CA2568510C - Processus en enceinte unique permettant de preparer des derives de la prednisolone - Google Patents

Processus en enceinte unique permettant de preparer des derives de la prednisolone Download PDF

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Publication number
CA2568510C
CA2568510C CA002568510A CA2568510A CA2568510C CA 2568510 C CA2568510 C CA 2568510C CA 002568510 A CA002568510 A CA 002568510A CA 2568510 A CA2568510 A CA 2568510A CA 2568510 C CA2568510 C CA 2568510C
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formula
compound
process according
catalyst
molar ratio
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CA2568510A1 (fr
Inventor
Minghua Ying
Dingwei Wu
Hongpeng Chen
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Zhejiang Xianju Pharmaceutical Co Ltd
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Zhejiang Xianju Pharmaceutical Co Ltd
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Priority to CA002568510A priority Critical patent/CA2568510C/fr
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

Divulgation d'un processus en enceinte unique permettant de préparer un dérivé de prednisolone de la formule I et qui consiste à faire réagir le composé de la formule II avec le composé de la formule III et le composé de la formule IV. Le processus ne nécessite pas la séparation et la purification du composé intermédiaire formé, ce qui permet de réduire le temps de réaction et d'augmenter le rendement du produit par rapport à l'état antérieur de la technique (voir formule II) (voir formule III) (voir formule IV) (voir la formule I).
CA002568510A 2006-11-21 2006-11-21 Processus en enceinte unique permettant de preparer des derives de la prednisolone Active CA2568510C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002568510A CA2568510C (fr) 2006-11-21 2006-11-21 Processus en enceinte unique permettant de preparer des derives de la prednisolone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002568510A CA2568510C (fr) 2006-11-21 2006-11-21 Processus en enceinte unique permettant de preparer des derives de la prednisolone

Publications (2)

Publication Number Publication Date
CA2568510A1 CA2568510A1 (fr) 2008-05-21
CA2568510C true CA2568510C (fr) 2009-12-15

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ID=39420393

Family Applications (1)

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CA002568510A Active CA2568510C (fr) 2006-11-21 2006-11-21 Processus en enceinte unique permettant de preparer des derives de la prednisolone

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CA (1) CA2568510C (fr)

Also Published As

Publication number Publication date
CA2568510A1 (fr) 2008-05-21

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