CA2646874C - Methodes de preparation de composes du type (e)-styrylbenzylsulfone et utilisations connexes dans le traitement de troubles a evolution chronique - Google Patents

Methodes de preparation de composes du type (e)-styrylbenzylsulfone et utilisations connexes dans le traitement de troubles a evolution chronique Download PDF

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Publication number
CA2646874C
CA2646874C CA2646874A CA2646874A CA2646874C CA 2646874 C CA2646874 C CA 2646874C CA 2646874 A CA2646874 A CA 2646874A CA 2646874 A CA2646874 A CA 2646874A CA 2646874 C CA2646874 C CA 2646874C
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Prior art keywords
compound
compounds
reaction
formula
och3
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CA2646874A
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CA2646874A1 (fr
Inventor
Reddy Sirigireddy
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Traws Pharma Inc
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Onconova Therapeutics Inc
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Priority to CA2646874A priority Critical patent/CA2646874C/fr
Publication of CA2646874A1 publication Critical patent/CA2646874A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Des procédés de préparation de (E)-2,4,6-(triméthoxystyryl)-3-0-phosphate disodium-4-méthoxybenzylsulfones et leur utilisation en tant quagents antiprolifératifs, y compris, par exemple, des agents anticancéreux, et en tant quagents radioprotecteurs et chimioprotecteurs.
CA2646874A 2008-12-17 2008-12-17 Methodes de preparation de composes du type (e)-styrylbenzylsulfone et utilisations connexes dans le traitement de troubles a evolution chronique Active CA2646874C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2646874A CA2646874C (fr) 2008-12-17 2008-12-17 Methodes de preparation de composes du type (e)-styrylbenzylsulfone et utilisations connexes dans le traitement de troubles a evolution chronique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA2646874A CA2646874C (fr) 2008-12-17 2008-12-17 Methodes de preparation de composes du type (e)-styrylbenzylsulfone et utilisations connexes dans le traitement de troubles a evolution chronique

Publications (2)

Publication Number Publication Date
CA2646874A1 CA2646874A1 (fr) 2010-06-17
CA2646874C true CA2646874C (fr) 2016-08-09

Family

ID=42263330

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2646874A Active CA2646874C (fr) 2008-12-17 2008-12-17 Methodes de preparation de composes du type (e)-styrylbenzylsulfone et utilisations connexes dans le traitement de troubles a evolution chronique

Country Status (1)

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CA (1) CA2646874C (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113584099B (zh) * 2021-07-28 2023-11-14 南京先进生物材料与过程装备研究院有限公司 一种采用微流场反应技术制备二氢香豆素或其衍生物的方法

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Publication number Publication date
CA2646874A1 (fr) 2010-06-17

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