CA2569095A1 - Structure cristalline de dipeptidyl peptidase iv (dpp-iv) et ses utilisations - Google Patents
Structure cristalline de dipeptidyl peptidase iv (dpp-iv) et ses utilisations Download PDFInfo
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- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Selon l'invention, une structure cristalline de dipeptidyl peptidase IV (DPP-IV) et les trois coordonnées atomiques tridimensionnelles du domaine extracellulaire de DPP-IV, telles que décrites et utilisées pour l'identification de ligands, dont les inhibiteurs de DPP-IV, sont utilisées pour traiter des maladies associées à des protéines soumises à un traitement par DPP-IV.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57687704P | 2004-06-03 | 2004-06-03 | |
| US60/576,877 | 2004-06-03 | ||
| PCT/IB2005/001630 WO2005119526A1 (fr) | 2004-06-03 | 2005-05-26 | Structure cristalline de dipeptidyl peptidase iv (dpp-iv) et ses utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2569095A1 true CA2569095A1 (fr) | 2005-12-15 |
Family
ID=34969993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002569095A Abandoned CA2569095A1 (fr) | 2004-06-03 | 2005-05-26 | Structure cristalline de dipeptidyl peptidase iv (dpp-iv) et ses utilisations |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1756740A1 (fr) |
| CA (1) | CA2569095A1 (fr) |
| MX (1) | MXPA06014083A (fr) |
| WO (1) | WO2005119526A1 (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1852108A1 (fr) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | Compositions d'inhibiteurs de la DPP IV |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| CN102838599A (zh) | 2006-05-04 | 2012-12-26 | 贝林格尔.英格海姆国际有限公司 | 多晶型 |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| US8513187B2 (en) | 2009-02-27 | 2013-08-20 | Trustees Of Tufts College | Soft protease inhibitors, and pro-soft forms thereof |
| US8716482B2 (en) * | 2009-09-25 | 2014-05-06 | Merck Sharp & Dohme Corp. | Substituted aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes |
| EP2366394A1 (fr) * | 2010-03-17 | 2011-09-21 | IMTM GmbH | Caractérisation et validation d'inhibiteurs et de ligands de la dipeptidyl-aminopeptidase de type IV (DP IV) |
| US8980929B2 (en) | 2010-05-21 | 2015-03-17 | Merck Sharp & Dohme Corp. | Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
| WO2012017391A2 (fr) * | 2010-08-03 | 2012-02-09 | Cadila Pharmaceuticals Limited | Nouveaux composés en tant qu'inhibiteurs de la dpp-iv et procédé de préparation associé |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| WO2012170702A1 (fr) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur gpr119 et traitement de troubles associés à celui-ci |
| US20130303554A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in sirs and/or sepsis |
| WO2017211979A1 (fr) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinaisons de linagliptine et de metformine |
-
2005
- 2005-05-26 CA CA002569095A patent/CA2569095A1/fr not_active Abandoned
- 2005-05-26 EP EP05744309A patent/EP1756740A1/fr not_active Withdrawn
- 2005-05-26 MX MXPA06014083A patent/MXPA06014083A/es unknown
- 2005-05-26 WO PCT/IB2005/001630 patent/WO2005119526A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06014083A (es) | 2007-02-15 |
| WO2005119526A1 (fr) | 2005-12-15 |
| EP1756740A1 (fr) | 2007-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20090526 |