CA2602185A1 - Enzymes and formulations for broad-specificity decontamination of chemical and biological warfare agents - Google Patents

Enzymes and formulations for broad-specificity decontamination of chemical and biological warfare agents Download PDF

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Publication number
CA2602185A1
CA2602185A1 CA002602185A CA2602185A CA2602185A1 CA 2602185 A1 CA2602185 A1 CA 2602185A1 CA 002602185 A CA002602185 A CA 002602185A CA 2602185 A CA2602185 A CA 2602185A CA 2602185 A1 CA2602185 A1 CA 2602185A1
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CA
Canada
Prior art keywords
seq
ala
leu
gly
val
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002602185A
Other languages
English (en)
French (fr)
Inventor
Dan E. Robertson
Toby Richardson
Karen Kustedjo
Gabriel Amitai
Keith Lejeune
Jason Berberich
Jennifer Ann Chaplin
Jessica Sinclair
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Life Science Research Israel Ltd
Agentase LLC
Verenium Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Life Science Research Israel Ltd, Agentase LLC, Verenium Corp filed Critical Life Science Research Israel Ltd
Publication of CA2602185A1 publication Critical patent/CA2602185A1/en
Abandoned legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A62LIFE-SAVING; FIRE-FIGHTING
    • A62DCHEMICAL MEANS FOR EXTINGUISHING FIRES OR FOR COMBATING OR PROTECTING AGAINST HARMFUL CHEMICAL AGENTS; CHEMICAL MATERIALS FOR USE IN BREATHING APPARATUS
    • A62D3/00Processes for making harmful chemical substances harmless or less harmful, by effecting a chemical change in the substances
    • A62D3/02Processes for making harmful chemical substances harmless or less harmful, by effecting a chemical change in the substances by biological methods, i.e. processes using enzymes or microorganisms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • AHUMAN NECESSITIES
    • A62LIFE-SAVING; FIRE-FIGHTING
    • A62DCHEMICAL MEANS FOR EXTINGUISHING FIRES OR FOR COMBATING OR PROTECTING AGAINST HARMFUL CHEMICAL AGENTS; CHEMICAL MATERIALS FOR USE IN BREATHING APPARATUS
    • A62D2101/00Harmful chemical substances made harmless, or less harmful, by effecting chemical change
    • A62D2101/02Chemical warfare substances, e.g. cholinesterase inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Business, Economics & Management (AREA)
  • Emergency Management (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002602185A 2005-04-06 2006-04-06 Enzymes and formulations for broad-specificity decontamination of chemical and biological warfare agents Abandoned CA2602185A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US66933005P 2005-04-06 2005-04-06
US60/669,330 2005-04-06
US68713005P 2005-06-02 2005-06-02
US60/687,130 2005-06-02
PCT/US2006/013031 WO2008036061A2 (en) 2005-04-06 2006-04-06 Enzymes and formulations for broad-specificity decontamination of chemical and biological warfare agents

Publications (1)

Publication Number Publication Date
CA2602185A1 true CA2602185A1 (en) 2006-10-06

Family

ID=39200998

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002602185A Abandoned CA2602185A1 (en) 2005-04-06 2006-04-06 Enzymes and formulations for broad-specificity decontamination of chemical and biological warfare agents

Country Status (5)

Country Link
EP (1) EP1928560A2 (de)
JP (1) JP2009517002A (de)
CA (1) CA2602185A1 (de)
IL (1) IL186399A0 (de)
WO (1) WO2008036061A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110562926A (zh) * 2019-09-10 2019-12-13 南宁绿普环保科技有限责任公司 便携式二氧化氯发生器

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US7439016B1 (en) 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
US7601497B2 (en) 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
CN101451144B (zh) * 2008-06-11 2011-06-01 贵州大学 一种能够自发消除农残的果实种质培育方法
TWI417389B (zh) 2008-10-27 2013-12-01 Qiagen Gaithersburg Inc 於自動平台上之快速結果雜交捕捉法
AU2010242867B2 (en) 2009-05-01 2016-05-12 Qiagen Gaithersburg, Inc. A non-target amplification method for detection of RNA splice-forms in a sample
CN106434596A (zh) * 2009-05-06 2017-02-22 诺维信公司 来自加州海兔的dfp酶
EP2248893A1 (de) * 2009-05-06 2010-11-10 Novozymes A/S DFPase-Enzyme aus Octopus Vulgaris
JP5826752B2 (ja) 2009-09-14 2015-12-02 キアジェン ゲイサーズバーグ インコーポレイテッド 細胞学用培地に固定された組織サンプルから核酸またはタンパク質を回収するための組成物および方法
EP2521778B1 (de) 2010-01-04 2014-03-19 QIAGEN Gaithersburg, Inc. Verfahren, zusammensetzungen und kits zur gewinnung von nukleinsäuren oder proteinen aus festen gewebeproben
CA2787781A1 (en) 2010-01-29 2011-08-04 Qiagen Gaithersburg, Inc. Method of determining and confirming the presence of an hpv in a sample
ES2615728T3 (es) 2010-01-29 2017-06-08 Qiagen Gaithersburg, Inc. Métodos y composiciones para una purificación y un análisis múltiple específico de secuencia de ácidos nucleicos
US20130197612A1 (en) * 2010-02-26 2013-08-01 Jack W. Lasersohn Electromagnetic Radiation Therapy
US9422593B2 (en) 2010-05-19 2016-08-23 Qiagen Gaithresburg, Inc Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
CA2799205A1 (en) 2010-05-25 2011-12-01 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically-truncated probes
WO2012087790A1 (en) * 2010-12-21 2012-06-28 E.I. Dupont De Nemours And Company Perhydrolase variant providing improved specific activity
WO2012087788A1 (en) * 2010-12-21 2012-06-28 E.I. Dupont De Nemours And Company Perhydrolase variant providing improved specific activity
WO2012087792A1 (en) * 2010-12-21 2012-06-28 E.I. Dupont De Nemours And Company Perhydrolase variant providing improved specific activity
US8389256B2 (en) * 2010-12-21 2013-03-05 E.I. Du Pont De Nemours And Company Perhydrolase variant providing improved specific activity
US8394616B2 (en) * 2010-12-21 2013-03-12 E.I. Du Pont De Nemours And Company Perhydrolase variant providing improved specific activity
AU2012220575B2 (en) 2011-02-24 2017-01-12 Qiagen Gaithersburg, Inc. Materials and methods for detection of HPV nucleic acid
CN103827297B (zh) 2011-08-10 2018-06-22 诺维信公司 具有过氧化酶活性的多肽及编码该多肽的多核苷酸
WO2013021065A1 (en) * 2011-08-10 2013-02-14 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
WO2013021064A1 (en) * 2011-08-10 2013-02-14 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
WO2013079533A1 (en) * 2011-12-02 2013-06-06 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
JP2015516804A (ja) 2012-03-31 2015-06-18 ノボザイムス アクティーゼルスカブ ペルオキシゲナーゼを用いたエポキシ化
EP2906687B1 (de) * 2012-10-12 2018-08-15 Novozymes A/S Polypeptide mit peroxygenaseaktivität
WO2014056922A2 (en) * 2012-10-12 2014-04-17 Novozymes A/S Polypeptides having peroxygenase activity
WO2014056924A2 (en) * 2012-10-12 2014-04-17 Novozymes A/S Polypeptides having peroxygenase activity
CN104704115B (zh) * 2012-10-12 2018-11-02 诺维信公司 具有过氧合酶活性的多肽
US9963688B2 (en) * 2013-03-22 2018-05-08 American University In Cairo Heavy metal resistant esterase
KR101892358B1 (ko) * 2016-10-21 2018-08-27 국방과학연구소 프롤리다아제 돌연변이체 및 이의 제조방법 및 이에 따라 제조된 프롤리다아제 돌연변이체의 용도
CN107500472B (zh) * 2017-09-05 2021-05-11 成都锐达机电实业有限公司 高效脱磷工艺
CN120795059A (zh) 2018-08-27 2025-10-17 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
CN109270033A (zh) * 2018-09-10 2019-01-25 南京市产品质量监督检验院 一种食品中危害因子的快速检测方法
CN112326623B (zh) * 2020-10-23 2024-05-14 中国人民解放军军事科学院军事医学研究院 一种双层拉曼分子标记的硅核银壳复合纳米标签、制备方法及免疫层析应用
CN112666141B (zh) * 2020-12-14 2024-02-27 广西大学 伏杀磷农药的荧光比率检测法
CN113371848B (zh) * 2021-06-29 2022-09-16 内蒙古阜丰生物科技有限公司 氨基酸废水的综合处理工艺
JP2024532463A (ja) * 2021-09-03 2024-09-05 アカデミー オブ ミリタリー メディカル サイエンシズ 除染組成物及びその用途
CN114181854B (zh) * 2021-12-03 2024-02-06 中国科学院微生物研究所 一种深海来源的马拉硫磷降解菌株及其应用
WO2026019621A1 (en) * 2024-07-15 2026-01-22 Merck Sharp & Dohme Llc Engineered carboxylesterase enzymes and methods for their use in macrocyclization of non-canonical tetrapeptides
CN121574205B (zh) * 2026-01-28 2026-04-07 中国科学院烟台海岸带研究所 一种具有ace抑制活性的五肽ra5及其制备方法和应用

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US6221821B1 (en) * 1998-03-18 2001-04-24 Novozymes A/S Patents Haloperoxidases with altered pH profiles
US6455751B1 (en) * 1999-03-03 2002-09-24 The Regents Of The University Of California Oxidizer gels for detoxification of chemical and biological agents
US20040048249A1 (en) * 2000-01-21 2004-03-11 Tang Y. Tom Novel nucleic acids and secreted polypeptides
US6703540B1 (en) * 2000-03-09 2004-03-09 The United States Of America As Represented By The Secretary Of Agriculture Transformation of plants with a chloroperoxidase gene to enhance disease resistance
WO2002020711A2 (en) * 2000-09-07 2002-03-14 Unilever N.V. Detergent compositions comprising phenol oxidizing enzymes
US20040109853A1 (en) * 2002-09-09 2004-06-10 Reactive Surfaces, Ltd. Biological active coating components, coatings, and coated surfaces

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110562926A (zh) * 2019-09-10 2019-12-13 南宁绿普环保科技有限责任公司 便携式二氧化氯发生器
CN110562926B (zh) * 2019-09-10 2023-08-01 南宁绿普环保科技有限责任公司 便携式二氧化氯发生器

Also Published As

Publication number Publication date
WO2008036061A3 (en) 2008-12-18
JP2009517002A (ja) 2009-04-30
EP1928560A2 (de) 2008-06-11
WO2008036061A2 (en) 2008-03-27
IL186399A0 (en) 2009-02-11

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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20100406