CA2614880C - Flacon - Google Patents

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Info

Publication number: CA2614880C
Authority: CA; Canada
Prior art keywords: vial; frit; vials; cartridge; solid support
Prior art date: 1998-06-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA2614880A

Other languages

English (en)

Other versions

CA2614880A1 (fr

Inventor

Gary R. Mcluen

Richard J. Hanney

Daniel W. Hugens

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

McLuen Design Inc

Original Assignee

McLuen Design Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-16

Filing date

1999-06-15

Publication date

2012-08-21

1998-06-16 Priority claimed from US09/097,966 external-priority patent/US6270730B1/en

1999-06-15 Application filed by McLuen Design Inc filed Critical McLuen Design Inc

1999-12-23 Publication of CA2614880A1 publication Critical patent/CA2614880A1/fr

2012-08-21 Application granted granted Critical

2012-08-21 Publication of CA2614880C publication Critical patent/CA2614880C/fr

2019-06-15 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000463 material Substances 0.000 claims abstract description 82
238000011010 flushing procedure Methods 0.000 claims abstract description 72
239000007787 solid Substances 0.000 claims abstract description 45
230000000717 retained effect Effects 0.000 claims abstract description 21
239000003153 chemical reaction reagent Substances 0.000 claims description 76
229920000642 polymer Polymers 0.000 claims description 28
239000011324 bead Substances 0.000 claims description 5
239000005289 controlled pore glass Substances 0.000 claims description 5
239000002699 waste material Substances 0.000 description 35
238000010926 purge Methods 0.000 description 14
238000000034 method Methods 0.000 description 12
108091034117 Oligonucleotide Proteins 0.000 description 10
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 10
230000015572 biosynthetic process Effects 0.000 description 10
238000003786 synthesis reaction Methods 0.000 description 10
238000006243 chemical reaction Methods 0.000 description 8
230000008569 process Effects 0.000 description 8
239000007789 gas Substances 0.000 description 6
150000002894 organic compounds Chemical class 0.000 description 5
239000004809 Teflon Substances 0.000 description 3
229920006362 Teflon® Polymers 0.000 description 3
230000004044 response Effects 0.000 description 3
230000006820 DNA synthesis Effects 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
230000008878 coupling Effects 0.000 description 2
238000010168 coupling process Methods 0.000 description 2
238000005859 coupling reaction Methods 0.000 description 2
239000003814 drug Substances 0.000 description 2
239000011261 inert gas Substances 0.000 description 2
238000011022 operating instruction Methods 0.000 description 2
108090000765 processed proteins & peptides Proteins 0.000 description 2
238000011160 research Methods 0.000 description 2
108091028043 Nucleic acid sequence Proteins 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
238000013459 approach Methods 0.000 description 1
238000003491 array Methods 0.000 description 1
238000007630 basic procedure Methods 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
230000006835 compression Effects 0.000 description 1
238000007906 compression Methods 0.000 description 1
238000010276 construction Methods 0.000 description 1
238000000151 deposition Methods 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
239000013070 direct material Substances 0.000 description 1
229920001971 elastomer Polymers 0.000 description 1
239000000806 elastomer Substances 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
230000000737 periodic effect Effects 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
-1 polyethylene Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
108091033319 polynucleotide Proteins 0.000 description 1
102000040430 polynucleotide Human genes 0.000 description 1
239000002157 polynucleotide Substances 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
238000012545 processing Methods 0.000 description 1
239000012858 resilient material Substances 0.000 description 1
230000000284 resting effect Effects 0.000 description 1
238000007789 sealing Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
230000007723 transport mechanism Effects 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Landscapes

Apparatus Associated With Microorganisms And Enzymes (AREA)
Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)

CA2614880A 1998-06-16 1999-06-15 Flacon Expired - Lifetime CA2614880C (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US09/097,966 US6270730B1 (en)	1998-06-16	1998-06-16	Multi-well rotary synthesizer
US09/097,966		1998-06-16
CA002331809A CA2331809C (fr)	1998-06-16	1999-06-15	Synthetiseur rotatif a puits multiples

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002331809A Division CA2331809C (fr)	1998-06-16	1999-06-15	Synthetiseur rotatif a puits multiples

Publications (2)

Publication Number	Publication Date
CA2614880A1 CA2614880A1 (fr)	1999-12-23
CA2614880C true CA2614880C (fr)	2012-08-21

Family

ID=39367233

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2614880A Expired - Lifetime CA2614880C (fr)	1998-06-16	1999-06-15	Flacon

Country Status (1)

Country	Link
CA (1)	CA2614880C (fr)

1999
- 1999-06-15 CA CA2614880A patent/CA2614880C/fr not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2614880A1 (fr)	1999-12-23

Legal Events

Date	Code	Title	Description
2007-12-03	EEER	Examination request
2019-08-19	MKEX	Expiry	Effective date: 20190617

Publication	Publication Date	Title
US8147776B2 (en)	2012-04-03	Multi-well rotary synthesizer
EP0916396B1 (fr)	2005-04-13	Stratégies associées pour la synthèse de polymères
US20150369267A1 (en)	2015-12-24	Well drain system for use with multi-well synthesizer
AU5486996A (en)	1996-11-07	Methods and apparatus for the generation of chemical libraries
US8211370B2 (en)	2012-07-03	Polymer synthesizer
US6932943B1 (en)	2005-08-23	Nucleic acid synthesizers
CA2614880C (fr)	2012-08-21	Flacon
AU775106B2 (en)	2004-07-15	A vial
WO2002028524A2 (fr)	2002-04-11	Dispositif de synthese rotatif multipuits pourvu d'un systeme de decharge tubulaire d'etancheite
EP3495038B1 (fr)	2020-06-10	Dispositif de synthèse d'oligomères parallèles, procédé de synthèse d'oligomères parallèles et son utilisation
CA2389355A1 (fr)	1993-05-27	Techniques combinees pour la synthese de polymeres