CA2648558A1 - Molecular dissection of the role of the pi3-kinase/akt pathway; redirection from pro-survival signaling to a death pathway through nuclear relocation of akt - Google Patents

Molecular dissection of the role of the pi3-kinase/akt pathway; redirection from pro-survival signaling to a death pathway through nuclear relocation of akt Download PDF

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Publication number
CA2648558A1
CA2648558A1 CA002648558A CA2648558A CA2648558A1 CA 2648558 A1 CA2648558 A1 CA 2648558A1 CA 002648558 A CA002648558 A CA 002648558A CA 2648558 A CA2648558 A CA 2648558A CA 2648558 A1 CA2648558 A1 CA 2648558A1
Authority
CA
Canada
Prior art keywords
apoptin
akt
cells
cdk2
kinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002648558A
Other languages
English (en)
French (fr)
Inventor
Los Marek
Ted Paranjothy
Subbareddy Maddika
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Manitoba
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2648558A1 publication Critical patent/CA2648558A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002648558A 2006-04-21 2007-04-23 Molecular dissection of the role of the pi3-kinase/akt pathway; redirection from pro-survival signaling to a death pathway through nuclear relocation of akt Abandoned CA2648558A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79365406P 2006-04-21 2006-04-21
US60/793,654 2006-04-21
PCT/CA2007/000681 WO2007121576A1 (en) 2006-04-21 2007-04-23 Methods of inducing apoptosis of cancerous cells using apoptin derivatives

Publications (1)

Publication Number Publication Date
CA2648558A1 true CA2648558A1 (en) 2007-11-01

Family

ID=38624501

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002648558A Abandoned CA2648558A1 (en) 2006-04-21 2007-04-23 Molecular dissection of the role of the pi3-kinase/akt pathway; redirection from pro-survival signaling to a death pathway through nuclear relocation of akt

Country Status (3)

Country Link
EP (1) EP2013228A1 (de)
CA (1) CA2648558A1 (de)
WO (1) WO2007121576A1 (de)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1199363A1 (de) * 2000-10-20 2002-04-24 Leadd B.V. Phosphorylationsmodifikationen von Apoptin
AU2003214721A1 (en) * 2002-04-19 2003-11-03 Leadd B.V. Fragments of apoptin
US7566548B2 (en) * 2004-08-13 2009-07-28 University Of Massachusetts Methods for identifying therapeutic agents and for treating disease

Also Published As

Publication number Publication date
EP2013228A1 (de) 2009-01-14
WO2007121576A1 (en) 2007-11-01

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Legal Events

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FZDE Dead