CA2540986A1 - Utilisation therapeutique du facteur xi - Google Patents

Utilisation therapeutique du facteur xi Download PDF

Info

Publication number: CA2540986A1
Authority: CA; Canada
Prior art keywords: fxi; polypeptide; patient; factor; buffer
Prior art date: 2003-11-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002540986A

Other languages

English (en)

Inventor

Rasmus Roejkjaer

Dorthe Viuff

Soeren Oestergaard

Simon Bjerregaard Jensen

Jens Jacob Hansen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novo Nordisk Health Care AG

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-20

Filing date

2004-11-22

Publication date

2005-06-02

2004-11-22 Application filed by Individual filed Critical Individual

2005-06-02 Publication of CA2540986A1 publication Critical patent/CA2540986A1/fr

Status Abandoned legal-status Critical Current

Links

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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21027—Coagulation factor XIa (3.4.21.27)

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Hematology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

CA002540986A 2003-11-20 2004-11-22 Utilisation therapeutique du facteur xi Abandoned CA2540986A1 (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
DKPA200301721		2003-11-20
DKPA200301721		2003-11-20
DKPA200401141		2004-07-23
DKPA200401141		2004-07-23
PCT/DK2004/000810 WO2005049070A1 (fr)	2003-11-20	2004-11-22	Utilisation therapeutique du facteur xi

Publications (1)

Publication Number	Publication Date
CA2540986A1 true CA2540986A1 (fr)	2005-06-02

Family

ID=34621448

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002540986A Abandoned CA2540986A1 (fr)	2003-11-20	2004-11-22	Utilisation therapeutique du facteur xi

Country Status (9)

Country	Link
EP (1)	EP1687020A1 (fr)
JP (1)	JP2007513881A (fr)
KR (1)	KR20060118486A (fr)
AU (1)	AU2004290869A1 (fr)
BR (1)	BRPI0416461A (fr)
CA (1)	CA2540986A1 (fr)
RU (1)	RU2006115783A (fr)
TW (1)	TW200529870A (fr)
WO (1)	WO2005049070A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006008266A2 (fr) *	2004-07-23	2006-01-26	Novo Nordisk Health Care Ag	Proteines de liaison au facteur xi
WO2006128497A1 (fr) *	2005-06-01	2006-12-07	Novo Nordisk A/S	Formule pharmaceutique de facteur xi
KR101792032B1 (ko)	2008-12-19	2017-11-02	백스터 인터내셔널 인코포레이티드	Ｔｆｐｉ 억제제 및 사용 방법
EP2305289A1 (fr) *	2009-09-16	2011-04-06	Bio-Products & Bio-Engineering Aktiengesellschaft	Produits médicinaux pour le traitement de troubles de la coagulation sanguine
DK2547355T3 (en)	2010-03-19	2017-03-20	Baxalta GmbH	TFPI INHIBITORS AND METHODS OF USE
BR112014022435B1 (pt)	2012-03-21	2023-02-14	Takeda Pharmaceutical Company Limited	Inibidores de tfpi e métodos de uso
DE102012022233A1 (de)	2012-11-14	2014-05-15	Instraction Gmbh	Verfahren zur Reinigung eines (Blut)plasmaproteins
DE102012022234A1 (de)	2012-11-14	2014-05-15	Instraction Gmbh	Einstufiges Verfahren zur Reinigung von (Blut)Plasmaproteinen wie Albumin aus Gemischen
PH12021552872A1 (en)	2020-04-05	2022-03-21	Pfizer	Compounds and methods for the treatment of covid-19

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2676231A1 (fr) *	1991-05-07	1992-11-13	Aetsrn	Concentre de facteur xi de la coagulation sanguine a haute activite specifique, approprie a usage therapeutique et son procede de preparation.
JP2003525634A (ja) *	2000-03-03	2003-09-02	キュラジェンコーポレイション	Ｆｃｔｒｘと命名されたタンパク質およびこれをコードする核酸
AU2002354846B2 (en) *	2001-07-20	2007-08-02	Novo Nordisk Health Care Ag	Pharmaceutical composition comprising factor VII polypeptides and factor XI polypeptides

2004
- 2004-11-22 RU RU2006115783/14A patent/RU2006115783A/ru not_active Application Discontinuation
- 2004-11-22 BR BRPI0416461-0A patent/BRPI0416461A/pt not_active IP Right Cessation
- 2004-11-22 AU AU2004290869A patent/AU2004290869A1/en not_active Abandoned
- 2004-11-22 WO PCT/DK2004/000810 patent/WO2005049070A1/fr not_active Ceased
- 2004-11-22 JP JP2006540175A patent/JP2007513881A/ja not_active Withdrawn
- 2004-11-22 CA CA002540986A patent/CA2540986A1/fr not_active Abandoned
- 2004-11-22 KR KR1020067009406A patent/KR20060118486A/ko not_active Withdrawn
- 2004-11-22 EP EP04797471A patent/EP1687020A1/fr not_active Withdrawn
- 2004-11-22 TW TW093135827A patent/TW200529870A/zh unknown

Also Published As

Publication number	Publication date
WO2005049070A1 (fr)	2005-06-02
JP2007513881A (ja)	2007-05-31
BRPI0416461A (pt)	2007-03-06
EP1687020A1 (fr)	2006-08-09
AU2004290869A1 (en)	2005-06-02
KR20060118486A (ko)	2006-11-23
TW200529870A (en)	2005-09-16
RU2006115783A (ru)	2007-12-27

Legal Events

Date	Code	Title	Description
2009-11-23	FZDE	Discontinued

Publication	Publication Date	Title
US20050181978A1 (en)	2005-08-18	Therapeutic use of factor XI
JP6029826B2 (ja)	2016-11-24	補因子の非存在下において凝固活性を有する第ｉｘ因子変異体および出血性疾患の処置のためのその使用
JP5037331B2 (ja)	2012-09-26	出血性障害の処置のための第ｉｘａ因子
JP2011517951A (ja)	2011-06-23	修飾された第ｉｘ因子ポリペプチドおよびそれらの使用
US8697844B2 (en)	2014-04-15	Method of purifying pegylated proteins
US8383776B2 (en)	2013-02-26	Purification of factor XIII polypeptides from biological materials
EP1651252B1 (fr)	2014-11-26	Variants de proteine c activee avec activite cytoprotectrice normale mais avec activite anticoagulante reduite
ES2481420T3 (es)	2014-07-30	Variantes de proteína C activada con actividad citoprotectora pero con actividad anticoagulante reducida
AU2023200825B2 (en)	2026-04-23	Preparation of factor Xa derivatives
CA2540986A1 (fr)	2005-06-02	Utilisation therapeutique du facteur xi
WO2006128497A1 (fr)	2006-12-07	Formule pharmaceutique de facteur xi
AU2008341008A1 (en)	2009-07-02	Haemostasis- modulating compositions and uses therefor
CN112423782A (zh)	2021-02-26	FX活化方法及其在FXa组合物制备中的用途
EP2948168A1 (fr)	2015-12-02	Inhibition d'inhibiteur de la voie du facteur tissulaire à l'aide de dérivés de facteur xa
JP2016536368A (ja)	2016-11-24	第Ｘａ因子の半減期を延ばす組成物および方法
MXPA06005477A (en)	2006-10-17	Therapeutic use of factor xi
JP2008531645A (ja)	2008-08-14	改善された特性を有するｆｘｉｉｉバリアント
JP7839737B2 (ja)	2026-04-02	動脈及び静脈血栓症を治療するための相乗作用標的化組成物
KR20110017359A (ko)	2011-02-21	폴리펩티드 변형 반응의 제어 방법
WO2026048976A1 (fr)	2026-03-05	Composition pharmaceutique stable contenant un facteur de coagulation x
Wu	2015	Characterization of TAFI activation by the thrombin-thrombomodulin complex
WO2009123573A1 (fr)	2009-10-08	Anticoagulants dérivés de venin de serpent naja nigricollis
KR20180089439A (ko)	2018-08-08	재조합 세린 프로테아제
HK1153481A (en)	2012-03-30	Modified factor ix polypeptides and uses thereof