CA2679309C - Reactif pour determiner la quantite de petite lipoproteine dense de faible densite - Google Patents

Reactif pour determiner la quantite de petite lipoproteine dense de faible densite Download PDF

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Publication number
CA2679309C
CA2679309C CA2679309A CA2679309A CA2679309C CA 2679309 C CA2679309 C CA 2679309C CA 2679309 A CA2679309 A CA 2679309A CA 2679309 A CA2679309 A CA 2679309A CA 2679309 C CA2679309 C CA 2679309C
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small
surfactant
ldls
cholesterol
dense
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CA2679309A
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CA2679309A1 (fr
Inventor
Yasuki Itoh
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Denka Co Ltd
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Denka Seiken Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/60—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving cholesterol
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104165—Lipid, cholesterol, or triglyceride standard or control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne un réactif pour la détermination fractionnaire de petite lipoprotéine dense de faible densité ne nécessitant aucun prétraitement d'un échantillon, rapide et simple, et applicable à un analyseur automatisé. L'invention concerne également un procédé de détermination de la quantité de cholestérol contenue dans une petite lipoprotéine dense de faible densité dans un échantillon, comprenant : une première étape pour l'entraînement d'une lipoprotéine autre que la petite lipoprotéine dense de faible densité en présence d'une cholestérol estérase et d'un tensioactif capable d'agir sut la lipoprotéine autre que la petite lipoprotéine dense de faible densité à une concentration comprise entre 0,05 et 1,0 g/L; et une seconde étape de détermination de la quantité de cholestérol dans la petite lipoprotéine dense de faible densité restante dans la première étape.
CA2679309A 2007-02-28 2008-02-28 Reactif pour determiner la quantite de petite lipoproteine dense de faible densite Active CA2679309C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2007-049533 2007-02-28
JP2007049533 2007-02-28
PCT/JP2008/053470 WO2008105486A1 (fr) 2007-02-28 2008-02-28 Réactif pour déterminer la quantité de petite lipoprotéine dense de faible densité

Publications (2)

Publication Number Publication Date
CA2679309A1 CA2679309A1 (fr) 2008-09-04
CA2679309C true CA2679309C (fr) 2015-05-26

Family

ID=39721310

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2679309A Active CA2679309C (fr) 2007-02-28 2008-02-28 Reactif pour determiner la quantite de petite lipoproteine dense de faible densite

Country Status (9)

Country Link
US (1) US8030081B2 (fr)
EP (1) EP2116612B1 (fr)
JP (2) JP5325093B2 (fr)
KR (1) KR101394802B1 (fr)
CN (1) CN101663404B (fr)
AU (1) AU2008220056B2 (fr)
CA (1) CA2679309C (fr)
DK (1) DK2116612T3 (fr)
WO (1) WO2008105486A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5081814B2 (ja) * 2006-05-01 2012-11-28 デンカ生研株式会社 家族性複合型高脂血症の検出方法
KR101586505B1 (ko) * 2007-10-10 2016-01-18 덴카 세이켄 가부시키가이샤 소입자 고비중 ｌｄｌ 콜레스테롤의 정량 방법 및 키트
WO2011136316A1 (fr) * 2010-04-30 2011-11-03 協和メデックス株式会社 Procédé de mesure du cholestérol des lipoprotéines de basse densité, réactif de mesure et trousse de mesure
CN103080748B (zh) * 2010-07-23 2015-05-27 电化生研株式会社 高密度脂蛋白3中的胆固醇的定量方法
DK2682476T3 (en) * 2011-02-28 2017-04-24 Denka Seiken Kk Method for Quantifying Cholesterol in High Density Lipoprotein 2 and Using a Reagent Kit for the Method
JP6054051B2 (ja) * 2012-04-11 2016-12-27 デンカ生研株式会社 高密度リポ蛋白（ｈｄｌ）中のコレステロール（−ｃ）の亜分画定量方法
IL282156B (en) * 2014-07-29 2022-07-01 Shenzhen Hightide Biopharmaceutical Ltd Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof
CN105652021B (zh) * 2016-03-11 2018-01-02 上海练佰生物技术中心 一种测定小而密脂蛋白的试剂、方法和试剂盒
CN107446989B (zh) * 2017-06-23 2020-07-14 美康生物科技股份有限公司 测定样本中的小而密低密度脂蛋白胆固醇的方法及试剂
JP7134667B2 (ja) * 2018-03-28 2022-09-12 デンカ株式会社 リポ蛋白コレステロールの定量方法、定量試薬及び定量キット
CN110736846B (zh) * 2018-07-20 2023-07-14 上海微鸿企业管理有限公司 一种小而密脂蛋白的测定试剂、方法和试剂盒
JP7311248B2 (ja) * 2018-08-08 2023-07-19 デンカ株式会社 リポ蛋白コレステロールの定量方法及び定量キット
JP7427522B2 (ja) * 2019-09-10 2024-02-05 デンカ株式会社 キットおよび方法
JP6869300B2 (ja) * 2019-09-10 2021-05-12 デンカ株式会社 ｓｍａｌｌ，ｄｅｎｓｅ ＬＤＬコレステロールの定量方法およびキット
JP6703175B1 (ja) * 2019-09-10 2020-06-03 デンカ生研株式会社 キットおよび方法
AU2020384066B2 (en) 2019-11-15 2025-10-30 Green Cross Corporation Novel derivatives having 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof and pharmaceutical compositions comprising the same
CN110791549B (zh) * 2019-12-03 2023-09-26 宁波普瑞柏生物技术股份有限公司 定量测定小而密低密度脂蛋白胆固醇的方法和试剂盒
US12571806B2 (en) 2020-02-04 2026-03-10 Denka Company Limited Method for assisting detection of non-alcoholic steatohepatitis
CN111551512B (zh) * 2020-06-11 2023-07-25 安徽大千生物工程有限公司 一种高灵敏度和特异度的sdLDL-C比色法检测试剂盒及其制备使用方法
JP7437263B2 (ja) * 2020-07-31 2024-02-22 デンカ株式会社 試薬組成物およびキット
CN117203347A (zh) * 2021-04-19 2023-12-08 电化株式会社 试剂组合物和试剂盒
CN113308513B (zh) * 2021-05-27 2022-02-18 宁波瑞源生物科技有限公司 一种小而密低密度脂蛋白胆固醇检测试剂盒及其检测方法
WO2023079599A1 (fr) * 2021-11-02 2023-05-11 デンカ株式会社 Composition de réactif et kit
CN113913492A (zh) * 2021-11-08 2022-01-11 东软威特曼生物科技(南京)有限公司 一种小而密低密度脂蛋白胆固醇检测试剂盒及其制备方法
CN114214389B (zh) * 2022-02-21 2022-07-12 北京沃森赛瑟生物技术有限公司 脂蛋白胆固醇检测方法和试剂盒
US20250327111A1 (en) * 2022-04-11 2025-10-23 Denka Company Limited Reagent composition and kit
CN115627289A (zh) * 2022-10-17 2023-01-20 青岛汉唐生物科技有限公司 一种小而密低密度脂蛋白胆固醇的检测试剂及制备方法
CN116804678A (zh) * 2023-06-14 2023-09-26 北京迈康源生物科技有限公司 一种检测小而低密度脂蛋白胆固醇的试剂盒及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3058602B2 (ja) * 1996-04-15 2000-07-04 デンカ生研株式会社 低密度リポ蛋白中のコレステロールの定量方法
US6194164B1 (en) 1997-04-14 2001-02-27 Denka Seiken Co., Ltd. Method for quantitating cholesterol present in low density lipoproteins
ATE278805T1 (de) 1998-09-18 2004-10-15 Kyowa Medex Co Ltd Verfahren zur quantifizierung von cholesterol in lipoproteinen und quantifizierungsreagenzien
JP4519239B2 (ja) 2000-02-17 2010-08-04 デンカ生研株式会社 低密度リポ蛋白中のコレステロールの定量方法
JP4593026B2 (ja) * 2001-07-18 2010-12-08 栄研化学株式会社 ＳｍａｌｌｄｅｎｓｅＬＤＬの測定方法
WO2004053500A1 (fr) 2002-12-06 2004-06-24 Denka Seiken Co., Ltd. Procede permettant de quantifier une lipoproteine de petite taille et de basse densite
DE602006018035D1 (de) * 2005-08-31 2010-12-16 Denka Seiken Kk Verfahren und kit zur quantitativen bestimmung von small, dense ldl cholesterol
DE602007012455D1 (de) * 2006-10-18 2011-03-24 Kyowa Medex Co Ltd Verfahren zur quantifizierung von cholesterin in kleinem dichtem low-density-lipoprotein

Also Published As

Publication number Publication date
JP5325093B2 (ja) 2013-10-23
US20100035288A1 (en) 2010-02-11
KR101394802B1 (ko) 2014-05-15
EP2116612A4 (fr) 2010-09-01
CA2679309A1 (fr) 2008-09-04
EP2116612B1 (fr) 2017-08-30
AU2008220056A1 (en) 2008-09-04
JPWO2008105486A1 (ja) 2010-06-03
WO2008105486A1 (fr) 2008-09-04
AU2008220056B2 (en) 2014-05-01
DK2116612T3 (en) 2017-10-09
JP2013148589A (ja) 2013-08-01
CN101663404A (zh) 2010-03-03
US8030081B2 (en) 2011-10-04
JP5730344B2 (ja) 2015-06-10
KR20090125794A (ko) 2009-12-07
CN101663404B (zh) 2013-05-01
EP2116612A1 (fr) 2009-11-11

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