CA2698508C - Implants lacrymaux et procedes associes - Google Patents

Implants lacrymaux et procedes associes Download PDF

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Publication number
CA2698508C
CA2698508C CA2698508A CA2698508A CA2698508C CA 2698508 C CA2698508 C CA 2698508C CA 2698508 A CA2698508 A CA 2698508A CA 2698508 A CA2698508 A CA 2698508A CA 2698508 C CA2698508 C CA 2698508C
Authority
CA
Canada
Prior art keywords
lacrimal
implant
implant body
canaliculus
proximal end
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2698508A
Other languages
English (en)
Other versions
CA2698508A1 (fr
Inventor
Alan R. Rapacki
John B. Holds
Sylvie Sim
Danny Shen
Valery Rubinchik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mati Therapeutics Inc
Original Assignee
Mati Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mati Therapeutics Inc filed Critical Mati Therapeutics Inc
Publication of CA2698508A1 publication Critical patent/CA2698508A1/fr
Application granted granted Critical
Publication of CA2698508C publication Critical patent/CA2698508C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/00772Apparatus for restoration of tear ducts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0061Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof swellable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008Fixation appliances for connecting prostheses to the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T407/00Cutters, for shaping
    • Y10T407/19Rotary cutting tool
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T409/00Gear cutting, milling, or planing
    • Y10T409/30Milling
    • Y10T409/3042Means to remove scale or raised surface imperfection
    • Y10T409/304256Means to remove flash or burr

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Prostheses (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des implants lacrymaux permettant de traiter certains troubles ou maladies. Plus particulièrement, la présente invention concerne des implants lacrymaux, des procédés permettant de fabriquer de tels implants, et des procédés permettant de traiter des maladies ou des troubles de l'il, de la respiration, de l'oreille interne ou autres, à l'aide de tels implants.
CA2698508A 2007-09-07 2008-09-05 Implants lacrymaux et procedes associes Active CA2698508C (fr)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US97072007P 2007-09-07 2007-09-07
US97069607P 2007-09-07 2007-09-07
US60/970,720 2007-09-07
US60/970,696 2007-09-07
US97436707P 2007-09-21 2007-09-21
US60/974,367 2007-09-21
US3321108P 2008-03-03 2008-03-03
US61/033,211 2008-03-03
US3681608P 2008-03-14 2008-03-14
US61/036,816 2008-03-14
US4936008P 2008-04-30 2008-04-30
US61/049,360 2008-04-30
US5259508P 2008-05-12 2008-05-12
US61/052,595 2008-05-12
US7530908P 2008-06-24 2008-06-24
US61/075,309 2008-06-24
PCT/US2008/010479 WO2009032328A1 (fr) 2007-09-07 2008-09-05 Implants lacrymaux et procédés associés

Publications (2)

Publication Number Publication Date
CA2698508A1 CA2698508A1 (fr) 2009-03-12
CA2698508C true CA2698508C (fr) 2017-06-06

Family

ID=40044129

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2698508A Active CA2698508C (fr) 2007-09-07 2008-09-05 Implants lacrymaux et procedes associes

Country Status (14)

Country Link
US (6) US8333726B2 (fr)
EP (2) EP2205191B1 (fr)
JP (2) JP5524841B2 (fr)
KR (1) KR20100050566A (fr)
AU (1) AU2008296872A1 (fr)
BR (1) BRPI0817082A2 (fr)
CA (1) CA2698508C (fr)
DK (2) DK2205191T3 (fr)
ES (2) ES2525125T3 (fr)
MX (1) MX2010002617A (fr)
NZ (1) NZ583861A (fr)
TW (1) TW200924725A (fr)
WO (1) WO2009032328A1 (fr)
ZA (1) ZA201001738B (fr)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002258754B2 (en) 2001-04-07 2006-08-17 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US20050232972A1 (en) * 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
DK1765454T3 (en) 2004-07-02 2016-05-02 Mati Therapeutics Inc Device for submission of treatment medium to eye
EP2004172B1 (fr) 2006-03-31 2019-03-13 Mati Therapeutics Inc. Structures d'administration de médicaments et compositions utilisées dans le système nasolacrymal
US8652090B2 (en) * 2006-05-18 2014-02-18 Cannuflow, Inc. Anti-extravasation surgical portal plug
AU2008300013A1 (en) 2007-09-07 2009-03-19 Qlt Inc. Drug cores for sustained release of therapeutic agents
NZ583858A (en) 2007-09-07 2012-08-31 Quadra Logic Tech Inc Lacrimal implant detection with detection device
CA2698508C (fr) 2007-09-07 2017-06-06 Alan R. Rapacki Implants lacrymaux et procedes associes
US8734377B2 (en) * 2007-09-24 2014-05-27 Ivantis, Inc. Ocular implants with asymmetric flexibility
US20090082862A1 (en) 2007-09-24 2009-03-26 Schieber Andrew T Ocular Implant Architectures
US7740604B2 (en) 2007-09-24 2010-06-22 Ivantis, Inc. Ocular implants for placement in schlemm's canal
US20170360609A9 (en) 2007-09-24 2017-12-21 Ivantis, Inc. Methods and devices for increasing aqueous humor outflow
US8808222B2 (en) 2007-11-20 2014-08-19 Ivantis, Inc. Methods and apparatus for delivering ocular implants into the eye
US8512404B2 (en) * 2007-11-20 2013-08-20 Ivantis, Inc. Ocular implant delivery system and method
JP2011513002A (ja) 2008-03-05 2011-04-28 イバンティス インコーポレイテッド 緑内障を治療する方法及び器具
WO2009134371A2 (fr) * 2008-04-30 2009-11-05 Qlt Plug Delivery, Inc. Insert lacrymal composite et procédés apparentés
CN102123713A (zh) * 2008-05-09 2011-07-13 Qlt栓塞输送公司 治疗青光眼和眼高血压的活性剂的持续释放递送
WO2009145755A1 (fr) 2008-05-30 2009-12-03 Qlt Plug Delivery, Inc Articles implantables traités en surface et procédés associés
EP2303184A4 (fr) * 2008-06-24 2013-06-19 Quadra Logic Tech Inc Traitement d'association du glaucome
CA2730101A1 (fr) * 2008-07-08 2010-01-14 Qlt Plug Delivery, Inc. Corps d'implant lacrymal comprenant un agent de confort
JP5520962B2 (ja) 2008-12-05 2014-06-11 イバンティス インコーポレイテッド 眼内インプラントを眼球内に送出するための装置
EP2376019A1 (fr) * 2008-12-19 2011-10-19 QLT, Inc. Implants pour punctum libérant une substance et procédés annexes
AU2010206610A1 (en) * 2009-01-23 2011-08-11 Qlt Inc. Sustained released delivery of one or more agents
US8409606B2 (en) 2009-02-12 2013-04-02 Incept, Llc Drug delivery through hydrogel plugs
KR20110132369A (ko) * 2009-02-23 2011-12-07 큐엘티 인코포레이티드 눈물 임플란트 및 관련 방법
EP2408409B8 (fr) * 2009-03-16 2016-06-08 Endoshape, Inc. Implants ophtalmologiques à mémoire de forme retenus de manière fiable
US9421127B2 (en) 2009-03-31 2016-08-23 Johnson & Johnson Vision Care, Inc. Punctal plugs
CA3186189A1 (fr) 2009-05-18 2010-11-25 Dose Medical Corporation Implant oculaire a elution de medicament
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
EP2437684B1 (fr) 2009-06-03 2022-06-15 ForSight Vision5, Inc. Distribution de médicament de segment antérieur
AU2010271218B2 (en) 2009-07-09 2017-02-02 Alcon Inc. Ocular implants and methods for delivering ocular implants into the eye
JP5726186B2 (ja) 2009-07-09 2015-05-27 イバンティス インコーポレイテッド 眼内インプラントを送出するための単オペレータデバイス
JP2013508096A (ja) 2009-10-23 2013-03-07 イバンティス インコーポレイテッド 眼内移植システムおよび眼内移植方法
WO2011079222A2 (fr) 2009-12-23 2011-06-30 Boston Scientific Scimed, Inc. Méthode moins traumatique de pose de dispositifs à maillage dans le corps humain
US9259351B2 (en) 2010-03-29 2016-02-16 Johnson & Johnson Vision Care, Inc. Punctal plugs
US9259352B2 (en) * 2010-03-29 2016-02-16 Johnson & Johnson Vision Care, Inc. Punctal plugs
WO2011163505A1 (fr) 2010-06-23 2011-12-29 Ivantis, Inc. Implants oculaires posés dans le canal de schlemm de l'œil
US9022967B2 (en) 2010-10-08 2015-05-05 Sinopsys Surgical, Inc. Implant device, tool, and methods relating to treatment of paranasal sinuses
US9668915B2 (en) 2010-11-24 2017-06-06 Dose Medical Corporation Drug eluting ocular implant
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
US8657776B2 (en) 2011-06-14 2014-02-25 Ivantis, Inc. Ocular implants for delivery into the eye
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
ES2727203T3 (es) * 2011-08-29 2019-10-14 Mati Therapeutics Inc Administración por liberación sostenida de agentes activos para tratar glaucoma e hipertensión ocular
EP2755615B1 (fr) 2011-09-14 2022-04-06 Forsight Vision5, Inc. Appareil pour insert oculaire
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
US8663150B2 (en) 2011-12-19 2014-03-04 Ivantis, Inc. Delivering ocular implants into the eye
US20130220346A1 (en) * 2012-02-28 2013-08-29 Victor Lust Balloon punctal plug
US9572964B2 (en) * 2012-04-11 2017-02-21 Sinapsys Surgical, Inc. Implantation tools, tool assemblies, kits and methods
US9358156B2 (en) 2012-04-18 2016-06-07 Invantis, Inc. Ocular implants for delivery into an anterior chamber of the eye
WO2013164671A1 (fr) 2012-05-03 2013-11-07 Qlt Inc. Système d'administration de médicament et procédés de traitement d'un glaucome à angle ouvert et de l'hypertension oculaire
EP2863841A2 (fr) * 2012-06-25 2015-04-29 Velimir-Josef Novak Implant pour produire un canal lacrymal sur le corps d'un homme ou d'un animal et trousse d'opération pour produire un canal lacrymal
DK2911623T3 (da) 2012-10-26 2019-10-28 Forsight Vision5 Inc Oftalmisk system til langvarig frigivelse af lægemiddel til øjet
US10617558B2 (en) 2012-11-28 2020-04-14 Ivantis, Inc. Apparatus for delivering ocular implants into an anterior chamber of the eye
EP2945686B1 (fr) * 2013-01-15 2024-11-20 The Regents of The University of Colorado, A Body Corporate Dispositif d'administration de médicament de système lacrymal
CN104968306B (zh) * 2013-01-25 2018-09-25 西诺普西斯外科股份有限公司 鼻窦进入植入装置及相关工具、方法和套件
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
CN105828755B (zh) 2013-10-16 2019-01-22 西诺普西斯外科股份有限公司 与鼻窦的流体操纵治疗相关的设备、工具、套件和方法
EP3677229A1 (fr) 2014-05-29 2020-07-08 Glaukos Corporation Implants ayant des caractéristiques d'administration contrôlée de médicaments
US10709547B2 (en) 2014-07-14 2020-07-14 Ivantis, Inc. Ocular implant delivery system and method
US10898375B2 (en) 2014-07-24 2021-01-26 Sinopsys Surgical, Inc. Paranasal sinus access implant devices and related products and methods
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
KR20180021741A (ko) * 2015-05-29 2018-03-05 에쥐 세라피틱스, 인코포레이티드 시각 손실을 감소시키기 위한 조성물 및 방법
US10004634B2 (en) 2015-06-16 2018-06-26 The Regents Of The University Of Colorado Nasolacrimal implants and related methods for tear stimulation
WO2017030917A1 (fr) 2015-08-14 2017-02-23 Ivantis, Inc. Implant oculaire ayant un capteur de pression et un système d'administration
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (fr) * 2015-09-25 2017-03-30 Glaukos Corporation Implants lacrymaux à caractéristiques d'administration de médicament régulée et leurs procédés d'utilisation
US11458041B2 (en) 2015-10-08 2022-10-04 Ocular Therapeutix, Inc. Punctal plug and bioadhesives
US20190117530A1 (en) * 2015-10-09 2019-04-25 Fernando Thome Kreutz Nanoemulsion compositions and methods
AU2016359288C1 (en) 2015-11-23 2022-03-17 The Regents Of The University Of Colorado, A Body Corporate Lacrimal system for drug delivery
US11938058B2 (en) 2015-12-15 2024-03-26 Alcon Inc. Ocular implant and delivery system
EP3442479B1 (fr) 2016-04-20 2026-03-04 Glaukos Corporation Dispositif d'administration de médicament oculaire biorésorbable
EP3458030B1 (fr) 2016-05-20 2021-05-12 The Regents of The University of Colorado, A Body Corporate Dispositif d'administration de médicament lacrymal
US12233017B2 (en) 2016-10-14 2025-02-25 Olympic Ophthalmics, Inc. Quiet handheld devices and methods for treatment of disorders
US11129972B2 (en) 2017-09-20 2021-09-28 Sinopsys Surgical, Inc. Paranasal sinus fluid access implantation tools, assemblies, kits and methods
US11116625B2 (en) 2017-09-28 2021-09-14 Glaukos Corporation Apparatus and method for controlling placement of intraocular implants
US12029683B2 (en) * 2018-02-22 2024-07-09 Alcon Inc. Ocular implant and delivery system
US11147737B2 (en) 2018-02-26 2021-10-19 Olympic Ophthalmics, Inc. Handheld device with motorized member for treatment of disorders
WO2021071975A1 (fr) * 2019-10-07 2021-04-15 Glaukos Corporation Implants méatiques, systèmes d'insertion et leurs procédés d'utilisation
US12213916B2 (en) * 2020-01-17 2025-02-04 Quest Medical, Inc. Nasolacrimal duct stent assembly and method
CA3166738A1 (fr) 2020-02-06 2021-08-12 Charles D. Blizzard Compositions de travoprost et methodes de traitement de maladies oculaires
CN111449834B (zh) * 2020-04-15 2022-03-01 贵州省人民医院 一种泪小管栓塞用泪道引流装置及其引流方法
WO2021222117A1 (fr) 2020-04-27 2021-11-04 Ocular Therapeutix, Inc. Procédés de traitement de la conjonctivite allergique
JP2024503989A (ja) 2021-01-11 2024-01-30 アルコン インコーポレイティド 粘弾性体送達のためのシステム及び方法
CN113208807A (zh) * 2021-03-24 2021-08-06 温州医科大学附属眼视光医院 一种稳定单管人工泪管
CN113288579B (zh) * 2021-06-21 2022-07-12 卢国华 一种新型人工泪管

Family Cites Families (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865108A (en) * 1971-05-17 1975-02-11 Ortho Pharma Corp Expandable drug delivery device
US3949750A (en) * 1974-10-07 1976-04-13 Freeman Jerre M Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same
US4014335A (en) * 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US5049142A (en) * 1984-11-07 1991-09-17 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US5053030A (en) * 1984-11-07 1991-10-01 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US4660546A (en) * 1984-11-07 1987-04-28 Robert S. Herrick Method for treating for deficiency of tears
US5229128A (en) * 1986-06-11 1993-07-20 Haddad Heskel M Drug delivery ophthalmic insert and method of preparing same
US5322691A (en) * 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US4886488A (en) 1987-08-06 1989-12-12 White Thomas C Glaucoma drainage the lacrimal system and method
US4915684A (en) * 1988-06-21 1990-04-10 Mackeen Donald L Method and apparatus for modulating the flow of lacrimal fluid through a punctum and associated canaliculus
US5133159A (en) * 1989-01-13 1992-07-28 Nestle S.A. Method for polishing silicone products
US4959048A (en) * 1989-01-17 1990-09-25 Helix Medical, Inc. Lacrimal duct occluder
US5128058A (en) * 1989-05-31 1992-07-07 Hoya Corporation Contact lens cleaner containing a microcapsular polishing agent
IE910450A1 (en) 1990-02-15 1991-08-28 Bausch & Lomb Soft contact lens processing aid
US5163959A (en) * 1990-03-29 1992-11-17 Herrick Robert S Method for treating an eye with a canalicular implant having a collapsible flared section
US5171270A (en) 1990-03-29 1992-12-15 Herrick Robert S Canalicular implant having a collapsible flared section and method
US5041081A (en) * 1990-05-18 1991-08-20 Odrich Ronald B Ocular implant for controlling glaucoma
CA2050235C (fr) * 1990-08-31 2000-12-12 Tanehiro Nakagawa Dispositif de changement electrothermique de couleurs et jouet utilisant ce dispositif
US5283063A (en) * 1992-01-31 1994-02-01 Eagle Vision Punctum plug method and apparatus
US5334137A (en) * 1992-02-21 1994-08-02 Eagle Vision, Inc. Lacrimal fluid control device
US5469867A (en) * 1992-09-02 1995-11-28 Landec Corporation Cast-in place thermoplastic channel occluder
US5318513A (en) 1992-09-24 1994-06-07 Leib Martin L Canalicular balloon fixation stent
US5707643A (en) * 1993-02-26 1998-01-13 Santen Pharmaceutical Co., Ltd. Biodegradable scleral plug
US5417651A (en) * 1993-07-01 1995-05-23 Guena; Nicolas Punctum plug and monocanalicular probe for lacrimal pathology
US5423777A (en) * 1993-10-27 1995-06-13 Tajiri; Akira Punctum plug
US5466233A (en) * 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
JP3486758B2 (ja) * 1994-06-24 2004-01-13 株式会社高研 注入可能な涙小管閉鎖剤
US5723005A (en) * 1995-06-07 1998-03-03 Herrick Family Limited Partnership Punctum plug having a collapsible flared section and method
US6149684A (en) 1995-06-07 2000-11-21 Herrick; Robert S. Punctum plug having a thin elongated lip and a distal starting tip and method of using
US5766243A (en) * 1995-08-21 1998-06-16 Oasis Medical, Inc. Abrasive polished canalicular implant
US5773019A (en) * 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5741292A (en) * 1995-10-26 1998-04-21 Eagle Vision Punctum dilating and plug inserting instrument with push-button plug release
US5824073A (en) * 1996-03-18 1998-10-20 Peyman; Gholam A. Macular indentor for use in the treatment of subretinal neovascular membranes
JPH1033584A (ja) * 1996-07-26 1998-02-10 M L C:Kk 涙道挿管器具
US5993407A (en) * 1996-10-25 1999-11-30 Moazed; Kambiz Thomas Transnasal lacrimal insert
ES2175485T3 (es) * 1996-11-01 2002-11-16 Alcon Lab Inc Metodo criogenico de pulir para articulos acrilicos blandos.
EP0944371A1 (fr) * 1997-02-04 1999-09-29 Alain Fouere Tampon meatique vissable pour canal lacrymal
US6016806A (en) * 1997-03-27 2000-01-25 Eaglevision, Inc Punctum plug
US6082362A (en) * 1997-03-27 2000-07-04 Eagle Vision, Inc. Punctum plug
US6027470A (en) * 1998-06-10 2000-02-22 Eagle Vision, Inc. Punctum plug and method for inserting the same into the punctual opening
US6041785A (en) 1997-03-27 2000-03-28 Eaglevision, Inc. Punctum plug
US5961370A (en) * 1997-05-08 1999-10-05 Chiron Vision Corporation Intraocular lens tumbling process using coated beads
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
US6306426B1 (en) * 1997-08-11 2001-10-23 Allergan Sales, Inc. Implant device with a retinoid for improved biocompatibility
US5830171A (en) * 1997-08-12 1998-11-03 Odyssey Medical, Inc. Punctal occluder
US6060439A (en) * 1997-09-29 2000-05-09 Kyzen Corporation Cleaning compositions and methods for cleaning resin and polymeric materials used in manufacture
NL1008090C2 (nl) 1998-01-22 1999-07-26 Lubberman Bernardus H M Plug voor het afsluiten van een traanbuis.
US6290684B1 (en) * 1998-03-02 2001-09-18 Herrick Family Limited Partnership Punctum plug having a collapsible expanded section and distal tip extending substantially perpendicular thereto and method of inserting same
WO1999044553A1 (fr) 1998-03-02 1999-09-10 Herrick Family Limited Partnership Obturateur du punctum lacrimale pourvu d'une section en forme de tromblon et susceptible de s'aplatir
US6196993B1 (en) 1998-04-20 2001-03-06 Eyelab Group, Llc Ophthalmic insert and method for sustained release of medication to the eye
US6306114B1 (en) * 1998-06-16 2001-10-23 Eagle Vision, Inc. Valved canalicular plug for lacrimal duct occlusion
JP2000070296A (ja) * 1998-08-27 2000-03-07 M L C:Kk 涙道内挿管器具
US6095901A (en) * 1998-12-09 2000-08-01 Alcon Laboratories, Inc. Polishing method for soft acrylic articles
US20040121014A1 (en) * 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6234175B1 (en) * 1999-03-23 2001-05-22 Medennium, Inc. Smart ocular plug design and method of insertion for punctal and intracanalicular implants
US6383192B1 (en) * 1999-04-28 2002-05-07 Mlc Limited Company Apparatus for intubation of lacrimal duct
US6428502B1 (en) * 1999-06-25 2002-08-06 Alcon Manufacturing, Ltd. Punctal cannula
US6706275B1 (en) * 1999-09-08 2004-03-16 Matthew W. Camp Scleral plug system
US7943162B2 (en) 1999-10-21 2011-05-17 Alcon, Inc. Drug delivery device
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6264971B1 (en) * 1999-11-04 2001-07-24 Btg International Limited Ocular insert
US6344047B1 (en) * 2000-02-02 2002-02-05 Eagle Vision Instrument for inserting a punctum plug and method for manufacturing the instrument
US7867186B2 (en) * 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US7708711B2 (en) * 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US6638239B1 (en) * 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US20040175410A1 (en) * 2000-04-26 2004-09-09 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors
US6375972B1 (en) * 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US6371122B1 (en) * 2000-06-20 2002-04-16 Robert M. Mandelkorn Gauge/dilator apparatus
US6629533B1 (en) * 2000-06-30 2003-10-07 Eagle Vision, Inc. Punctum plug with at least one anchoring arm
EP1305061B1 (fr) 2000-08-04 2004-11-03 Medennium, Inc. Obturateur oculaire pour implants d'orifices lacrymaux et intracanaliculaires
EP1345588A2 (fr) * 2000-12-29 2003-09-24 Bausch & Lomb Incorporated Dispositif d'apport de medicaments en continu
JP2004521882A (ja) 2001-01-03 2004-07-22 ボシュ・アンド・ロム・インコーポレイテッド 組立式透過性プラグを備えた徐放薬剤送達装置
US6991808B2 (en) * 2001-01-26 2006-01-31 Bausch & Lomb Inc. Process for the production of sustained release drug delivery devices
US6981958B1 (en) * 2001-05-02 2006-01-03 Glaukos Corporation Implant with pressure sensor for glaucoma treatment
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
AU2002258754B2 (en) 2001-04-07 2006-08-17 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US6605108B2 (en) * 2001-04-13 2003-08-12 Eagle Vision, Inc. Monocanalicular stent
US6982090B2 (en) * 2001-05-10 2006-01-03 Gillespie Donald E More easily visualized punctum plug configurations
US7404825B2 (en) 2001-06-11 2008-07-29 Herrick Ii Robert S Implant capable of forming a differential image in an eye
FR2829019B3 (fr) 2001-08-31 2003-10-31 Alain Fouere Bouchons lacrymaux et methodes de mise en place de ces dispositifs
WO2003022242A1 (fr) 2001-09-11 2003-03-20 Smart Drug Systems Inc Preparation d'une composition pharmaceutique a liberation prolongee
US6729939B2 (en) * 2001-12-17 2004-05-04 Bausch & Lomb Incorporated Polishing method for intraocular lens
FR2834446B1 (fr) 2002-01-08 2004-02-13 Ioltechnologie Production Clou meatique a expansion
US7204995B2 (en) * 2002-01-31 2007-04-17 El-Sherif Dalia M Treatment and control of dry eye by use of biodegradable polymer capsules
US9301875B2 (en) 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
US20040147870A1 (en) * 2002-04-08 2004-07-29 Burns Thomas W. Glaucoma treatment kit
US6866563B2 (en) * 2002-06-27 2005-03-15 Bausch & Lomb Incorporated Apparatus and method for target polishing intraocular lenses
FR2841770B1 (fr) * 2002-07-05 2004-10-01 Ioltechnologie Production Clou meatique d'obturation d'un meat lacrymal
FR2844182B1 (fr) 2002-09-11 2004-12-03 Humanoptics Ag Bouchon d'obturation d'un canalicule lacrymal
US7169163B2 (en) * 2002-09-30 2007-01-30 Bruce Becker Transnasal method and catheter for lacrimal system
CA2513751C (fr) * 2003-01-24 2012-01-10 Control Delivery Systems, Inc. Dispositif et procede a liberation prolongee pour l'administration oculaire d'agents adrenergiques
US20050283109A1 (en) 2003-03-07 2005-12-22 Peyman Gholam A Method and apparatus for lacrimal canal obstruction
WO2004098565A2 (fr) * 2003-05-02 2004-11-18 Surmodics, Inc. Dispositif de relargage d'agent bioactif a liberation controlee
US7017580B2 (en) 2003-05-22 2006-03-28 Clarity Corporation Punctum plug system including a punctum plug and passive insertion tool therefor
US7204253B2 (en) 2003-05-22 2007-04-17 Clarity Corporation Punctum plug
US20040236343A1 (en) 2003-05-23 2004-11-25 Taylor Jon B. Insertion tool for ocular implant and method for using same
JP4104137B2 (ja) 2003-05-30 2008-06-18 有限会社エム・エル・シー 涙点プラグ
JP4339635B2 (ja) * 2003-06-12 2009-10-07 有限会社エム・エル・シー 涙点プラグ
US6994684B2 (en) * 2003-06-16 2006-02-07 Alphamed Inc. Punctum plugs having fluid collecting recesses and methods of punctal occlusion
US20040265356A1 (en) 2003-06-30 2004-12-30 Bausch & Lomb Incorporated Drug delivery device
JP4280128B2 (ja) 2003-08-19 2009-06-17 有限会社エム・エル・シー 涙点プラグ
JP2005110765A (ja) 2003-10-03 2005-04-28 M L C:Kk 涙点プラグセット
JP2005110930A (ja) 2003-10-07 2005-04-28 M L C:Kk 涙点プラグセット
US20050095269A1 (en) * 2003-11-04 2005-05-05 Ainpour Parviz R. Gel plug for blockage of the canaliculus
US20050220882A1 (en) * 2004-03-04 2005-10-06 Wilson Pritchard Materials for medical implants and occlusive devices
US20050197614A1 (en) * 2004-03-04 2005-09-08 Wilson Pritchard Occlusive biomedical devices, punctum plugs, and methods of use thereof
US20050232972A1 (en) * 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
JP2004202276A (ja) 2004-04-16 2004-07-22 M L C:Kk 涙道再建用挿管器具
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
JP2005312835A (ja) 2004-04-30 2005-11-10 M L C:Kk 糸で補強した涙道ステント
JP4644438B2 (ja) 2004-05-11 2011-03-02 有限会社エム・エル・シー ツバつき涙道ステント
JP4510511B2 (ja) 2004-05-18 2010-07-28 有限会社エム・エル・シー ツバを円盤で補強した涙道ステント及び涙道プラグ
DK1765454T3 (en) 2004-07-02 2016-05-02 Mati Therapeutics Inc Device for submission of treatment medium to eye
US7117870B2 (en) * 2004-07-26 2006-10-10 Clarity Corporation Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
US20060020253A1 (en) * 2004-07-26 2006-01-26 Prescott Anthony D Implantable device having reservoir with controlled release of medication and method of manufacturing the same
WO2006031658A2 (fr) 2004-09-10 2006-03-23 Allergan, Inc. Inserts therapeutiques pour canal lacrymal et methodes connexes
US20060074370A1 (en) * 2004-09-24 2006-04-06 Medennium, Inc. Ocular occluder and method of insertion
US20060110429A1 (en) 2004-11-24 2006-05-25 Therakine Corporation Implant for intraocular drug delivery
US20060233858A1 (en) 2005-03-08 2006-10-19 Allergan, Inc. Systems and methods providing targeted intraocular drug delivery
US7862532B2 (en) * 2005-10-07 2011-01-04 Delta Life Sciences, Inc. Punctum plugs having insertion guides and strengthening beams
US20070132125A1 (en) * 2005-12-08 2007-06-14 Bausch & Lomb Incorporated Use of a super-cooled fluid in lens processing
JP4078371B2 (ja) 2006-01-27 2008-04-23 章弘 小栗 涙点プラグ
EP2004172B1 (fr) 2006-03-31 2019-03-13 Mati Therapeutics Inc. Structures d'administration de médicaments et compositions utilisées dans le système nasolacrymal
US9474645B2 (en) 2006-06-21 2016-10-25 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
US20080045911A1 (en) * 2006-06-21 2008-02-21 Borgia Maureen J Punctal plugs for the delivery of active agents
US9173773B2 (en) * 2006-06-21 2015-11-03 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
FR2908042B1 (fr) * 2006-11-08 2009-06-05 Bruno Fayet Ensemble d'intubation monocanaliculonasal et/ou monocanaliculaire,notamment pour l'imperforation lacrymonasale.
UY30883A1 (es) * 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
CA2698508C (fr) * 2007-09-07 2017-06-06 Alan R. Rapacki Implants lacrymaux et procedes associes
CN102670352A (zh) * 2007-09-07 2012-09-19 Qlt股份有限公司 用于泪腺植入物的插入和抽出工具
AU2008300013A1 (en) * 2007-09-07 2009-03-19 Qlt Inc. Drug cores for sustained release of therapeutic agents
CN102123713A (zh) 2008-05-09 2011-07-13 Qlt栓塞输送公司 治疗青光眼和眼高血压的活性剂的持续释放递送
WO2009145755A1 (fr) 2008-05-30 2009-12-03 Qlt Plug Delivery, Inc Articles implantables traités en surface et procédés associés
AU2010206610A1 (en) * 2009-01-23 2011-08-11 Qlt Inc. Sustained released delivery of one or more agents
KR20110132369A (ko) 2009-02-23 2011-12-07 큐엘티 인코포레이티드 눈물 임플란트 및 관련 방법

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US8333726B2 (en) 2012-12-18
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US11951038B2 (en) 2024-04-09
CA2698508A1 (fr) 2009-03-12
US9763824B2 (en) 2017-09-19
BRPI0817082A2 (pt) 2015-03-31
US20120318281A1 (en) 2012-12-20
EP2865361B1 (fr) 2019-05-22
US20200030144A1 (en) 2020-01-30
NZ583861A (en) 2012-08-31
AU2008296872A1 (en) 2009-03-12
TW200924725A (en) 2009-06-16
EP2865361A1 (fr) 2015-04-29
US20180000642A1 (en) 2018-01-04
KR20100050566A (ko) 2010-05-13
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JP2010537775A (ja) 2010-12-09
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JP5524841B2 (ja) 2014-06-18
US20140180253A1 (en) 2014-06-26
EP2205191B1 (fr) 2014-11-12
US9445944B2 (en) 2016-09-20
EP2205191A1 (fr) 2010-07-14
US20160361199A1 (en) 2016-12-15
DK2205191T3 (en) 2014-12-08
US20090104248A1 (en) 2009-04-23
JP2014193367A (ja) 2014-10-09
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US8702643B2 (en) 2014-04-22
US10434009B2 (en) 2019-10-08
WO2009032328A1 (fr) 2009-03-12

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