CA2629468A1 - Derives de pyrazolyluree utilisables dans le traitement du cancer - Google Patents

Derives de pyrazolyluree utilisables dans le traitement du cancer Download PDF

Info

Publication number: CA2629468A1
Authority: CA; Canada
Prior art keywords: cancer; pyrazol; fluorophenyl; oxy; aminopyridin
Prior art date: 2005-11-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002629468A

Other languages

English (en)

Inventor

Louis-David Cantin

Roger Smith

Zhi Chen

Holia N. Hatoum-Mokdad

Eric Mull

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharmaceuticals Corp

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-11-15

Filing date

2006-11-15

Publication date

2007-05-24

2006-11-15 Application filed by Individual filed Critical Individual

2007-05-24 Publication of CA2629468A1 publication Critical patent/CA2629468A1/fr

Status Abandoned legal-status Critical Current

Links

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MHXBHWLGRWOABW-UHFFFAOYSA-N tetradecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC MHXBHWLGRWOABW-UHFFFAOYSA-N 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
HFRXJVQOXRXOPP-UHFFFAOYSA-N thionyl bromide Chemical compound BrS(Br)=O HFRXJVQOXRXOPP-UHFFFAOYSA-N 0.000 description 1
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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
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125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
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FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
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239000000341 volatile oil Substances 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CA002629468A 2005-11-15 2006-11-15 Derives de pyrazolyluree utilisables dans le traitement du cancer Abandoned CA2629468A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US73640005P	2005-11-15	2005-11-15
US60/736,400		2005-11-15
PCT/US2006/044322 WO2007059202A2 (fr)	2005-11-15	2006-11-15	Derives de pyrazolyluree utilisables dans le traitement du cancer

Publications (1)

Publication Number	Publication Date
CA2629468A1 true CA2629468A1 (fr)	2007-05-24

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ID=38016517

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002629468A Abandoned CA2629468A1 (fr)	2005-11-15	2006-11-15	Derives de pyrazolyluree utilisables dans le traitement du cancer

Country Status (3)

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EP (1)	EP1960394A2 (fr)
CA (1)	CA2629468A1 (fr)
WO (1)	WO2007059202A2 (fr)

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DE102006029795A1 (de) *	2006-06-27	2008-01-03	Schebo Biotech Ag	Neue Harnstoff-Derivate und deren Verwendungen
NZ586418A (en)	2007-12-19	2012-09-28	Cancer Rec Tech Ltd	Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
JP2012504591A (ja)	2008-10-02	2012-02-23	レスピバート・リミテツド	ｐ３８ＭＡＰキナーゼ阻害剤
GB0818033D0 (en)	2008-10-02	2008-11-05	Respivert Ltd	Novel compound
MX2011006219A (es) *	2008-12-11	2011-06-28	Respivert Ltd	Inhibidores de la proteina cinasa activada por el mitogeno p38.
WO2010089773A2 (fr) *	2009-02-02	2010-08-12	Indoco Remedies Limited	Procédé pour la préparation de dérivés de nitropyridine
GB0905955D0 (en)	2009-04-06	2009-05-20	Respivert Ltd	Novel compounds
JP5760010B2 (ja)	2010-02-01	2015-08-05	キャンサー・リサーチ・テクノロジー・リミテッド	１−（５−ｔｅｒｔ−ブチル−２−フェニル−２Ｈ−ピラゾール−３−イル）−３−［２−フルオロ−４−（１−メチル−２−オキソ−２，３−ジヒドロ−１Ｈ−イミダゾ［４，５−Ｂ］ピリジン−７−イルオキシ）−フェニル］−尿素および関連化合物ならびに治療におけるそれらの使用
US20130315895A1 (en)	2010-07-01	2013-11-28	Takeda Pharmaceutical Company Limited	COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
CA2835835C (fr)	2011-05-13	2019-04-02	Array Biopharma Inc.	Composes de pyrrolidinyle-uree et de pyrrolidinyle thiouree en tant qu'inhibiteurs de kinase trka
WO2014078378A1 (fr)	2012-11-13	2014-05-22	Array Biopharma Inc.	Composés de n-pyrrolidinyle urée, thio-urée,guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka
RS55593B1 (sr) *	2012-11-13	2017-06-30	Array Biopharma Inc	Jedinjenja biciklične uree, tiouree, guanidina i cijanoguanidina korisna za lečenje bola
US9981959B2 (en)	2012-11-13	2018-05-29	Array Biopharma Inc.	Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
WO2014078325A1 (fr)	2012-11-13	2014-05-22	Array Biopharma Inc.	Composés de n-aryle monocycliques, n'-pyrazolyl-urée, thiourée, guanidine et cyanoguanidine utiles comme inhibiteurs de trka kinase
MX374242B (es)	2012-11-13	2025-03-05	Array Biopharma Inc	Compuestos de n-pirrolidinil, n' -pirazolil-urea, tiourea, guanidina y cianoguanidina como inhibidores de trka cinasa.
WO2014078331A1 (fr)	2012-11-13	2014-05-22	Array Biopharma Inc.	Composés de n-(arylalkyle)-n'-pyrazolyle-urée, de thiourée, de guanidine et de cyanoguanidine en tant qu'inhibiteurs de la kinase trka
US9822118B2 (en)	2012-11-13	2017-11-21	Array Biopharma Inc.	Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
WO2014078372A1 (fr)	2012-11-13	2014-05-22	Array Biopharma Inc.	Composés de n-pyrrolidinyle urée, thio-urée,guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka
WO2014078417A1 (fr)	2012-11-13	2014-05-22	Array Biopharma Inc.	Composés de pyrazolylurée, d'urée, de thiourée, de guanidine et de cyanoguianidine en tant qu'inhibiteurs de la trka kinase
WO2014078328A1 (fr)	2012-11-13	2014-05-22	Array Biopharma Inc.	Composés de n-pyrrolidinyle, n'-pyrazolyl-urée, thio-urée,guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka
GB201320732D0 (en)	2013-11-25	2014-01-08	Cancer Rec Tech Ltd	Methods of chemical synthesis
GB201320729D0 (en)	2013-11-25	2014-01-08	Cancer Rec Tech Ltd	Therapeutic compounds and their use
MA40434B1 (fr)	2014-05-15	2019-09-30	Array Biopharma Inc	1-((3s,4r)-4-(3-fluorophényl)-1-(2-méthoxyéthyl)pyrrolidin-3-yl)-3-(4-méthyl-3-(2-méthylpyrimidin-5-yl)-1-phényl-1h-pyrazol-5-yl)urée comme inhibiteur de la kinase trka
JP6864953B2 (ja)	2014-12-09	2021-04-28	アンスティチュナショナルドゥラサンテエドゥラルシェルシュメディカル	Ａｘｌに対するヒトモノクローナル抗体
WO2016135041A1 (fr)	2015-02-26	2016-09-01	INSERM (Institut National de la Santé et de la Recherche Médicale)	Protéines de fusion et anticorps les contenant pour favoriser l'apoptose
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DE69831013T2 (de) *	1997-12-22	2006-04-20	Bayer Pharmaceuticals Corp., West Haven	Inhibierung der raf-kinase durch substituierte heterocyclische harnstoffverbindungen
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2006
- 2006-11-15 EP EP06837652A patent/EP1960394A2/fr not_active Withdrawn
- 2006-11-15 CA CA002629468A patent/CA2629468A1/fr not_active Abandoned
- 2006-11-15 WO PCT/US2006/044322 patent/WO2007059202A2/fr not_active Ceased

Also Published As

Publication number	Publication date
EP1960394A2 (fr)	2008-08-27
WO2007059202A3 (fr)	2007-08-09
WO2007059202A2 (fr)	2007-05-24

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Date	Code	Title	Description
2009-11-16	FZDE	Dead

Publication	Publication Date	Title
EP1751139B1 (fr)	2011-07-27	Derives de pyrazolyl uree substitues utiles dans le traitement du cancer
CA2629468A1 (fr)	2007-05-24	Derives de pyrazolyluree utilisables dans le traitement du cancer
US7557129B2 (en)	2009-07-07	Cyanopyridine derivatives useful in the treatment of cancer and other disorders
EP2023926B1 (fr)	2011-10-12	Dérivés de pyridonecarboxamide utiles pour traiter des troubles hyperprolifératifs et liés à l'angiogenèse
US8101773B2 (en)	2012-01-24	Hydroxy methyl phenyl pyrazolyl urea compounds useful in the treatment of cancer
US20110195110A1 (en)	2011-08-11	Urea compounds useful in the treatment of cancer
EP2134677B1 (fr)	2011-10-12	4-{4-[({3-tert-butyl-1-[3-(hydroxyméthyl)phényl]-1h-pyrazol-5-yl}carbamoyl)-amino]-3-chlorophénoxy}-n-méthylpyridine-2-carboxamide en tant que inhibiteur de la kinase vegfr pour le traitement du cancer
HK1138841A (en)	2010-09-03	Urea compounds useful in the treatment of cancer