CA2682385A1 - Traitement du cancer par des glycosides cardiaques - Google Patents

Traitement du cancer par des glycosides cardiaques Download PDF

Info

Publication number
CA2682385A1
CA2682385A1 CA002682385A CA2682385A CA2682385A1 CA 2682385 A1 CA2682385 A1 CA 2682385A1 CA 002682385 A CA002682385 A CA 002682385A CA 2682385 A CA2682385 A CA 2682385A CA 2682385 A1 CA2682385 A1 CA 2682385A1
Authority
CA
Canada
Prior art keywords
cancer
cells
cardiac glycoside
apoptosis
digoxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002682385A
Other languages
English (en)
Inventor
Jr. Roland Valdes
Kenneth Ihenetu
Rafael Fernandes-Botran
Hassan Qazzaz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Louisville Research Foundation ULRF
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2682385A1 publication Critical patent/CA2682385A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002682385A 2006-05-09 2006-10-27 Traitement du cancer par des glycosides cardiaques Abandoned CA2682385A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79919906P 2006-05-09 2006-05-09
US60/799,199 2006-05-09
PCT/US2006/042014 WO2007130124A1 (fr) 2006-05-09 2006-10-27 Traitement du cancer par des glycosides cardiaques

Publications (1)

Publication Number Publication Date
CA2682385A1 true CA2682385A1 (fr) 2007-11-15

Family

ID=38668065

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002682385A Abandoned CA2682385A1 (fr) 2006-05-09 2006-10-27 Traitement du cancer par des glycosides cardiaques

Country Status (4)

Country Link
EP (1) EP2032143A1 (fr)
AU (1) AU2006343317A1 (fr)
CA (1) CA2682385A1 (fr)
WO (1) WO2007130124A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007089688A2 (fr) 2006-01-31 2007-08-09 The University Of Toledo LIGAND Na/K-ATPase
CN103463621B (zh) 2006-10-31 2016-01-06 托莱多大学 Src和Src家族激酶的Na+/K+-ATP酶特异性肽抑制剂/激活剂
CN102227635A (zh) * 2008-10-29 2011-10-26 托莱多大学 Na/K-ATP酶表达作为癌症治疗的指示剂
PL2563803T3 (pl) * 2010-04-27 2016-08-31 Pharma Mar Sa Przeciwnowotworowe laktony steroidowe nienasycone w pozycji 7(8)
US9066974B1 (en) 2010-11-13 2015-06-30 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US9095606B1 (en) 2010-11-13 2015-08-04 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US8597695B1 (en) 2010-11-13 2013-12-03 Sirbal Ltd. Herbal combinations for treatment of a skin condition
US8541382B2 (en) 2010-11-13 2013-09-24 Sirbal Ltd. Cardiac glycoside analogs in combination with emodin for cancer therapy
US20170049687A1 (en) 2015-07-29 2017-02-23 Sirbal Ltd. Herbal Combinations For Treating Scalp Conditions
WO2013012997A1 (fr) * 2011-07-21 2013-01-24 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Lyse osmotique ciblée de cellules cancéreuses
EP3076984B1 (fr) 2013-12-02 2018-11-14 Sirbal Ltd. Combinaisons de plantes pour le traitement d'une affection cutanée
US20180002371A1 (en) * 2014-12-30 2018-01-04 Baylor College Of Medicine Bufalin phosphate prodrugs and methods of use thereof
CN113444136B (zh) * 2021-03-15 2023-05-02 济南大学 一种抗乳腺癌的乙型强心苷的制备及其抗肝癌应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5872103A (en) * 1986-11-26 1999-02-16 Belletti; Dino A. Prevention of mammary tumors by treatment with cardiac glycosides
US5656434A (en) * 1990-12-28 1997-08-12 Suntory Limited Monoclonal antibody against cardiac glycoside and utilization thereof
JP2002536415A (ja) * 1999-02-12 2002-10-29 セルパス インコーポレイテッド 抗腫瘍療法
CA2273699A1 (fr) * 1999-06-03 2000-12-03 Sergei N. Orlov Nouvelles utilisations de l'ouabaine et de molecules semblables dans des pathologies reliees a l'apoptose

Also Published As

Publication number Publication date
AU2006343317A1 (en) 2007-11-15
EP2032143A1 (fr) 2009-03-11
WO2007130124A1 (fr) 2007-11-15

Similar Documents

Publication Publication Date Title
US20090018088A1 (en) Treating cancer with cardiac glycosides
Li et al. Metformin induces cell cycle arrest, apoptosis and autophagy through ROS/JNK signaling pathway in human osteosarcoma
Filomeni et al. Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease
Zhang et al. Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells
Wang et al. Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway
Zhang et al. β-Elemene reverses the resistance of p53-deficient colorectal cancer cells to 5-fluorouracil by inducing pro-death autophagy and cyclin D3-dependent cycle arrest
Pesakhov et al. Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid
Jin et al. Baicalin alleviates benign prostate hyperplasia through androgen-dependent apoptosis
CA2682385A1 (fr) Traitement du cancer par des glycosides cardiaques
Wu et al. Regulatory mechanism of α-hederin upon cisplatin sensibility in NSCLC at safe dose by destroying GSS/GSH/GPX2 axis–mediated glutathione oxidation-reduction system
Liu et al. Tetrahydrocurcumin is more effective than curcumin in inducing the apoptosis of H22 cells via regulation of a mitochondrial apoptosis pathway in ascites tumor-bearing mice
Lee et al. SH003‑induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells
Shi et al. Mitochondrial inhibitor sensitizes non-small-cell lung carcinoma cells to TRAIL-induced apoptosis by reactive oxygen species and Bcl-XL/p53-mediated amplification mechanisms
Liu et al. Nrf2 down-regulation by camptothecin favors inhibiting invasion, metastasis and angiogenesis in hepatocellular carcinoma
Li et al. Aucubin alleviates doxorubicin-induced cardiotoxicity through crosstalk between NRF2 and HIPK2 mediating autophagy and apoptosis
Su et al. Gambogenic acid triggers apoptosis in human nasopharyngeal carcinoma CNE-2Z cells by activating volume-sensitive outwardly rectifying chloride channel
Byun et al. C-27-carboxylated oleanane triterpenoids up-regulate TRAIL DISC assembly via p38 MAPK and CHOP-mediated DR5 expression in human glioblastoma cells
Ke et al. SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice
Lu et al. Saponins from Paris forrestii (Takht.) H. Li display potent activity against acute myeloid leukemia by suppressing the RNF6/AKT/mTOR signaling pathway
Hu et al. Icariin treatment protects against gentamicin-induced ototoxicity via activation of the AMPK-SIRT3 pathway
Dai et al. Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A
Zhu et al. Bufotalin enhances apoptosis and TMZ chemosensitivity of glioblastoma cells by promoting mitochondrial dysfunction via AKT signaling pathway
Liu et al. Panax notoginseng saponins induce apoptosis in retinoblastoma Y79 cells via the PI3K/AKT signalling pathway
Qiu et al. LPM3770277, a potent novel CDK4/6 degrader, exerts antitumor effect against triple-negative breast cancer
Wu et al. OSW-1 induces apoptosis and cyto-protective autophagy, and synergizes with chemotherapy on triple negative breast cancer metastasis

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20131029