CA2565685A1 - Compositions et procedes pour l'amelioration de l'administration d'acides nucleiques dans des cellules et pour la modification de l'expression de genes cibles dans des cellules - Google Patents

Compositions et procedes pour l'amelioration de l'administration d'acides nucleiques dans des cellules et pour la modification de l'expression de genes cibles dans des cellules Download PDF

Info

Publication number: CA2565685A1
Authority: CA; Canada
Prior art keywords: nucleic acid; polynucleotide delivery; enhancing polypeptide; sirna; histone
Prior art date: 2004-05-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002565685A

Other languages

English (en)

Inventor

Lishan Chen

Kunyuan Cui

Yuching Chen

Sasha J. Mayer

Michael E. Houston, Jr.

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Marina Biotech Inc

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-04

Filing date

2005-05-04

Publication date

2005-12-15

2005-05-04 Application filed by Individual filed Critical Individual

2005-12-15 Publication of CA2565685A1 publication Critical patent/CA2565685A1/fr

Status Abandoned legal-status Critical Current

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific

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Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

CA002565685A 2004-05-04 2005-05-04 Compositions et procedes pour l'amelioration de l'administration d'acides nucleiques dans des cellules et pour la modification de l'expression de genes cibles dans des cellules Abandoned CA2565685A1 (fr)

Applications Claiming Priority (13)

Application Number	Priority Date	Filing Date	Title
US56802704P	2004-05-04	2004-05-04
US60/568,027		2004-05-04
US57051204P	2004-05-12	2004-05-12
US57051304P	2004-05-12	2004-05-12
US60/570,513		2004-05-12
US60/570,512		2004-05-12
US61341604P	2004-09-27	2004-09-27
US60/613,416		2004-09-27
US65657205P	2005-02-25	2005-02-25
US60/656,572		2005-02-25
US66783305P	2005-04-01	2005-04-01
US60/667,833		2005-04-01
PCT/US2005/015574 WO2005117991A2 (fr)	2004-05-04	2005-05-04	Compositions et procedes pour l'amelioration de l'administration d'acides nucleiques dans des cellules et pour la modification de l'expression de genes cibles dans des cellules

Publications (1)

Publication Number	Publication Date
CA2565685A1 true CA2565685A1 (fr)	2005-12-15

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ID=35311390

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002565685A Abandoned CA2565685A1 (fr)	2004-05-04	2005-05-04	Compositions et procedes pour l'amelioration de l'administration d'acides nucleiques dans des cellules et pour la modification de l'expression de genes cibles dans des cellules

Country Status (5)

Country	Link
EP (1)	EP1750775A2 (fr)
JP (1)	JP2007536253A (fr)
CA (1)	CA2565685A1 (fr)
MX (1)	MXPA06012605A (fr)
WO (1)	WO2005117991A2 (fr)

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AU2007272906B2 (en) *	2006-07-12	2013-01-31	The Regents Of The University Of California	Transducible delivery of nucleic acids by reversible phosphotriester charge neutralization protecting groups
ES2911034T3 (es)	2006-08-08	2022-05-17	Univ Bonn Rheinische Friedrich Wilhelms	Estructura y uso de oligonucleótidos 5' fosfato
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KR20080076622A (ko) *	2007-02-16	2008-08-20	포항공과대학교 산학협력단	올리고머화된 단백질 전달체와 이를 이용한 세포내바이러스 벡터 전달 방법
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2005
- 2005-05-04 JP JP2007511576A patent/JP2007536253A/ja active Pending
- 2005-05-04 CA CA002565685A patent/CA2565685A1/fr not_active Abandoned
- 2005-05-04 MX MXPA06012605A patent/MXPA06012605A/es not_active Application Discontinuation
- 2005-05-04 WO PCT/US2005/015574 patent/WO2005117991A2/fr not_active Ceased
- 2005-05-04 EP EP05804803A patent/EP1750775A2/fr not_active Withdrawn

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Publication number	Publication date
JP2007536253A (ja)	2007-12-13
WO2005117991A3 (fr)	2007-01-18
MXPA06012605A (es)	2006-12-15
WO2005117991A2 (fr)	2005-12-15
EP1750775A2 (fr)	2007-02-14

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US8299236B2 (en)	2012-10-30	Compositions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells
CA2565685A1 (fr)	2005-12-15	Compositions et procedes pour l'amelioration de l'administration d'acides nucleiques dans des cellules et pour la modification de l'expression de genes cibles dans des cellules
US20060035815A1 (en)	2006-02-16	Pharmaceutical compositions for delivery of ribonucleic acid to a cell
EP1942943A2 (fr)	2008-07-16	Conjugues de peptide-arn substrat dicer utilises comme excipients d'administration pour arnsi
US20080076701A1 (en)	2008-03-27	Dicer substrate rna peptide conjugates and methods for rna therapeutics
US20070281900A1 (en)	2007-12-06	COMPOSITIONS AND METHODS FOR LIPID AND POLYPEPTIDE BASED siRNA INTRACELLULAR DELIVERY
US20070275923A1 (en)	2007-11-29	CATIONIC PEPTIDES FOR siRNA INTRACELLULAR DELIVERY
JP2010503382A (ja)	2010-02-04	低分子干渉核酸（ｓｉＮＡ）を用いたプロタンパク質転換酵素サブチリシンケクシン９（ＰＣＳＫ９）遺伝子発現のＲＮＡ干渉媒介性阻害
AU2006287481A1 (en)	2007-03-15	Pharmaceutical compositions for delivery of ribonucleic acid to a cell
US20070269892A1 (en)	2007-11-22	FORMULATIONS FOR INTRACELLULAR DELIVERY dsRNA
US7696343B2 (en)	2010-04-13	Method for opening tight junctions
US20070213257A1 (en)	2007-09-13	Compositions and methods for complexes of nucleic acids and peptides
US20070276134A1 (en)	2007-11-29	Compositions and methods for complexes of nucleic acids and organic cations
KR20080044909A (ko)	2008-05-21	세포 내로 리보핵산의 전달을 위한 약학 조성물
US20070293657A1 (en)	2007-12-20	Complexes and methods of forming complexes of ribonucleic acids and peptides
CN101355970A (zh)	2009-01-28	作为sirna递送媒介物的肽-dicer底物rna轭合物
MX2008003380A (en)	2008-10-03	Pharmaceutical compositions for delivery of ribonucleic acid to a cell
CN101208438A (zh)	2008-06-25	使用双链核糖核酸治疗炎性疾病的方法
HK1123069A (en)	2009-06-05	Pharmaceutical compositions for delivery of ribonucleic acid to a cell
MX2007003667A (en)	2008-10-03	Method of treating an inflammatory disease by double stranded ribonucleic acid