CA2615046C - Constituants du cacao, produits comestibles presentant une teneur accrue en polyphenols, leurs procedes de production et utilisations et utilisations medicales - Google Patents

Constituants du cacao, produits comestibles presentant une teneur accrue en polyphenols, leurs procedes de production et utilisations et utilisations medicales Download PDF

Info

Publication number: CA2615046C
Authority: CA; Canada
Prior art keywords: cocoa; chocolate; beans; polyphenols; per gram
Prior art date: 1996-09-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA2615046A

Other languages

English (en)

Other versions

CA2615046A1 (fr

Inventor

Kirk S. Kealey

Rodney M. Snyder

Leo J. Romanczyk, Jr.

Hans M. Geyer

Mary E. Myers

Eric J. Whitacre

John F. Hammerstone, Jr.

Harold H. Schmitz

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mars Inc

Original Assignee

Mars Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-06

Filing date

1997-09-08

Publication date

2012-10-30

1996-09-06 Priority claimed from US08/709,406 external-priority patent/US6015913A/en

1997-09-08 Application filed by Mars Inc filed Critical Mars Inc

1997-09-08 Priority to CA2795629A priority Critical patent/CA2795629C/fr

1998-03-12 Publication of CA2615046A1 publication Critical patent/CA2615046A1/fr

2012-10-30 Application granted granted Critical

2012-10-30 Publication of CA2615046C publication Critical patent/CA2615046C/fr

2017-09-08 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

235000009470 Theobroma cacao Nutrition 0.000 title claims abstract description 1080
235000013824 polyphenols Nutrition 0.000 title abstract description 480
150000008442 polyphenolic compounds Chemical class 0.000 title abstract description 476
238000000034 method Methods 0.000 title abstract description 148
244000240602 cacao Species 0.000 title description 2
244000299461 Theobroma cacao Species 0.000 claims abstract description 1393
235000019219 chocolate Nutrition 0.000 claims abstract description 312
239000000203 mixture Substances 0.000 claims abstract description 207
239000007787 solid Substances 0.000 claims abstract description 131
239000000284 extract Substances 0.000 claims abstract description 37
CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 claims description 44
229920002414 procyanidin Polymers 0.000 claims description 44
235000013305 food Nutrition 0.000 claims description 25
235000007164 Oryza sativa Nutrition 0.000 claims description 20
235000009566 rice Nutrition 0.000 claims description 20
239000006188 syrup Substances 0.000 claims description 19
235000020357 syrup Nutrition 0.000 claims description 18
235000011962 puddings Nutrition 0.000 claims description 14
235000013861 fat-free Nutrition 0.000 claims description 11
235000014510 cooky Nutrition 0.000 claims description 10
235000015067 sauces Nutrition 0.000 claims description 9
235000005135 Micromeria juliana Nutrition 0.000 claims description 3
235000007315 Satureja hortensis Nutrition 0.000 claims description 3
241000209094 Oryza Species 0.000 claims 4
241000246354 Satureja Species 0.000 claims 2
235000016019 chocolate confectionery Nutrition 0.000 claims 1
235000010627 Phaseolus vulgaris Nutrition 0.000 abstract description 435
244000046052 Phaseolus vulgaris Species 0.000 abstract description 434
235000019197 fats Nutrition 0.000 abstract description 71
235000019868 cocoa butter Nutrition 0.000 abstract description 64
229940110456 cocoa butter Drugs 0.000 abstract description 64
238000012545 processing Methods 0.000 abstract description 62
230000008569 process Effects 0.000 abstract description 54
241000124008 Mammalia Species 0.000 abstract description 15
IAIWVQXQOWNYOU-BAQGIRSFSA-N [(z)-(5-nitrofuran-2-yl)methylideneamino]urea Chemical compound NC(=O)N\N=C/C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-BAQGIRSFSA-N 0.000 abstract description 15
230000036541 health Effects 0.000 abstract description 10
239000007858 starting material Substances 0.000 abstract description 8
239000000306 component Substances 0.000 description 128
239000000843 powder Substances 0.000 description 90
239000000047 product Substances 0.000 description 90
239000003925 fat Substances 0.000 description 70
238000000855 fermentation Methods 0.000 description 67
230000004151 fermentation Effects 0.000 description 67
238000010438 heat treatment Methods 0.000 description 67
239000004615 ingredient Substances 0.000 description 61
235000012970 cakes Nutrition 0.000 description 46
235000009508 confectionery Nutrition 0.000 description 44
235000000346 sugar Nutrition 0.000 description 42
239000000796 flavoring agent Substances 0.000 description 40
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 40
235000019634 flavors Nutrition 0.000 description 38
238000009472 formulation Methods 0.000 description 38
238000004519 manufacturing process Methods 0.000 description 31
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 24
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 24
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 22
235000013336 milk Nutrition 0.000 description 22
239000008267 milk Substances 0.000 description 22
210000004080 milk Anatomy 0.000 description 22
235000019220 whole milk chocolate Nutrition 0.000 description 22
238000004140 cleaning Methods 0.000 description 21
239000000463 material Substances 0.000 description 20
235000014121 butter Nutrition 0.000 description 18
150000001875 compounds Chemical class 0.000 description 18
235000021243 milk fat Nutrition 0.000 description 18
-1 /or Species 0.000 description 17
239000000787 lecithin Substances 0.000 description 17
235000010445 lecithin Nutrition 0.000 description 17
239000002245 particle Substances 0.000 description 17
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 16
MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 16
240000007594 Oryza sativa Species 0.000 description 16
239000000654 additive Substances 0.000 description 16
229940067606 lecithin Drugs 0.000 description 16
239000008370 chocolate flavor Substances 0.000 description 15
230000007423 decrease Effects 0.000 description 15
238000001035 drying Methods 0.000 description 15
238000003825 pressing Methods 0.000 description 15
230000000996 additive effect Effects 0.000 description 14
238000003801 milling Methods 0.000 description 14
238000000926 separation method Methods 0.000 description 14
235000019221 dark chocolate Nutrition 0.000 description 13
238000000227 grinding Methods 0.000 description 13
235000015145 nougat Nutrition 0.000 description 13
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
235000013736 caramel Nutrition 0.000 description 12
238000001816 cooling Methods 0.000 description 12
239000003995 emulsifying agent Substances 0.000 description 12
238000011282 treatment Methods 0.000 description 12
MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 11
238000012360 testing method Methods 0.000 description 11
235000013399 edible fruits Nutrition 0.000 description 10
235000011187 glycerol Nutrition 0.000 description 10
238000002156 mixing Methods 0.000 description 10
239000012071 phase Substances 0.000 description 10
239000002904 solvent Substances 0.000 description 10
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 9
235000009499 Vanilla fragrans Nutrition 0.000 description 9
235000012036 Vanilla tahitensis Nutrition 0.000 description 9
235000013339 cereals Nutrition 0.000 description 9
235000013312 flour Nutrition 0.000 description 9
239000000178 monomer Substances 0.000 description 9
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 9
239000003921 oil Substances 0.000 description 9
235000019198 oils Nutrition 0.000 description 9
150000003839 salts Chemical class 0.000 description 9
239000003765 sweetening agent Substances 0.000 description 9
XFZJEEAOWLFHDH-UHFFFAOYSA-N (2R,2'R,3R,3'R,4R)-3,3',4',5,7-Pentahydroxyflavan(48)-3,3',4',5,7-pentahydroxyflavan Natural products C=12OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C(O)C=C(O)C=1C(C1=C(O)C=C(O)C=C1O1)C(O)C1C1=CC=C(O)C(O)=C1 XFZJEEAOWLFHDH-UHFFFAOYSA-N 0.000 description 8
MOJZMWJRUKIQGL-FWCKPOPSSA-N Procyanidin C2 Natural products O[C@@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c([C@H]3[C@H](O)[C@@H](c4cc(O)c(O)cc4)Oc4c3c(O)cc(O)c4)c(O)cc(O)c2[C@@H]1c1c(O)cc(O)c2c1O[C@@H]([C@H](O)C2)c1cc(O)c(O)cc1 MOJZMWJRUKIQGL-FWCKPOPSSA-N 0.000 description 8
229930006000 Sucrose Natural products 0.000 description 8
240000008042 Zea mays Species 0.000 description 8
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 8
235000002017 Zea mays subsp mays Nutrition 0.000 description 8
230000003113 alkalizing effect Effects 0.000 description 8
235000012467 brownies Nutrition 0.000 description 8
235000005822 corn Nutrition 0.000 description 8
230000000694 effects Effects 0.000 description 8
230000007407 health benefit Effects 0.000 description 8
238000012986 modification Methods 0.000 description 8
HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 description 8
239000005720 sucrose Substances 0.000 description 8
235000012141 vanillin Nutrition 0.000 description 8
FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 8
MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 8
235000008939 whole milk Nutrition 0.000 description 8
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
244000290333 Vanilla fragrans Species 0.000 description 7
244000237494 forastero Species 0.000 description 7
235000011846 forastero Nutrition 0.000 description 7
230000004048 modification Effects 0.000 description 7
235000019871 vegetable fat Nutrition 0.000 description 7
102000008299 Nitric Oxide Synthase Human genes 0.000 description 6
108010021487 Nitric Oxide Synthase Proteins 0.000 description 6
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical class CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
238000004458 analytical method Methods 0.000 description 6
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 6
235000020303 café frappé Nutrition 0.000 description 6
238000000576 coating method Methods 0.000 description 6
230000001419 dependent effect Effects 0.000 description 6
235000003599 food sweetener Nutrition 0.000 description 6
239000008173 hydrogenated soybean oil Substances 0.000 description 6
235000013372 meat Nutrition 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
230000005855 radiation Effects 0.000 description 6
230000002195 synergetic effect Effects 0.000 description 6
PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 5
244000215068 Acacia senegal Species 0.000 description 5
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 5
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 5
244000223760 Cinnamomum zeylanicum Species 0.000 description 5
229920000084 Gum arabic Polymers 0.000 description 5
206010020772 Hypertension Diseases 0.000 description 5
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 5
229930064664 L-arginine Natural products 0.000 description 5
235000014852 L-arginine Nutrition 0.000 description 5
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
241000245026 Scoliopus bigelovii Species 0.000 description 5
235000010489 acacia gum Nutrition 0.000 description 5
239000000205 acacia gum Substances 0.000 description 5
230000008901 benefit Effects 0.000 description 5
244000309464 bull Species 0.000 description 5
235000017803 cinnamon Nutrition 0.000 description 5
239000011248 coating agent Substances 0.000 description 5
238000010411 cooking Methods 0.000 description 5
239000008103 glucose Substances 0.000 description 5
238000001727 in vivo Methods 0.000 description 5
239000003112 inhibitor Substances 0.000 description 5
239000008101 lactose Substances 0.000 description 5
235000014594 pastries Nutrition 0.000 description 5
239000002002 slurry Substances 0.000 description 5
239000008347 soybean phospholipid Substances 0.000 description 5
235000013311 vegetables Nutrition 0.000 description 5
235000016623 Fragaria vesca Nutrition 0.000 description 4
235000011363 Fragaria x ananassa Nutrition 0.000 description 4
241000199361 Villosa perpurpurea Species 0.000 description 4
239000002253 acid Substances 0.000 description 4
239000008346 aqueous phase Substances 0.000 description 4
239000011230 binding agent Substances 0.000 description 4
239000006227 byproduct Substances 0.000 description 4
150000001720 carbohydrates Chemical class 0.000 description 4
235000014633 carbohydrates Nutrition 0.000 description 4
235000013351 cheese Nutrition 0.000 description 4
235000019877 cocoa butter equivalent Nutrition 0.000 description 4
235000019878 cocoa butter replacer Nutrition 0.000 description 4
235000019879 cocoa butter substitute Nutrition 0.000 description 4
229920002770 condensed tannin Polymers 0.000 description 4
239000008367 deionised water Substances 0.000 description 4
229910021641 deionized water Inorganic materials 0.000 description 4
238000000605 extraction Methods 0.000 description 4
238000011049 filling Methods 0.000 description 4
238000004108 freeze drying Methods 0.000 description 4
230000014759 maintenance of location Effects 0.000 description 4
230000003647 oxidation Effects 0.000 description 4
238000007254 oxidation reaction Methods 0.000 description 4
230000004044 response Effects 0.000 description 4
239000000126 substance Substances 0.000 description 4
201000001320 Atherosclerosis Diseases 0.000 description 3
244000075850 Avena orientalis Species 0.000 description 3
235000007319 Avena orientalis Nutrition 0.000 description 3
235000000459 Camassia leichtlinii Nutrition 0.000 description 3
240000002317 Camassia leichtlinii Species 0.000 description 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
240000009088 Fragaria x ananassa Species 0.000 description 3
108010010803 Gelatin Proteins 0.000 description 3
102000003820 Lipoxygenases Human genes 0.000 description 3
108090000128 Lipoxygenases Proteins 0.000 description 3
239000005913 Maltodextrin Substances 0.000 description 3
229920002774 Maltodextrin Polymers 0.000 description 3
241001465754 Metazoa Species 0.000 description 3
102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 description 3
108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 description 3
241001047198 Scomberomorus semifasciatus Species 0.000 description 3
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 3
102000007537 Type II DNA Topoisomerases Human genes 0.000 description 3
108010046308 Type II DNA Topoisomerases Proteins 0.000 description 3
238000013019 agitation Methods 0.000 description 3
230000003610 anti-gingivitis Effects 0.000 description 3
230000003110 anti-inflammatory effect Effects 0.000 description 3
230000000845 anti-microbial effect Effects 0.000 description 3
230000000118 anti-neoplastic effect Effects 0.000 description 3
239000003963 antioxidant agent Substances 0.000 description 3
230000003078 antioxidant effect Effects 0.000 description 3
235000006708 antioxidants Nutrition 0.000 description 3
235000013361 beverage Nutrition 0.000 description 3
239000008280 blood Substances 0.000 description 3
210000004369 blood Anatomy 0.000 description 3
238000009835 boiling Methods 0.000 description 3
239000004067 bulking agent Substances 0.000 description 3
230000008859 change Effects 0.000 description 3
239000003086 colorant Substances 0.000 description 3
230000000052 comparative effect Effects 0.000 description 3
230000001276 controlling effect Effects 0.000 description 3
238000011161 development Methods 0.000 description 3
235000014113 dietary fatty acids Nutrition 0.000 description 3
238000005516 engineering process Methods 0.000 description 3
229940125532 enzyme inhibitor Drugs 0.000 description 3
239000002532 enzyme inhibitor Substances 0.000 description 3
239000000194 fatty acid Substances 0.000 description 3
229930195729 fatty acid Natural products 0.000 description 3
239000012467 final product Substances 0.000 description 3
239000012530 fluid Substances 0.000 description 3
239000008273 gelatin Substances 0.000 description 3
229920000159 gelatin Polymers 0.000 description 3
235000019322 gelatine Nutrition 0.000 description 3
235000011852 gelatine desserts Nutrition 0.000 description 3
239000012535 impurity Substances 0.000 description 3
239000007788 liquid Substances 0.000 description 3
238000012423 maintenance Methods 0.000 description 3
229940035034 maltodextrin Drugs 0.000 description 3
235000012054 meals Nutrition 0.000 description 3
230000036542 oxidative stress Effects 0.000 description 3
208000028169 periodontal disease Diseases 0.000 description 3
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 3
230000001766 physiological effect Effects 0.000 description 3
235000020183 skimmed milk Nutrition 0.000 description 3
235000011888 snacks Nutrition 0.000 description 3
239000008279 sol Substances 0.000 description 3
238000000638 solvent extraction Methods 0.000 description 3
208000010110 spontaneous platelet aggregation Diseases 0.000 description 3
239000004575 stone Substances 0.000 description 3
230000035882 stress Effects 0.000 description 3
235000021092 sugar substitutes Nutrition 0.000 description 3
229920002994 synthetic fiber Polymers 0.000 description 3
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
241000208140 Acer Species 0.000 description 2
WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 2
108010011485 Aspartame Proteins 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
241000207199 Citrus Species 0.000 description 2
102000004127 Cytokines Human genes 0.000 description 2
108090000695 Cytokines Proteins 0.000 description 2
SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 2
SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
241000282326 Felis catus Species 0.000 description 2
GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
235000010469 Glycine max Nutrition 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 2
PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 2
235000007688 Lycopersicon esculentum Nutrition 0.000 description 2
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 2
239000004743 Polypropylene Substances 0.000 description 2
ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
240000003768 Solanum lycopersicum Species 0.000 description 2
210000001744 T-lymphocyte Anatomy 0.000 description 2
244000098338 Triticum aestivum Species 0.000 description 2
244000263375 Vanilla tahitensis Species 0.000 description 2
235000010358 acesulfame potassium Nutrition 0.000 description 2
239000000619 acesulfame-K Substances 0.000 description 2
229940076005 apoptosis modulator Drugs 0.000 description 2
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
239000000605 aspartame Substances 0.000 description 2
235000010357 aspartame Nutrition 0.000 description 2
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 2
229960003438 aspartame Drugs 0.000 description 2
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 2
229940093797 bioflavonoids Drugs 0.000 description 2
210000004204 blood vessel Anatomy 0.000 description 2
RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
229910000019 calcium carbonate Inorganic materials 0.000 description 2
235000019947 caprenin Nutrition 0.000 description 2
230000015556 catabolic process Effects 0.000 description 2
210000002421 cell wall Anatomy 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
235000015218 chewing gum Nutrition 0.000 description 2
235000020971 citrus fruits Nutrition 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical class OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 2
235000013365 dairy product Nutrition 0.000 description 2
IOUFSANXGVHMIB-UHFFFAOYSA-N decanoic acid docosanoic acid octanoic acid propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCC(O)=O.CCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCCCCCC(O)=O IOUFSANXGVHMIB-UHFFFAOYSA-N 0.000 description 2
230000003247 decreasing effect Effects 0.000 description 2
239000008121 dextrose Substances 0.000 description 2
238000009826 distribution Methods 0.000 description 2
229940079593 drug Drugs 0.000 description 2
239000003814 drug Substances 0.000 description 2
235000013601 eggs Nutrition 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
230000008020 evaporation Effects 0.000 description 2
150000004665 fatty acids Chemical class 0.000 description 2
239000001307 helium Substances 0.000 description 2
229910052734 helium Inorganic materials 0.000 description 2
SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
235000019534 high fructose corn syrup Nutrition 0.000 description 2
238000004128 high performance liquid chromatography Methods 0.000 description 2
235000012907 honey Nutrition 0.000 description 2
239000001257 hydrogen Substances 0.000 description 2
229910052739 hydrogen Inorganic materials 0.000 description 2
235000015243 ice cream Nutrition 0.000 description 2
229910052500 inorganic mineral Inorganic materials 0.000 description 2
229960004903 invert sugar Drugs 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
239000011159 matrix material Substances 0.000 description 2
229910052751 metal Inorganic materials 0.000 description 2
239000002184 metal Substances 0.000 description 2
239000011785 micronutrient Substances 0.000 description 2
235000013369 micronutrients Nutrition 0.000 description 2
238000000874 microwave-assisted extraction Methods 0.000 description 2
239000011707 mineral Substances 0.000 description 2
235000010755 mineral Nutrition 0.000 description 2
235000013379 molasses Nutrition 0.000 description 2
229930014626 natural product Natural products 0.000 description 2
230000000050 nutritive effect Effects 0.000 description 2
230000008789 oxidative DNA damage Effects 0.000 description 2
235000017807 phytochemicals Nutrition 0.000 description 2
229930000223 plant secondary metabolite Natural products 0.000 description 2
239000004033 plastic Substances 0.000 description 2
229920001155 polypropylene Polymers 0.000 description 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
239000003755 preservative agent Substances 0.000 description 2
238000002203 pretreatment Methods 0.000 description 2
235000018102 proteins Nutrition 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
238000010926 purge Methods 0.000 description 2
230000000717 retained effect Effects 0.000 description 2
235000019204 saccharin Nutrition 0.000 description 2
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
229940081974 saccharin Drugs 0.000 description 2
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
238000004904 shortening Methods 0.000 description 2
235000021309 simple sugar Nutrition 0.000 description 2
239000003549 soybean oil Substances 0.000 description 2
235000012424 soybean oil Nutrition 0.000 description 2
235000013599 spices Nutrition 0.000 description 2
230000003637 steroidlike Effects 0.000 description 2
238000003860 storage Methods 0.000 description 2
150000005846 sugar alcohols Chemical class 0.000 description 2
239000013589 supplement Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
235000019640 taste Nutrition 0.000 description 2
YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 description 2
230000024883 vasodilation Effects 0.000 description 2
229940088594 vitamin Drugs 0.000 description 2
235000013343 vitamin Nutrition 0.000 description 2
239000011782 vitamin Substances 0.000 description 2
229930003231 vitamin Natural products 0.000 description 2
239000000341 volatile oil Substances 0.000 description 2
PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 description 1
PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 description 1
NUFKRGBSZPCGQB-FLBSXDLDSA-N (3s)-3-amino-4-oxo-4-[[(2r)-1-oxo-1-[(2,2,4,4-tetramethylthietan-3-yl)amino]propan-2-yl]amino]butanoic acid;pentahydrate Chemical compound O.O.O.O.O.OC(=O)C[C@H](N)C(=O)N[C@H](C)C(=O)NC1C(C)(C)SC1(C)C.OC(=O)C[C@H](N)C(=O)N[C@H](C)C(=O)NC1C(C)(C)SC1(C)C NUFKRGBSZPCGQB-FLBSXDLDSA-N 0.000 description 1
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 1
SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 1
239000004377 Alitame Substances 0.000 description 1
235000019737 Animal fat Nutrition 0.000 description 1
244000105624 Arachis hypogaea Species 0.000 description 1
241000599985 Beijerinckia mobilis Species 0.000 description 1
235000016068 Berberis vulgaris Nutrition 0.000 description 1
241000335053 Beta vulgaris Species 0.000 description 1
235000002568 Capsicum frutescens Nutrition 0.000 description 1
235000003255 Carthamus tinctorius Nutrition 0.000 description 1
244000020518 Carthamus tinctorius Species 0.000 description 1
241000208365 Celastraceae Species 0.000 description 1
VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
235000019499 Citrus oil Nutrition 0.000 description 1
235000009854 Cucurbita moschata Nutrition 0.000 description 1
240000001980 Cucurbita pepo Species 0.000 description 1
235000009852 Cucurbita pepo Nutrition 0.000 description 1
244000304337 Cuminum cyminum Species 0.000 description 1
235000007129 Cuminum cyminum Nutrition 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
235000002767 Daucus carota Nutrition 0.000 description 1
244000000626 Daucus carota Species 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
239000001329 FEMA 3811 Substances 0.000 description 1
239000001422 FEMA 4092 Substances 0.000 description 1
244000307700 Fragaria vesca Species 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
239000005792 Geraniol Substances 0.000 description 1
GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
239000004378 Glycyrrhizin Substances 0.000 description 1
241001556407 Herrania Species 0.000 description 1
241000282412 Homo Species 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
206010061217 Infestation Diseases 0.000 description 1
LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
235000010643 Leucaena leucocephala Nutrition 0.000 description 1
240000007472 Leucaena leucocephala Species 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
235000010582 Pisum sativum Nutrition 0.000 description 1
240000004713 Pisum sativum Species 0.000 description 1
229920001100 Polydextrose Polymers 0.000 description 1
240000002114 Satureja hortensis Species 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
235000000336 Solanum dulcamara Nutrition 0.000 description 1
235000002595 Solanum tuberosum Nutrition 0.000 description 1
244000061456 Solanum tuberosum Species 0.000 description 1
HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
238000000944 Soxhlet extraction Methods 0.000 description 1
244000228451 Stevia rebaudiana Species 0.000 description 1
239000004376 Sucralose Substances 0.000 description 1
244000269722 Thea sinensis Species 0.000 description 1
241000219161 Theobroma Species 0.000 description 1
244000237562 Theobroma cacao f. pentagonum Species 0.000 description 1
235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
235000021307 Triticum Nutrition 0.000 description 1
244000098345 Triticum durum Species 0.000 description 1
235000007264 Triticum durum Nutrition 0.000 description 1
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
230000009471 action Effects 0.000 description 1
239000008186 active pharmaceutical agent Substances 0.000 description 1
235000019409 alitame Nutrition 0.000 description 1
108010009985 alitame Proteins 0.000 description 1
239000003513 alkali Substances 0.000 description 1
WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
235000010208 anthocyanin Nutrition 0.000 description 1
239000004410 anthocyanin Substances 0.000 description 1
229930002877 anthocyanin Natural products 0.000 description 1
150000004636 anthocyanins Chemical class 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
230000001093 anti-cancer Effects 0.000 description 1
230000000259 anti-tumor effect Effects 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
230000006907 apoptotic process Effects 0.000 description 1
PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
235000008452 baby food Nutrition 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
235000015173 baked goods and baking mixes Nutrition 0.000 description 1
239000002585 base Substances 0.000 description 1
OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000036760 body temperature Effects 0.000 description 1
235000015155 buttermilk Nutrition 0.000 description 1
235000001046 cacaotero Nutrition 0.000 description 1
VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
229960001948 caffeine Drugs 0.000 description 1
235000012839 cake mixes Nutrition 0.000 description 1
239000011575 calcium Substances 0.000 description 1
YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
229940095710 chewable product Drugs 0.000 description 1
229940112822 chewing gum Drugs 0.000 description 1
235000020434 chocolate syrup Nutrition 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
239000010500 citrus oil Substances 0.000 description 1
238000004040 coloring Methods 0.000 description 1
235000008504 concentrate Nutrition 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
238000002788 crimping Methods 0.000 description 1
230000007547 defect Effects 0.000 description 1
230000007123 defense Effects 0.000 description 1
230000005860 defense response to virus Effects 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
150000005690 diesters Chemical class 0.000 description 1
230000000916 dilatatory effect Effects 0.000 description 1
230000003292 diminished effect Effects 0.000 description 1
XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
235000011180 diphosphates Nutrition 0.000 description 1
235000019820 disodium diphosphate Nutrition 0.000 description 1
GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
238000004821 distillation Methods 0.000 description 1
239000000428 dust Substances 0.000 description 1
244000013123 dwarf bean Species 0.000 description 1
210000003278 egg shell Anatomy 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
210000003038 endothelium Anatomy 0.000 description 1
150000002085 enols Chemical class 0.000 description 1
LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 description 1
235000012734 epicatechin Nutrition 0.000 description 1
238000011067 equilibration Methods 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
239000002024 ethyl acetate extract Substances 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000004880 explosion Methods 0.000 description 1
230000006355 external stress Effects 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
235000011194 food seasoning agent Nutrition 0.000 description 1
235000013572 fruit purees Nutrition 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
239000007789 gas Substances 0.000 description 1
238000005227 gel permeation chromatography Methods 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
229940113087 geraniol Drugs 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000011491 glass wool Substances 0.000 description 1
125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
229960004949 glycyrrhizic acid Drugs 0.000 description 1
235000019410 glycyrrhizin Nutrition 0.000 description 1
LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
235000011868 grain product Nutrition 0.000 description 1
230000005484 gravity Effects 0.000 description 1
235000021331 green beans Nutrition 0.000 description 1
238000003621 hammer milling Methods 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002431 hydrogen Chemical class 0.000 description 1
XSEOYPMPHHCUBN-FGYWBSQSSA-N hydroxylated lecithin Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCC[C@@H](O)[C@H](O)CCCCCCCC XSEOYPMPHHCUBN-FGYWBSQSSA-N 0.000 description 1
230000000260 hypercholesteremic effect Effects 0.000 description 1
230000006872 improvement Effects 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
239000000905 isomalt Substances 0.000 description 1
235000010439 isomalt Nutrition 0.000 description 1
HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
239000000832 lactitol Substances 0.000 description 1
235000010448 lactitol Nutrition 0.000 description 1
VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
229960003451 lactitol Drugs 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
235000004213 low-fat Nutrition 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
235000010449 maltitol Nutrition 0.000 description 1
239000000845 maltitol Substances 0.000 description 1
VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
229940035436 maltitol Drugs 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
229960001855 mannitol Drugs 0.000 description 1
239000000155 melt Substances 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
229910000150 monocalcium phosphate Inorganic materials 0.000 description 1
235000019691 monocalcium phosphate Nutrition 0.000 description 1
ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 description 1
229940089953 neohesperidin dihydrochalcone Drugs 0.000 description 1
235000010434 neohesperidine DC Nutrition 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
230000004792 oxidative damage Effects 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
235000020232 peanut Nutrition 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
239000005426 pharmaceutical component Substances 0.000 description 1
WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
230000006461 physiological response Effects 0.000 description 1
239000000049 pigment Substances 0.000 description 1
239000001259 polydextrose Substances 0.000 description 1
235000013856 polydextrose Nutrition 0.000 description 1
229940035035 polydextrose Drugs 0.000 description 1
229920000223 polyglycerol Chemical class 0.000 description 1
239000003996 polyglycerol polyricinoleate Substances 0.000 description 1
235000010958 polyglycerol polyricinoleate Nutrition 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
235000012015 potatoes Nutrition 0.000 description 1
239000002243 precursor Substances 0.000 description 1
238000002953 preparative HPLC Methods 0.000 description 1
239000000473 propyl gallate Substances 0.000 description 1
235000010388 propyl gallate Nutrition 0.000 description 1
229940075579 propyl gallate Drugs 0.000 description 1
238000004080 punching Methods 0.000 description 1
238000011002 quantification Methods 0.000 description 1
HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
239000013557 residual solvent Substances 0.000 description 1
239000011435 rock Substances 0.000 description 1
238000005096 rolling process Methods 0.000 description 1
238000011012 sanitization Methods 0.000 description 1
238000012216 screening Methods 0.000 description 1
229930004725 sesquiterpene Natural products 0.000 description 1
150000004354 sesquiterpene derivatives Chemical class 0.000 description 1
230000035939 shock Effects 0.000 description 1
238000007873 sieving Methods 0.000 description 1
235000020374 simple syrup Nutrition 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000002639 sodium chloride Nutrition 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical class [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
238000007711 solidification Methods 0.000 description 1
230000008023 solidification Effects 0.000 description 1
239000001587 sorbitan monostearate Substances 0.000 description 1
235000011076 sorbitan monostearate Nutrition 0.000 description 1
229940035048 sorbitan monostearate Drugs 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
229960002920 sorbitol Drugs 0.000 description 1
235000010356 sorbitol Nutrition 0.000 description 1
241000894007 species Species 0.000 description 1
238000005507 spraying Methods 0.000 description 1
235000020354 squash Nutrition 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
238000010025 steaming Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
235000019408 sucralose Nutrition 0.000 description 1
BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
150000003445 sucroses Chemical class 0.000 description 1
235000012094 sugar confectionery Nutrition 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
230000009469 supplementation Effects 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
238000005496 tempering Methods 0.000 description 1
150000003505 terpenes Chemical class 0.000 description 1
235000007586 terpenes Nutrition 0.000 description 1
235000010436 thaumatin Nutrition 0.000 description 1
239000000892 thaumatin Substances 0.000 description 1
229960004559 theobromine Drugs 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
239000013638 trimer Substances 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
230000003612 virological effect Effects 0.000 description 1
238000011179 visual inspection Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1
235000015099 wheat brans Nutrition 0.000 description 1
235000019222 white chocolate Nutrition 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1

Landscapes

Confectionery (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Medicines Containing Plant Substances (AREA)

CA2615046A 1996-09-06 1997-09-08 Constituants du cacao, produits comestibles presentant une teneur accrue en polyphenols, leurs procedes de production et utilisations et utilisations medicales Expired - Lifetime CA2615046C (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA2795629A CA2795629C (fr)	1996-09-06	1997-09-08	Constituants du cacao, produits comestibles presentant une teneur accrue en polyphenols, leurs procedes de production et utilisations et utilisations medicales

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/709,406		1996-09-06
US08/709,406 US6015913A (en)	1996-09-06	1996-09-06	Method for producing fat and/or solids from cocoa beans
CA002264822A CA2264822C (fr)	1996-09-06	1997-09-08	Constituants du cacao, produits comestibles presentant une teneur accrue en polyphenols, leurs procedes de production et utilisations et utilisations medicales

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002264822A Division CA2264822C (fr)	1996-09-06	1997-09-08	Constituants du cacao, produits comestibles presentant une teneur accrue en polyphenols, leurs procedes de production et utilisations et utilisations medicales

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2795629A Division CA2795629C (fr)	1996-09-06	1997-09-08	Constituants du cacao, produits comestibles presentant une teneur accrue en polyphenols, leurs procedes de production et utilisations et utilisations medicales

Publications (2)

Publication Number	Publication Date
CA2615046A1 CA2615046A1 (fr)	1998-03-12
CA2615046C true CA2615046C (fr)	2012-10-30

Family

ID=39277231

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2615046A Expired - Lifetime CA2615046C (fr)	1996-09-06	1997-09-08	Constituants du cacao, produits comestibles presentant une teneur accrue en polyphenols, leurs procedes de production et utilisations et utilisations medicales

Country Status (1)

Country	Link
CA (1)	CA2615046C (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2016020854A1 (fr)	2014-08-08	2016-02-11	Rottapharm Biotech S.R.L.	Extraits de fèves de cacao purifiés, leur production et leur utilisation dans le traitement de maladies humaines du système nerveux central et périphérique
WO2016020855A1 (fr)	2014-08-08	2016-02-11	Rottapharm Biotech S.R.L.	Extraits de pépins de raisin purifiés, leur production et leur utilisation pour le traitement de maladies centrales et périphériques chez l'homme
WO2016020853A1 (fr)	2014-08-08	2016-02-11	Rottapharm Biotech S.R.L.	Extraits purifiés de fèves de cacao et de pépins de raisin, leur production et leur utilisation en vue du traitement de maladies centrales et périphériques chez l'être humain
CN117222323A (zh) *	2021-04-07	2023-12-12	株式会社明治	含有可可组合物的软糖组合物
DK181354B1 (en) *	2022-01-14	2023-08-24	Mellow Chocolate Aps	A method of processing cocoa beans for producing a chocolate that is high in antioxidant content, and chocolate obtained from the processed cocoa beans.
CN119111675A (zh) *	2024-10-31	2024-12-13	江南大学	一种可可粉高效碱化的方法

1997
- 1997-09-08 CA CA2615046A patent/CA2615046C/fr not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2615046A1 (fr)	1998-03-12

Legal Events

Date	Code	Title	Description
2008-06-27	EEER	Examination request
2017-11-12	MKEX	Expiry	Effective date: 20170908

Publication	Publication Date	Title
CA2795629C (fr)	2015-02-17	Constituants du cacao, produits comestibles presentant une teneur accrue en polyphenols, leurs procedes de production et utilisations et utilisations medicales
US6312753B1 (en)	2001-11-06	Cocoa components, edible products having enriched polyphenol content, methods of making same and medical uses
US6599553B2 (en)	2003-07-29	Dry drink mix and chocolate flavored drink made therefrom
US7678407B2 (en)	2010-03-16	Processes for making chocolate
RU2476075C2 (ru)	2013-02-27	Пищевые продукты с высоким содержанием полифенолов какао, улучшенным вкусом и ароматом и измельченными экстрактами какао
CA2615046C (fr)	2012-10-30	Constituants du cacao, produits comestibles presentant une teneur accrue en polyphenols, leurs procedes de production et utilisations et utilisations medicales
AU2002301733B2 (en)	2007-04-26	Cocoa components, edible products having enhanced polyphenol content, methods of making same and medical uses
AU2007203454B2 (en)	2010-12-02	Cocoa components, edible products having enhanced polyphenol content, methods of making same and medical uses
MXPA99002178A (es)	1999-09-01	Componentes de cacao, productos comestibles que tienen un contenido realzado de polifenol, metodos para elaborarlos y usos medicos