CA2675416A1 - Composes a base de lipoxine et leur utilisation - Google Patents

Composes a base de lipoxine et leur utilisation Download PDF

Info

Publication number
CA2675416A1
CA2675416A1 CA002675416A CA2675416A CA2675416A1 CA 2675416 A1 CA2675416 A1 CA 2675416A1 CA 002675416 A CA002675416 A CA 002675416A CA 2675416 A CA2675416 A CA 2675416A CA 2675416 A1 CA2675416 A1 CA 2675416A1
Authority
CA
Canada
Prior art keywords
carbon atoms
branched
inclusive
straight chain
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002675416A
Other languages
English (en)
Inventor
Charles N. Serhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2675416A1 publication Critical patent/CA2675416A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002675416A 1999-03-18 2000-03-14 Composes a base de lipoxine et leur utilisation Abandoned CA2675416A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12520999P 1999-03-18 1999-03-18
US60/125,209 1999-03-18
CA002365204A CA2365204C (fr) 1999-03-18 2000-03-14 Composes a base de lipoxine et leur utilisation

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002365204A Division CA2365204C (fr) 1999-03-18 2000-03-14 Composes a base de lipoxine et leur utilisation

Publications (1)

Publication Number Publication Date
CA2675416A1 true CA2675416A1 (fr) 2000-09-21

Family

ID=22418667

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002365204A Expired - Fee Related CA2365204C (fr) 1999-03-18 2000-03-14 Composes a base de lipoxine et leur utilisation
CA002675416A Abandoned CA2675416A1 (fr) 1999-03-18 2000-03-14 Composes a base de lipoxine et leur utilisation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002365204A Expired - Fee Related CA2365204C (fr) 1999-03-18 2000-03-14 Composes a base de lipoxine et leur utilisation

Country Status (12)

Country Link
US (8) US6433202B1 (fr)
EP (1) EP1163204B1 (fr)
JP (1) JP2002539181A (fr)
AT (1) ATE303355T1 (fr)
AU (2) AU776271B2 (fr)
CA (2) CA2365204C (fr)
DE (1) DE60022327T2 (fr)
DK (1) DK1163204T3 (fr)
ES (1) ES2246230T3 (fr)
HK (1) HK1043357B (fr)
PT (1) PT1163204E (fr)
WO (1) WO2000055109A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2615917C (fr) * 1999-03-18 2011-10-04 Brigham And Women's Hospital Utilisation de composes de lipoxine afin d'inhiber la reponse de neutrophile induite par tnf-(alpha)
EP2236140A1 (fr) * 1999-03-18 2010-10-06 The Brigham and Women's Hospital, Inc. Régulation de l'activité phospholipase D
CA2365204C (fr) * 1999-03-18 2009-10-27 Brigham And Women's Hospital Composes a base de lipoxine et leur utilisation
EP1762557B1 (fr) 2000-02-16 2011-04-06 The Brigham And Women's Hospital, Inc. Mediateurs lipidiques actives par l'aspirine
EP1268393A2 (fr) 2000-03-20 2003-01-02 Trustees Of Boston University Composes analogues a la lipoxine et procedes de traitement de parodontopathie
US6409541B1 (en) * 2000-11-02 2002-06-25 Autonetworks Technologies, Ltd. Waterproof structure in cable insertion section, method of manufacturing the same, and die for waterproof molding
WO2002065303A1 (fr) * 2001-02-13 2002-08-22 Fujitsu Limited Terminal de reseau a mode d"economie d"energie
EP1406698B1 (fr) * 2001-03-02 2008-10-29 The Brigham and Women's Hospital Analogues de la lipoxine en tant qu'inhibiteurs de l'angiogenese
US8722654B2 (en) 2001-03-02 2014-05-13 The Brigham And Women's Hospital, Inc. Lipoxin analogs as novel inhibitors of angiogenesis
GB0119583D0 (en) * 2001-08-10 2001-10-03 Unilever Plc Cosmetic composition and method of treating skin
US6831186B2 (en) * 2001-11-06 2004-12-14 Schering Aktiengesellschft Lipoxin A4 analogs
WO2003039533A1 (fr) * 2001-11-06 2003-05-15 The Brigham And Women's Hospital, Inc. Lipoxines et lipoxines activees par aspirine et leurs analogues stables dans le traitement de l'asthme et de maladies respiratoires inflammatoires
EP2361622A1 (fr) * 2001-12-18 2011-08-31 The Brigham and Women's Hospital Utilisation d'analogue de la lipoxine pour améliorer la défense cellulaire contre les infections gram-négatives
US8481772B2 (en) 2002-04-01 2013-07-09 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
US7902257B2 (en) * 2002-04-01 2011-03-08 University Of Southern California Trihydroxy polyunsaturated eicosanoid
EP1537069B1 (fr) 2002-06-17 2008-01-02 Resolvyx Pharmaceuticals ANALOGUES DE MEDIATEURS LIPIDIQUES DERIVES DE OMEGA-3 PUFAs, ET METHODES D'UTILISATION
AU2003258194B2 (en) * 2002-08-12 2009-11-12 The Brigham And Women's Hospital, Inc. Resolvins: biotemplates for therapeutic interventions
US7759395B2 (en) 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
WO2004078143A2 (fr) * 2003-03-05 2004-09-16 The Brigham And Women's Hospital Inc. Procede destine a l'identification et l'utilisation de recepteurs anti-inflammatoires pour les analogues d'acides eicosapentaenoiques
EP1755537A4 (fr) * 2004-04-14 2009-12-09 Univ Boston Procédés et compositions servant à prévenir ou à traiter des maladies parodontales
US8273792B2 (en) 2005-10-03 2012-09-25 The Brigham And Women's Hospital, Inc. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and it's natural stereoisomers
US8636986B2 (en) * 2005-11-18 2014-01-28 The Forsyth Institute Treatment and prevention of bone loss using resolvins
US7906678B2 (en) 2006-12-04 2011-03-15 Bayer Schering Pharma Aktiengesellschaft Crystalline potassium salt of lipoxin A4 analogs
EP2806028B1 (fr) 2008-11-04 2017-07-12 InDex Pharmaceuticals AB Composés et procédés de réduction du recrutement et/ou de la migration de cellules polymorphonucléaires
CN110709138A (zh) 2017-01-31 2020-01-17 布里格姆及妇女医院股份有限公司 Alx受体配体定义炎症性疾病的生化内型
ES2986149T3 (es) 2018-10-09 2024-11-08 Univ Rochester Tratamiento de trastornos vulvovaginales

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US309533A (en) * 1884-12-23 Saw-tooth-swaging device
US54761A (en) * 1866-05-15 Improved egg-beater
US6048897A (en) * 1993-06-15 2000-04-11 Brigham And Women's Hospital Lipoxin compounds and their use in treating cell proliferative disorders
US5441951A (en) 1994-06-15 1995-08-15 Brigham & Women's Hospital Lipoxin compounds
CA2365204C (fr) * 1999-03-18 2009-10-27 Brigham And Women's Hospital Composes a base de lipoxine et leur utilisation
CA2615917C (fr) * 1999-03-18 2011-10-04 Brigham And Women's Hospital Utilisation de composes de lipoxine afin d'inhiber la reponse de neutrophile induite par tnf-(alpha)
EP2236140A1 (fr) * 1999-03-18 2010-10-06 The Brigham and Women's Hospital, Inc. Régulation de l'activité phospholipase D
WO2003039533A1 (fr) 2001-11-06 2003-05-15 The Brigham And Women's Hospital, Inc. Lipoxines et lipoxines activees par aspirine et leurs analogues stables dans le traitement de l'asthme et de maladies respiratoires inflammatoires

Also Published As

Publication number Publication date
US6659282B2 (en) 2003-12-09
US6960674B2 (en) 2005-11-01
ATE303355T1 (de) 2005-09-15
EP1163204A1 (fr) 2001-12-19
US20080064747A1 (en) 2008-03-13
WO2000055109A1 (fr) 2000-09-21
HK1043357B (en) 2005-12-09
US20030055275A1 (en) 2003-03-20
US20030069435A1 (en) 2003-04-10
AU776271B2 (en) 2004-09-02
HK1043357A1 (en) 2002-09-13
US20050192350A1 (en) 2005-09-01
AU3743100A (en) 2000-10-04
WO2000055109A9 (fr) 2001-12-27
DE60022327D1 (de) 2005-10-06
AU2008207590A1 (en) 2008-09-25
US6433202B1 (en) 2002-08-13
PT1163204E (pt) 2005-11-30
US7227031B2 (en) 2007-06-05
US8022105B2 (en) 2011-09-20
US7579494B2 (en) 2009-08-25
US7615576B2 (en) 2009-11-10
DE60022327T2 (de) 2006-06-29
US20070259958A1 (en) 2007-11-08
US20100048702A1 (en) 2010-02-25
CA2365204C (fr) 2009-10-27
US6720354B2 (en) 2004-04-13
US20030191332A1 (en) 2003-10-09
CA2365204A1 (fr) 2000-09-21
ES2246230T3 (es) 2006-02-16
EP1163204B1 (fr) 2005-08-31
AU2008207590B2 (en) 2010-12-16
JP2002539181A (ja) 2002-11-19
DK1163204T3 (da) 2005-12-19

Similar Documents

Publication Publication Date Title
AU2008207590B2 (en) Lipoxin compounds and their use
CA2265708C (fr) Composes de lipoxines et leur utilisation dans le traitement des pathologies dues a la proliferation cellulaire
US7825271B2 (en) Lipoxin compounds and their use in treating cell proliferative disorders
EP0703897A1 (fr) Composes de la lipoxine
AU2004235617B2 (en) Lipoxin compounds and their use
EP1586550A1 (fr) Composés à base de lipoxine et leur utilisation
US20120010286A1 (en) Prevention of neutrophil recruitment
HK1075246A (en) Lipoxin compounds and their use
AU2003271275B2 (en) Lipoxin compounds and their use in treating cell proliferative disorders

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20140521