CA2672973C - Procede de fabrication d'emulsions ophtalmiques huile-dans-eau - Google Patents
Procede de fabrication d'emulsions ophtalmiques huile-dans-eau Download PDFInfo
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- CA2672973C CA2672973C CA2672973A CA2672973A CA2672973C CA 2672973 C CA2672973 C CA 2672973C CA 2672973 A CA2672973 A CA 2672973A CA 2672973 A CA2672973 A CA 2672973A CA 2672973 C CA2672973 C CA 2672973C
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- oil
- process according
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- concentrate
- emulsion
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- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 229950008081 unoprostone isopropyl Drugs 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 229940093257 valacyclovir Drugs 0.000 description 1
- 239000002525 vasculotropin inhibitor Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention porte sur de nouveaux procédés pour la préparation d'émulsions huile-dans-eau utiles dans des applications ophtalmiques. En particulier, l'invention concerne des procédés comprenant la préparation d'un pré-concentré de l'émulsion huile-dans-eau, et la dilution du préconcentré obtenu pour former l'émulsion huile-dans-eau désirée. La présente invention concerne également des compositions pharmaceutiques comprenant une émulsion huile-dans-eau préparée par un procédé de l'invention, et des procédés d'utilisation de ces compositions pour le traitement d'une maladie ou d'un état de l'AEil.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87620006P | 2006-12-21 | 2006-12-21 | |
| US60/876,200 | 2006-12-21 | ||
| PCT/EP2007/064489 WO2008074885A2 (fr) | 2006-12-21 | 2007-12-21 | Procédé de fabrication d'émulsions ophtalmiques huile-dans-eau |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2672973A1 CA2672973A1 (fr) | 2008-06-26 |
| CA2672973C true CA2672973C (fr) | 2016-03-08 |
Family
ID=39410514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2672973A Active CA2672973C (fr) | 2006-12-21 | 2007-12-21 | Procede de fabrication d'emulsions ophtalmiques huile-dans-eau |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9364461B2 (fr) |
| EP (1) | EP2129364B1 (fr) |
| JP (1) | JP5850602B2 (fr) |
| AU (1) | AU2007336206B2 (fr) |
| CA (1) | CA2672973C (fr) |
| ES (1) | ES2796116T3 (fr) |
| IL (1) | IL199458A (fr) |
| WO (1) | WO2008074885A2 (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8410102B2 (en) | 2003-05-27 | 2013-04-02 | Galderma Laboratories Inc. | Methods and compositions for treating or preventing erythema |
| SG177184A1 (en) | 2006-12-01 | 2012-01-30 | Anterios Inc | Amphiphilic entity nanoparticles |
| CN101765423B (zh) * | 2007-05-31 | 2014-08-06 | 安特里奥公司 | 核酸纳米粒子和其用途 |
| US9629852B2 (en) | 2007-10-16 | 2017-04-25 | Sun Pharma Advanced Research Company Ltd. | Ophthalmic composition comprising a prostaglandin |
| EP2228057A1 (fr) | 2009-03-04 | 2010-09-15 | Novagali Pharma S.A. | Émulsions cationiques d'huile dans l'eau contenant des prostaglandines et leurs utilisations |
| EP2228058A1 (fr) * | 2009-03-04 | 2010-09-15 | Novagali Pharma S.A. | Émulsion anionique d'huile dans l'eau contenant des prostaglandines et leurs utilisations |
| US20100303915A1 (en) * | 2009-06-02 | 2010-12-02 | Abbott Medical Optics Inc. | Therapeutic opthalmic emulsions |
| EP2394636B1 (fr) * | 2010-05-28 | 2014-03-19 | Novagali Pharma S.A. | Procédé de traitement de conditions de la rétine en utilisant une tamponnade intraoculaire |
| EP2389939A1 (fr) | 2010-05-28 | 2011-11-30 | Novagali Pharma S.A. | Utilisation de prostaglandines F2alpha et analogues pour la cicatrisation des lésions de la cornée et du conjonctif |
| US8916562B2 (en) | 2010-03-26 | 2014-12-23 | Galderma Research & Development Snc | Methods and compositions for safe and effective treatment of telangiectasia |
| CN106038476B (zh) | 2010-03-26 | 2020-04-17 | 盖尔德马研究及发展公司 | 安全和有效治疗红斑的改进的方法和组合物 |
| IT1404931B1 (it) * | 2010-06-11 | 2013-12-09 | Medivis S R L | Composizioni oftalmiche per la somministrazione di principi attivi liposolubili . |
| US8053427B1 (en) | 2010-10-21 | 2011-11-08 | Galderma R&D SNC | Brimonidine gel composition |
| EP2629757A2 (fr) | 2010-10-21 | 2013-08-28 | Galderma S.A. | Compositions de gel de brimonidine et leurs procédés d'utilisation |
| RU2473363C1 (ru) * | 2012-02-24 | 2013-01-27 | Илья Александрович Марков | Противовирусное средство - глазные капли |
| WO2016013993A1 (fr) | 2014-07-25 | 2016-01-28 | Imuneks Farma Llac Sanayi Ve Ticaret A.Ş. | Formulations ophtalmiques d'antagonistes opioïdes stables sans conservateur |
| MX2019005833A (es) | 2016-11-21 | 2019-10-30 | Eirion Therapeutics Inc | Administracion transdermica de agentes grandes. |
| US20180333357A1 (en) * | 2017-05-19 | 2018-11-22 | Ocugen, Inc. | Nanoemulsions with anti-inflammatory activity |
| WO2020070751A1 (fr) * | 2018-10-03 | 2020-04-09 | Tathagata Dutta | Forme galénique semi-solide pour administration d'antioxydants par voie ophtalmique |
| EP4069220A4 (fr) * | 2019-12-04 | 2024-04-24 | Restore Vision, LLC. | Formulations ophtalmiques pour le traitement de la presbyopie |
| CN113577025B (zh) * | 2021-09-07 | 2022-08-16 | 中国药科大学 | 一种氯替泼诺眼用微乳及其制备方法 |
| WO2024059133A1 (fr) * | 2022-09-13 | 2024-03-21 | Twenty Twenty Therapeutics Llc | Procédés et appareil pour l'application de gouttes oculaires expansées |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL101241A (en) * | 1992-03-16 | 1997-11-20 | Yissum Res Dev Co | Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier |
| EP0656779B1 (fr) * | 1992-08-28 | 2000-04-12 | Pharmos Corporation | Emulsion sous-micronique comme vehicule pour l'administration oculaire d'un medicament |
| DE4335045A1 (de) | 1993-10-14 | 1995-04-20 | Henkel Kgaa | Fließfähiges Emulsionskonzentrat |
| ES2094688B1 (es) | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
| ZA966579B (en) * | 1995-08-04 | 1998-02-02 | Wakamoto Pharma Co Ltd | O/W emulsion composition for eye drops. |
| US6245349B1 (en) * | 1996-02-23 | 2001-06-12 | éLAN CORPORATION PLC | Drug delivery compositions suitable for intravenous injection |
| EP0882498B1 (fr) | 1997-06-02 | 2004-02-11 | Hodogaya Chemical Co Ltd | Procédé de préparation d'émulsions d'huile dans l'eau sans solvent |
| WO1999029316A1 (fr) * | 1997-12-10 | 1999-06-17 | Severson, Mary, L. | Compositions pharmaceutiques contenant une huile d'acide gras omega-3 |
| JP3335151B2 (ja) | 1999-12-02 | 2002-10-15 | 花王株式会社 | マイクロエマルション |
| CN1461210A (zh) | 2000-09-20 | 2003-12-10 | 尼库麦德制药As | 乳剂及其浓缩物的制备 |
| KR100441167B1 (ko) | 2001-12-27 | 2004-07-21 | 씨제이 주식회사 | 마이크로에멀젼 예비 농축액 조성물 |
| US20030165545A1 (en) * | 2002-01-30 | 2003-09-04 | Allergan, Inc. | Ophthalmic compositions including oil-in-water emulsions, and methods for making and using same |
| US20050196370A1 (en) * | 2003-03-18 | 2005-09-08 | Zhi-Jian Yu | Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye |
| US20050059583A1 (en) * | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
| JP5272307B2 (ja) * | 2004-07-16 | 2013-08-28 | 大正製薬株式会社 | 水性点眼剤 |
| AU2005304035B2 (en) | 2004-11-09 | 2010-07-22 | Santen Sas | Ophthalmic oil-in-water type emulsion with stable positive zeta potential |
| DE102005011785A1 (de) | 2005-03-11 | 2006-09-21 | Goldschmidt Gmbh | Langzeitstabile kosmetische Emulsionen |
| JP2009531297A (ja) | 2006-02-24 | 2009-09-03 | ダウ グローバル テクノロジーズ インコーポレイティド | 液体水相中の液体フッ素化油相のエマルジョン |
| EP2001439A2 (fr) * | 2006-03-07 | 2008-12-17 | Novavax, Inc. | Emulsions nano-structurees des agents actifs mauvais soluble et leurs procedes de fabrication |
-
2007
- 2007-12-21 JP JP2009542104A patent/JP5850602B2/ja not_active Expired - Fee Related
- 2007-12-21 CA CA2672973A patent/CA2672973C/fr active Active
- 2007-12-21 EP EP07858100.6A patent/EP2129364B1/fr active Active
- 2007-12-21 AU AU2007336206A patent/AU2007336206B2/en active Active
- 2007-12-21 WO PCT/EP2007/064489 patent/WO2008074885A2/fr not_active Ceased
- 2007-12-21 ES ES07858100T patent/ES2796116T3/es active Active
- 2007-12-21 US US11/962,324 patent/US9364461B2/en active Active
-
2009
- 2009-06-18 IL IL199458A patent/IL199458A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IL199458A (en) | 2015-04-30 |
| JP2011506266A (ja) | 2011-03-03 |
| US9364461B2 (en) | 2016-06-14 |
| WO2008074885A2 (fr) | 2008-06-26 |
| US20080181867A1 (en) | 2008-07-31 |
| CA2672973A1 (fr) | 2008-06-26 |
| EP2129364A2 (fr) | 2009-12-09 |
| AU2007336206B2 (en) | 2014-02-20 |
| JP5850602B2 (ja) | 2016-02-03 |
| ES2796116T3 (es) | 2020-11-25 |
| WO2008074885A3 (fr) | 2008-10-09 |
| EP2129364B1 (fr) | 2020-04-15 |
| AU2007336206A1 (en) | 2008-06-26 |
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