CA2703807C - Composites hydrogels a gelification thermique inversee presentant une stabilite accrue - Google Patents

Composites hydrogels a gelification thermique inversee presentant une stabilite accrue Download PDF

Info

Publication number
CA2703807C
CA2703807C CA2703807A CA2703807A CA2703807C CA 2703807 C CA2703807 C CA 2703807C CA 2703807 A CA2703807 A CA 2703807A CA 2703807 A CA2703807 A CA 2703807A CA 2703807 C CA2703807 C CA 2703807C
Authority
CA
Canada
Prior art keywords
hydrogel
group
hamc
particles
hyaluronan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2703807A
Other languages
English (en)
Other versions
CA2703807A1 (fr
Inventor
Molly S. Shoichet
Catherine E. Kang
M. Douglas Baumann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Toronto
Original Assignee
University of Toronto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Toronto filed Critical University of Toronto
Priority to CA2703807A priority Critical patent/CA2703807C/fr
Publication of CA2703807A1 publication Critical patent/CA2703807A1/fr
Application granted granted Critical
Publication of CA2703807C publication Critical patent/CA2703807C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/262—Cellulose; Derivatives thereof, e.g. ethers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
    • C08J2301/08—Cellulose derivatives
    • C08J2301/26—Cellulose ethers
    • C08J2301/28—Alkyl ethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention porte sur un hydrogel composite comprenant un mélange dune solution aqueuse dun polysaccharide anionique ou dun dérivé de celui-ci, comme du hyaluronane (aussi communément appelé de lacide hyaluronique) ou un dérivé de celui-ci, et dune solution de méthylcellulose ou autre dérivé de cellulose soluble dans leau de celui-ci, comportant des particules polymères dispersées, comme des particules hydrophobes polymères dans celui-ci sélectionnées à partir de microparticules et de nanoparticules, et dans lequel la stabilité de lhydrogel est améliorée par rapport à la stabilité de lhydrogel seul. Les particules polymères peuvent contenir au moins un agent thérapeutique, auquel cas chaque agent thérapeutique présente une vitesse de libération soutenue qui peut être accordée ou modifiée en sélectionnant la composition polymère appropriée de microparticules ou de nanoparticules. Le composite peut être injectable et, en labsence dun agent thérapeutique, être utilisé en tant quagent de gonflement à des fins de chirurgie reconstructrice et esthétique, ou il peut servir de plateforme pour ladministration dagents thérapeutiques.
CA2703807A 2010-05-12 2010-05-12 Composites hydrogels a gelification thermique inversee presentant une stabilite accrue Active CA2703807C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2703807A CA2703807C (fr) 2010-05-12 2010-05-12 Composites hydrogels a gelification thermique inversee presentant une stabilite accrue

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA2703807A CA2703807C (fr) 2010-05-12 2010-05-12 Composites hydrogels a gelification thermique inversee presentant une stabilite accrue

Publications (2)

Publication Number Publication Date
CA2703807A1 CA2703807A1 (fr) 2011-11-12
CA2703807C true CA2703807C (fr) 2017-10-24

Family

ID=44912984

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2703807A Active CA2703807C (fr) 2010-05-12 2010-05-12 Composites hydrogels a gelification thermique inversee presentant une stabilite accrue

Country Status (1)

Country Link
CA (1) CA2703807C (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150250203A1 (en) * 2012-01-26 2015-09-10 Wikifoods, Inc. Enclosing materials in natural transport systems
US9622506B2 (en) 2014-02-19 2017-04-18 Incredible Foods, Inc. Encapsulated soft food compositions and methods of making
US10321987B2 (en) 2014-04-23 2019-06-18 Medtronic, Inc. Paravalvular leak resistant prosthetic heart valve system
WO2016115532A1 (fr) * 2015-01-16 2016-07-21 Spineovations, Inc. Procédé de traitement de disque vertébral
US10561680B2 (en) 2015-02-26 2020-02-18 Fundació Institut D'investigació En Ciències De La Salut Germans Trias I Pujol Topical composition for the treatment of mucosal lesions
CN105330902A (zh) * 2015-11-20 2016-02-17 清华大学 一种透明质酸-甲基纤维素复合水凝胶及其制备和应用
CN105815757A (zh) * 2016-03-24 2016-08-03 李�杰 一种降低食物、食品、中药中重金属浸出毒性，提升食安、环保的稳定剂及其制备方法
WO2018017610A1 (fr) * 2016-07-18 2018-01-25 Tissuegen, Inc. Procédés et compositions pour maintenir la conformation et l'intégrité structurale de biomolécules
WO2018019881A1 (fr) 2016-07-27 2018-02-01 Fundació Institut D'investigació En Ciències De La Salut Germans Trias I Pujol Plateforme bioadhésive pour un traitement bioactif.
WO2018225060A1 (fr) 2017-06-04 2018-12-13 Technion Research & Development Foundation Limited Compositions de congélation inverse et utilisation de celles-ci
KR102649858B1 (ko) * 2019-05-03 2024-03-20 아이게이트 파마슈티칼스, 인코포레이티드 안질환의 치료를 위한 조성물 및 방법
EP4729574A2 (fr) 2019-05-17 2026-04-22 The Governing Council of the University of Toronto Composition d'hydrogel anesthésique local à libération prolongée
US12005621B2 (en) * 2019-05-17 2024-06-11 Canon Virginia, Inc. Manufacturing method and injection molding system
EP4072998A4 (fr) * 2019-12-20 2024-01-31 Veri Nano Inc. Composition de gel binaire nanostructuré et utilisation de celle-ci
CN112121032B (zh) * 2020-10-30 2022-11-01 山东华熙海御生物医药有限公司 一种皮肤护理用水凝胶贴及其制备方法
CN114042188B (zh) * 2021-08-31 2023-03-31 上海市第六人民医院 一种促进腱骨愈合的复合水凝胶及其制备方法和应用
CN113995891B (zh) * 2021-10-12 2023-11-24 重庆医科大学附属第一医院 一种自更新水合润滑载药水凝胶微球及其制备方法与应用
US12611313B2 (en) 2023-04-06 2026-04-28 33 Medical, Inc. Minimally invasive compliant devices for total lumbar disc replacement
KR20260021016A (ko) 2023-06-02 2026-02-12 33 메디칼, 인크. 추간판성 통증의 치료를 위한 조성물, 및 그의 제조 및 사용 방법

Also Published As

Publication number Publication date
CA2703807A1 (fr) 2011-11-12

Similar Documents

Publication Publication Date Title
US9205046B2 (en) Enhanced stability of inverse thermal gelling composite hydrogels
CA2703807C (fr) Composites hydrogels a gelification thermique inversee presentant une stabilite accrue
US7767656B2 (en) Blends of temperature sensitive and anionic polymers for drug delivery
Tortorella et al. Zein as a versatile biopolymer: different shapes for different biomedical applications
Baumann et al. An injectable drug delivery platform for sustained combination therapy
Sanjanwala et al. Polysaccharide-based hydrogels for drug delivery and wound management: a review
Noreen et al. Natural polysaccharide-based biodegradable polymeric platforms for transdermal drug delivery system: a critical analysis
Chaturvedi et al. Polymeric hydrogels for oral insulin delivery
ES2895947T3 (es) Composición y conjuntos para matrices de microgel pseudoplástico
Ruel-Gariepy et al. Characterization of thermosensitive chitosan gels for the sustained delivery of drugs
KR102385203B1 (ko) 골 형태 발생 단백질 및 폴리-l-락틱산 필러와 히알루론산 필러 결합체를 함유하는 서방성 주사제제 및 그 제조방법
Parhi et al. Applications of polysaccharides in topical and transdermal drug delivery: A recent update of literature
Midha et al. Microspheres: a recent update
Manna et al. Recent update on alginate based promising transdermal drug delivery systems
EP1891941A1 (fr) Formulations des gel aqueuses comprenant des microsphères
Farooq et al. Advancement in microsphere preparation using natural polymers and recent patents
CN101766584B (zh) 聚乙二醇/水溶性壳聚糖协同修饰的长循环可降解聚合物纳米微囊及其制备方法
Surya et al. PLGA–the smart polymer for drug delivery
Wang et al. Microsphere technologies
Vora et al. Injectable depot-forming hydrogels for long-acting drug delivery
Lopes et al. Application of chitosan based materials for drug delivery
Muthal et al. A brief overview of nanogel
Snežana et al. Polymeric matrix systems for drug delivery
Pathak et al. Polysaccharides for drug delivery
Cassano et al. Hydrogel based on hyaluronic acid

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150512

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 15TH ANNIV.) - SMALL

Year of fee payment: 15

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250318

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20250318

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250318

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 16TH ANNIV.) - SMALL

Year of fee payment: 16

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20260219

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20260219