CA2673428A1 - Tetrahydrobenzoisoxazole and tetrahydroindazole derivatives as modulators of the mitotic motor protein - Google Patents

Tetrahydrobenzoisoxazole and tetrahydroindazole derivatives as modulators of the mitotic motor protein Download PDF

Info

Publication number: CA2673428A1
Authority: CA; Canada
Prior art keywords: compounds; formula; denotes; bis; salts
Prior art date: 2006-12-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002673428A

Other languages

English (en)

French (fr)

Inventor

Kai Schiemann

Dirk Finsinger

Frank Zenke

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Patent GmbH

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-21

Filing date

2007-11-22

Publication date

2008-07-10

2007-11-22 Application filed by Individual filed Critical Individual

2008-07-10 Publication of CA2673428A1 publication Critical patent/CA2673428A1/en

Status Abandoned legal-status Critical Current

Links

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229940046008 vitamin d Drugs 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1
238000009736 wetting Methods 0.000 description 1
230000029663 wound healing Effects 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
239000008096 xylene Substances 0.000 description 1
ZPUHVPYXSITYDI-HEUWMMRCSA-N xyotax Chemical compound OC(=O)[C@@H](N)CCC(O)=O.O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 ZPUHVPYXSITYDI-HEUWMMRCSA-N 0.000 description 1
229950003684 zibotentan Drugs 0.000 description 1
150000003751 zinc Chemical class 0.000 description 1
229950005752 zosuquidar Drugs 0.000 description 1
229930195724 β-lactose Natural products 0.000 description 1
JLYXXMFPNIAWKQ-UHFFFAOYSA-N γ Benzene hexachloride Chemical compound ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl JLYXXMFPNIAWKQ-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

CA002673428A 2006-12-21 2007-11-22 Tetrahydrobenzoisoxazole and tetrahydroindazole derivatives as modulators of the mitotic motor protein Abandoned CA2673428A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE102006060598A DE102006060598A1 (de)	2006-12-21	2006-12-21	Tetrahydrobenzoisoxazole
DE102006060598.5		2006-12-21
PCT/EP2007/010122 WO2008080455A1 (de)	2006-12-21	2007-11-22	Tetrahydrobenzoisoxazole- und tetrahydroindazole-derivate als modulatoren der mitotische motor-protein

Publications (1)

Publication Number	Publication Date
CA2673428A1 true CA2673428A1 (en)	2008-07-10

Family

ID=39048886

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002673428A Abandoned CA2673428A1 (en)	2006-12-21	2007-11-22	Tetrahydrobenzoisoxazole and tetrahydroindazole derivatives as modulators of the mitotic motor protein

Country Status (7)

Country	Link
US (1)	US20100022530A1 (de)
EP (1)	EP2104664A1 (de)
JP (1)	JP2010513335A (de)
AU (1)	AU2007341749A1 (de)
CA (1)	CA2673428A1 (de)
DE (1)	DE102006060598A1 (de)
WO (1)	WO2008080455A1 (de)

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CN108473484B (zh)	2015-10-01	2021-06-29	弗门尼舍公司	可用作trpm8调节剂的化合物
US11389444B2 (en) *	2017-06-15	2022-07-19	Belite Bio, Inc	Methods of treating metabolic diseases with fused bicyclic pyrazoles
US10245259B2 (en)	2017-06-15	2019-04-02	Belite Bio, Inc	Methods of treating RBP4 related diseases with triazolopyridines
IL283725B2 (en)	2017-06-20	2024-04-01	Imbria Pharmaceuticals Inc	Compositions and methods for increasing efficiency of cardiac metabolism
TWI767148B (zh)	2018-10-10	2022-06-11	美商弗瑪治療公司	抑制脂肪酸合成酶(fasn)
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2006
- 2006-12-21 DE DE102006060598A patent/DE102006060598A1/de not_active Withdrawn
2007
- 2007-11-22 AU AU2007341749A patent/AU2007341749A1/en not_active Abandoned
- 2007-11-22 EP EP07856223A patent/EP2104664A1/de not_active Withdrawn
- 2007-11-22 WO PCT/EP2007/010122 patent/WO2008080455A1/de not_active Ceased
- 2007-11-22 CA CA002673428A patent/CA2673428A1/en not_active Abandoned
- 2007-11-22 JP JP2009541799A patent/JP2010513335A/ja active Pending
- 2007-11-22 US US12/520,451 patent/US20100022530A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20100022530A1 (en)	2010-01-28
WO2008080455A1 (de)	2008-07-10
EP2104664A1 (de)	2009-09-30
AU2007341749A1 (en)	2008-07-10
DE102006060598A1 (de)	2008-06-26
JP2010513335A (ja)	2010-04-30

Legal Events

Date	Code	Title	Description
2014-01-19	FZDE	Discontinued	Effective date: 20131122

Publication	Publication Date	Title
CA2673428A1 (en)	2008-07-10	Tetrahydrobenzoisoxazole and tetrahydroindazole derivatives as modulators of the mitotic motor protein
CA2550350C (en)	2013-03-12	2-(hetero)aryl-substituted tetrahydroquinoline derivatives
US20080234299A1 (en)	2008-09-25	Quinazolinones
CA2681256C (en)	2015-06-02	Substituted pyranyl quinolines
US20120130147A1 (en)	2012-05-24	Methods for the treatment of tumors with indane compounds
US20100076012A1 (en)	2010-03-25	Tetrahydroquinoline derivatives and the use thereof for the treatment of cancer
ZA200700819B (en)	2008-01-30	Tetrahydroquinolines
US7875614B2 (en)	2011-01-25	Phthalazinones
US8207345B2 (en)	2012-06-26	Tetrahydroquinolines for use as modulators of the mitotic motor protein Eg5
US7893082B2 (en)	2011-02-22	Substituted tetrahydroquinolines
US20100120818A1 (en)	2010-05-13	Substituted tetrahydropyrroloquinolines
US8110583B2 (en)	2012-02-07	Tetrahydroquinoline derivatives
US20070219246A1 (en)	2007-09-20	Dihydrobenzothiophenes