CA2563656C - Fraction pag-55 enrichie et methodes de detection precoce d'une gestation chez des animaux ongules - Google Patents

Fraction pag-55 enrichie et methodes de detection precoce d'une gestation chez des animaux ongules Download PDF

Info

Publication number
CA2563656C
CA2563656C CA2563656A CA2563656A CA2563656C CA 2563656 C CA2563656 C CA 2563656C CA 2563656 A CA2563656 A CA 2563656A CA 2563656 A CA2563656 A CA 2563656A CA 2563656 C CA2563656 C CA 2563656C
Authority
CA
Canada
Prior art keywords
pag
bovine
progesterone
sample
day
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2563656A
Other languages
English (en)
Other versions
CA2563656A1 (fr
Inventor
Nagappan Mathialagan
Michael Mcgrath
Robert Schenkel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Technology LLC
Original Assignee
Monsanto Technology LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Technology LLC filed Critical Monsanto Technology LLC
Publication of CA2563656A1 publication Critical patent/CA2563656A1/fr
Application granted granted Critical
Publication of CA2563656C publication Critical patent/CA2563656C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/811—Drug, bio-affecting and body treating compositions involving sex selection or contraception

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des méthodes de détermination de l'état de gestation d'un animal ongulé par détection du niveau de la fraction protéique PAG-55. Ces méthodes peuvent impliquer la détection de protéines enrichies en PAG-55 dans la fraction protéique PAG-55 par utilisation de nouveaux anticorps polyclonaux et monoclonaux qui ont été produits à l'aide de la fraction protéique enrichie en PAG-55, en tant qu'immunogène. Cette nouvelle fraction protéique PAG-55 indique si l'animal est gravide, lorsque la fraction protéique PAG-55 acide ou des composés antigéniques associés sont présents à un niveau élevé dans un échantillon. Ladite invention a aussi pour objet des méthodes d'obtention de la fraction protéique enrichie en PAG-55, ainsi que d'autres méthodes précises de détection de la gestation à un stade précoce. Les méthodes de cette invention ont l'avantage de permettre une détection précoce post-partum de l'état de gestation avec peu de résultats positifs faux. Les anticorps de détection de protéines PAG-55 sont également utilisés en combinaison avec des niveaux de progestérone élevés chez l'animal, ce qui permet d'engendrer une méthode de détection de gestation encore plus efficace. L'avantage de cette détection de gestation précoce repose sur l'identification d'animaux qui ne sont pas gravides très peu de temps après l'accouplement, il est ainsi possible d'opérer en temps opportun à un nouvel accouplement et de minimiser le temps durant lequel l'animal est disponible. Ladite invention concerne, en outre, des méthodes de prise de décision liée à l'accouplement d'un animal. Ces méthodes permettent à un gérant de troupeau de prendre les décisions liées à l'accouplement en fonction des niveaux de la fraction protéique PAG-55 et, facultativement, des niveaux de progestérone détectés dans un échantillon biologique prélevé chez un animal susceptible d'être à un stade précoce de gestation.
CA2563656A 2004-04-29 2005-04-27 Fraction pag-55 enrichie et methodes de detection precoce d'une gestation chez des animaux ongules Expired - Lifetime CA2563656C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56628204P 2004-04-29 2004-04-29
US60/566,282 2004-04-29
PCT/US2005/014458 WO2006073447A2 (fr) 2004-04-29 2005-04-27 Fraction pag-55 enrichie et methodes de detection precoce d'une gestation chez des animaux ongules

Publications (2)

Publication Number Publication Date
CA2563656A1 CA2563656A1 (fr) 2006-07-13
CA2563656C true CA2563656C (fr) 2017-06-27

Family

ID=36647907

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2563656A Expired - Lifetime CA2563656C (fr) 2004-04-29 2005-04-27 Fraction pag-55 enrichie et methodes de detection precoce d'une gestation chez des animaux ongules

Country Status (7)

Country Link
US (1) US7604950B2 (fr)
EP (1) EP1756584B1 (fr)
AR (1) AR048935A1 (fr)
AU (1) AU2005323518B2 (fr)
CA (1) CA2563656C (fr)
ES (1) ES2390783T3 (fr)
WO (1) WO2006073447A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009126889A1 (fr) * 2008-04-10 2009-10-15 The Curators Of The University Of Missouri Dosages pour détecter des glycoprotéines associées à la grossesse
WO2011037444A2 (fr) * 2009-09-28 2011-03-31 Carlos Alberto Barcelo Rojas Méthode de détermination par palpation des stades physiologico-reproductifs de l'utérus
US8541187B2 (en) 2011-03-01 2013-09-24 Bio Tracking, LLC Systems and methods for detecting animal pregnancy
RU2471421C1 (ru) * 2011-11-03 2013-01-10 Государственное научное учреждение Институт экспериментальной ветеринарии Сибири и Дальнего Востока Российской академии сельскохозяйственных наук (ГНУ ИЭВСиДВ Россельхозакадемии) Способ диагностики беременности у коров
CN115426876A (zh) * 2020-04-28 2022-12-02 利拉伐控股有限公司 用于妊娠检测的计算机实现方法、控制器、设备以及挤奶系统

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455009A (en) * 1993-09-14 1995-10-03 Becton, Dickinson And Company Blood collection assembly including clot-accelerating plastic insert
EP1141727A2 (fr) 1998-03-20 2001-10-10 Curators Of The University Of Missouri Compositions et methodes pour un diagnostic precoce de la grossesse
US7393696B2 (en) * 2001-09-28 2008-07-01 Aspenbio Pharma, Inc. Bovine pregnancy test
AU2002366097B2 (en) * 2001-11-20 2008-09-18 Monsanto Technology Llc Compositions and methods for accurate early pregnancy diagnosis

Also Published As

Publication number Publication date
US20080003695A1 (en) 2008-01-03
EP1756584A2 (fr) 2007-02-28
CA2563656A1 (fr) 2006-07-13
US7604950B2 (en) 2009-10-20
ES2390783T3 (es) 2012-11-16
AU2005323518A1 (en) 2006-07-13
AU2005323518B2 (en) 2010-05-27
EP1756584B1 (fr) 2012-08-01
WO2006073447A3 (fr) 2006-12-21
AR048935A1 (es) 2006-06-14
WO2006073447A2 (fr) 2006-07-13

Similar Documents

Publication Publication Date Title
US8182999B2 (en) Compositions and methods for early pregnancy diagnosis
JP5679818B2 (ja) 早期妊娠診断のための組成物および方法
WO2004059282A2 (fr) Methode et moyen de detection precoce de gestation chez des animaux a l'aide d'essais combines
US7575861B2 (en) Compositions and method for accurate early pregnancy diagnosis
US20140024057A1 (en) Systems and methods for detecting animal pregnancy
JP3742649B2 (ja) 切迫分娩についての危険にある女性における膜の破裂を決定するための検定方法
AU2005323518B2 (en) Enriched PAG-55 fraction and methods for early detection of pregnancy in ungulate animals
Chapman et al. Implantation: biological and clinical aspects
WO2013099376A1 (fr) Marqueur d'ovule mature pour l'utilisation dans la fécondation in vitro et utilisation de ce marqueur
WO2022149410A1 (fr) Biomarqueur pour déterminer la fertilité et méthode de détermination l'utilisant

Legal Events

Date Code Title Description
EEER Examination request