CA2552086C - Systeme d'electrodes de nanovaporisation realise par microtechnologie - Google Patents

Systeme d'electrodes de nanovaporisation realise par microtechnologie Download PDF

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Publication number
CA2552086C
CA2552086C CA2552086A CA2552086A CA2552086C CA 2552086 C CA2552086 C CA 2552086C CA 2552086 A CA2552086 A CA 2552086A CA 2552086 A CA2552086 A CA 2552086A CA 2552086 C CA2552086 C CA 2552086C
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CA
Canada
Prior art keywords
capillary
input
electrode
nanospray
substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2552086A
Other languages
English (en)
Other versions
CA2552086A1 (fr
Inventor
Richard Syms
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microsaic Systems PLC
Original Assignee
Microsaic Systems PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0514843.2A external-priority patent/GB0514843D0/en
Application filed by Microsaic Systems PLC filed Critical Microsaic Systems PLC
Publication of CA2552086A1 publication Critical patent/CA2552086A1/fr
Application granted granted Critical
Publication of CA2552086C publication Critical patent/CA2552086C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0013—Miniaturised spectrometers, e.g. having smaller than usual scale, integrated conventional components
    • H01J49/0018—Microminiaturised spectrometers, e.g. chip-integrated devices, Micro-Electro-Mechanical Systems [MEMS]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/067—Ion lenses, apertures, skimmers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

Un procédé pour aligner une aiguille capillaire de nanopulvérisation, un jeu d'électrodes et une entrée du capillaire dans un spectromètre de masse est décrit. Le système d'électrodes est formé à l'aide de technologies de micro-ingénierie sous la forme d'un assemblage de deux puces séparées. Chaque puce est formée sur un substrat de plastique isolant. La première puce comporte des caractéristiques d'alignement mécanique pour l'aiguille d'électropulvérisation capillaire et l'entrée de spectromètre de masse à ionisation par pression atmosphérique, ainsi qu'un jeu d'électrodes partielles. La deuxième puce est pourvue d'un jeu d'électrodes partielles. Le système d'électrodes complet est formé lorsque les puces sont assemblées dans une configuration empilée et consiste en une lentille d'Einzel capable de créer un cône de Taylor et de séparer les ions des particules neutres par focalisation.
CA2552086A 2005-07-20 2006-07-14 Systeme d'electrodes de nanovaporisation realise par microtechnologie Active CA2552086C (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB0514843.2A GB0514843D0 (en) 2005-07-20 2005-07-20 Microengineered nanospray electrode system
GBGB0514843.2 2005-07-20
GBGB0519439.4 2005-09-23
GB0519439A GB2428514B (en) 2005-07-20 2005-09-23 Microengineered nanospray electrode system

Publications (2)

Publication Number Publication Date
CA2552086A1 CA2552086A1 (fr) 2007-01-20
CA2552086C true CA2552086C (fr) 2014-09-09

Family

ID=37305854

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2552086A Active CA2552086C (fr) 2005-07-20 2006-07-14 Systeme d'electrodes de nanovaporisation realise par microtechnologie

Country Status (3)

Country Link
EP (1) EP1746631B1 (fr)
JP (1) JP5265095B2 (fr)
CA (1) CA2552086C (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1959476A1 (fr) * 2007-02-19 2008-08-20 Technische Universität Hamburg-Harburg Spectromètre de masse
US8242441B2 (en) * 2009-12-18 2012-08-14 Thermo Finnigan Llc Apparatus and methods for pneumatically-assisted electrospray emitter array
GB2527803B (en) * 2014-07-02 2018-02-07 Microsaic Systems Plc A method and system for monitoring biomolecule separations by mass spectrometry
JP7308218B2 (ja) * 2018-03-02 2023-07-13 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 統合された低費用のカーテン板、オリフィスｐｃｂ、およびイオンレンズアセンブリ
US20240242956A1 (en) * 2021-05-28 2024-07-18 Restek Corporation Taylor cone emitter devices and taylor cone analysis systems

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5386115A (en) 1993-09-22 1995-01-31 Westinghouse Electric Corporation Solid state micro-machined mass spectrograph universal gas detection sensor
CN100525876C (zh) 1998-09-17 2009-08-12 阿德文生物系统公司 产生液体电喷射的方法
US6633031B1 (en) * 1999-03-02 2003-10-14 Advion Biosciences, Inc. Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method
US6396057B1 (en) * 2000-04-18 2002-05-28 Waters Investments Limited Electrospray and other LC/MS interfaces
JP2002190272A (ja) * 2000-12-21 2002-07-05 Jeol Ltd エレクトロスプレー・イオン源
US6803568B2 (en) 2001-09-19 2004-10-12 Predicant Biosciences, Inc. Multi-channel microfluidic chip for electrospray ionization
GB2391694B (en) * 2002-08-01 2006-03-01 Microsaic Systems Ltd Monolithic micro-engineered mass spectrometer
GB2422951B (en) * 2005-02-07 2010-07-28 Microsaic Systems Ltd Integrated analytical device

Also Published As

Publication number Publication date
EP1746631B1 (fr) 2013-06-19
EP1746631A3 (fr) 2009-02-25
CA2552086A1 (fr) 2007-01-20
EP1746631A2 (fr) 2007-01-24
JP2007027131A (ja) 2007-02-01
JP5265095B2 (ja) 2013-08-14

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Legal Events

Date Code Title Description
EEER Examination request
H11 Ip right ceased following rejected request for revival

Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED

Effective date: 20250115