description 5
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 4
229910052739 hydrogen Inorganic materials 0.000 claims description 4
239000001257 hydrogen Substances 0.000 claims description 4
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IXKPEYHRIVQTCU-UHFFFAOYSA-N n-[(2,4-difluorophenyl)methyl]-2-[2-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]phenyl]benzamide Chemical compound C1=CC(OC)=CC=C1CC(=O)NCC1=CC=CC=C1C1=CC=CC=C1C(=O)NCC1=CC=C(F)C=C1F IXKPEYHRIVQTCU-UHFFFAOYSA-N 0.000 claims description 3
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HXYRIIDLHHAJHV-UHFFFAOYSA-N 2-[2-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]phenyl]benzoic acid Chemical compound C1=CC(OC)=CC=C1CC(=O)NCC1=CC=CC=C1C1=CC=CC=C1C(O)=O HXYRIIDLHHAJHV-UHFFFAOYSA-N 0.000 claims 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA002538009A 2003-09-08 2004-09-03 Combinaison d'amides de l'acide phenylcarboxylique avec des bloquants des recepteurs beta-adrenergiques et leur utilisation dans le traitement d'arythmies atriales Abandoned CA2538009A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10341233A DE10341233A1 (de)	2003-09-08	2003-09-08	Kombination von Phenylcarbonsäureamiden mit beta-Adrenozeptoren-Blockern und deren Verwendung zur Behandlung von Vorhofarrhythmien
DE10341233.6		2003-09-08
PCT/EP2004/009837 WO2005025674A1 (fr)	2003-09-08	2004-09-03	Combinaison d'amides de l'acide phenylcarboxylique avec des bloquants des recepteurs beta-adrenergiques et leur utilisation dans le traitement d'arythmies atriales

Publications (1)

Publication Number	Publication Date
CA2538009A1 true CA2538009A1 (fr)	2005-03-24

Family

ID=34202398

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002538009A Abandoned CA2538009A1 (fr)	2003-09-08	2004-09-03	Combinaison d'amides de l'acide phenylcarboxylique avec des bloquants des recepteurs beta-adrenergiques et leur utilisation dans le traitement d'arythmies atriales

Country Status (12)

Country	Link
EP (1)	EP1670551A1 (fr)
JP (1)	JP2007505036A (fr)
AR (1)	AR045601A1 (fr)
AU (1)	AU2004271697A1 (fr)
BR (1)	BRPI0414203A (fr)
CA (1)	CA2538009A1 (fr)
DE (1)	DE10341233A1 (fr)
IL (1)	IL173919A0 (fr)
MX (1)	MXPA06002103A (fr)
PE (1)	PE20050373A1 (fr)
TW (1)	TW200526580A (fr)
WO (1)	WO2005025674A1 (fr)

Families Citing this family (3)

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2003
- 2003-09-08 DE DE10341233A patent/DE10341233A1/de not_active Withdrawn
2004
- 2004-09-02 PE PE2004000848A patent/PE20050373A1/es not_active Application Discontinuation
- 2004-09-03 WO PCT/EP2004/009837 patent/WO2005025674A1/fr not_active Ceased
- 2004-09-03 AU AU2004271697A patent/AU2004271697A1/en not_active Abandoned
- 2004-09-03 MX MXPA06002103A patent/MXPA06002103A/es not_active Application Discontinuation
- 2004-09-03 CA CA002538009A patent/CA2538009A1/fr not_active Abandoned
- 2004-09-03 BR BRPI0414203-9A patent/BRPI0414203A/pt not_active Application Discontinuation
- 2004-09-03 JP JP2006525115A patent/JP2007505036A/ja not_active Abandoned
- 2004-09-03 EP EP04764792A patent/EP1670551A1/fr not_active Withdrawn
- 2004-09-06 TW TW093126817A patent/TW200526580A/zh unknown
- 2004-09-06 AR ARP040103199A patent/AR045601A1/es unknown
2006
- 2006-02-23 IL IL173919A patent/IL173919A0/en unknown

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MXPA06002103A (es)	2006-05-31
TW200526580A (en)	2005-08-16
AR045601A1 (es)	2005-11-02
JP2007505036A (ja)	2007-03-08
EP1670551A1 (fr)	2006-06-21
IL173919A0 (en)	2006-07-05
BRPI0414203A (pt)	2006-10-31
DE10341233A1 (de)	2005-03-24
WO2005025674A1 (fr)	2005-03-24
AU2004271697A1 (en)	2005-03-24
PE20050373A1 (es)	2005-07-05

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2008-09-03	FZDE	Discontinued

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CA2519002A1 (fr)	2004-09-30	Association d'amides de l'acide phenylcarboxylique et d'inhibiteurs du canal ik<sb>r</sb> et utilisation de cette association pour traiter des arythmies atriales
ZA200506328B (en)	2006-04-26	2-(butyl-1sylfonylamino)-N-Ä1(R)-6methoxy-pyridin-3-yl)-propylÜ-benzamid, the use thereof in the form of drug an pharmaceutical preperations containing said compound
US20070043091A1 (en)	2007-02-22	Kv1.5-BLOCKER FOR THE SELECTIVE INCREASE OF ATRIAL CONTRACTILITY AND TREATMENT OF CARDIAC INSUFFICIENCY
US20080081926A1 (en)	2008-04-03	Sulfonylaminobenzoic acid and salt
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