CA2574972C - Dispositifs medicaux metalliques de liberation de medicaments et leur procede de fabrication - Google Patents

Dispositifs medicaux metalliques de liberation de medicaments et leur procede de fabrication Download PDF

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Publication number
CA2574972C
CA2574972C CA2574972A CA2574972A CA2574972C CA 2574972 C CA2574972 C CA 2574972C CA 2574972 A CA2574972 A CA 2574972A CA 2574972 A CA2574972 A CA 2574972A CA 2574972 C CA2574972 C CA 2574972C
Authority
CA
Canada
Prior art keywords
drug
medical device
releasing
microperforations
metallic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2574972A
Other languages
English (en)
Other versions
CA2574972A1 (fr
Inventor
Steven R. Bailey
Christopher T. Boyle
Christopher E. Banas
Julio C. Palmaz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vactronix Scientific LLC
Original Assignee
Advanced Bio Prosthetic Surfaces Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Bio Prosthetic Surfaces Ltd filed Critical Advanced Bio Prosthetic Surfaces Ltd
Publication of CA2574972A1 publication Critical patent/CA2574972A1/fr
Application granted granted Critical
Publication of CA2574972C publication Critical patent/CA2574972C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/06—Implements for therapeutic treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01—Filters implantable into blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0035—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in release or diffusion time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/0097—Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Dentistry (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Ceramic Engineering (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention a trait à des dispositifs médicaux implantables de libération de médicaments fabriqués en films métalliques ou pseudo-métalliques comprenant une pluralité de micro-perforations traversant le film en une configuration qui procure des caractéristiques de tissu au dispositif et/ou permet la déformation géométrique du dispositif médical. Le dispositif médical implantable est de préférence fabriqué par dépôt sous vide de matériaux métalliques et/ou pseudo-métalliques en des structures monocouche ou multicouche avec une pluralité de micro-perforations soit formées en cours de dépôt ou suite au dépôt par l'élimination sélective de sections du film déposé. Le dispositif médical implantable est apte à être utilisé comme greffons endoluminaux ou chirurgicaux et peut être utilisé, par exemple, comme greffons vasculaires, greffons endovasculaires, greffons cutanés, valves, greffons osseux, pièces chirurgicales, conduits non vasculaires, feuillets valvulaires, filtres, membranes d'occlusion, sphincters, tendons et ligaments artificiels.
CA2574972A 2004-07-29 2005-07-28 Dispositifs medicaux metalliques de liberation de medicaments et leur procede de fabrication Expired - Lifetime CA2574972C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90166104A 2004-07-29 2004-07-29
US10/901,661 2004-07-29
PCT/US2005/026875 WO2006015161A2 (fr) 2004-07-29 2005-07-28 Dispositifs medicaux metalliques de liberation de medicaments et leur procede de fabrication

Publications (2)

Publication Number Publication Date
CA2574972A1 CA2574972A1 (fr) 2006-02-09
CA2574972C true CA2574972C (fr) 2015-07-07

Family

ID=35787838

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2574972A Expired - Lifetime CA2574972C (fr) 2004-07-29 2005-07-28 Dispositifs medicaux metalliques de liberation de medicaments et leur procede de fabrication

Country Status (6)

Country Link
EP (1) EP1786361A4 (fr)
JP (1) JP5102029B2 (fr)
CN (1) CN101014300A (fr)
AU (1) AU2005267886A1 (fr)
CA (1) CA2574972C (fr)
WO (1) WO2006015161A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8999364B2 (en) 2004-06-15 2015-04-07 Nanyang Technological University Implantable article, method of forming same and method for reducing thrombogenicity
EP2120807A2 (fr) * 2007-02-13 2009-11-25 Cinvention Ag Implants dégradables à réservoir
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
JP2010533563A (ja) 2007-07-19 2010-10-28 ボストン サイエンティフィック リミテッド 吸着抑制表面を有する内部人工器官
JP2010535541A (ja) 2007-08-03 2010-11-25 ボストン サイエンティフィック リミテッド 広い表面積を有する医療器具用のコーティング
EP2271380B1 (fr) 2008-04-22 2013-03-20 Boston Scientific Scimed, Inc. Dispositifs médicaux revêtus d une substance inorganique
WO2009132176A2 (fr) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Dispositifs médicaux comportant des couches de particules inorganiques
US10898620B2 (en) 2008-06-20 2021-01-26 Razmodics Llc Composite stent having multi-axial flexibility and method of manufacture thereof
US8206636B2 (en) 2008-06-20 2012-06-26 Amaranth Medical Pte. Stent fabrication via tubular casting processes
US8206635B2 (en) 2008-06-20 2012-06-26 Amaranth Medical Pte. Stent fabrication via tubular casting processes
CN103445895B (zh) * 2013-09-12 2015-11-11 徐贵丽 一种可缓慢释放药物的医用腔道支架
US9579427B2 (en) * 2014-06-28 2017-02-28 Cordis Corporation Thin-film composite retrievable endovascular devices and method of use
CN106730373B (zh) * 2017-02-06 2023-12-08 中国人民解放军总医院 钴锆钼合金标
CN107095728A (zh) * 2017-05-19 2017-08-29 东莞颠覆产品设计有限公司 管腔内载药支架
CN107802377A (zh) * 2017-11-29 2018-03-16 成都创客之家科技有限公司 一种钛合金覆膜血管支架
CN107802385A (zh) * 2017-11-29 2018-03-16 成都创客之家科技有限公司 一种钛合金血管支架
CN114601602B (zh) * 2022-05-12 2022-08-30 北京理贝尔生物工程研究所有限公司 植入假体
CN116135177A (zh) * 2023-02-23 2023-05-19 赫美康健(北京)医疗器械有限公司 一种可分解自固定的腹膜前补片

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774278B1 (en) * 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
ZA9710342B (en) * 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
EP1214108B1 (fr) * 1999-09-03 2007-01-10 Advanced Cardiovascular Systems, Inc. Prothese poreuse et procede de depot de substances dans les pores
US6379382B1 (en) * 2000-03-13 2002-04-30 Jun Yang Stent having cover with drug delivery capability
US8252044B1 (en) * 2000-11-17 2012-08-28 Advanced Bio Prosthestic Surfaces, Ltd. Device for in vivo delivery of bioactive agents and method of manufacture thereof

Also Published As

Publication number Publication date
WO2006015161A2 (fr) 2006-02-09
AU2005267886A1 (en) 2006-02-09
WO2006015161A3 (fr) 2006-06-29
CN101014300A (zh) 2007-08-08
EP1786361A4 (fr) 2014-12-10
EP1786361A2 (fr) 2007-05-23
JP5102029B2 (ja) 2012-12-19
CA2574972A1 (fr) 2006-02-09
JP2008508054A (ja) 2008-03-21

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