CA2652981C - Formulations robustes a liberation prolongee - Google Patents

Formulations robustes a liberation prolongee Download PDF

Info

Publication number: CA2652981C
Authority: CA; Canada
Prior art keywords: sustained release; ethanol; oxymorphone; formulation; robust
Prior art date: 2006-10-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA2652981A

Other languages

English (en)

Other versions

CA2652981A1 (fr

Inventor

Anand R. Baichwal

Kevin Fitzmaurice

Steve Labudzinski

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Penwest Pharmaceuticals Co

Original Assignee

Penwest Pharmaceuticals Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-10

Filing date

2006-10-10

Publication date

2012-05-01

2006-10-10 Application filed by Penwest Pharmaceuticals Co filed Critical Penwest Pharmaceuticals Co

2008-04-17 Publication of CA2652981A1 publication Critical patent/CA2652981A1/fr

2012-05-01 Application granted granted Critical

2012-05-01 Publication of CA2652981C publication Critical patent/CA2652981C/fr

Status Expired - Fee Related legal-status Critical Current

2026-10-10 Anticipated expiration legal-status Critical

Links

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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Addiction (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA2652981A 2006-10-10 2006-10-10 Formulations robustes a liberation prolongee Expired - Fee Related CA2652981C (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2006/039923 WO2008045060A1 (fr)	2006-10-10	2006-10-10	Formulations robustes à libération prolongée

Publications (2)

Publication Number	Publication Date
CA2652981A1 CA2652981A1 (fr)	2008-04-17
CA2652981C true CA2652981C (fr)	2012-05-01

Family

ID=38048029

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2652981A Expired - Fee Related CA2652981C (fr)	2006-10-10	2006-10-10	Formulations robustes a liberation prolongee

Country Status (10)

Country	Link
EP (1)	EP2079453A1 (fr)
JP (1)	JP5422388B2 (fr)
KR (1)	KR20090113243A (fr)
CN (1)	CN101578096A (fr)
AU (1)	AU2006349402A1 (fr)
BR (1)	BRPI0621947A2 (fr)
CA (1)	CA2652981C (fr)
IL (1)	IL198168A0 (fr)
MX (1)	MX2009003771A (fr)
WO (1)	WO2008045060A1 (fr)

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CN1610551A (zh)	2001-07-06	2005-04-27	恩德制药公司	用作止痛剂的6－羟基羟吗啡酮的肠胃外给药
US7776314B2 (en)	2002-06-17	2010-08-17	Grunenthal Gmbh	Abuse-proofed dosage system
DE102005005446A1 (de)	2005-02-04	2006-08-10	Grünenthal GmbH	Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10361596A1 (de)	2003-12-24	2005-09-29	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102004032049A1 (de)	2004-07-01	2006-01-19	Grünenthal GmbH	Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de)	2005-02-04	2006-08-10	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
TWI473628B (zh)	2009-07-22	2015-02-21		用於對氧化敏感之類鴉片藥劑之抗破壞劑型
CA2808219C (fr)	2010-09-02	2019-05-14	Gruenenthal Gmbh	Forme pharmaceutique inviolable comportant un sel inorganique
ES2648129T3 (es)	2011-07-29	2017-12-28	Grünenthal GmbH	Pastilla a prueba de manipulación que proporciona una liberación inmediata de un medicamento
AU2012289764B2 (en)	2011-07-29	2017-03-02	Grünenthal GmbH	Tamper-resistant tablet providing immediate drug release
AR090245A1 (es)	2012-03-06	2014-10-29	Otsuka Pharma Co Ltd	Preparacion solida oral de liberacion sostenida, metodo de preparacion
PL2838512T3 (pl)	2012-04-18	2018-12-31	Grünenthal GmbH	Farmaceutyczna postać dawkowania odporna na niewłaściwe użycie i odporna na uderzeniowe uwalnianie dawki
JP6449871B2 (ja)	2013-07-12	2019-01-09	グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング	エチレン−酢酸ビニルポリマーを含有する改変防止剤形
EP3073994A1 (fr)	2013-11-26	2016-10-05	Grünenthal GmbH	Préparation de composition pharmaceutique en poudre par cryo-broyage
EA201692388A1 (ru) *	2014-05-26	2017-05-31	Грюненталь Гмбх	Лекарственная форма в виде множества частиц, защищенная от вызываемого этанолом сброса дозы
CN104622791A (zh) *	2015-02-13	2015-05-20	扬子江药业集团有限公司	地佐辛口服制剂
WO2017042325A1 (fr)	2015-09-10	2017-03-16	Grünenthal GmbH	Protection contre un surdosage par voie orale à l'aide de formulations à libération immédiate dissuasives d'abus
US20170296476A1 (en) *	2016-04-15	2017-10-19	Grünenthal GmbH	Modified release abuse deterrent dosage forms
KR102380498B1 (ko) *	2021-02-24	2022-04-01	주식회사 청안오가닉스	건강기능식품에 있어서 유효성분의 지속적인 방출을 제어할 수 있는 서방형 정제를 제조하기 위한 조성물
US11977085B1 (en)	2023-09-05	2024-05-07	Elan Ehrlich	Date rape drug detection device and method of using same

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US4994276A (en) *	1988-09-19	1991-02-19	Edward Mendell Co., Inc.	Directly compressible sustained release excipient
US5169639A (en) *	1988-09-19	1992-12-08	Edward Mendell Co., Inc.	Controlled release verapamil tablets
US5773025A (en) *	1993-09-09	1998-06-30	Edward Mendell Co., Inc.	Sustained release heterodisperse hydrogel systems--amorphous drugs
FR2729857B1 (fr) *	1995-01-27	1997-04-04	Rhone Poulenc Chimie	Compositions pharmaceutiques sous forme de comprimes a liberation prolongee a base de granules en polysaccharides de haut poids moleculaire
US5904937A (en) *	1997-10-03	1999-05-18	Fmc Corporation	Taste masked pharmaceutical compositions
NO329694B1 (no) *	1999-04-13	2010-12-06	Beecham Pharm Pte Ltd	Farmasoytisk formulering og anvendelse derav, samt belagt tablett
US20030118641A1 (en) *	2000-07-27	2003-06-26	Roxane Laboratories, Inc.	Abuse-resistant sustained-release opioid formulation
KR20030048026A (ko) *	2001-07-06	2003-06-18	펜웨스트 파머슈티칼즈 컴파니	옥시모르폰의 서방형 제제
CN1610551A (zh) *	2001-07-06	2005-04-27	恩德制药公司	用作止痛剂的6－羟基羟吗啡酮的肠胃外给药
AU2002337686B2 (en) *	2001-09-26	2008-05-15	Penwest Pharmaceuticals Company	Opioid formulations having reduced potential for abuse
US20060193912A1 (en) *	2005-02-28	2006-08-31	Penwest Pharmaceuticals Co.	Controlled release O-desmethylvenlafaxine formulations

2006
- 2006-10-10 WO PCT/US2006/039923 patent/WO2008045060A1/fr not_active Ceased
- 2006-10-10 CA CA2652981A patent/CA2652981C/fr not_active Expired - Fee Related
- 2006-10-10 BR BRPI0621947-0A patent/BRPI0621947A2/pt not_active IP Right Cessation
- 2006-10-10 CN CNA2006800560384A patent/CN101578096A/zh active Pending
- 2006-10-10 AU AU2006349402A patent/AU2006349402A1/en not_active Abandoned
- 2006-10-10 KR KR1020097007890A patent/KR20090113243A/ko not_active Ceased
- 2006-10-10 EP EP06825846A patent/EP2079453A1/fr not_active Withdrawn
- 2006-10-10 JP JP2009532331A patent/JP5422388B2/ja not_active Expired - Fee Related
- 2006-10-10 MX MX2009003771A patent/MX2009003771A/es unknown
2009
- 2009-04-16 IL IL198168A patent/IL198168A0/en unknown

Also Published As

Publication number	Publication date
MX2009003771A (es)	2009-07-22
JP5422388B2 (ja)	2014-02-19
CA2652981A1 (fr)	2008-04-17
AU2006349402A1 (en)	2008-04-17
JP2010505949A (ja)	2010-02-25
KR20090113243A (ko)	2009-10-29
WO2008045060A1 (fr)	2008-04-17
BRPI0621947A2 (pt)	2011-10-18
IL198168A0 (en)	2009-12-24
EP2079453A1 (fr)	2009-07-22
CN101578096A (zh)	2009-11-11

Legal Events

Date	Code	Title	Description
2009-02-26	EEER	Examination request
2020-11-24	MKLA	Lapsed	Effective date: 20201013

Publication	Publication Date	Title
US20080085304A1 (en)	2008-04-10	Robust sustained release formulations
CA2644992C (fr)	2013-07-30	Formulations a liberation soutenue et resistant a l'ethanol
CA2652981C (fr)	2012-05-01	Formulations robustes a liberation prolongee
AU2002337686B2 (en)	2008-05-15	Opioid formulations having reduced potential for abuse
US8501160B2 (en)	2013-08-06	Crush-resistant oxycodone tablets intended for preventing accidental misuse and unlawful diversion
AU2002337686A1 (en)	2003-06-26	Opioid formulations having reduced potential for abuse
WO2008027350A2 (fr)	2008-03-06	Compositions pharmaceutiques à base d'acétaminophène
US20080085305A1 (en)	2008-04-10	Robust sustained release formulations of oxymorphone
AU2006349472A1 (en)	2008-04-17	Robust sustained release formulations of oxymorphone and methods of use thereof
US20080085303A1 (en)	2008-04-10	Robust sustained release formulations of oxymorphone and methods of use thereof
AU2006349471A1 (en)	2008-04-17	Robust sustained release formulations of oxymorphone
KR20090065543A (ko)	2009-06-22	옥시모르폰의 강건한 서방형 제제 및 이의 제조 및 사용