CA2616888C - Procede de spectrometrie de masse - Google Patents

Procede de spectrometrie de masse Download PDF

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Publication number
CA2616888C
CA2616888C CA2616888A CA2616888A CA2616888C CA 2616888 C CA2616888 C CA 2616888C CA 2616888 A CA2616888 A CA 2616888A CA 2616888 A CA2616888 A CA 2616888A CA 2616888 C CA2616888 C CA 2616888C
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CA
Canada
Prior art keywords
mass
molecules
physico
chemical property
ppm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2616888A
Other languages
English (en)
Other versions
CA2616888A1 (fr
Inventor
Scott Geromanos
Ashok Dongre
Gregory Opiteck
Jeffrey Silva
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Priority claimed from CA2465297A external-priority patent/CA2465297C/fr
Publication of CA2616888A1 publication Critical patent/CA2616888A1/fr
Application granted granted Critical
Publication of CA2616888C publication Critical patent/CA2616888C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente concerne une méthode permettant d'identifier des molécules d'origine biologique. Les molécules sont identifiées sur la base du rapport masse sur charge des molécules déterminé avec précision et d'au moins une autre propriété physicochimique comme le temps d'élution ou l'état de charge. D'autres propriétés physicochimiques peuvent être utilisées. La masse précise déterminée de façon expérimentale et les propriétés peuvent être comparées avec des renseignements de la table de recherche. La table de recherche peut générer des propriétés physicochimiques de données dans une base de données traditionnelle qui peuvent être calculées. La capacité de reconnaître et d'identifier, de préférence, les mêmes molécules dans deux échantillons différents peut être utilisée pour déterminer si des molécules biologiques spécifiques ont été exprimées différemment dans un échantillon expérimental par rapport à un échantillon de contrôle.
CA2616888A 2001-12-08 2002-12-09 Procede de spectrometrie de masse Expired - Fee Related CA2616888C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US34046001P 2001-12-08 2001-12-08
US60/340,460 2001-12-08
US36484702P 2002-03-14 2002-03-14
US60/364,847 2002-03-14
CA2465297A CA2465297C (fr) 2001-12-08 2002-12-09 Procede de spectrometrie de masse

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2465297A Division CA2465297C (fr) 2001-12-08 2002-12-09 Procede de spectrometrie de masse

Publications (2)

Publication Number Publication Date
CA2616888A1 CA2616888A1 (fr) 2003-07-03
CA2616888C true CA2616888C (fr) 2011-07-12

Family

ID=39420475

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2616888A Expired - Fee Related CA2616888C (fr) 2001-12-08 2002-12-09 Procede de spectrometrie de masse

Country Status (1)

Country Link
CA (1) CA2616888C (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106018535B (zh) * 2016-05-11 2018-11-09 中国科学院计算技术研究所 一种完整糖肽鉴定的方法与系统

Also Published As

Publication number Publication date
CA2616888A1 (fr) 2003-07-03

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20210831

MKLA Lapsed

Effective date: 20191209