CA2543132A1 - Procedes d'utilisations et compositions comprenant des medicaments selectifs inhibiteurs de la cytokine utilises dans le traitement, la modification et la gestion de la douleur - Google Patents

Procedes d'utilisations et compositions comprenant des medicaments selectifs inhibiteurs de la cytokine utilises dans le traitement, la modification et la gestion de la douleur Download PDF

Info

Publication number: CA2543132A1
Authority: CA; Canada
Prior art keywords: carbon atoms; pain; alkyl; substituted; cytokine inhibitory
Prior art date: 2003-10-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002543132A

Other languages

English (en)

Inventor

Jerome B. Zeldis

Herbert Faleck

Donald C. Manning

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Celgene Corp

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-23

Filing date

2004-04-23

Publication date

2005-05-19

2003-10-23 Priority claimed from US10/693,722 external-priority patent/US20040087558A1/en

2004-04-23 Application filed by Individual filed Critical Individual

2004-04-23 Priority claimed from PCT/US2004/012722 external-priority patent/WO2005043971A2/fr

2005-05-19 Publication of CA2543132A1 publication Critical patent/CA2543132A1/fr

Status Abandoned legal-status Critical Current

Links

208000002193 Pain Diseases 0.000 title claims abstract description 214
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108090000695 Cytokines Proteins 0.000 title claims abstract description 157
230000002401 inhibitory effect Effects 0.000 title claims abstract description 157
238000000034 method Methods 0.000 title claims abstract description 70
238000011282 treatment Methods 0.000 title claims description 33
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238000012986 modification Methods 0.000 title claims description 10
239000000203 mixture Substances 0.000 title description 39
238000007726 management method Methods 0.000 title description 20
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239000008194 pharmaceutical composition Substances 0.000 claims abstract description 39
238000001356 surgical procedure Methods 0.000 claims abstract description 16
238000000554 physical therapy Methods 0.000 claims abstract description 15
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-1 antihypertensive Substances 0.000 claims description 240
125000000217 alkyl group Chemical group 0.000 claims description 193
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229910052739 hydrogen Inorganic materials 0.000 claims description 84
239000001257 hydrogen Substances 0.000 claims description 82
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 82
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125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 72
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 67
125000001424 substituent group Chemical group 0.000 claims description 56
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DHKAFTYWTCIWJX-UHFFFAOYSA-N 3-(3,4-dimethoxyphenyl)-3-(3-oxo-1h-isoindol-2-yl)propanamide Chemical compound C1=C(OC)C(OC)=CC=C1C(CC(N)=O)N1C(=O)C2=CC=CC=C2C1 DHKAFTYWTCIWJX-UHFFFAOYSA-N 0.000 claims description 16
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CDBRNDSHEYLDJV-FVGYRXGTSA-M naproxen sodium Chemical compound [Na+].C1=C([C@H](C)C([O-])=O)C=CC2=CC(OC)=CC=C21 CDBRNDSHEYLDJV-FVGYRXGTSA-M 0.000 claims description 8
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CTRLABGOLIVAIY-UHFFFAOYSA-N oxcarbazepine Chemical compound C1C(=O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 CTRLABGOLIVAIY-UHFFFAOYSA-N 0.000 claims description 7
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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)

CA002543132A 2003-10-23 2004-04-23 Procedes d'utilisations et compositions comprenant des medicaments selectifs inhibiteurs de la cytokine utilises dans le traitement, la modification et la gestion de la douleur Abandoned CA2543132A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US10/693,722		2003-10-23
US10/693,722 US20040087558A1 (en)	2002-10-24	2003-10-23	Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
PCT/US2004/012722 WO2005043971A2 (fr)	2003-10-23	2004-04-23	Procedes d'utilisations et compositions comprenant des medicaments selectifs inhibiteurs de la cytokine utilises dans le traitement, la modification et la gestion de la douleur

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Cited By (3)

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CN110200978A (zh) *	2016-04-22	2019-09-06	维京治疗股份有限公司	甲状腺β-激动剂的应用
CN111743871A (zh) *	2020-07-14	2020-10-09	天方药业有限公司	盐酸酚苄明片剂及其制备方法
US11951114B2 (en)	2016-04-22	2024-04-09	Viking Therapeutics, Inc.	Use of thyroid beta-agonists

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US5463063A (en) *	1993-07-02	1995-10-31	Celgene Corporation	Ring closure of N-phthaloylglutamines
US5726156A (en) *	1995-03-06	1998-03-10	Trega Biosciences, Inc.	Cytokine regulatory agents and methods of use in pathologies and conditions associated with altered cytokine levels
CA2295295A1 (fr) *	1997-07-31	1999-02-11	Celgene Corporation	Acides alcanohydroxamiques substitues et procede permettant de reduire le niveau de tnf-.alpha.
US6020358A (en) *	1998-10-30	2000-02-01	Celgene Corporation	Substituted phenethylsulfones and method of reducing TNFα levels
US6667316B1 (en) *	1999-11-12	2003-12-23	Celgene Corporation	Pharmaceutically active isoindoline derivatives
SE0101256D0 (sv) *	2001-04-06	2001-04-06	A & Science Invest Ab	Treatment of low back pain
US6962940B2 (en) *	2002-03-20	2005-11-08	Celgene Corporation	(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof

2004
- 2004-04-23 CA CA002543132A patent/CA2543132A1/fr not_active Abandoned
- 2004-04-23 JP JP2006536543A patent/JP2007524656A/ja active Pending

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN110200978A (zh) *	2016-04-22	2019-09-06	维京治疗股份有限公司	甲状腺β-激动剂的应用
CN110200978B (zh) *	2016-04-22	2023-10-31	维京治疗股份有限公司	甲状腺β-激动剂的应用
US11951114B2 (en)	2016-04-22	2024-04-09	Viking Therapeutics, Inc.	Use of thyroid beta-agonists
US12440502B2 (en)	2016-04-22	2025-10-14	Viking Therapeutics, Inc.	Use of thyroid beta-agonists
CN111743871A (zh) *	2020-07-14	2020-10-09	天方药业有限公司	盐酸酚苄明片剂及其制备方法

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Publication	Publication Date	Title
ZA200603461B (en)	2007-09-26	Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
AU2003284979B2 (en)	2008-07-17	Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
AU2003286663B2 (en)	2009-08-13	Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
US20060106085A1 (en)	2006-05-18	Methods and compositions using PDE4 modulators for treatment and management of central nervous system injury
US20070161696A1 (en)	2007-07-12	Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
US7612096B2 (en)	2009-11-03	Methods for treatment, modification and management of radiculopathy using 1-oxo-2-(2,6-dioxopiperidin-3yl)-4-aminoisoindoline
CA2543132A1 (fr)	2005-05-19	Procedes d'utilisations et compositions comprenant des medicaments selectifs inhibiteurs de la cytokine utilises dans le traitement, la modification et la gestion de la douleur
HK1112414A (en)	2008-09-05	Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
HK1088225B (en)	2008-02-22	Compositions comprising immunomodulatory compounds for treatment, modification and management of pain