CA2620430C - Implant neural forme de soie semblable au fil d'araignee - Google Patents
Implant neural forme de soie semblable au fil d'araignee Download PDFInfo
- Publication number
- CA2620430C CA2620430C CA2620430A CA2620430A CA2620430C CA 2620430 C CA2620430 C CA 2620430C CA 2620430 A CA2620430 A CA 2620430A CA 2620430 A CA2620430 A CA 2620430A CA 2620430 C CA2620430 C CA 2620430C
- Authority
- CA
- Canada
- Prior art keywords
- spider silk
- nerve
- neural
- neural implant
- thread
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007943 implant Substances 0.000 title claims abstract description 90
- 230000001537 neural effect Effects 0.000 title claims abstract description 83
- 229920001872 Spider silk Polymers 0.000 title claims abstract description 81
- 210000005036 nerve Anatomy 0.000 claims abstract description 56
- 230000007547 defect Effects 0.000 claims abstract description 46
- 210000000264 venule Anatomy 0.000 claims description 30
- 241000326710 Argiope lobata Species 0.000 claims description 2
- 230000008929 regeneration Effects 0.000 abstract description 9
- 238000011069 regeneration method Methods 0.000 abstract description 9
- 238000001356 surgical procedure Methods 0.000 abstract description 9
- 208000014674 injury Diseases 0.000 abstract description 2
- 230000008733 trauma Effects 0.000 abstract 1
- 239000000835 fiber Substances 0.000 description 35
- 210000001640 nerve ending Anatomy 0.000 description 19
- 210000004116 schwann cell Anatomy 0.000 description 18
- 210000000944 nerve tissue Anatomy 0.000 description 13
- 239000011159 matrix material Substances 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 8
- 239000003356 suture material Substances 0.000 description 7
- 238000002513 implantation Methods 0.000 description 6
- 210000002569 neuron Anatomy 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 239000012634 fragment Substances 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 210000000578 peripheral nerve Anatomy 0.000 description 4
- 239000002953 phosphate buffered saline Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 238000009958 sewing Methods 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 3
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 102000004142 Trypsin Human genes 0.000 description 3
- 108090000631 Trypsin Proteins 0.000 description 3
- 238000004026 adhesive bonding Methods 0.000 description 3
- 210000003050 axon Anatomy 0.000 description 3
- 239000000560 biocompatible material Substances 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 238000010562 histological examination Methods 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000012588 trypsin Substances 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000238902 Nephila clavipes Species 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- YRQNKMKHABXEJZ-UVQQGXFZSA-N chembl176323 Chemical compound C1C[C@]2(C)[C@@]3(C)CC(N=C4C[C@]5(C)CCC6[C@]7(C)CC[C@@H]([C@]7(CC[C@]6(C)[C@@]5(C)CC4=N4)C)CCCCCCCC)=C4C[C@]3(C)CCC2[C@]2(C)CC[C@H](CCCCCCCC)[C@]21C YRQNKMKHABXEJZ-UVQQGXFZSA-N 0.000 description 2
- 210000000860 cochlear nerve Anatomy 0.000 description 2
- 108010007093 dispase Proteins 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 108010008217 nidogen Proteins 0.000 description 2
- 210000001328 optic nerve Anatomy 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000239290 Araneae Species 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000008055 Heparan Sulfate Proteoglycans Human genes 0.000 description 1
- 229920002971 Heparan sulfate Polymers 0.000 description 1
- 108010085895 Laminin Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000238903 Nephila Species 0.000 description 1
- 208000028389 Nerve injury Diseases 0.000 description 1
- 102100037369 Nidogen-1 Human genes 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 108090000054 Syndecan-2 Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
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- 238000009739 binding Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000003461 brachial plexus Anatomy 0.000 description 1
- 238000009954 braiding Methods 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 210000000078 claw Anatomy 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- -1 e.g. Polymers 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 238000011990 functional testing Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
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- 238000005304 joining Methods 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 108010082117 matrigel Proteins 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000008764 nerve damage Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/11—Surgical instruments, devices or methods for performing anastomosis; Buttons for anastomosis
- A61B17/1128—Surgical instruments, devices or methods for performing anastomosis; Buttons for anastomosis of nerves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3675—Nerve tissue, e.g. brain, spinal cord, nerves, dura mater
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/383—Nerve cells, e.g. dendritic cells, Schwann cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3878—Nerve tissue, brain, spinal cord, nerves, dura mater
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/11—Surgical instruments, devices or methods for performing anastomosis; Buttons for anastomosis
- A61B2017/1132—End-to-end connections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Immunology (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
L'invention concerne un implant nerveux biocompatible servant à ponter, dans des nerfs, des interruptions ou des points défectueux apparaissant, par exemple, en raison de blessures par accident ou à la suite d'opérations. Les implants nerveux selon l'invention contiennent des fils en soie d'araignée naturelle ou synthétique et permettent la régénération de nerfs interrompus par-delà les points défectueux, de sorte qu'une transmission d'excitation fonctionnelle est possible en peu de temps.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005042455A DE102005042455A1 (de) | 2005-09-06 | 2005-09-06 | Nervenimplantat |
| DE102005042455.4 | 2005-09-06 | ||
| PCT/EP2006/066049 WO2007028801A2 (fr) | 2005-09-06 | 2006-09-06 | Implant nerveux |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2620430A1 CA2620430A1 (fr) | 2007-03-15 |
| CA2620430C true CA2620430C (fr) | 2013-08-20 |
Family
ID=37743748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2620430A Expired - Fee Related CA2620430C (fr) | 2005-09-06 | 2006-09-06 | Implant neural forme de soie semblable au fil d'araignee |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8409227B2 (fr) |
| EP (1) | EP1922093B1 (fr) |
| CN (1) | CN101257936B (fr) |
| AT (1) | ATE516053T1 (fr) |
| CA (1) | CA2620430C (fr) |
| DE (1) | DE102005042455A1 (fr) |
| ES (1) | ES2369792T3 (fr) |
| WO (1) | WO2007028801A2 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005042455A1 (de) * | 2005-09-06 | 2007-04-12 | Medizinische Hochschule Hannover | Nervenimplantat |
| RU2394593C2 (ru) * | 2008-09-25 | 2010-07-20 | Андрей Степанович БРЮХОВЕЦКИЙ | Имплантируемая нейроэндопротезная система, способ ее получения и способ проведения реконструктивной нейрохирургической операции |
| US20120141553A1 (en) * | 2009-06-30 | 2012-06-07 | Abdellah Ajji | Biocompatible polymer fibres for neuroimplants |
| JP5703804B2 (ja) * | 2011-02-08 | 2015-04-22 | ニプロ株式会社 | 組織再生器具の前駆体、その製造方法 |
| US10813643B2 (en) * | 2017-10-19 | 2020-10-27 | Axogen Corporation | Materials and methods for breast neurotization with nerve grafts |
| US11147558B2 (en) | 2018-11-15 | 2021-10-19 | Axogen Corporation | Materials and methods for nerve repair with animal-sourced grafts |
| TR201906978A2 (tr) * | 2019-05-09 | 2020-11-23 | Hacettepe Ueniversitesi | Bi̇r doku onarim malzemesi̇ |
| CA3183969A1 (fr) | 2020-07-08 | 2022-01-13 | Alexander Woods | Pontage de pertes nerveuses peripheriques avec des conduits pour une regeneration nerveuse amelioree |
| EP3991762A1 (fr) | 2020-11-02 | 2022-05-04 | Medizinische Hochschule Hannover | Implant pour la régénération des nerfs |
| CN114288470B (zh) * | 2021-12-29 | 2022-07-19 | 东南大学 | 一种基于蝴蝶鳞翅的导电神经导管及其制备方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5019087A (en) * | 1986-10-06 | 1991-05-28 | American Biomaterials Corporation | Nerve regeneration conduit |
| EP1716864A1 (fr) * | 1993-08-26 | 2006-11-02 | Genetics Institute, LLC | Régéneration nerveuse utilisant des protéines morphogénetiques osseuses chez l'homme |
| US5656605A (en) * | 1994-01-26 | 1997-08-12 | Institute Of Molecular Biology, Inc. | Device to promote drug-induced nerve regeneration |
| US6551618B2 (en) * | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
| US5925053A (en) * | 1997-09-02 | 1999-07-20 | Children's Medical Center Corporation | Multi-lumen polymeric guidance channel, method for promoting nerve regeneration, and method of manufacturing a multi-lumen nerve guidance channel |
| CN1304296A (zh) | 1998-06-10 | 2001-07-18 | 清水庆彦 | 人造神经管 |
| US6436129B1 (en) * | 1999-01-20 | 2002-08-20 | Oratec Interventions, Inc. | Method and apparatus for stimulating nerve regeneration |
| US20010053931A1 (en) | 1999-11-24 | 2001-12-20 | Salvatore J. Abbruzzese | Thin-layered, endovascular silk-covered stent device and method of manufacture thereof |
| AU2001233168A1 (en) * | 2000-01-31 | 2001-08-07 | Children's Medical Center Corporation | Neural regeneration conduit |
| WO2001056626A1 (fr) * | 2000-02-03 | 2001-08-09 | Nexia Biotechnologies, Inc. | Fil de suture chirurgical a base de soie d'araignee |
| DE10053611A1 (de) * | 2000-10-28 | 2002-05-02 | Inst Textil & Faserforschung | Bioresorbierbare Nervenleitschiene |
| US6716225B2 (en) * | 2001-08-02 | 2004-04-06 | Collagen Matrix, Inc. | Implant devices for nerve repair |
| US6902932B2 (en) * | 2001-11-16 | 2005-06-07 | Tissue Regeneration, Inc. | Helically organized silk fibroin fiber bundles for matrices in tissue engineering |
| AU2003249366A1 (en) * | 2002-06-24 | 2004-01-06 | Tufts University | Silk biomaterials and methods of use thereof |
| US7163545B2 (en) * | 2002-07-29 | 2007-01-16 | Mayo Foundation For Medical Education And Research | Spinal cord surgical implant |
| AU2003300022A1 (en) * | 2002-12-30 | 2004-07-29 | Angiotech International Ag | Silk-containing stent graft |
| US20050085894A1 (en) | 2003-10-16 | 2005-04-21 | Kershner James R. | High strength and lubricious materials for vascular grafts |
| GB2407576A (en) * | 2003-10-30 | 2005-05-04 | Spinox Ltd | Fibres embedded in a glassy protein matrix |
| GB0405045D0 (en) * | 2004-03-05 | 2004-04-07 | Spinox Ltd | Composite materials |
| US7775965B2 (en) * | 2004-03-09 | 2010-08-17 | The Board Of Regents Of The University Of Oklahoma | Decellularized grafts from umbilical cord vessels and process for preparing and using same |
| US20060282173A1 (en) * | 2004-03-09 | 2006-12-14 | Mcfetridge Peter S | Substantially decellularized grafts from umbilical cord vessels and process for preparing and using same |
| EP1735333A2 (fr) * | 2004-03-24 | 2006-12-27 | Diversa Corporation | Proteines de canules chimeres, acides nucleiques les codant, et leurs methodes d'elaboration et d'utilisation |
| US8106014B2 (en) * | 2004-09-14 | 2012-01-31 | Neurotex Limited | Methods and apparatus for enhanced growth of peripheral nerves and nervous tissue |
| DE102005042455A1 (de) * | 2005-09-06 | 2007-04-12 | Medizinische Hochschule Hannover | Nervenimplantat |
| CN100382772C (zh) * | 2005-09-28 | 2008-04-23 | 南通大学 | 含蚕丝丝素的医用神经移植物的制备方法 |
| US8696762B2 (en) * | 2006-12-11 | 2014-04-15 | Medizinische Hochschule Hannover | Implant of cross-linked spider silk threads |
-
2005
- 2005-09-06 DE DE102005042455A patent/DE102005042455A1/de not_active Withdrawn
-
2006
- 2006-09-06 CA CA2620430A patent/CA2620430C/fr not_active Expired - Fee Related
- 2006-09-06 EP EP06806752A patent/EP1922093B1/fr active Active
- 2006-09-06 US US11/991,483 patent/US8409227B2/en not_active Expired - Fee Related
- 2006-09-06 AT AT06806752T patent/ATE516053T1/de active
- 2006-09-06 CN CN2006800326781A patent/CN101257936B/zh not_active Expired - Fee Related
- 2006-09-06 WO PCT/EP2006/066049 patent/WO2007028801A2/fr not_active Ceased
- 2006-09-06 ES ES06806752T patent/ES2369792T3/es active Active
-
2013
- 2013-03-08 US US13/790,068 patent/US20130190786A1/en not_active Abandoned
-
2015
- 2015-11-20 US US14/947,699 patent/US20160074042A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20160074042A1 (en) | 2016-03-17 |
| CN101257936A (zh) | 2008-09-03 |
| US20130190786A1 (en) | 2013-07-25 |
| CN101257936B (zh) | 2012-06-27 |
| ES2369792T3 (es) | 2011-12-07 |
| US20080281420A1 (en) | 2008-11-13 |
| US8409227B2 (en) | 2013-04-02 |
| CA2620430A1 (fr) | 2007-03-15 |
| ATE516053T1 (de) | 2011-07-15 |
| DE102005042455A1 (de) | 2007-04-12 |
| WO2007028801A2 (fr) | 2007-03-15 |
| WO2007028801A3 (fr) | 2007-09-13 |
| EP1922093B1 (fr) | 2011-07-13 |
| EP1922093A2 (fr) | 2008-05-21 |
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| Publication | Publication Date | Title |
|---|---|---|
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