CA2586845A1 - Traitement therapeutique de resorption osseuse acceleree - Google Patents

Traitement therapeutique de resorption osseuse acceleree Download PDF

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Publication number
CA2586845A1
CA2586845A1 CA002586845A CA2586845A CA2586845A1 CA 2586845 A1 CA2586845 A1 CA 2586845A1 CA 002586845 A CA002586845 A CA 002586845A CA 2586845 A CA2586845 A CA 2586845A CA 2586845 A1 CA2586845 A1 CA 2586845A1
Authority
CA
Canada
Prior art keywords
group
alkyl
amino
meca
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002586845A
Other languages
English (en)
Inventor
Pnina Fishman
Sara Bar Yehuda
Lea Madi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Can Fite Biopharma Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2586845A1 publication Critical patent/CA2586845A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne l'utilisation d'un agoniste du récepteur d'adénosine A3 (agoniste de A3AR) pour le traitement de la résorption osseuse accélérée, plus particulièrement de la résorption osseuse induite par une inflammation. Plus spécifiquement, l'invention concerne un procédé et une composition pharmaceutique pour le traitement de cet état pathologique, l'agoniste de A3AR étant formulé en tant que composition pharmaceutique administrée à un sujet souffrant de résorption osseuse accélérée. L'invention concerne également l'utilisation de l'agoniste de A3AR dans la préparation de cette composition pharmaceutique.
CA002586845A 2004-11-08 2005-11-08 Traitement therapeutique de resorption osseuse acceleree Abandoned CA2586845A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62556404P 2004-11-08 2004-11-08
US60/625,564 2004-11-08
PCT/IL2005/001166 WO2006048884A1 (fr) 2004-11-08 2005-11-08 Traitement therapeutique de resorption osseuse acceleree

Publications (1)

Publication Number Publication Date
CA2586845A1 true CA2586845A1 (fr) 2006-05-11

Family

ID=36001028

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002586845A Abandoned CA2586845A1 (fr) 2004-11-08 2005-11-08 Traitement therapeutique de resorption osseuse acceleree

Country Status (9)

Country Link
EP (1) EP1811982A1 (fr)
JP (1) JP2008519029A (fr)
KR (1) KR20070085839A (fr)
CN (1) CN101072554A (fr)
AU (1) AU2005302090A1 (fr)
BR (1) BRPI0517639A (fr)
CA (1) CA2586845A1 (fr)
MX (1) MX2007005525A (fr)
WO (1) WO2006048884A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5339916B2 (ja) * 2005-11-30 2013-11-13 キャン−ファイト・バイオファーマ・リミテッド 骨関節炎の治療におけるa3アデノシン受容体アゴニストの使用
US9102698B2 (en) 2007-03-14 2015-08-11 Can-Fite Biopharma Ltd. Process for the synthesis of IB-MECA
WO2009061516A1 (fr) * 2007-11-08 2009-05-14 New York University School Of Medicine Implants médicaux contenant des agonistes du récepteur de l'adénosine et procédés pour inhiber un relâchement d'implant médical
JP5849044B2 (ja) * 2009-05-17 2016-01-27 キャン−ファイト バイオファーマ リミテッド 眼圧低下のためのa3アデノシン受容体作動薬
UA117095C2 (uk) 2011-12-22 2018-06-25 Аліос Біофарма, Інк. Нуклеозидна сполука або її фармацевтично прийнятна сіль
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5294100A (en) * 1999-05-27 2000-12-18 University Of Virginia Patent Foundation Method and compositions for treating the inflammatory response
IL133680A0 (en) * 1999-09-10 2001-04-30 Can Fite Technologies Ltd Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
US7141553B2 (en) * 2002-11-19 2006-11-28 Can-Fite Biopharma Ltd. Israel A3AR agonists for the treatment of inflammatory arthritis
GB0305150D0 (en) * 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Use of therapeutic compounds
CA2557285A1 (fr) * 2004-03-05 2005-09-15 Cambridge Biotechnology Limited Composes therapeutiques

Also Published As

Publication number Publication date
KR20070085839A (ko) 2007-08-27
BRPI0517639A (pt) 2008-10-14
WO2006048884A1 (fr) 2006-05-11
CN101072554A (zh) 2007-11-14
JP2008519029A (ja) 2008-06-05
AU2005302090A1 (en) 2006-05-11
MX2007005525A (es) 2007-07-05
EP1811982A1 (fr) 2007-08-01

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CA2586845A1 (fr) Traitement therapeutique de resorption osseuse acceleree
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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20101108